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2 lation of Nf1 in bone-forming cells leads to supraphysiologic accumulation of pyrophosphate (PPi), a
3 activity levels of CD8(+) T cells expressing supraphysiologic affinity TCR were gradually restored.
4 re was a gradual attenuation in activity for supraphysiologic affinity TCR with K(D) < approximately
5 ical, region of acinar cells observed during supraphysiologic agonist stimulation were dependent on R
8 lls isolated from tumors stably overproduced supraphysiologic amounts of IL-12, and the therapeutic e
10 Initially, we investigated the effects of supraphysiologic amounts of ProCT administered to animal
11 th a wide range of C. albicans inocula under supraphysiologic and near-physiologic (at estrus) concen
12 ndrogen therapy (BAT) - the rapid cycling of supraphysiologic androgen (SPA) and low serum testostero
15 engraftment of gene-corrected cells and had supraphysiologic blood IDUA activity within a month, whi
18 FA supplements suggest that these doses are supraphysiologic but with no evidence of altered 1-carbo
20 y enhancing BCR signaling, only B cells with supraphysiologic CD45 expression became anergic, whereas
21 Although both E613R B cells and those with supraphysiologic CD45 expression exhibited hyperresponsi
24 gic concentrations of carbachol (1 muM) to a supraphysiologic concentration (1 mM) that leads to prot
25 otoxic effects caused by chronic exposure to supraphysiologic concentration of glucose are only minim
27 titis models is created by administration of supraphysiologic concentrations of caerulein, an ortholo
28 Chronic exposure of pancreatic islets to supraphysiologic concentrations of glucose causes advers
30 Prolonged exposure of isolated islets to supraphysiologic concentrations of palmitate decreases i
35 s to increase physical strength of scars via supraphysiologic deposition of collagen and other ECM fa
36 promises to minimize complications from the supraphysiologic doses and burst release involved in cur
37 nerve agent poisoning will likely need both supraphysiologic doses and frequent re-dosing of atropin
39 patients with high doses of oral calcium and supraphysiologic doses of 1 alpha,25-dihydroxyvitamin D(
40 in isolated pancreatic acini stimulated with supraphysiologic doses of cholecystokinin (CCK-8), remai
41 mone agonist leuprolide acetate, adding back supraphysiologic doses of estradiol and progesterone for
43 fortification but remain very responsive to supraphysiologic doses of folic acid-based supplementati
44 ed in the analysis because they had received supraphysiologic doses of GCs (doses above the lowest te
47 ansgenic overexpression or administration of supraphysiologic doses, rather than in a physiologic set
48 e treatment with glucocorticoids, usually at supraphysiologic doses, to address cortisol insufficienc
50 ditions mimicking pregnancy and parturition: supraphysiologic E2 + P-addback; supraphysiologic E2 + P
51 arturition: supraphysiologic E2 + P-addback; supraphysiologic E2 + P-withdrawal; and no added E2 + P
52 rradiated murine hearts reveals a persistent supraphysiologic electrical phenotype, mediated by incre
54 ically, the administration and withdrawal of supraphysiologic estradiol and progesterone (E2 + P) can
59 asmid into hemophilia A (HemA) mice achieved supraphysiologic FVIII expression, but triggered product
60 ases or in normal aging, or about the use of supraphysiologic GH doses to treat catabolic states.
61 nal-derived androgen excess usually requires supraphysiologic glucocorticoid dosing, which predispose
63 ulture of HIT-T15 cells in medium containing supraphysiologic glucose concentrations (11.1 mmol/l) ca
64 ly that chronic exposure of HIT-T15 cells to supraphysiologic glucose concentrations causes decreased
65 osure of pancreatic islet beta-cell lines to supraphysiologic glucose concentrations causes defects i
66 stimulates NHE3 transport activity, whereas, supraphysiologic glucose concentrations inhibit this exc
69 tly packaged within AAV virions and mediated supraphysiologic hFVIII expression (732 +/- 162% of norm
70 s heparin or glycerol during physiologic and supraphysiologic hyperinsulinemia, by combining microdia
75 , renal adaptation to a physiologic, but not supraphysiologic, K(+) load can be achieved in aldostero
76 scAAV particles led to expression of hFIX at supraphysiologic levels (8I U/mL) and correction of the
77 pg/mL), whereas the E2 50 group still showed supraphysiologic levels 360 min after administration (24
84 ays a major role in scavenging exogenous and supraphysiologic levels of H2O2, although this enzyme ca
86 ussis intoxicates target cells by generating supraphysiologic levels of intracellular cyclic AMP (cAM
87 c macrophages were activated with H. pylori, supraphysiologic levels of L-Arg were required to permit
89 increased protein half-life of R248Q led to supraphysiologic levels of R248Q, which was critically r
90 onally, neither dietary supplementation with supraphysiologic levels of SCFA nor the induction of hep
92 et of prostate cancer upon administration of supraphysiologic levels of testosterone (SupraT), both e
93 i in vitro by an NO-dependent mechanism, but supraphysiologic levels of the iNOS substrate l-arginine
97 of elevated brain alphaTOC establish that at supraphysiologic levels, alphaTOC potentiates neuroinfla
98 , peripheral concentrations are increased to supraphysiologic levels, with likely effects on diverse
101 characterize the effects of physiologic and supraphysiologic loads of intraduodenal leucine on eatin
103 (TRPV4) and PIEZO1 transduce physiologic and supraphysiologic magnitudes of mechanical signals in the
107 atural affinity range, along with an extreme supraphysiologic one having 1400-fold enhanced affinity,
108 mutant and wild-type p53 in conjunction with supraphysiologic p53R248Q accumulation underlies the dom
109 ting evidence on harm related to exposure to supraphysiologic Pa(O(2)) (hyperoxemia) in critically il
111 besity body-fat depletion by leptin requires supraphysiologic plasma concentrations that exceed the l
112 ow this subproteome leads to physiologic and supraphysiologic proliferation responses in PCa cells, a
116 ir initial reinforcing effects by triggering supraphysiologic surges of dopamine in the nucleus accum
117 ited robust T-cell recoveries by day 14 with supraphysiologic T-cell counts accompanied by a sustaine
120 ranging from 40 degrees C to 60 degrees C, a supraphysiologic temperature range not accessible by unp
123 surgery (SHAM), gonadectomy (GX), or GX plus supraphysiologic testosterone-enanthate (TE) administrat
124 ings provide evidence that administration of supraphysiologic thyroid hormone improves depressive sym
125 h a decrease in the glucocorticoid dose from supraphysiologic to physiologic levels while androstened