ライフサイエンスコーパス: sustained-release

1 ork materials with potential applications in sustained release.

2 provided by the microspheres together with a sustained release.

3 ascular injectable drug delivery systems for sustained release.

4 n exciting rational engineering strategy for sustained release.

5 a and none are able to provide controlled or sustained release.

6 the immobilization of FGF and controlled its sustained release.

7 6391 patients (81.5%) were taking verapamil sustained release; 4934 (62.9%) were taking trandolapril

8 ated gastric fluids (pH 1.2 and 4); while, a sustained release (77% during 12h) was observed in simul

9 development of particle-based approaches for sustained release after IVT injection.

10 ered in a single infusion, or from a two-day sustained-release alginate implant, produced an antidepr

11 ed an initial fast release, MCM-41, showed a sustained release along the time.

12 d on LDH, the dsRNA does not wash off, shows sustained release and can be detected on sprayed leaves

13 manipulation for delivery systems, providing sustained release and the ability to target specific cel

14 ation, whereas ON synapses showed relatively sustained release and weak rectification.

15 saponin resulted in high loading efficiency, sustained release, and catalase preservation against pro

16 on, prolonged circulation, reduced toxicity, sustained release, and improved efficacy.

17 The combination of improved tolerability, sustained release, and vascular targeting could potentia

18 from the 3 categories of immediate-release, sustained-release, and no-flush were purchased at health

19 ti-VEGF therapy suggests that higher dose or sustained-release anti-VEGF therapy may be effective for

20 ul as a carrier for therapeutic proteins for sustained release applications.

21 specializations that provide for graded and sustained release are not well-defined.

22 in a PLGA matrix resulted in vivo in a more sustained release as well as a higher amount of drug rel

23 a, supported by a mass action model, suggest sustained release at hair cell afferent fiber synapse is

24 g changes in light intensity into changes in sustained release at the cone ribbon synapse.

25 is loaded into silica nanopollens and shows sustained release behavior, potent antimicrobial activit

26 ransport of nanoparticle carboplatin, with a sustained-release behavior but without any associated sh

27 Moreover, niosomes exhibited more sustained release behaviour in simulated blood fluid tha

28 al burst release (25 %) between 0-24 h and a sustained release between 24-120 h with a cumulative rel

29 atment of abdominal fascial incisions with a sustained-release bFGF polymer significantly lowered the

30 sone intravitreal implant (DEX implant) is a sustained-release biodegradable implant approved for tre

31 rect nose-brain delivery of neuropeptides in sustained-release biodegradable nanoparticles (NPs) is a

32 e of the following drugs for up to 14 weeks: sustained-release bupropion (239 patients) at a maximal

33 (mean final dose, 55 mg per day) to receive sustained-release bupropion (at a dose of up to 400 mg p

34 m were randomly assigned either to switch to sustained-release bupropion (N=239), sertraline (N=238),

35 ing citalopram and receive augmentation with sustained-release bupropion (N=279) or buspirone (N=286)

36 tained-release naltrexone 32 mg per day plus sustained-release bupropion 360 mg per day combined in f

37 tained-release naltrexone 16 mg per day plus sustained-release bupropion 360 mg per day combined in f

38 her antidepressant (N=86; sertraline [N=27], sustained-release bupropion [N=28], or extended-release

39 therapy (N=65) or medication (N=117; either sustained-release bupropion [N=56] or buspirone [N=61])

40 Augmentation with sustained-release bupropion does have certain advantages

41 f combination treatment with varenicline and sustained-release bupropion for smokers who, based on an

42 The sustained-release bupropion group and the buspirone grou

43 Sustained-release bupropion hydrochloride was started at

44 Augmentation of citalopram with either sustained-release bupropion or buspirone appears to be u

45 -release venlafaxine or an augmentation with sustained-release bupropion or buspirone was provided (l

46 vely, were 21.3 percent and 25.5 percent for sustained-release bupropion, 17.6 percent and 26.6 perce

47 S-SR-16 response rates were 26.1 percent for sustained-release bupropion, 26.7 percent for sertraline

48 Sustained-release bupropion, however, was associated wit

49 onditions: nicotine lozenge, nicotine patch, sustained-release bupropion, nicotine patch plus nicotin

50 al (level 1), either a switch to sertraline, sustained-release bupropion, or extended-release venlafa

51 treatments: switch to another antidepressant-sustained-release bupropion; combination with another an

52 ion; combination with another antidepressant-sustained-release bupropion; or augmentation with an ant

53 drug delivery, as nanoparticles can provide sustained release, cellular targeting, and even intrinsi

54 e) (pHEMA) hydrogel was developed to achieve sustained release characteristics of antibiotics.

