ライフサイエンスコーパス: sumoylation

1 its a cross-talk between phosphorylation and SUMOylation.

2 pression, thus increasing the amount of Rac1 SUMOylation.

3 activity can regulate the extent of protein SUMOylation.

4 ations of PIASy for their ability to mediate SUMOylation.

5 d demonstrated that it can mediate effective SUMOylation.

6 nslationally modified by phosphorylation and sumoylation.

7 of topotecan as a novel inhibitor of global SUMOylation.

8 il segment and is predicted to disrupt STAT1 sumoylation.

9 er post-translational modifications, such as sumoylation.

10 ubiquitin-like modifier E3 ligase for FOXP2 sumoylation.

11 the graft endothelium due to increased GATA2 SUMOylation.

12 Ns largely prevent heat shock-triggered poly-SUMOylation.

13 eins results primarily from inhibition of de-SUMOylation.

14 nsights into the mechanism of PIASy-mediated SUMOylation.

15 istry also induces clustering independent of sumoylation.

16 anner, while GEI-17 undergoes extensive auto-sumoylation.

17 velopment of parasite-specific inhibitors of SUMOylation.

18 cruitment during SG disassembly and impaired SUMOylation.

19 i-methylation potentiates subsequent histone sumoylation.

20 bstitution (K1370R) in the M-domain disables SUMOylation.

21 They also show reduced level of MeCP2 SUMOylation.

22 ctin, its aggregation, and its regulation by SUMOylation.

23 fications of Zta include phosphorylation and sumoylation.

24 t, INDEHISCENT (CrIND in C. rubella), via de-SUMOylation.

25 evated in ALT+ cells due to MMS21 associated SUMOylation.

26 tability, SUMO/SIM affinity, and the rate of SUMOylation.

27 A and other FXR agonists due to enhanced FXR SUMOylation.

28 ith PML, and this interaction is enhanced by sumoylation.

29 iquitin-like modifier (SUMO1-3) conjugation (SUMOylation), a posttranslational modification, modulate

30 organelles, inhibition by posttranslational sumoylation, a hydrophobic barrier within the pore, and

31 Here, we show that SUMOylation, a posttranslational modification characteri

32 he first proteins reported to be modified by SUMOylation, a ubiquitin-like posttranslational modifica

33 are therefore consistent with the model that SUMOylation acts as a brake on GSIS, and we have identif

34 on-defective Rfa1 mutant suggested that Rfa1 sumoylation acts in parallel with the 9-1-1 checkpoint c

35 ponsive transcription factor OsbZIP23 for de-SUMOylation affecting its stability.

36 Several reports suggest histone sumoylation affects transcription negatively, but parado

37 In vitro studies indicated that Sf1 SUMOylation, although not directly influencing DNA bindi

38 As a consequence of CRMP2 loss of SUMOylation and binding to NaV1.7, the channel displays

39 s define a crucial repressor function of Sf1 SUMOylation and Dax1 in the physiological cessation of F

40 the consecutive ubiquitylation, methylation, sumoylation and deacetylation of histones, which maintai

41 ciferase (FLuc), to quantitatively image p53 sumoylation and desumoylation in cells and living mice.

42 rlying EE is mediated through enhanced MeCP2 SUMOylation and increased Wnt6 expression in these anima

43 Here, we have examined the function of Sf1 SUMOylation and its interaction with Dax1 on FAdE functi

44 ted deSUMOylation of MDC1 prevents excessive SUMOylation and its RNF4-VCP mediated clearance from DSB

45 njugating enzyme Ubc9, which induces protein sumoylation and may contribute to LMP1-mediated oncogene

46 findings highlight a novel mechanism whereby SUMOylation and phosphorylation of the viral cis-E3 liga

47 the Drosophila beta-arrestin 2, inhibits Smo sumoylation and prevents Smo accumulation through Krz re

48 and (iv) a PML II mutant lacking both lysine SUMOylation and SIM was not recognized by ICP0 for degra

49 In this Primer, we explain the process of SUMOylation and summarize how SUMOylation regulates a nu

50 Our findings indicate that sumoylation and SUMO binding are not essential for TDG-m

51 Histone H2B sumoylation and the Set3 HDAC coordinately suppress cryp

52 ly, EGF and oncogenic KRAS induce OTUB2 poly-SUMOylation and thereby activate YAP/TAZ.

53 Sumoylation and translocation are required for the AtBAG

54 ndent RNA polymerase 3D and induced enhanced sumoylation and ubiquitination of the 3D polymerase that

55 drastically increased IE2-SUMO affinity, IE2 SUMOylation, and cis-E3 activity of IE2.

