ライフサイエンスコーパス: supraphysiological

1 These levels could be considered as supraphysiological.

2 both physiological (300 pM or 70 pg/mL) and supraphysiological (10 nM or 2.3 ng/mL) concentrations o

3 stitutive, IL-7R-STAT5B signaling promotes a supraphysiological accumulation of CD8alphabeta(+) gamma

4 ction or SUMOylation are sufficient to drive supraphysiological accumulation of RNF168, increased ubi

5 Here, we demonstrate that supraphysiological activation of TAK1 in skeletal muscle

6 armacological targeting of MEK1/2 results in supraphysiological activity of the ERK5 pathway.

7 increase in systemic FIX protein levels and supraphysiological activity over a range of vector doses

8 mal function (K(d) = 5 to 1 muM), those with supraphysiological affinity (K(d) = 1 muM to 15 nM) show

9 ering B-vitamin treatment regimens featuring supraphysiological amounts of FA or the reduced folate,

10 e cultures to proliferate in the presence of supraphysiological amounts of p27(kip1) but did not stim

11 rite selectively dilates conduit arteries at supraphysiological and near-physiological concentrations

12 However, supraphysiological androgen (SPA) concentrations can pro

13 Supraphysiological androgen (SPA) treatment can paradoxi

14 nstrated that the cyclical administration of supraphysiological androgen (SPA), termed bipolar androg

15 ression of multiple genes including MYC, and supraphysiological androgen is effective in some patient

16 decreased MYC may contribute to responses to supraphysiological androgen therapy.

17 now clinical data have shown that high dose, supraphysiological androgen treatment (SPA) results in g

18 Determining the molecular pathways by which supraphysiological androgens promote growth arrest and t

19 at treatment in the preservation of myelin, supraphysiological ARSA levels may slow demyelination of

20 BAT involves rapid cycling from supraphysiological back to near-castration testosterone

21 ein-coupled bile acid receptor 1 (TGR5), but supraphysiological bile acid levels were found to stimul

22 Moreover, supraphysiological boosting of 4-1BB in the airways duri

23 Supraphysiological Ca(2+) levels diminished stimulation

24 The supraphysiological [Ca(2+)] needed for TRPM2 warmth sens

25 layer studies had been commonly conducted at supraphysiological [Ca2+] and [K+], we determined the ef

26 lar myocardium, mouse cardiac muscle resists supraphysiological [Ca2+]o.

27 host cell cytosol where it rapidly generates supraphysiological cAMP concentrations, which inhibit ho

28 us derivative of whole blood that contains a supraphysiological concentration of platelets, is though

29 fter 7 days of elevated resistin levels at a supraphysiological concentration, the animals displayed

30 ted with platelet additive solution (PAS) at supraphysiological concentrations at room temperature, o

31 ely low abundance serum protein biomarker at supraphysiological concentrations in a WHO standard.

32 d DnaJ was observed, but the requirement for supraphysiological concentrations makes it unlikely that

33 ivo at physiological levels (pg/ml), whereas supraphysiological concentrations of 17-beta E(2) (ng/ml

34 h betaAPP-expressing HEK293 cells triggering supraphysiological concentrations of Abeta peptides, NF-

35 By contrast, supraphysiological concentrations of Adn resulting from

36 We postulate that media containing supraphysiological concentrations of chloride or other i

37 nzymatic activity and is induced in vitro by supraphysiological concentrations of citrate (> 5 mM).