55 A sustained-release combination of naltrexone plus bupropi

56 th aspirin and hydrochlorothiazide and three sustained release compartments containing pravastatin, a

57 mendous advancements over the controlled and sustained release complemented from their high surface a

58 ncluding the newly approved aflibercept eye; sustained-release compounds that may allow for fewer inj

59 cent advances have led to the development of sustained-release corticosteroid devices using different

60 ns of CsA-loaded DIANAs in mice provided CsA sustained release, decreasing alloantigen-induced immune

61 rocess to produce polymeric microspheres for sustained-release delivery of protein drugs with preserv

62 lucosamine that has the dual properties of a sustained-release delivery system and a potent adjuvant.

63 methods - including hyperthermia, mechanical sustained released devices and nanoparticle drug conjuga

64 ch as intravitreal injection and intraocular sustained-release devices facilitate high local angiosta

65 of FDA-approved ranibizumab (Lucentis) and a sustained release dexamethasone implant (Ozurdex), along

66 y pro re nata (PRN) treatment (n = 124) or 1 sustained-release dexamethasone implant followed by PRN

67 Sustained release drug delivery systems remain a major c

68 ore effective drug delivery systems, such as sustained-release drug implants, to overcome these limit

69 ne therapy, and microparticle or viscous gel sustained-release drug-delivery platforms.

70 er 2/3 to layer 5 synapses were incapable of sustained release during prolonged, complex trains of pr

71 by a random but time-modulated appearance of sustained release events, which have a high potential to

72 every 4 hours as needed) or morphine (15 mg sustained release every 12 hours and 5 mg every 4 hours

73 study assessed efficacy and safety of oral, sustained-release fampridine in people with ambulatory d

74 aster muscle in mice treated for 4 days with sustained-release FGF-2.

75 To date, most sustained release fibers have been restricted to the del

76 h groups received 100 microg of perivascular sustained-release fibroblast growth factor (FGF)-2 in th

77 Half of the animals received intramuscular sustained-release fibroblast growth factor-2 (FGF-2).

78 Twenty-seven sustained-release fluocinolone acetonide implant (Retise

79 Sustained-release fluocinolone acetonide implant (Retise

80 Retrospective review of 27 consecutive sustained-release fluocinolone acetonide implant (Retise

81 n initial bolus in the 1st week, followed by sustained release for the remaining 3 weeks.

82 t our polymeric microspheres are suitable as sustained release formulation for targeted protein const

83 Sustained release formulation of larger biological molec

84 months old) were treated daily with either a sustained release formulation of MPH or placebo (N=8 per

85 n in 1952 with the introduction of the first sustained release formulation.

86 ence; these limitations may be obviated by a sustained release formulation.

87 The drug is administered as a sustained-release formulation.

88 of two polymeric microparticle (MP) EPO-R76E sustained release formulations based on conventional hyd

89 Improvements in sustained-release formulations and patient-controlled an

90 itors are applied may also be critical, with sustained-release formulations and vaginal ring delivery

91 Sustained-release formulations of contraceptive hormones

92 The initial sustained-release formulations of methylphenidate had re

93 Potassium chloride depolarization caused sustained release from synaptoneurosomes of Abeta(42) as

94 Thermo-reversible sustained-release green tea catechin gel was prepared an

95 empt was made to develop a thermo-reversible sustained-release green tea gel and to study its clinica

96 e of abdominal wall incisional hernias using sustained release growth factor therapy.

97 y other solubilization methods, and provided sustained release (>14 and > 7 days for the nMIC and nFI

98 Sustained-release IGF-1 pellets were implanted bilateral

99 wering effect of a biodegradable bimatoprost sustained-release implant (Bimatoprost SR).

100 the posterior segment was evaluated, using a sustained-release implant containing gadolinium-DTPA (Gd

101 al implant (DEX implant) is a biodegradable, sustained-release implant that releases dexamethasone fo

102 developing countries where newer options of sustained-release implants and oral valganciclovir are u

103 ions over a 6-month period was 11.7% that of sustained-release implants for unilateral treatment and

104 Because sustained release in darkness is governed by vesicle rep

105 the bulk material with possible utility for sustained release in robust, programmably shapeable mech

106 olubility and bioavailability, and providing sustained release in the GI tract.