56 ated by the post-translational modification, SUMOylation, and indeed SUMOylation has been proposed to

57 trate that Pol eta is targeted for multisite SUMOylation, and that collectively these SUMO modificati

58 related with an increase in cellular protein SUMOylation, and that inhibition of deSUMOylation reduce

59 ponse to insulin is not regulated by protein SUMOylation, and that SUMOylation does not therefore rep

60 nd repurposed small molecules that alter p53 sumoylation, and to preclinically evaluate candidate ant

61 lational control, including phosphorylation, SUMOylation, and ubiquitination.

62 t pathways depending on either mono- or poly-SUMOylation are largely missing.

63 njugating E2s, whereas residues critical for SUMOylation are not conserved.

64 Protein ubiquitination and SUMOylation are required for the maintenance of cellular

65 These data reinforce sumoylation as a key posttranslational regulatory modifi

66 Here, we identify SUMOylation as a major mechanism that counteracts ubiqui

67 s) revealed two SIMs in IE2, and a real-time SUMOylation assay indicated that the N-terminal SIM (IE2

68 Here, we show that FOXP1 SUMOylation at lysine 670 is required for recruiting the

69 , we summarise our emerging understanding of SUMOylation both as a distinct modification and as a coo

70 ogeneous and dynamic protein with attenuated SUMOylation both in vitro and in cells.

71 ified by the post-translational modification SUMOylation, but it is not known whether SUMOylation is

72 Conversely, increasing Drp1 SUMOylation by knocking down SENP3 reduces both Drp1 bin

73 Consistent with this, preventing Drp1 SUMOylation by mutating the SUMO acceptor sites enhances

74 We also provide evidence that inhibition of SUMOylation by topotecan is associated with reduced leve

75 In particular, phosphorylation and SUMOylation can distinctly regulate the activity of the

76 r important example of the role that protein SUMOylation can play in regulating key cellular processe

77 dependent manner that requires SUMOylated or SUMOylation-competent PML.

78 Third, DA-gated, activity-dependent SUMOylation contributed to a feedback mechanism that res

79 In summary, our findings suggest that SUMOylation could be a target to inhibit CSCs and ultima

80 SUMOylation-defective mHTT, Rhes C263S (cannot SUMOylate

81 Mice expressing a SUMOylation-defective mutant of LRH-1 (LRH-1 K289R mice)

82 Findings using a sumoylation-defective Rfa1 mutant suggested that Rfa1 su

83 -La(WT)) grow faster than cells expressing a sumoylation-deficient mutant La (GFP-La(SD)), suggesting

84 al cortex (X-zone) were detected in both the SUMOylation-deficient-Sf1(2KR/2KR) and Dax1 knockout mou

85 Through this sumoylation-dependent mechanism, intravascular pressure

86 SUMOylation depends on the sequential activities of E1 a

87 Disruption of the sumoylation/desumoylation equilibrium is associated with

88 mplex (HDAC) by H3K4 di-methylation, histone sumoylation directly recruits the Set3 complex to both p

89 t regulated by protein SUMOylation, and that SUMOylation does not therefore represent a viable therap

90 pon inflammation, endothelial SENP1-mediated SUMOylation drives GA by regulating the synergistic effe

91 human bacillary dysentery, switches off host sumoylation during epithelial cell infection in vitro an

92 o be poly-SUMOylated on lysine 233, and this SUMOylation enables it to bind YAP/TAZ.

93 st-translational modification of proteins or SUMOylation ensures normal cell function.

94 However, the participating SUMOylation enzymes are not fully characterized.

95 interacting motifs (SIMs) can translate the SUMOylation event into functional consequences.

96 Second, SUMOylation facilitates alpha-synuclein aggregation by b

97 in transfected cells confirmed absent STAT1 sumoylation for E705V, whereas it was present in wild-ty

98 SUMO1-ylation levels, manipulating cellular SUMOylation had no effect on insulin-responsive GLUT4 su

99 SUMOylation has also been shown to play a role in the pa

100 tional modification, SUMOylation, and indeed SUMOylation has been proposed to act as a 'brake' on ins

101 mediated phosphorylation, DNA damage-induced sumoylation has recently been shown to promote genotoxin

102 2 is observed at PML bodies, which are known SUMOylation hotspots.

103 spite this importance, little is known about SUMOylation in crop species.

