ライフサイエンスコーパス: surrogate light chain

1 e requirement for a pre-BCR and pairing with surrogate light chain.

2 t chain variable genes and expression of the surrogate light chain.

3 ostulated to function in the assembly of the surrogate light chain.

4 oth proteins did not inhibit the assembly of surrogate light chain.

5 Mutations in Btk, mu heavy chain, or the surrogate light chain account for 85-90% of patients wit

6 cell surface mu heavy chain associated with surrogate light chain and the 1E8 immature B cell line e

7 he ability of mu(s)-chains to associate with surrogate light chains and assemble into a pre-B cell re

8 development: one which is activated through surrogate light chains and mIg mu, and an alternative pa

9 pre-BCR), consisting of an Ig mu H chain, Ig surrogate light chain, and associated signal transducing

10 gement and/or efficiency of pairing with the surrogate light chain at the surface Ig-negative, early

11 also to enhance signaling through the micro-surrogate light chain complex of primary pre-B cells.

12 Pro-B cells bearing surrogate light chain components were found in mice, but

13 consisting of a rearranged mu heavy chain, a surrogate light chain composed of lambda5/14.1 and VpreB

14 s an immunoglobulin heavy chain (Igmu) and a surrogate light chain composed of the invariant lambda5

15 nd three-parameter flow cytometry for VpreB (surrogate light chain), cytoplasmic mu chain, and surfac

16 Surrogate light-chain-deficient (SLC-/-) mice harbored e

17 .1 completely abrogated the formation of the surrogate light chain, demonstrating that complementatio

18 regulatory factors 4 and 8 (IRF4,8) suppress surrogate light chain expression and down-regulate pre-B

19 sion of either one is sufficient to suppress surrogate light chain expression and down-regulate pre-B

20 Surrogate light chain expression during B lineage differ

21 s reveal two novel mechanisms for regulating surrogate light chain formation: (i) the presence of an

22 d that loss of the pre-B cell receptors from surrogate light chain gene silencing was linked with exi

23 unction as a genetic switch to down-regulate surrogate light-chain gene expression and induce convent

24 expression of the endogenous immunoglobulin surrogate light chain genes, lambda5 and VpreB, whereas

25 on, proliferation and down-regulation of the surrogate light chain genes.

26 ll surface and assembled into a complex with surrogate light chains, Ig alpha, and Ig beta.

27 te light chains, we have studied the role of surrogate light chains in B cell development.

28 Lacking companion heavy chains, the surrogate light chains in pro-B cells do not associate w

29 re-B cell receptor, composed of Ig heavy and surrogate light chains, in the negative selection of cel

30 immunoglobulin heavy chain and lambda 5/14.1 surrogate light chain loci disrupt B-cell development to

31 g of the VRC26UCA heavy chain with the mouse surrogate light chain may contribute to this phenotype.

32 intronic and 3' enhancers, lambda5 and VpreB surrogate light chain promoters, the EBF locus promoter

33 kD intermediate is gradually replaced by the surrogate light chain protein complex, and the Ig(alpha)

34 The 14.1 surrogate light chain protein is expressed on human pre-

35 s, by contrast, a significant portion of the surrogate light chain proteins associate with mu heavy c

36 In pro-B cells, the nascent surrogate light chain proteins form a complex that trans

37 These were associated with the surrogate light chain proteins lambda5 and VpreB, and th

38 chain does not associate efficiently with a surrogate light chain, providing a previously unrecogniz

39 mice that expressed neither conventional nor surrogate light chains (RAG-1-/-, lambda 5-/-).

40 se that diminished expression of the lambda5 surrogate light chain results in decreased pre-B cell re

41 d of an antibody heavy chain paired with two surrogate light chain (SLC) components.

42 receptor (pre-BCR), composed of Ig heavy and surrogate light chain (SLC), signals pre-BII-cell prolif

43 ains that are each paired with a two-subunit surrogate light chain (SLC).

44 ns, heavy chain association is essential for surrogate light chain survival and transport to the cell

45 an antibody heavy chain (HC) paired with the surrogate light chain, the "unique regions" of VpreB and

46 u heavy chain and subsequent assembly with a surrogate light chain to form the pre-B cell receptor co

47 addition to mu, the pre-BCR consists of the surrogate light chains VpreB and lambda5 and the transme

48 The two proteins that comprise the surrogate light chain, VpreB and lambda5/14.1, contain b

49 cated, form of mu that cannot associate with surrogate light chains, we have studied the role of surr

50 Surrogate light chains were easily detected on pre-B cel

51 The absence of the surrogate light chain, which assembles with antibody hea

52 Surrogate light chain, which escorts the mu heavy chain

53 f two immunoglobulin mu heavy chains and two surrogate light chains, which associate with the signali

54 These experiments lead us to conclude that surrogate light chains, while necessary for the assembly