ライフサイエンスコーパス: sustained expression

1 n of MAPK phosphatase-1 (MKP-1) mRNA and its sustained expression.

2 r of advantages, including the potential for sustained expression.

3 moter and/or insertion site are critical for sustained expression.

4 exosomes with consistent miRNA contents and sustained expression.

5 e regulatory regions, likely to ensure their sustained expression.

6 lizing antibodies dramatically inhibited the sustained expression (6-24 h) of collagenase-1 mRNA, whe

7 gh iterative acute stimulations also induced sustained expression and epigenetic remodelling of commo

8 in multipotent CNS progenitor cells but also sustained expression and proneural functions in the form

9 skeletal muscle and are capable of achieving sustained expression and systemic delivery of a therapeu

10 ed in the heart after tissue injury, and its sustained expression can contribute to the development o

11 -encoded sensors, which contributes to their sustained expression during the G(1)-S transition.

12 specifically binds to IL13Ralpha2 to provide sustained expression, effective anti-GBM cytotoxicity, a

13 lpha(1)-antitrypsin (hAAT) gene, resulted in sustained expression for longer than 10 months with negl

14 deno-associated viral vector, we demonstrate sustained expression (>17 months) of factor IX in a larg

15 in previous studies to have upregulated and sustained expression in a biofilm, both in vitro and in

16 m sequence from the K6a gene fails to direct sustained expression in any adult tissue, including thos

17 The third phase is characterized by high and sustained expression in the adult cerebellum and dorsal

18 ecific expression in muscle progenitors, and sustained expression in the differentiated musculatures.

19 In contrast, Sox7-sustained expression in the earliest committed hematopoi

20 ucleus at embryonic day 18 (E18), areas with sustained expression into adulthood.

21 ion of an F.IX transgene in mouse liver, but sustained expression is critically dependent on the choi

22 ensates for the transcription of genes whose sustained expression is important for critical cellular

23 MYC and Twist1 cooperate and their sustained expression is required to elicit a transcripti

24 -beta stimulates Foxp3 expression, for which sustained expression is then associated with acquisition

25 igher protein levels than circular RNA, with sustained expression lasting for over 2 weeks.

26 straightforward guidelines on how to induce sustained expression modulation for any given gene are s

27 dministration of AAV2/8 vector have achieved sustained expression of 10% and 26% of normal levels of

28 ntly, DUXBL deficiency in embryos results in sustained expression of 2C-associated transcripts leadin

29 sis in transgenic Arabidopsis lines detected sustained expression of a large MLA1-dependent gene clus

30 least in part, chromatin remodeling to allow sustained expression of a large number of genes critical

31 tissue levels of HIV and does not result in sustained expression of a previously silent quasi specie

32 ocuments that a local immune response limits sustained expression of a secreted protein in muscle gen

33 f sequential controls critical to robust and sustained expression of a target mRNA.

34 effective agents for the direct delivery and sustained expression of a transgene in several tissues,

35 thophysiological changes associated with the sustained expression of abnormal pain.

36 Here, we show that sustained expression of active RB, and prolonged G1 arre

37 tivating factor), has been implicated in the sustained expression of amyloidogenic SAA under chronic

38 gradation of pro-inflammatory mRNAs from the sustained expression of anti-inflammatory mRNAs.

39 The sustained expression of anti-Mullerian hormone did not i

40 regulator EZH2 at serine 21, leading to the sustained expression of antiapoptotic genes, including I

41 :CD21 and either cytokine alone; and 4) BAFF-sustained expression of antiapoptotic Mcl-1 within repli

42 us-induced chromosomal DNA fragmentation and sustained expression of apoptogenic p53 and IL-1beta con

43 Thus, sustained expression of Aurora-B induces tetraploidy, wh

44 Early and sustained expression of autophagy-related proteins in th

45 The mechanism of sustained expression of autoreactive RF B cells in norma

46 Sustained expression of B-cell lymphoma 6 causes maligna

47 In contrast, sustained expression of Bcl-2 in transgenic mice by a me

48 Sustained expression of beta-catenin results in the gene

49 xpression cassette into the human genome for sustained expression of beta-globin.