107 edication (i.e., brimonidine) formulated for sustained release in the supraciliary space of the eye a

108 d 50% drug release within 38.5 h followed by sustained release in therapeutic doses over 2 weeks.

109 DT)-treated steel surfaces demonstrated both sustained release in vitro over 30 days and localized gr

110 teria 1.5 log units the first day and showed sustained release, inhibiting 0.52 and 0.76 log units, r

111 ulation half-life and achieve controlled and sustained release into tumor cells, anticancer miRNAs ne

112 ngle formulation (DMQ-MSs) to create a novel sustained-release intraocular drug delivery system (IODD

113 Sustained-release intravitreal drug implants for posteri

114 osterior segment either via nanoparticles or sustained-release intravitreal implants may supplant rep

115 As such, controlled and sustained release is a significant concern as the locali

116 resumes upon fluid exchange, suggesting that sustained release is possible under flow conditions.

117 lied to a variety of protein drugs requiring sustained release kinetics.

118 isorders significantly improved while taking sustained-release lithium carbonate compared to placebo

119 re) was also lower in the group treated with sustained-release lithium carbonate compared to placebo.

120 with bipolar spectrum disorders; it compares sustained-release lithium carbonate to placebo.

121 blind, placebo-controlled treatment study of sustained-release lithium carbonate.

122 2 completers were rated as responders in the sustained-release lithium group versus five (29%) of 17

123 Sustained-released lithium may be an effective treatment

124 s, an enormous opportunity exists to develop sustained-release, local delivery systems that enable bo

125 ain paclitaxel within the lungs, achieve its sustained release locally, and thereby, improve its effi

126 the best candidate for a passively targeted sustained release lung delivery system.

127 s a vaccine candidate when administered in a sustained-release manner.

128 een silk and drug molecules, near-zero order sustained release may be achieved through diffusion- and

129 This depletion of release sites implies that sustained release may be rate limited by vesicle deliver

130 was to investigate the use of an injectable sustained release microparticle formulation of curcumin

131 horoid-RPE in pigmented rats is also true of sustained-release microparticle systems.

132 Extended-release naltrexone, a sustained-release monthly injectable formulation of the

133 chronic treatment with therapeutic doses of sustained release MPH did not have a significant influen

134 in fixed-dose tablets (also known as NB32), sustained-release naltrexone 16 mg per day plus sustaine

135 andomly assigned in a 1:1:1 ratio to receive sustained-release naltrexone 32 mg per day plus sustaine

136 Combination treatment with sustained-release naltrexone and bupropion was developed

137 Conjugation of GIRLRG to a sustained-release nanoparticle drug delivery system yiel

138 The sustained-release nascent-HBr enabled the chemoselective

139 t the central-most levels, with increasingly sustained release near the borders.

140 atic toxicity is common with higher doses of sustained-release niacin but rare with immediate-release

141 Over-the-counter sustained-release niacin contains free nicotinic acid, b

142 g for immediate-release niacin, 502.6 mg for sustained-release niacin, and 0 for no-flush niacin.

143 Additionally, sustained-release NP-EFs, administered 24 h prior to inf

144 e purpose of this study was to assess if the sustained release of 4% doxycycline through a bioabsorba

145 lymer implants and RF ablation shows uniform sustained release of 5-FU for 48 hours at least 8 mm fro

146 material that exhibits stable, near-linear, sustained release of a model hydrophilic protein (e.g.,

147 Here, we report on the encapsulation and sustained release of a model hydrophobic drug (dexametha

148 e conduit with aligned microchannels for the sustained release of a small molecule drug that promotes

149 antibiotic conjugate ('nanobiotics') deliver sustained release of active drug upon hydrolysis in acid

150 a type of drug formulation that enables the sustained release of an active therapeutic agent (payloa

151 he use of direct genetic programming via the sustained release of an exogenously delivered transcript

152 as adjuvants or immunomodulators, allow for sustained release of antigen, enable single dose deliver

153 ze the design of lipodisks, for example, for sustained release of antimicrobial peptides in therapeut

154 from Alternaria alternata evoked a rapid and sustained release of ATP with greater efficacy observed

155 Sustained release of basal insulin also correlated with

156 Overall, our data shows the potential of sustained release of betaCAB via a nanofluidic implant f

157 icles allow shielded, targeted transport and sustained release of bioactive cargo material.

