ライフサイエンスコーパス: sunburn

1 relatives were particularly likely to report sunburn.

2 e solar spectrum that does not readily cause sunburn.

3 ude, history of phototherapy, and history of sunburn.

4 ile tissue repair utilizing a mouse model of sunburn.

5 lla nor sunscreen alone completely prevented sunburn.

6 biopsy specimens 48 hours after experimental sunburn.

7 in indoor tanning had experienced at least 1 sunburn.

8 and inability to tan than susceptibility to sunburn.

9 f hyperthermia, hypothermia, dehydration, or sunburn.

10 roderma pigmentosum were more susceptible to sunburn.

11 ing effects on the skin beyond the immediate sunburn.

12 y 4% per year of age and by 6% per number of sunburns.

13 rns: OR = 2.0 (95% CI 1.0-4.0) for 4+ severe sunburns.

14 3.1 (95% CI 1.7-5.3) for 4+ severe childhood sunburns.

15 higher lifetime number of severe/blistering sunburns.

16 .007) and those with a history of blistering sunburn (12 of 12 [100%] vs 0; P = .005) were more likel

17 75% of the patients and was characterized by sunburn after brief sun exposure.

18 d the association between indoor tanning and sunburn among US high school students.

19 Sunburn, an acute inflammatory response to UVB-induced c

20 Short-wavelength UVB radiation induces sunburn and is a potent immunomodulator, yet longer-wave

21 Sunscreens prevent sunburn and may also prevent skin cancer by protecting f

22 ular surface disease, and, in some patients, sunburn and neurological degeneration.

23 They also suggest sunburn and NMSC etiologies are immunologically linked.

24 udies have assessed the relationship between sunburn and risk of different skin cancers (melanoma, sq

25 Because sunburn and skin cancer are causally related, we investi

26 y of individuals with blonde and red hair to sunburn and skin cancer.

27 d, and childhood UVR exposure and history of sunburn and sunlamp use.

28 reduce the prevalence of indoor tanning and sunburn and thus prevent future cases of skin cancer.

29 ians to assess a person's risk of developing sunburn and, by extension, the need for sun protection t

30 s of sun behavior in the US reveal extensive sunburning and use of tanning beds in adolescents and ad

31 previous UVR exposure (represented by prior sunburns and signs of actinic skin damage identified by

32 Sunscreen users reported significantly more sunburns and sunbathing vacations and were more likely t

33 n (ie, sun-safety practices and the risk for sunburn) and alerted users to apply or to reapply sunscr

34 ection (ie, protection practices and risk of sunburn) and alerts (to apply or reapply sunscreen and g

35 ma, higher number of nevi, history of severe sunburn, and light hair color were each associated with

36 ide critical protection against skin cancer, sunburn, and photoaging, a genome-wide perspective of ge

37 olet B light (290 to 320 nm) associated with sunburn, and ultraviolet AII light (320 to 340 nm), and

38 ling for age, sex, lifetime number of severe sunburns, and skin type [BCC: odds ratio (OR), 0.7; 95%

39 r; green, hazel, or blue eyes; a tendency to sunburn; and north European ancestry.

40 = 2.0 (95% CI 1.2-3.1) for 4+ severe teenage sunburns; and OR = 3.1 (95% CI 1.7-5.3) for 4+ severe ch

41 causally related, we investigated UV-induced sunburn apoptosis and erythema in mouse skin as a functi

42 Interestingly, we observed that sunburn apoptosis, inflammatory cytokine induction, and

43 53, which is known to control the process of sunburn apoptosis.

44 adiation on the time course for induction of sunburn (apoptotic) cells and expression of proteins kno

45 wear long-sleeved shirts but less likely to sunburn, apply sunscreen, tan indoors, and receive TBSE

46 These data suggest that childhood sunburns are important in the etiology of nevi.

47 of extremity moles, higher susceptibility to sunburn as a child/adolescent, and higher lifetime numbe

48 that UVA makes a greater contribution toward sunburn at temperate latitudes than under the laboratory

49 ancer risk associated with history of severe sunburns at different body sites (face/arms, trunk, and

50 tle is known about the association of severe sunburns at different body sites with skin cancer risk.