38 emonstrate that when evaluated individually, supraphysiological concentrations of either E2 (200 nM)

39 arterial smooth muscle cells are exposed to supraphysiological concentrations of glucose, and this e

40 Supraphysiological concentrations of IL3 or SCF prevent

41 rrow microenvironment and in the presence of supraphysiological concentrations of interleukin-3 (IL3)

42 by partial proteolysis or by the binding of supraphysiological concentrations of polyunsaturated lon

43 e exploited this effect by administration of supraphysiological concentrations of T, resulting in cli

44 Many in vitro reports use supraphysiological concentrations of these drugs to demo

45 f various cancer cells; however, significant supraphysiological concentrations of this compound are r

46 sion specifically formulated for delivery of supraphysiological concentrations of ubidecarenone (oxid

47 ne formation after injury; however, the high supraphysiological concentrations required for desired o

48 Plasma triiodothyronine levels increased to supraphysiological concentrations with hormonal therapy.

49 etic Abeta peptides of one defined length at supraphysiological concentrations, but the existence of

50 ngle-channel analysis, we show that, even at supraphysiological concentrations, flecainide did not in

51 At supraphysiological concentrations, glucocorticoids alone

52 inflammatory activities in vivo, but only at supraphysiological concentrations.

53 elet activation under specific conditions at supraphysiological concentrations.

54 re effective against CHIKV as monotherapy at supraphysiological concentrations.

55 However, under supraphysiological conditions, upon infusion with increa

56 ty stems mainly from studies performed under supraphysiological conditions.

57 Supraphysiological dofetilide concentrations substantial

58 embryos, 9-cis-RA was undetectable unless a supraphysiological dose of all-trans-RA was administered

59 assemblies drastically reduce the dangerous supraphysiological dose of BMP-2 used clinically for spi

60 who have recently tapered or discontinued a supraphysiological dose of glucocorticoids.

61 Exposing the developing brain to a supraphysiological dose of IL-33 altered the microglial

62 We found that a single injection of a supraphysiological dose of natural or synthetic AAS stre

63 ther restated or challenged the conventional supraphysiological doses of 'stress steroids', while oth

64 ned oral B-vitamin supplementation featuring supraphysiological doses of folic acid.

65 insufficiency is caused by administration of supraphysiological doses of glucocorticoids.

66 Supraphysiological doses of insulin enhance total limb b

67 ected with P. berghei inocula incubated with supraphysiological doses of NO (< or =150 microM) or wit

68 Effective bleeding control requires supraphysiological doses of rFVIIa, posing both high exp

69 ation of V2 receptors induced by exposure to supraphysiological doses of vasopressin.

70 When administered to rodents at supraphysiological doses, ghrelin activates hypothalamic

71 ase insulin sensitivity when administered at supraphysiological doses, we determined the effect of 6

72 Further, supraphysiological dosing of exogenous long-lasting GIP

73 ed an attenuated trabecular bone response to supraphysiological E2 treatment.

74 ion or differentiation, but IL-2 can promote supraphysiological expansion when supplied exogenously.

75 Sustained and supraphysiological expression of 770% normal was observe

76 Supraphysiological expression of DKF-1 limited C. elegan

77 In contrast to wild type, supraphysiological expression of the mutant causes short

78 Superelevation of [Ca2+]i in supraphysiological extracellular [Ca2+] boosted secretio

79 Exposure of slices to supraphysiological extracellular Ca(2+) concentration in

80 CC16 (rCC16) used in preclinical studies are supraphysiological for clinical applications.

81 gen and coagulation factor XIII (FXIII), and supraphysiological FXIII improved adhesive strength.

82 Ionotropic activity is only triggered at supraphysiological GABA concentrations, effectively deco

83 metabolite biomarkers readily discriminates supraphysiological glucocorticoid replacement doses in p

84 ally, we observed that prolonged exposure to supraphysiological glucose concentration impaired SOCs f

85 idation, and via hexosamine metabolism under supraphysiological glucose concentrations, we hypothesiz

86 m the adverse effects of chronic exposure to supraphysiological glucose concentrations.

87 insulin gene transcription in conditions of supraphysiological glucose levels.

88 rowth of gmps null cells was only rescued by supraphysiological guanine concentrations (100 muM) or b

89 ed mitochondrial metabolic deficiencies, and supraphysiological H(2)S concentrations can pro health s

90 e, at concentrations generally thought to be supraphysiological, has the potential for disrupting glu

91 treatment consisting of administration of a supraphysiological heat dose in the presence of an antip

92 Supraphysiological IGF-I concentrations were maintained

93 lly produce IDUA, and resulted in a >10-fold supraphysiological increase in IDUA activity.

