ライフサイエンスコーパス: surfactant protein D

1 tion analysis showed that baseline values of surfactant protein D (46.6 ng/mL vs 34.6 ng/mL, p=0.0018

2 KGF treatment increases BAL surfactant protein D, a marker of type II alveolar epith

3 iagnosis and compare these results to plasma surfactant protein-D, a marker of pure alveolar epitheli

4 Surfactant protein D also increased phagocytosis of apop

5 monstrate that reduced pulmonary edema fluid surfactant protein D and elevated plasma surfactant prot

6 olar lavage and various serum markers (e.g., surfactant protein D and KL-6) each may provide useful i

7 and blood concentrations of pneumoproteins (surfactant protein-D and club cell secretory protein), a

8 In a subset, we compared plasma levels of surfactant protein-D and von Willebrand factor antigen b

9 on molecules in the collectin family, namely surfactant proteins D and A (Sp-D and Sp-A, respectively

10 ptor for advanced glycation end products and surfactant protein D) and endothelial injury (angiopoiet

11 nterleukin-1ra, tumor necrosis factor alpha, surfactant protein D, and interleukin-10.

12 s in SP-A than in the homologous collectins, surfactant protein D, and mannose-binding protein.

13 r inhibitor-1 (PAI-1), surfactant protein-A, surfactant protein-D, and intracellular adhesion molecul

14 n molecule-1, von Willebrand factor antigen, surfactant protein-D, and soluble tumor necrosis factor

15 eceptor for advanced glycation end products, surfactant protein D, angiopoietin-2, interleukin-6, int

16 soluble multitrimers of BAFF and APRIL using surfactant protein D as a scaffold, and we vaccinated mi

17 In contrast, pulmonary edema fluid surfactant protein D, but not surfactant protein A, was

18 a levels of fibrinogen, chemokine ligand 18, surfactant protein D, C-reactive protein, Clara cell sec

19 surfactant protein A-deficient (SP-A-/-) or surfactant protein D-deficient (SP-D-/-) BALF, or a mixt

20 multitrimerized using the lung protein SP-D (surfactant protein D), enhancing immune responses.

21 in, which evolved through duplication of the surfactant protein D gene in ruminants, prefers mannose

22 oluble tumor necrosis factor receptor-1, and surfactant protein-D) had nearly equivalent prognostic v

23 ding of three innate immune lectins, namely, surfactant protein D, human galectin-8, and Siglec-14, t

24 actor receptor 1, angiopoietin 2 (ANG2), and surfactant protein D increased in nonsurvivors, while DA

25 nt of peritoneal Mos with the lung collectin surfactant protein D inhibited AC uptake, and fluticason

26 Surfactant protein D is a pattern recognition molecule t

27 Surfactant protein D is characterized by two relatively

28 e equivalent Arg-343 in the homologous human surfactant protein D, is sufficiently small to allow con

29 ated proteins such as endogenous eotaxin and surfactant protein D levels, which were both increased f

30 KGF increased BAL concentrations of surfactant protein D, matrix metalloproteinase (MMP)-9,

31 alysis, we identified four serum biomarkers (surfactant protein D, matrix metalloproteinase 7, CA19-9

32 ptor for advanced glycation end products and surfactant protein-D measurements within 24 hours (day 1

33 + carbohydrate recognition domains of human surfactant protein D (NCRD) with CL-43 (RCL-43-NCRD) and

34 re generally not inhibited by the collectins surfactant protein D or mannose binding lectin because o

35 ct of leukoreduced blood on plasma levels of surfactant protein-D or von Willebrand factor antigen wa

36 However, unlike surfactant protein-D, plasma soluble receptor for advanc

37 However, unlike surfactant protein-D, plasma soluble receptor for advanc

38 Similar to surfactant protein-D, plasma soluble receptor for advanc

39 Surfactant protein D preferentially binds to glucose and

40 es, including von Willebrand factor antigen, surfactant protein D, protein C, plasminogen activator i

41 RATIONALE: Recombinant fragment of human surfactant protein D (rfhSP-D) has been shown to suppres

42 We used here several recombinant human surfactant protein D (RhSP-D) preparations to determine

43 Mice deficient in surfactant protein D (Sftpd) develop progressive age-rel

44 Finally, an innate immune protein named surfactant protein D showed broad affinities to spike pr

45 nary and activation-regulated chemokine, and surfactant protein D significantly increased the areas u

46 nary and activation-regulated chemokine, and surfactant protein D significantly strengthens this asso

47 This suggests that unlike surfactant protein-D, soluble receptor for advanced glyc

48 Mice lacking surfactant protein surfactant protein D (SP-D(-/-)) and wild-type mice (SP-

49 tudies reveal that substantial quantities of surfactant protein D (SP-D) accumulate in the airspaces

50 Surfactant protein D (SP-D) and CD14 are important innat

51 or the lung extracellular matrix components surfactant protein D (SP-D) and mucin 5b (Muc5b).

52 Surfactant protein D (SP-D) and serum conglutinin are cl

53 Circulating levels of the biomarkers surfactant protein D (SP-D) and soluble receptor for adv

54 Surfactant protein A (SP-A) and surfactant protein D (SP-D) are high abundance pulmonary

55 collectins mannose-binding lectin (MBL) and surfactant protein D (SP-D) are regulated by tissue fibr

56 Increasing evidence now identifies surfactant protein D (SP-D) as an important element of t

57 ins such as mannose-binding lectin (MBL) and surfactant protein D (SP-D) become temporarily deposited

58 Surfactant protein D (SP-D) binds to and agglutinates M.

59 Lung surfactant protein D (SP-D) binds to Mycobacterium tuber

60 Lung surfactant protein D (SP-D) can directly interact with c

61 Targeted ablation of the surfactant protein D (SP-D) gene caused chronic inflamma

62 Targeted ablation of the surfactant protein D (SP-D) gene caused progressive pulm

63 Surfactant protein D (SP-D) gene-targeted mice develop s

64 m mannose-binding lectin (MBL) and pulmonary surfactant protein D (SP-D) have distinctive monosacchar

65 t, on pulmonary function and serum levels of surfactant protein D (SP-D) in type 2 diabetes.