51 not risk of SCC and BCC, when compared with sunburns at other body sites (face/arms and lower limbs)

52 tionnaires, 169 768 received questions about sunburns at study inclusion.

53 ors often exhibited a concurrent tendency to sunburn, avoid sun protection, and avoid skin cancer scr

54 ors often exhibited a concurrent tendency to sunburn, avoid sun protection, and avoid skin cancer scr

55 llment were also independent predictors, but sunburns, baseline sun exposure, and other sun-protectiv

56 ed, the absence of sunscreen 'caused' Suzy's sunburn, but the sun 'burned' her skin.

57 Although sunburn can produce severe uncontrollable itching, the u

58 ls after ultraviolet radiation (UVR) through sunburn cell (apoptotic keratinocyte) formation is thoug

59 n epidermal cyclobutane pyrimidine dimers or sunburn cell (SBC) formation were observed between pigme

60 0-320 nm) exposure, thus implicating CHOP in sunburn cell (SBC) formation.

61 We found that the inhibition of UVR-induced sunburn cell formation in PKCepsilon transgenic mice may

62 Sunburn cell formation requires the Trp53 tumor suppress

63 Sunburn cell formation was found to be dependent on Fas

64 nduced apoptosis in vitro and in vivo (i.e., sunburn cell formation), whereas it did not affect Fas-i

65 nificant decrease in UV-induced hypertrophy, sunburn cell formation, and apoptosis when the mice were

66 tely 8-fold as measured by both erythema and sunburn cell formation.

67 Xpa-/- mice were 7-10-fold more sensitive to sunburn cell induction than wild-type mice, indicating t

68 dependence was seen for epidermal thickness, sunburn cell numbers, dermal thickness, glycosaminoglyca

69 neum thickening, viable epidermal thickening sunburn cell production), as well as dermal alterations

70 tal effects of acute UV irradiation, namely, sunburn cell/apoptosis, inflammation, and a hyperprolife

71 Their skin was analyzed for the presence of sunburn cells (apoptotic keratinocytes) and for Fas and

72 4/Bcl-2 mice developed about 5-10-fold fewer sunburn cells (ie, apoptotic keratinocytes) in the basal

73 hanced the UVB-induced increase in apoptotic sunburn cells 6 h later by 127% and 563%, respectively.

74 owed a dose-dependent increase in numbers of sunburn cells and TUNEL-positive cells although their pr

75 in the numbers of morphologically identified sunburn cells and TUNEL-positive cells was detected as e

76 anced the UVB-induced increases in apoptotic sunburn cells at 6 h by 214% and 467%, respectively, and

77 The UVB-induced increase in apoptotic sunburn cells in Bax(-/-) mice at 6 h after exposure to

78 ddition to C1q, we detected C3 deposition on sunburn cells in both wild-type and C1q-deficient mice,

79 The UVB-induced increase in apoptotic sunburn cells in p53(-/-) mice at 6-10 h after exposure

80 the inhibition of UVR-induced appearance of sunburn cells in PKCepsilon transgenic mice.

81 lated the formation of UVB-induced apoptotic sunburn cells in the epidermis by 96, 120, and 376%, res

82 p21(WAF1/CIP1)-positive cells, and apoptotic sunburn cells in the epidermis.

83 r the first time that C1q is also present on sunburn cells in vivo.

84 p21(WAF1/CIP1)-positive cells, and apoptotic sunburn cells may play a role in the inhibitory effects

85 three strains, as was apoptosis measured as sunburn cells or as keratinocytes containing active casp

86 o, no difference in the rate of clearance of sunburn cells was found in C1q-deficient mice from three

87 of UVB-induced DNA damage and the numbers of sunburn cells were not significantly different in the EG

88 tosis of ultraviolet-damaged keratinocytes ("sunburn cells").