104 As2O3 exposure increased MTHFD1 SUMOylation in cultured cells and in in vitro SUMOylatio

105 own that H3K9me3 deposition requires protein SUMOylation in different contexts, suggesting that the S

106 an important regulatory role for periplakin SUMOylation in dynamic reorganization and stability of k

107 igases, as essential for mitotic chromosomal SUMOylation in frog egg extracts and demonstrated that i

108 e, we investigate the role of SENP1-mediated SUMOylation in graft arteriosclerosis (GA), the major ca

109 , our data also demonstrate that the role of SUMOylation in GSIS is complex and may involve many subs

110 al communication, demonstrating evidence for sumoylation in regulating mammalian behaviors.

111 , our results demonstrate a pivotal role for SUMOylation in septin filament bundling and cell divisio

112 (Panulirus interruptus), focused on dynamic SUMOylation in the context of activity homeostasis.

113 erlying the up-regulation of alpha-synuclein SUMOylation in the disease.

114 Next, we discuss multiple roles of SUMOylation in the epigenetic control of transcription.

115 In addition, we evaluate the role of SUMOylation in the etiology of neurodegenerative disorde

116 el roles for Pif1, Rad52, and Siz1-dependent sumoylation in the spatial exclusion of telomerase from

117 ation with small ubiquitin-related modifier (SUMOylation) in Sox11, which suppresses Sox11's nuclear

118 P1, the major protease of post-translational SUMOylation, in cardiovascular disorders.

119 licated the post-translational modification, SUMOylation, in insulin signalling and insulin resistanc

120 of the SUMO E1 enzyme SAE2, thus leading to sumoylation inhibition.

121 this activity have been suggested including: SUMOylation inhibition; blocking formation of the E1-SUM

122 was reproduced by ginkolic acid, a specific SUMOylation inhibitor.

123 promising therapeutic approach by combining SUMOylation inhibitors and FXR agonists for liver fibros

124 Therapeutic coadministration of OCA and SUMOylation inhibitors drastically impedes liver fibrosi

125 SUMOylation inhibitors rescue FXR signaling and thereby

126 This activity requires the sumoylation-interacting motif within p150N, which is als

127 Protein SUMOylation is a dynamic post-translational modification

128 Sumoylation is a posttranslational reversible modificati

129 SUMOylation is a ubiquitin-related transient posttransla

130 prime SMT7 target and demonstrated that its SUMOylation is an important modulator of cell division i

131 Accordingly, SUMOylation is critical in maintaining cellular homeosta

132 Because increased protein sumoylation is detected in numerous cancers, we wanted t

133 When subunit SUMOylation is dysregulated, conductance densities media

134 We determined that CRMP2 SUMOylation is enhanced by prior phosphorylation by cycl

135 SUMOylation is essential for cell growth, division, and

136 Our data indicate that PPL SUMOylation is essential for the proper reorganization o

137 In conclusion, whereas SUMOylation is generally connected to different stress r

138 Regulation of ion channel SUMOylation is poorly understood.

139 offered via the selective control of global SUMOylation is readily apparent.

140 el non-canonical site (K1520) and that K1520 sumoylation is required for chromosome segregation but n

141 ural studies and in vitro biochemistry, that sumoylation is required for efficient TDG enzymatic turn

142 ion SUMOylation, but it is not known whether SUMOylation is required for function of the oocyte-speci

143 In particular, sumoylation is required for optimal checkpoint function,

144 We demonstrated that FOXP2 sumoylation is required for regulation of cerebellar mot

145 However, whether sumoylation is required for TDG activity in vivo has not

146 oocyte-specific transcription factors or if SUMOylation is required in oocytes during their developm

147 Together, these studies show that SUMOylation is required in the mammalian oocyte during f

148 FOXP1 SUMOylation is tightly controlled by neuronal activity,

149 reversible post-translational modification, SUMOylation, is widely conserved in the eukaryotic kingd

150 from specific substrates and how curtailing sumoylation levels can regulate transcription in this nu

151 this possibility by manipulation of cellular SUMOylation levels using multiple different tools, and a

152 calpains as powerful modulators of cellular sumoylation levels with potentially broad implications i

153 Hinokiflavone increases protein SUMOylation levels, both in in vitro splicing reactions

154 strate that manipulation of cellular protein SUMOylation levels, by overexpression of several differe

155 s biology and identify a third member of the sumoylation machinery that is manipulated by LMP1 during

156 ional mechanisms by which LMP1 modulates the sumoylation machinery.