50 We demonstrate that sustained expression of both Ephrin-A3 and novel EFNA3 l

51 Additionally, we show that sustained expression of C/EBPalpha in these LIP-expressi

52 Upon sustained expression of Cas9 and appropriately chosen gu

53 Sustained expression of CBX7 in EC cells confers a growt

54 t during BCG infection, the inflammation and sustained expression of CCL19 result in the recruitment,

55 saccharide (LPS) and interferon (IFN) induce sustained expression of CD154 on liver-derived macrophag

56 imp-1-deficient CD8(+) T cells resulted from sustained expression of CD25 and CD27 and persistent cyt

57 Induction of B7-1 (CD80) and increased or sustained expression of CD44H, ICAM-1 (CD54), and B7-2 (

58 grating a crucial developmental pathway into sustained expression of cell-type-specific programmes, a

59 ic reticulum stress caused a much higher and sustained expression of CHOP protein.

60 ze molecular and cellular changes induced by sustained expression of ciliary neurotrophic factor (CNT

61 These changes were concurrent with sustained expression of complement and other innate immu

62 We demonstrated that sustained expression of constitutively active stathmin d

63 cts geminin from degradation in G1, allowing sustained expression of core pluripotency factors.

64 Alveolar macrophages exhibited sustained expression of cosignaling molecule CD86 in iNO

65 rgeted genomic elements without the need for sustained expression of CRISPR systems.

66 naling maintained functional Treg cells with sustained expression of CTLA-4 and Blimp-1, allowing act

67 Therefore, our data demonstrated that sustained expression of CXCL12 by MSCs in the primary tu

68 CNS was consistent with their recruitment by sustained expression of CXCR3 ligands during viral persi

69 Sustained expression of CXCR4 was maintained on synovial

70 , Wnt5A expression was also required for the sustained expression of CXCR4.

71 Induction of c-Jun results in sustained expression of cyclin A in the nonadherent stat

72 in cdk1 protein levels, and an elevated and sustained expression of cyclin B1.

73 Mechanistically, sustained expression of cyclin D3 was found to be regula

74 of cycling lymphoblasts was associated with sustained expression of cyclooxygenase 2 (COX-2), the ra

75 acteristics of immature enterocytes, notably sustained expression of cytokeratin and alkaline phospha

76 ponses of coronary SMCs were associated with sustained expression of differentiation markers (alpha-s

77 Sustained expression of dma-1 was found only in the elab

78 ervated striatum of the 6-OHDA-lesioned rat, sustained expression of each enzyme and effective produc

79 Sustained expression of each of these individual signali

80 mediate aspects of beta-selection including sustained expression of early growth response (Egr) gene

81 Notably, sustained expression of EBF in Pax5-/- hematopoietic pro

82 f miR-17 approximately 92, we show here that sustained expression of endogenous miR-17 approximately

83 reduces EC apoptosis, ALI, and mortality via sustained expression of endothelial Alox15.

84 Conversely, a loss of Twist1 leads to a sustained expression of epithelial and cell adhesion mar

85 moted gene expression program, including the sustained expression of Ets transcription factors such a

86 Complementary studies showed that sustained expression of exogenous MKP-3 inhibited palyto

87 tor IX (FIX) into skeletal muscle results in sustained expression of F.IX at levels sufficient to cor

88 proved adenoviral vectors for high levels of sustained expression of factor VIII in mice, stable ther

89 gency granulopoiesis, we found increased and sustained expression of Fap1 and Gas2 in bone marrow mye

90 Two naive HB dogs showed sustained expression of FIX-Padua with an 8- to 12-fold

91 tosis, and this protection corresponded with sustained expression of FLIP.

92 nt accumulation of many viral lytic RNAs and sustained expression of four previously described latenc

93 Aire(+) mTECs; responsiveness to RANKL; and sustained expression of FoxN1, Aire, and tissue-restrict

94 D, which could substantially be prevented by sustained expression of FoxO1 in beta-cells.

95 g a potential role of TNFR2 in promoting the sustained expression of Foxp3.

96 y cells induced by IL-25 are associated with sustained expression of GATA-3, c-MAF, and JunB in an IL

97 H11 delayed differentiation characterized by sustained expression of Gata2, Il1rl1, and Csf2rb, a phe

98 n this study, we report that STAT5CA induced sustained expression of genes controlling tissue homing,

99 erocysts or hormogonia resulted in rapid and sustained expression of genes required for utilization o

100 such repressor identified to date, and that sustained expression of Gfi-1B blocks IL-6-induced G1 ar

101 In contrast, sustained expression of glycogen metabolism genes under

102 iPSCs without off-target inserts resulted in sustained expression of gp91(phox) and substantially res

103 pon cells by the accumulated lipids requires sustained expression of GPX4, a negative regulator of fe

104 esolve tubular injury after U-IRI results in sustained expression of granulocyte-macrophage colony-st

105 ion with a gfp(flexon) transgene, strong and sustained expression of green fluorescent protein (GFP)

106 Sustained expression of green fluorescent protein (GFP),

107 The requirement for a selective and sustained expression of growth factors during the early

108 Sustained expression of hFVIII at physiologic levels (10

109 t that tolerance to hFVIII can be induced by sustained expression of hFVIII in a mouse model.