89 imidone dimer, (2) reduced the appearance of sunburn cells, (3) induced extensive hyperplasia and inc

90 ASA similarly reduced UVB-induced sunburn cells, 8-oxoguanine, and cyclobutane pyrimidine

91 orter wavelengths (320-345 nm) elicited more sunburn cells, although these differences did not reach

92 reases in morphologically distinct apoptotic sunburn cells, and decreases in the number of epidermal

93 by gavage exhibited less inflammation, fewer sunburn cells, and reduced 8-oxoguanine lesions than ski

94 d by the formation of CPDs and the number of sunburn cells, was resolved more rapidly in the skin of

95 cell carcinomas and suppressed formation of sunburn cells, which are DNA-damaged keratinocytes under

96 ng by flow cytometry, and/or the presence of sunburn cells.

97 reduces UV-induced apoptotic keratinocytes, "sunburn cells." Consequently, Gadd45a-null mice are more

98 evi: OR = 1.9 (95% CI 0.9-3.9) for 3+ severe sunburns compared with none in the last 5 years; OR = 2.

99 orbic acid has been shown to protect against sunburn, delay the onset of skin tumors, and reduce ultr

100 er, the innate immune mechanisms controlling sunburn development are not considered relevant in NMSC

101 phic characteristics of patients who receive sunburn diagnoses.

102 of chronically irradiated skin to an acute "sunburn dose" of ultraviolet-B also produced significant

103 Sunburn due to cutaneous sensitivity to sunlight exposur

104 7.9%-86.0%) of indoor tanners had at least 1 sunburn during the preceding year compared with 53.7% (9

105 t, hours spent in the summer sun, blistering sunburns during adolescence, and moles, all increased me

106 on whether ultraviolet radiation, including sunburns, early childhood and adolescent sun exposure, a

107 In humans, sunburn enhances epidermal expression of TRPV4 and endot

108 traviolet radiation dose-response curves for sunburn/erythema and suppression of the contact hypersen

109 Clinical sunburn evaluation of each individual for all exposed bo

110 such as tanning ability and number of severe sunburns experienced throughout life.

111 rradiation, equivalent to a mild to moderate sunburn exposure for intact skin.

112 density, hair color, tanning ability, adult sunburns, family history, other cancer prior to baseline

113 This cohort study showed that high sunburn frequency throughout life was associated with in

114 Individuals with a history of severe sunburns had an increased risk of nevi: OR = 1.9 (95% CI

115 omen who experienced at least one blistering sunburn (hazard ratio = 2.17, 95% confidence interval =

116 novel insights to the existing literature on sunburn history and skin cancer risk.

117 relative risk of SCC associated with painful sunburn history was significantly higher for homozygous

118 VR exposures during childhood and adulthood, sunburn history, and sunlamp use, but we found no signif

119 type, freckle density, age, hair color, and sunburn history.

120 mily history), sun exposure-related factors (sunburns, history of skin cancers and actinic lesions),

121 r from 2009 to 2015 and its association with sunburn in 2015.

122 This cross-sectional study examines sunburn in claims data as well as the clinical settings

123 g epidemiological data implicating childhood sunburn in CMM.

124 tes, a single dose of UVR that mimicked mild sunburn in humans induced clonal expansion of the melano

125 In 2015, indoor tanning was associated with sunburn in the adjusted model: 82.3% (95% CI, 77.9%-86.0

126 Thirty-one percent of relatives reported sunburn in the previous summer, compared with 41% of con

127 Furthermore, sunburns in childhood are especially important for subse

128 ion of XRCC1 genotype and lifetime number of sunburns in SCC [likelihood ratio test (2 d.f.), P < 0.0

129 dday sun (days and hours), and the number of sunburns in the last 3 months.