157 xpression profile caused by reducing histone sumoylation matches well to the profile in cells lacking

158 ultured cells, consistent with the idea that SUMOylation may govern PIM1 substrate specificity under

159 ssion in cancers and suggest that inhibiting SUMOylation may improve current cancer therapeutic appro

160 her, our findings suggest that inhibition of SUMOylation may serve as a potential strategy to address

161 Finally, we discuss the possibility that SUMOylation may stimulate survival and neurogenesis of n

162 Finally, we tested the protective role of SUMOylation-mediated autophagy by expressing UBC9 in a m

163 Our findings indicate that a SUMOylation-mediated mechanism regulates nuclear localiz

164 n of recombination, potentially dependent on SUMOylation, Mer2 mediates global chromosome compaction

165 PTMs, such as phosphorylation, acetylation, SUMOylation, methylation, O-GlcNAcylation, ubiquitinatio

166 SUMOylation modifies the interactome, localization, acti

167 This sumoylation modifies transcriptional regulation by FOXP2

168 Furthermore, SUMOylation modulated the interaction of ErbB4 with chro

169 independent sites: K169, within a consensus SUMOylation motif (IK(169)DE(171)) in the active site of

170 The negatively charged amino acid-dependent sumoylation motif (NDSM) carries an additional stretch o

171 the first report of a mutation in the STAT1 sumoylation motif associated with clinical disease.

172 dues downstream of the consensus Psi-K-x-E/D sumoylation motif.

173 Protein SUMOylation, N-terminal acetylation, and phosphorylation

174 Inhibition of SUMOylation not only resulted in reduced EZH2 mRNA and p

175 We show that telomere-binding protein sumoylation nucleates APB condensation via interactions

176 ndings indicated that Hsp27-Ubc9 targets the SUMOylation of a transitional, non-native conformation o

177 Our observations suggest that SUMOylation of alpha-synuclein by PIAS2 promotes alpha-s

178 We report that PIAS2 promotes SUMOylation of alpha-synuclein, leading to a decrease in

179 In this study, we show that SUMOylation of BZR1, a key transcription factor of BR si

180 O-protease activity, resulting in reduced de-sumoylation of cellular proteins, which contributes to t

181 Loss of SENP6 results in hyper-SUMOylation of CENP-C and CENP-I but not CENP-A itself.

182 -actin interaction might be regulated by the SUMOylation of CPEB3, based on bioinformatic searches fo

183 SUMOylation of DAF-16 modulates mitochondrial homeostasi

184 Furthermore, we demonstrated that sumoylation of Foxp1 affects neuronal differentiation an

185 ht into Foxp1 function by demonstrating that sumoylation of Foxp1 during embryonic brain development

186 ylatable FOXP1-K670R mutant, indicating that SUMOylation of FOXP1 is essential for regulation of prop

187 hese results suggest that activity-dependent SUMOylation of FOXP1 may be an important mediator of ear

188 We identified sumoylation of FOXP2 at K674 (K673 in mice) in the cereb

189 We characterized sumoylation of FOXP2 biochemically and analyzed the regi

190 Sumoylation of FOXP2 in neonatal mouse cerebellum regula

191 nd analyzed the region-specific function and sumoylation of FOXP2 in the developing mouse cerebellum.

192 lly, BCA2 serves as an E3 SUMO ligase in the SUMOylation of IkappaBalpha, which in turn enhances the

193 ns.SIGNIFICANCE STATEMENT Post-translational SUMOylation of ion channel subunits controls their inter

194 SUMOylation of KCNQ1 is KCNE1 dependent and determines t

195 echanistic insights into the complex role of SUMOylation of key BER proteins during active DNA demeth

196 is study, we address the question of whether sumoylation of La contributes to cell proliferation of H

197 our study support a novel mechanism whereby sumoylation of La promotes cell proliferation by avertin

198 Sumoylation of La regulates not only the trafficking of

199 These findings suggest that compromised SUMOylation of LRH-1 promotes the development of NAFLD u

200 We also provide evidence that Shh stimulates sumoylation of mammalian Smo (mSmo) and that sumoylation

201 onger capable of mediating E1B-55K-dependent SUMOylation of p53, inhibition of p53-mediated transacti

202 and cytoskeletal architecture induce hyper--SUMOylation of periplakin.

203 ich possess only PIF3(K13R), indicating that SUMOylation of PIF3 also alters photomorphogenesis via t

204 eratin IF network results in a similar hyper-SUMOylation of PPL.