110 Here we report sustained expression of hFVIII in immunocompetent mice u

111 ctor encoding polysialyltransferase leads to sustained expression of high levels of PSA.

112 Sustained expression of Hnf6 also results in downregulat

113 (PGRP-LC), is required for the induction and sustained expression of homeostatic synaptic plasticity.

114 In fact, sustained expression of Hox D3 in vivo on the chick chor

115 Here we show that sustained expression of Hoxa3 in diabetic-derived BMD Gr

116 Sustained expression of Hoxa3 in vivo in db wounds reduc

117 We have previously shown that sustained expression of Hoxa3 reduces the excessive numb

118 Moreover, sustained expression of HoxD10 impaired endothelial cell

119 miR156 promotes sustained expression of HS-responsive genes and is criti

120 The sustained expression of I-FABP transcripts in the villar

121 nance of epidermal Trm cells, as well as the sustained expression of ICRs.

122 nscription of the IFN-gamma gene in B cells, sustained expression of IFN-gamma and T-bet by B cells i

123 Sustained expression of IFN-gamma protein by effector T

124 Together, these data suggest that the sustained expression of IFN-gammaR2 inhibits Th1 differe

125 Moreover, sustained expression of IK17-EGFP effectively prevented

126 persistence is associated with an early and sustained expression of IL-10 by lung leukocytes.

127 Pneumonia induced sustained expression of IL-10 mRNA and protein in lungs,

128 Th17 cells required TGF-beta for sustained expression of IL-17F and IL-17A.

129 ced IL-12p40 production was accompanied by a sustained expression of IL-23p19, but not IL-12p35, resu

130 coding IL-4 into the hippocampus resulted in sustained expression of IL-4, reduced astro/microgliosis

131 ntly, using IL6 knockout mice, we found that sustained expression of IL6 in the salivary gland long a

132 ression may provide a versatile platform for sustained expression of immunogenic transgenes in gene a

133 al long-term potentiation (LTP) leading to a sustained expression of increased synaptic strength.

134 ng that loss of ARF strongly correlates with sustained expression of inflammatory and cell survival p

135 However, Egr-1 does contribute to the sustained expression of inflammatory mediators and to th

136 It is defined by poor effector function, sustained expression of inhibitory receptors and a trans

137 a progressive decrease in effector function, sustained expression of inhibitory receptors, metabolic

138 Indeed, sustained expression of intact sarcoglycan-sarcospan com

139 h results in mild inflammation, demonstrated sustained expression of interferon-stimulated genes (ISG

140 cfu of Streptococcus pneumoniae resulted in sustained expression of interleukin (IL)-6 mRNA in lungs

141 Sustained expression of KLF2 reduced and deficiency of K

142 xclusively in the endothelium, we found that sustained expression of KLF4 promotes ineffective angiog

143 through a novel signaling cascade involving sustained expression of Kruppel-like factor 4 (KLF4), a

144 Either transient or sustained expression of KSHV-GPCR activated both Rac1 an

145 the central nervous system (CNS) often have sustained expression of labile genes, including angiogen

146 duction of preexisting host signal cascades, sustained expression of latency-associated genes, transi

147 duction of preexisting host signal cascades, sustained expression of latency-associated genes, transi

148 ver is repopulated by human hepatocytes, and sustained expression of lentiviral vector transduced gen

149 y epithelium, and perk deletion inhibits the sustained expression of lipogenic enzymes FAS, ACL, and

150 We show here that sustained expression of Lmx1a and Lmx1b is required for

151 th the MC amplicon exhibited higher and more sustained expression of luciferase than those injected w

152 Sustained expression of lymphotoxin-like inducible prote

153 To determine if sustained expression of Mect1-Maml2 is required for tumo

154 sensitization occurs against a background of sustained expression of melanoma resistance genes, produ

155 nts after its internalization and promotes a sustained expression of MHC class I/peptide complexes in

156 Nevertheless, sustained expression of MICA by tumors can also elicit N

157 transcription factor CREB dependent, and the sustained expression of miR-132/-212 was responsible for

158 growth of TAL1-positive T-ALL cells and that sustained expression of miR-223 partially rescues T-ALL

159 Infused NK cells showed sustained expression of most activating receptors, upreg

160 d Isl1/Onecut1-bound enhancers contribute to sustained expression of motor neuron effector genes, dem

161 tor CD4+ T cell longevity is associated with sustained expression of multiple genes involved in mitoc

162 a progressive loss of effector functions and sustained expression of multiple inhibitory receptors.