130 e was no significant difference in number of sunburns in the past 3 months (mean, 0.60 in the treatme

131 and minutes) in the midday sun and number of sunburns in the past 3 months were collected.

132 y, as well as more likely to report multiple sunburns in the past year (aPR, 1.21; 95% CI, 1.00-1.45)

133 After adjustment for sex, age, sunburns in the past, and signs of actinic skin damage,

134 ed by overexposure to UVB irradiation (i.e., sunburn) in the mouse plantar skin.

135 RPV4 as a therapeutic target for UVB-induced sunburn, in particular pain.

136 There was a total of 142 sunburn incidences in the umbrella group vs 17 in the su

137 cholecalciferol) one hour after experimental sunburn induced by an erythemogenic dose of UVR.

138 Sunburn is a commonly occurring acute inflammatory proce

139 ed melanomagenesis and strongly suggest that sunburn is a highly significant risk factor, particularl

140 Sunburn is characterized by overlapping sequential profi

141 e of a lack of experimental animal models of sunburn itch.

142 At sunburn levels of UV exposure, every cell would have a h

143 mmon mucocutaneous findings were generalized sunburn-like erythema without scale, conjunctivitis, and

144 f patients presenting with acute generalized sunburn-like erythema, conjunctivitis, systemic symptoms

145 vity of skin types I/II for a given level of sunburn may play a role in their greater sensitivity to

146 elp reduce the risk for skin cancer, prevent sunburns, mitigate photoaging, and treat photosensitive

147 Additionally, lifetime number of severe sunburns modestly altered the effects of the CTLA4 haplo

148 Sunburn on all exposed body sites 22 to 24 hours after s

149 Sunburn on the trunk appeared to be more closely associa

150 xperimental evidence regarding the effect of sunburns on cutaneous malignant melanoma and the possibl

151 I: 1.00, 1.28; P = 0.051), getting a painful sunburn once (RR = 1.24, 95% CI: 0.98, 1.57; P = 0.073)

152 e beneficial in treating victims from severe sunburn or exposure to other chemical agents known to tr

153 r activities, and number of children who had sunburn or skin irritation.

154 .05; 95% CI, 1.03-1.07; P < .001), number of sunburns (OR, 1.05; 95% CI, 1.00-1.10; P = .047), and hi

155 ; 95% CI, 1.02-1.07; P < .001) and number of sunburns (OR, 1.06; 95% CI, 1.00-1.11; P = .04) were sta

156 % CI, 2.79-11.99]), greater number of severe sunburns (OR, 2.59 [95% CI, 1.31-5.10]), light eye color

157 ction reduces intermediate outcomes (such as sunburn) or skin cancer.

158 atitude, history of phototherapy, history of sunburn, or occupational exposure were used as measures

159 ly of sun sensitivity and teenage and recent sunburns: OR = 2.0 (95% CI 1.0-4.0) for 4+ severe sunbur

160 l factors, time spent in the sun, and severe sunburns over three time periods and were asked to count

161 among individuals with history of blistering sunburn (P = .019), and prevalent MCPyV SSW infections p

162 C tumors associated with a history of severe sunburns (P<0.08).

163 hose with a higher lifetime number of severe sunburns (P(interaction) = 0.0074).

164 Indoor tanning and sunburns, particularly during adolescence and young adul

165 dge, no study has prospectively investigated sunburn patterns over age periods from childhood to adul

166 for epidemiological evidence that childhood sunburn poses a significant risk of developing this pote

167 when assessing sun protection due to its low sunburning potential, but it generates reactive oxygen s

168 B (UVB) radiation from the sun can result in sunburn, premature aging and carcinogenesis, but the mec

169 r traits, including its risk factors such as sunburn propensity.

170 To directly measure sunburn protection offered by a standard beach umbrella

171 n was strongest among those with tendency to sunburn rather than tan.