94 monitored the effects of more modest versus supraphysiological increases in cytosolic and mitochondr

95 7.5%-60.0%), and the area under the curve of supraphysiological inspired oxygen was 7951% min (5870-1

96 Both a postprandial and supraphysiological insulin clamp significantly increased

97 ke in excess of energy expenditures, chronic supraphysiological intake of dietary sodium, excessive a

98 Supraphysiological leptin levels were necessary to resto

99 Further increase in dietary selenium to supraphysiological levels (0.4 ppm) had very little or n

100 ficantly induce the release of HMGB1 even at supraphysiological levels (up to 200 ng/ml).

101 (V600E)BRAF, expressed at supraphysiological levels because of (V600E)BRAF ultra-a

102 dequate (0.08 ppm; sodium selenite), and two supraphysiological levels in the form of Se-supplemented

103 been largely derived from their activity at supraphysiological levels in tumor cell lines.

104 Supraphysiological levels of 4HNE triggered ferroptosis,

105 differentially regulated at physiological or supraphysiological levels of amyloid beta (Abeta) peptid

106 ivated by endogenous calmodulin, it produces supraphysiological levels of cAMP.

107 biased and unbiased approaches, we show that supraphysiological levels of CoQ10 induces an increase i

108 We hypothesize that supraphysiological levels of CSO(4) in keratinocyte memb

109 Previous studies demonstrated that supraphysiological levels of D-mannose inhibit tumour gr

110 Here we show that supraphysiological levels of D-mannose safely achievable

111 Supraphysiological levels of estrogens act as antioxidan

112 ent mice treated with the hgAI vector showed supraphysiological levels of expression of human APOA-I

113 not observed in physiological or even highly supraphysiological levels of fluid flow.

114 MglA-dependent proteins was repressed by the supraphysiological levels of free amino acids present in

115 Although AAV2/5 alone provided supraphysiological levels of GALC activity and reduced p

116 stinct from canonical responses generated by supraphysiological levels of H2O2.

117 ection, they relied on ectopic expression of supraphysiological levels of human ACE2 (hACE2).

118 Supraphysiological levels of LXA4 are generated during i

119 tudies in B-cells used pathophysiological or supraphysiological levels of Myc and reported enhanced B

120 ies in beta-cells used pathophysiological or supraphysiological levels of Myc and reported enhanced b

121 How cells discriminate physiological from supraphysiological levels of Myc is largely unknown.

122 mediator Stat5 in the presence of normal and supraphysiological levels of PRL.

123 an adaptive antioxidant response to prevent supraphysiological levels of ROS from causing oxidative

124 ine suggested increased oxidation of PGE2 at supraphysiological levels of Se that also correlated wel

125 l studies have suggested that treatment with supraphysiological levels of testosterone can retard pro

126 a phenomenon relevant to the requirement for supraphysiological levels of this hormone in differentia

127 Furthermore, supraphysiological levels of uridine are required to pro

128 homeostasis in vivo, it is commonly used at supraphysiological levels to induce NK cell proliferatio

129 n deliver a lysosomal enzyme continuously at supraphysiological levels to the bloodstream and can cor

130 eeks later when oestrogen production reached supraphysiological levels.

131 atory and gene-expression pathways; often at supraphysiological levels.

132 oxically suppress its growth when present at supraphysiological levels.

133 Our results imply that relatively small (but supraphysiological) levels of dATP increase the number o

134 timulatory effect (22-27%) was observable at supraphysiological maximal ADP-stimulated respiration at

135 Supraphysiological mechanical stretching in smooth muscl

136 slation of the viral Mecp2 transgene, limits supraphysiological Mecp2 protein levels.