163 Enhanced cell survival and sustained expression of multiple oncogenic proteins down

164 piggyBac (PB) vectors to deliver uniform and sustained expression of multiplexed gRNAs.

165 P125A substitution (P125A-endostatin) showed sustained expression of mutant endostatin.

166 We show that sustained expression of mutant p53 is required to mainta

167 AAV-D76A in adult Ldlr null mice resulted in sustained expression of myostatin pro-peptide in the liv

168 e cells from passages (P) 1 to P6, whereas a sustained expression of nestin and PAX6 was observed thr

169 be an alternative to immunisation to induce sustained expression of neutralising antibodies to preve

170 Finally, single-cell RNA-sequencing revealed sustained expression of notch3 in MG of cep290 mutants a

171 gfp) transgenic mice, we observed robust and sustained expression of Nrp2 in the SM compartments of t

172 These data demonstrate that local, sustained expression of NT-3 will support axonal plastic

173 lial cell proliferation and an increased and sustained expression of nuclear p53 in the hormone-treat

174 Sustained expression of Olig2 is counterintuitive becaus

175 There is sustained expression of osteoclast-promoting factors, RA

176 ore, the high basal SA level is required for sustained expression of OsWRKY45 to modulate the steady-

177 During chronic or allergic inflammation, sustained expression of P-selectin on the endothelial ce

178 r a transient quiescent state, maintained by sustained expression of p21, which disappears upon reent

179 aired cell proliferation in association with sustained expression of p27(Kip1) and decreased expressi

180 Sustained expression of p38alpha(D176A+F327S) did not ap

181 There was a uniform and sustained expression of p53 protein as well as a strong

182 table nucleotide analog ATPgammaS stimulated sustained expression of PAI-1 and MCP-1 in vitro, wherea

183 Functionally, sustained expression of Pax3 proteins inhibited myogenic

184 infection was associated with increased and sustained expression of PD-1 on lung lymphocytes, includ

185 hosphatase activity in vitro and resulted in sustained expression of PhoP-dependent mRNAs in vivo.

186 ue to abrogated Evening Complex function and sustained expression of PHYTOCHROME INTERACTING FACTORs

187 n 2.6 x 10(11) vg/kg body weight resulted in sustained expression of plasma ADAMTS13 activity at ther

188 Forcing sustained expression of Pou2f1 or Pou2f2 in RPCs expands

189 Additionally, Isl1 was required for the sustained expression of Pou4f2, suggesting that Isl1 pos

190 This achieved sustained expression of PPT1 protein across the CNS, inc

191 actors is linked to the SA-induced onset and sustained expression of PR-1.

192 ess distinctive patterns of genes, including sustained expression of programmed cell death protein 1

193 Sustained expression of prohibitin in intestinal epithel

194 Consequently, sustained expression of proinflammatory cytokines from t

195 on of the pathophysiological consequences of sustained expression of proinflammatory mediators in pre

196 to our knowledge, that bacteria can promote sustained expression of proliferating cell nuclear Ag an

197 Abundant, sustained expression of prosurvival Mcl-1 is an importan

198 er technology is very efficient in achieving sustained expression of proteins in vivo, we examined th

199 long 5' UTRs via EIF4A1 suppression leads to sustained expression of proteins involved in respiration

200 Sustained expression of RAGE and its ligand S100B was ob

201 Sustained expression of RAGE by critical target cells, i

202 Sustained expression of RBPMS2 inhibits the expression o

203 ected to nonneural cell types did we observe sustained expression of reactivated tumor suppressors an

204 The sustained expression of RIG-I and ISGs in response to vi

205 the most common strategy employed to provide sustained expression of RNAi effectors.

206 ograms ILC3 metabolism toward glycolysis and sustained expression of RORgammat.

207 In this study, we show that sustained expression of Runx2 modulates Cbfbeta-smooth m

208 6 production but instead was associated with sustained expression of several antiapoptotic members of

209 Functionally, sustained expression of SIRT3 decreases membrane potenti

210 enesis at progenitor stages, as indicated by sustained expression of Sox2(+) in Mef2c(OE) DGCs.