172 tify candidate eicosanoids formed during the sunburn reaction in relation to its clinical and histolo

173 The sunburn reaction is the most common consequence of human

174 These patients have normal sunburn reactions and are therefore diagnosed later and

175 These results indicate that sunburn reactions culminate from inflammatory events tha

176 , we examined whether experimentally induced sunburn reactions in mice could be prevented by blocking

177 es have suggested that repeated inflammatory sunburn reactions, which include the induction of cycloo

178 ts aimed for clinically related targets (eg, sunburn reduction).

179 nd provide potential therapeutic targets for sunburn-related itch.

180 In this study, we established a sunburn-related mouse model and found that broad-band UV

181 skin cancer and suggest that the etiology of sunburn-related SCC may be significantly different by XR

182 ental studies with mouse models suggest that sunburn resulting from exposure to excessive UV light an

183 atistically significant increase in clinical sunburn scores compared with baseline and had higher pos

184 ia and New Zealand to describe patients with sunburns severe enough to warrant admission to specialis

185 d not block infiltration of macrophages into sunburned skin; and (ii) RA did decrease autologous and

186 Patients with an acute sunburning skin phenotype were less likely to develop co

187 rcinomas in the 5 years prior to enrollment, sunburns, sun sensitivity, and recreational sun exposure

188 ponses to a personal interview on history of sunburns, sunbathing, and time spent outdoors.

189 Family history of melanoma, number of severe sunburns, sunburn susceptibility, hair color, and Fitzpa

190 Originally developed to protect against sunburn, sunscreen has been assumed to prevent skin canc

191 tory of melanoma, number of severe sunburns, sunburn susceptibility, hair color, and Fitzpatrick skin

192 studies on hair color, eye color, number of sunburns, tanning ability and number of non-melanoma ski

193 21.0%Delta; women: -28.5%Delta) and, in men, sunburn tendency was associated with less wrinkling.

194 If Suzy forgets sunscreen and gets sunburned, the absence of sunscreen 'caused' Suzy's sunb

195 After supplementation, median (IQR) sunburn threshold (minimal erythema dose) was 28 (20-28)

196 not alter the erythemal response, either the sunburn threshold or the resolution of erythema, as asse

197 Avoiding sunburns throughout life, in particular in childhood, is

198 lved from beach products designed to prevent sunburn to more cosmetically elegant skincare products i

199 low, and stable high) of individual lifetime sunburn trajectories with similar shapes were estimated

200 ppression of CHS (P < 0.001), and a moderate sunburn (two minimal erythema doses [2 MED]) was suffici

201 can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms.

202 ction to first summer sun for 1 hour (severe sunburn vs. tan odds ratio (OR)=12.27, 95% confidence in

203 factors, overall baseline history of severe sunburn was more apparently associated with risk of mela

204 Propensity to sunburn was not associated with melanoma after tanning i

205 The lifetime number of blistering sunburns was also positively associated with BCC risk (p

206 w that skin aging and reported experience of sunburns was proportional to the degree of penetrance fo

207 ugh the absolute risk of SCC associated with sunburns was similar across genotypes, the relative risk

208 ng factors (e.g., lifetime number of painful sunburns), we found a modest increase in risk of SCC (od

209 o achieve a tan, and history of a blistering sunburn were associated with a higher risk of developing

210 Furthermore, childhood sunburns were related to nevi independently of sun sensi

211 Annual frequencies of sunburns were reported for childhood, adolescence, and a

212 Age and number of sunburns were significantly associated with the severity

213 n associated with an increased prevalence of sunburn, which is an established skin cancer risk factor

214 UV overexposure leads to sunburn with tissue injury and pain.

215 , we compared the protection from cumulative sunburn with two sunscreens labeled SPF 6, but with diff

216 Any sunburn within the last year; sun-protective behaviors i

217 screen, protective clothing, shade; multiple sunburns within the past year; previous full-body skin e

218 screen, protective clothing, shade; multiple sunburns within the past year; previous full-body skin e