137 formation, its clinical applications require supraphysiological milligram-level doses that increase p

138 o short telomeres, DNA damage, oncogenes and supraphysiological mitogenic signals, and overexpression

139 Supraphysiological MYC levels are oncogenic.

140 ical trials in which NAD(+) replenishment or supraphysiological NAD(+) elevations are assessed for th

141 tolerant of diverse NES sequences, including supraphysiological NES (SNES) peptides that otherwise ar

142 eptide that contains both nuclear import and supraphysiological nuclear export signals.

143 isease, tumor-bearing mice treated i.v. with supraphysiological numbers of syngeneic gammadelta T cel

144 sulin signaling, possibly due to exposure to supraphysiological nutrient and hormone conditions.

145 maximum deformability when equilibrated with supraphysiological O(2) concentrations.

146 Ventilator treatment with supraphysiological O2 concentrations (hyperoxia) contrib

147 of MLL leukemia pathogenesis, but often use supraphysiological oncogene expression with uncertain im

148 cell lymphomas (BCLs), we demonstrated that supraphysiological or physiological concentrations of as

149 uced during the natural menstrual cycle, the supraphysiological ovarian stimulation needed to produce

150 uteum, and evaluate how it is altered by the supraphysiological ovarian stimulation used during IVF.

151 Increased supraphysiological oxygen administration during surgery

152 Supraphysiological oxygen administration, defined as the

153 hile most cartilage research is performed in supraphysiological oxygen levels (19-21%), culturing cho

154 Cell free NMP at supraphysiological oxygen partial pressure seems to be a

155 MLL-ENL target loci showed supraphysiological PAF1 binding, hyperubiquitination of

156 a single intravenous dose of EXG110 achieved supraphysiological plasma alpha-Gal A activity and near-

157 ng the albumin locus resulted in continuous, supraphysiological plasma and tissue a-Gal A activities,

158 proximately 1.0 mmol/L and as much as 60% at supraphysiological plasma lactate concentrations when th

159 CONCLUSIONS; GIP, given to achieve supraphysiological plasma levels, still had an early, sh

160 th PAS that is scalable to physiological and supraphysiological platelet concentrations.

161 ican culture frequently leads to exaggerated supraphysiological post-prandial spikes in blood glucose

162 This triple agonist demonstrates supraphysiological potency and equally aligned constitue

163 an be evoked by depolarization of a rod to a supraphysiological potential (-20 mV) that activates a l

164 re of rabbit aorta, longitudinal stretch and supraphysiological pressure applied for 3 hours during i

165 At supraphysiological release rates (>2 micrometer/s) NO( s

166 dulate Myc activity from essentially null to supraphysiological resulted in a significantly increased

167 heories offer different explanations for the supraphysiological rFVIIa dosing requirement: (1) the ne

168 R regulatory subunit RRM2 (Rrm2(TG)) present supraphysiological RNR activity and reduced chromosomal

169 o this affinity support, and are released at supraphysiological salt concentrations in a relatively p

170 ype of Sepp1(-/-) mice, as these mice needed supraphysiological selenium supplementation to survive,

171 0(9) transducing particles of either vector, supraphysiological serum levels of hFIX were obtained, w

172 d in animal models, the effect of long-term, supraphysiological sex hormone treatment on drug metabol

173 gests that sublethal blood trauma-induced by supraphysiological shear exposure-paradoxically increase

174 We discover that a supraphysiological, stable OCT4 level is required, but n

175 Using supraphysiological stimulation of 4-1BB in the boost pha

176 and dehydrated state, which is maintained at supraphysiological temperatures.

177 e been used to investigate administration of supraphysiological testosterone to patients with prostat

178 transcription that is essential for global, supraphysiological transcription in cancer.

179 (R47H) rats, we previously demonstrated that supraphysiological tumor necrosis factor-a (TNF-a) boost

180 (R47H) rats, we previously demonstrated that supraphysiological tumor necrosis factor-alpha (TNF-alph

181 ent without a requirement for stimulation of supraphysiological tyrosine phosphorylation levels or ma

182 Daily supraphysiological vitamin K supplementation restores cl

183 n antibody limiting VWF degradation, and (5) supraphysiological VWF plasma concentrations.