211 thermore, our data demonstrate that the mere sustained expression of Sox7 is sufficient to completely

212 bit functional properties of CAFs, including sustained expression of stromal-derived factor-1 (SDF-1)

213 Depletion of JMJD2b or sustained expression of SUV39H1 delays the repair of HC

214 distinguishes between rapid induction versus sustained expression of synaptic homeostasis and disting

215 Finally, both the rapid induction and the sustained expression of synaptic homeostasis are blocked

216 nction is required postembryonically for the sustained expression of synaptic homeostasis.

217 uced pluripotent stem cells (hiPSCs) exhibit sustained expression of testis-specific genes, secrete a

218 red high levels of FoxM1 protein to overcome sustained expression of the alternative reading frame tu

219 Here we show sustained expression of the antiangiogenic factors angio

220 ations require biallelic TET2 disruption and sustained expression of the AP-1 factor BATF3 to drive a

221 f B lymphoblasts with IL-4 and IL-5 elicited sustained expression of the beta-chain and promoted secr

222 removal of doxycycline led to pronounced and sustained expression of the caMKKs and dnMKKs.

223 uous exposure of macrophages to IL-10 caused sustained expression of the chemokine receptors CCR1 and

224 er toxicity that would otherwise result from sustained expression of the copper transport genes.

225 of BMSSC-Ts was correlated with a higher and sustained expression of the early pre-osteogenic stem ce

226 TBI triggered sustained expression of the ER stress marker proteins in

227 Sustained expression of the estrogen receptor-alpha (ESR

228 G-repeats in the FMR1 mRNA, also resulted in sustained expression of the FMR1 gene in AZA-treated cel

229 ed for the treatment of hemophilia B, led to sustained expression of the high-activity factor IX vari

230 Sustained expression of the histone demethylase, KDM2B (

231 cient to account for the rapid induction and sustained expression of the homeostatic change in vesicl

232 Presentation by these migrants sustained expression of the IL-2 receptor and promoted d

233 cells in chronic infections and cancer have sustained expression of the inhibitory receptor programm

234 Pdap1 deficiency leads to sustained expression of the integrated stress response (

235 duction of preexisting host signal cascades; sustained expression of the latency-associated open read

236 The sustained expression of the MAFB transcription factor in

237 s oncogenic alleles of RAS typically require sustained expression of the mutant allele for survival,

238 Sustained expression of the MYC transgene culminated in

239 Excitatory neurons exhibited sustained expression of the Na(+)-K(+)-Cl(-) cotransport

240 ed to the oligodendrocyte lineage, marked by sustained expression of the oligodendrocyte transcriptio

241 With inhibitory signals diminished and sustained expression of the positive factors SHH and VEG

242 chwann cell genes (Id2, c-Jun, and p75), and sustained expression of the promyelinating Schwann cell

243 AP itself was proteolyzed by CatL, promoting sustained expression of the protease during podocyte inj

244 Empirically, sustained expression of the redox-sensitive S70pBcl2 pre

245 Intra-amniotic IL-1beta also induced the sustained expression of the surfactant proteins in the l

246 Conversely, sustained expression of the transcription factor BATF en

247 Sustained expression of the transcription factor Foxp3,

248 hes will require efficient gene delivery and sustained expression of the transgene in recipients.

249 Here, we show that sustained expression of the zebrafish transcription fact

250 Sustained expression of therapeutic factor IX (FIX) leve

251 e been several reports over the past year of sustained expression of therapeutic levels of clotting f

252 BDNF mRNA in stg/stg mice demonstrates that sustained expression of this neurotrophin is not require

253 mechanism distinct from that regulating the sustained expression of this proteinase in activated mac

254 no-associated virus (rAAV) vectors allow for sustained expression of transgene products from mouse li

255 nscription factor, NeuroD1, is necessary for sustained expression of TRbeta2 in immature cone photore

256 infection, and induced the most dramatic and sustained expression of type I interferons and inflammat

257 from ovarian HB-EGF deficiency is a cause of sustained expression of uterine amphiregulin before the

258 However, sustained expression of WT MMP-8 by breast cancer cells

259 In contrast, sustained expression of YAP alone results in expansion o

260 Multiple cancers are dependent on sustained expression of YAP1 for cell proliferation, sur

261 file, deficient activation of NF-kappaB, and sustained expression of zDC and CCR2.

262 Finally, sustained expressions of c-Fos in GM3 KO MEFs were shown

263 owever, the functional significance of their sustained expression remains unclear.

264 Diminishing Hes1 oscillations by enforcing sustained expression slows down the cell cycle, impairs

265 e of cleaved caspase-1 in cells by day 1 and sustained expression until day 7 after radiation.

266 A rapid and sustained expression was noted in most amygdaloid and hy

267 Sustained expression was observed in all participants du