205 proteins, hardly anything is known about the SUMOylation of proteins targeted to membrane-enclosed or

206 domain to upregulate the phosphorylation and SUMOylation of PTEN and then correspondingly inactivated

207 1), which in turn inhibits SENP1-mediated de-SUMOylation of Rac1 to activate Rac1.

208 The SUMOylation of ROS1 is reduced in siz1 mutant plants.

209 Our results suggest that SIZ1-mediated SUMOylation of ROS1 promotes its stability and positivel

210 sically interacts with ROS1 and mediates the SUMOylation of ROS1.

211 nclusion, our data show that TORC1-dependent sumoylation of Rpc82 bolsters the transcriptional capaci

212 TORC1-dependent sumoylation of Rpc82 in particular is required for robus

213 Mechanistically, sumoylation of Rpc82 is important for assembly of the RN

214 LMP1 expression corresponded with increased sumoylation of SENP2 at K48 and K447 in a CTAR-dependent

215 Interestingly, independent of LMP1-induced sumoylation of SENP2, LMP1 also decreased SENP2 activity

216 Second, Smc5/6-dependent SUMOylation of Sgs1 and Top3 is required for the efficie

217 ts demonstrate a function of RanBP2-mediated SUMOylation of SHP in maintaining BA homoeostasis and pr

218 The time-course for SUMOylation of single NaV1.2 channels at the cell surfac

219 Sumoylation of Smo in turn recruits a deubiquitinase UBP

220 the NDSM and renders a selective decrease in sumoylation of substrates with the NDSM motif.

221 s as a brake on GSIS, and we have identified SUMOylation of syntaxin 1 A as a potential component of

222 function as an intramolecular E3 ligase for SUMOylation of the cell cycle regulatory domain 1 (CRD1)

223 To address this question, we examined the sumoylation of the first responder to DNA lesions, the s

224 We recently reported that SUMOylation of the GR at position K293 in humans (K310 i

225 II, which activates the checkpoint, leads to SUMOylation of the Topo II C-terminal domain (CTD).

226 y licensed by ZATTZNF451 SUMO2 E3 ligase and SUMOylation of TOP2.

227 These findings establish SUMOylation of ZIKV NS5 as critical in the regulation of

228 Mono- and poly-SUMOylations of target proteins provide docking sites fo

229 ge to NPCs and the inhibitory effect of poly-SUMOylation on HR-mediated DNA synthesis.

230 Consistent with the effects of SUMOylation on other classes of nuclear receptors, dexam

231 Thus, SUMOylation partially stabilizes TOC159 against UPS-depe

232 proteasome-deficient cells, suggesting that SUMOylation participates in cellular protein quality con

233 ssion of several different components of the SUMOylation pathway, have varied and complex effects on

234 e post-translational modifications including SUMOylation, phosphorylation, persulfidation and acetyla

235 Mounting evidence indicates that SUMOylation plays a crucial role in maintaining and regu

236 cannot totally exclude the possibility that SUMOylation plays a role in the insulin signalling pathw

237 This process of 'SUMOylation' plays essential roles in plant and animal d

238 Maize SUMOylation primarily impacts nuclear substrates, is str

239 e, we investigate the role of E4-ORF3 in the sumoylation process by using transcription intermediary

240 second mechanism by which LMP1 dysregulates sumoylation processes and adds EBV-associated lymphomas

241 logy, but they involve impairment in dynamic SUMOylation processes associated with synaptic plasticit

242 Mechanistically, SUMOylation promoted ubiquitin-mediated degradation of P

243 sumoylation of mammalian Smo (mSmo) and that sumoylation promotes ciliary localization of mSmo and Sh

244 Therefore, inhibitors of alpha-synuclein SUMOylation provide a strategy to reduce alpha-synuclein

245 fied F508del nucleotide-binding domain 1 and SUMOylation reaction components.

246 UMOylation in cultured cells and in in vitro SUMOylation reactions, and increased MTHFD1 ubiquitinati

247 SUMOylation regulated EZH2 expression by enhancing bindi

248 the process of SUMOylation and summarize how SUMOylation regulates a number of signal transduction pa

249 We further demonstrate that SUMOylation regulates SG disassembly and SG formation.

250 and complex effects on GSIS, indicating that SUMOylation regulates this process at multiple stages.