66 The innate host defense component surfactant protein D (SP-D) interacts with glycans on th

67 Surfactant protein D (SP-D) is a 43-kDa member of the co

68 Surfactant protein D (SP-D) is a collectin family member

69 Surfactant protein D (SP-D) is a member of the collectin

70 Surfactant protein D (SP-D) is a molecule of the innate

71 Surfactant protein D (SP-D) is an important effector of

72 Surfactant protein D (SP-D) is an important regulator of

73 Surfactant protein D (SP-D) is an innate immune effector

74 Surfactant Protein D (SP-D) is an oligomerized C-type le

75 Surfactant protein D (SP-D) is critical for maintenance

76 he recognition of influenza A virus (IAV) by surfactant protein D (SP-D) is mediated by interactions

77 Surfactant protein D (SP-D) is one of two collectins fou

78 Surfactant protein D (SP-D) is preferentially secreted a

79 Our previous studies showed that surfactant protein D (SP-D) is present in human tear flu

80 Surfactant protein D (SP-D) molecules are preferentially

81 Innate immune molecule surfactant protein D (SP-D) plays a critical role in hos

82 Surfactant protein D (SP-D) plays critical roles in host

83 Surfactant protein D (SP-D) plays diverse and important

84 Surfactant protein D (SP-D) plays important roles in ant

85 Surfactant protein D (SP-D) plays important roles in inn

86 Surfactant protein D (SP-D) plays important roles in inn

87 Surfactant protein D (SP-D) plays important roles in lun

88 Recent studies strongly suggest that surfactant protein D (SP-D) plays important roles in pul

89 Surfactant protein D (SP-D) plays important roles in the

90 Surfactant protein D (SP-D) plays roles in pulmonary hos

91 Surfactant protein D (SP-D) plays roles in pulmonary hos

92 previous studies documenting that pulmonary surfactant protein D (SP-D) protects C. neoformans cells

93 recognition domains (CRDs) of lung collectin surfactant protein D (SP-D) recognize sugar patterns on

94 Surfactant protein D (SP-D) shows specific interactions

95 t-associated surfactant protein A (SP-A) and surfactant protein D (SP-D) to Mtb.

96 Surfactant protein D (SP-D), a C-type lectin, is an impo

97 Surfactant protein D (SP-D), a component of innate immun

98 Lung surfactant protein D (SP-D), a key factor in first-line

99 Pulmonary surfactant protein D (SP-D), a lung host defense protein

100 Pulmonary surfactant protein D (SP-D), a member of the collectin f

101 Polymorphisms of surfactant protein D (SP-D), an important molecule withi

102 ins, Clara cell secretory protein (CC16) and surfactant protein D (SP-D), and five systemic inflammat

103 The roles of NK cells, surfactant protein D (SP-D), and IFN-gamma, as well as t

104 emonstrated direct interactions of HNPs with surfactant protein D (SP-D), another important effector

105 f a collagenous C-type lectin, rat pulmonary surfactant protein D (SP-D), are sufficient to drive the

106 Surfactant protein D (SP-D), shown to play a role in hos

107 The role of surfactant protein D (SP-D), which inhibits P. aeruginos

108 Surfactant protein D (SP-D)-deficient (SP-D-/-) mice exh

109 t on virulence in naive BALB/c, C57BL/6, and surfactant protein D (SP-D)-deficient mice.

110 es can be removed from the lung by pulmonary surfactant protein D (SP-D).

111 a) production and the enhanced expression of surfactant protein D (SP-D).

112 ve and gram-positive bacteria than pulmonary surfactant protein D (SP-D).

113 Surfactant protein-D (SP-D) is a collectin produced in t

114 Pulmonary surfactant protein-D (SP-D) is a member of the collectin

115 Surfactant protein-D (SP-D) participates in several of t

116 The innate immune molecule surfactant protein-D (SP-D) plays an important regulator

117 Surfactant protein-D (SP-D), a member of the "collectin"

118 After challenge with high-dose surfactant protein-D (SP-D)-sensitive influenza A/Philad

119 production, and proteolysis of the collectin surfactant protein-D (SP-D).

120 Surfactant protein D (SPD) plays an important role in su

121 d, a tripartite fusion protein was made from surfactant protein D (SPD), HIV-1 Gag as a test antigen,

122 luid and in mice instilled with MAA-adducted surfactant protein D (SPD-MAA) were studied herein.

123 e was no detectable compensatory increase in surfactant protein D, the other known pulmonary collecti

124 infection, and, when combined with pulmonary surfactant protein D, their antiviral effects were addit

125 exons 1-8 fused to the lectin domain of rat surfactant protein D was used as a substrate.

126 e 2-trimer form, and fusion with the body of surfactant protein D was used to produce the 4-trimer fo

127 Plasma surfactant protein A, but not surfactant protein D, was higher in patients with fewer

128 matrix metalloproteinase (MMP)-7, MMP-1, and surfactant protein D were assessed by ELISA.

129 Unlike surfactant protein-D, which is primarily localized to th

130 ombinant homotrimeric fragment of human lung surfactant protein D with a series of bound ligands have