251 AC-based proteomics to survey pan-viral host SUMOylation responses, creating a resource of almost 600

252 g enzyme SAE2 or pharmacologic inhibition of SUMOylation resulted in decreased levels of EZH2 mRNA an

253 We further determined that sumoylation selectively promotes interactions with synta

254 E171 (within the consensus motif) abolished SUMOylation, significantly increased the half-life of PI

255 Additionally, the K252 SUMOylation site and NS5 nuclear localization were requi

256 Mutation of the SUMOylation site compromised neither ErbB4-induced phosp

257 he TOC159 GTPase domain and a SUMO3 covalent SUMOylation site in the membrane domain.

258 nterestingly, 1 mutation damaged a predicted sumoylation site, and another disrupted a predicted CK1

259 ased on bioinformatic searches for potential SUMOylation sites as well as SUMO interacting motifs in

260 development, it is important to identify the sumoylation sites in proteins.

261 We delineated the sumoylation sites of the RPA large subunit, Rfa1 on the

262 Proteome-wide detection of SUMOylation sites on target proteins typically requires

263 Moreover, mutation of the conserved CTD SUMOylation sites perturbs Aurora B recruitment and chec

264 We then map SUMOylation sites to the C-terminal domain of septins be

265 yl-cysteine, pyrrolidone-carboxylic-acid and SUMOylation sites.

266 SUMOylation (small ubiquitin-like modifier) in the DNA d

267 SUMOylation stabilizes BZR1 in the nucleus by inhibiting

268 We further show that Hh-induced-sumoylation stabilizes Smo, whereas desumoylation by Ulp

269 This basal state is affected by the SUMOylation state of CPEB3.

270 g in utero electroporation to manipulate the sumoylation state of FOXP2 as well as Foxp2 expression l

271 la promotes its own invasion by altering the sumoylation state of RhoGDIalpha, a master negative regu

272 rovide a mechanistic explanation for how the SUMOylation status of Drp1 acts as a key switch in cell

273 Our findings thus suggest that sumoylation stimulates COP1 activity within NBs.

274 on of SUMOylation that can be applied to any SUMOylation substrate and SUMO isoform.

275 Here we describe development of an in vitro SUMOylation system using Chlamydomonas components and us

276 mal consensus criteria for the validation of SUMOylation that can be applied to any SUMOylation subst

277 ered a novel mechanism for Smo activation by sumoylation that is regulated by Hh and Smo interacting

278 ome-wide, site-level detection of endogenous SUMOylation that uses alpha-lytic protease, WaLP.

279 Among the proteins involved in SUMOylation, the protein inhibitor of activated STAT (PI

280 B4 kinase activity was not necessary for the SUMOylation, the SUMOylated ErbB4 ICD was tyrosine phosp

281 ating cognition and the mechanisms that link SUMOylation to cognitive processes remain unknown.

282 a novel, rapid feedback mechanism that uses SUMOylation to continuously adjust ionic current densiti

283 5 nm dopamine (DA) gated activity-dependent SUMOylation to permit and prevent activity-dependent reg

284 nstrated that neuronal activity can regulate SUMOylation to reconfigure ionic current densities over

285 n Arabidopsis (Arabidopsis thaliana) linking SUMOylation to stress tolerance via its modification of

286 , we have assessed the contribution of LRH-1 SUMOylation to the development of nonalcoholic fatty liv

287 ase RNF4 contains multiple SIMs and connects SUMOylation to the ubiquitin pathway.

288 borates with Ubc9, the E2 enzyme for protein SUMOylation, to selectively degrade F508del CFTR via the

289 l degradation of retinoid receptors involves sumoylation, ubiquitination and recognition by the valos

290 t the N-terminal SIM (IE2-SIM1) enhances IE2 SUMOylation up to 4-fold.

291 er demonstrate that inhibition of syntaxin1A SUMOylation, via a knockdown-rescue strategy, greatly en

292 Dynamic SUMOylation was necessary to maintain specific aspects o

293 ibit poly-SUMO chain formation, whereas mono-SUMOylation was not impaired.

294 In contrast, SUMOylation was required for nuclear accumulation of the

295 To address how PIASy catalyzes SUMOylation, we examined various truncations of PIASy fo

296 egrity of nascent strands and generates poly-SUMOylation which promote relocation to NPCs but impede

297 Cardiolipin induces PPARgamma SUMOylation, which causes recruitment of a repressive NC

298 istone-H2B ubiquitylation stimulates histone sumoylation, which in turn appears to inhibit nucleosome

299 estrogen E2 program appears to depend on GR SUMOylation, which leads to stable trans-recruitment of

300 point to tissue/cell-specific functions for SUMOylation, with potentially significant roles during e