158 ansplantation, and PEAD-base Coa exhibited a sustained release of bioactive IGF-1 over 3 weeks.

159 rmination, generation of advanced materials, sustained release of bioactive molecules, and control of

160 onalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorph

161 d force generation and muscle size caused by sustained release of BMP-4 suggests that myogenic signal

162 A-LL37 NP) promotes wound closure due to the sustained release of both LL37 and lactate.

163 Gel matrix enabled sustained release of both oAd and DCs while preserving t

164 timulating factor (GM-CSF) (oAd) and DCs for sustained release of both therapeutics.

165 The second phase consisted of a sustained release of calcium from the vacuole via the ca

166 rug delivery system that produces a slow and sustained release of chemotherapeutic agent, has recentl

167 ndages are developed for either targeted and sustained release of chemotherapeutic nanodrug for liver

168 ed as Safe (GRAS) materials that can provide sustained release of corticosteroids to prevent corneal

169 solubilized higher amounts and provided more sustained release of CsA in vitro, nFIB enhanced cellula

170 -NPs could be internalized in the DCs with a sustained release of CsA to the culture medium, suppress

171 This activity is responsible for the sustained release of dopamine necessary for the proper f

172 EG5K-Fmoc-VE2/DOX mixed micelles showed more sustained release of DOX in comparison to the counterpar

173 The sustained release of Doxo from Doxo-PLA NCs was achieved

174 ned, facilitating the enhanced retention and sustained release of drug cargos for improved cancer the

175 The cyclosporine implants showed sustained release of drug over time with in vitro assays

176 Additionally, successful treatments require sustained release of drug payloads to maintain the effec

177 ery devices offers an effective strategy for sustained release of drugs with immediate applicability

178 hese locations, and subsequently maintaining sustained release of drugs.

179 m a subsecond abrupt burst release to a slow sustained release of encapsulant over many minutes.

180 These findings suggest that pSNL induced a sustained release of endogenous prodynorphin-derived opi

181 Both PLGA and PPS MPs enabled sustained release of EPO-R76E, providing therapeutic ben

182 e(3+) ternary nanoparticle system to provide sustained release of exendin-4 in vivo.

183 represents an efficient, tunable method for sustained release of gene vectors to the vasculature.

184 nt against devastating diseases by providing sustained release of high concentrations of therapeutic

185 This study shows that the sustained release of IGF-1 can enhance tissue formation

186 mors and can be reactivated by the local and sustained release of IL-12 to proliferate and secrete IF

187 ion of transplanted cancer cells and provide sustained release of immunomodulators.

188 nt homing to lymph nodes can be modulated by sustained release of inflammatory signals and adjuvants

189 icity in synchrony with a photoinitiated and sustained release of inhibitors that suppress tumour reg

190 o primary s.c. tumors to achieve a local and sustained release of interleukin 12 (IL-12), granulocyte

191 This ternary nanoparticle formulation offers sustained release of liraglutide for >8 days by optimizi

192 ontact of T cells and the paAPCs and require sustained release of low levels of IL-2.

193 P2Y(2)R) agonist UTP stimulates a strong and sustained release of LTA from WT but not P2Y(2)R(-/-) SM

194 ring hydrogel scaffold was developed for the sustained release of macromolecules to enhance the diffe

195 cle provides efficient local, selective, and sustained release of miR-96/miR-182, markedly suppressin

196 applications that require encapsulation and sustained release of molecules in aqueous environments.

197 of the IHC ribbon synapses not only enables sustained release of neurotransmitter but also imposes t

198 Sustained release of neurotransmitter depends upon the r

199 signal graded changes in light intensity via sustained release of neurotransmitter.

200 We verified the sustained release of neurotrophin-3 from peptide-conjuga

201 g molecule in cardiovascular system, and the sustained release of NO by endothelial cells plays a vit

202 A) nanoparticles loaded with SA-2 provided a sustained release of NO over days, improved aqueous stab

203 stomach and intestinal simulation, showed a sustained release of PAs from PLA-NPs.

204 ntly encapsulate nucleic acid cargo, exhibit sustained release of payload, and can stably transfect c

205 termined that the thioether linkage provided sustained release of peptide over 72h.

206 Importantly, the NP-mediated sustained release of pGFP generates enhanced GFP express

207 Coupled with the sustained release of physiological amounts of osteoinduc

208 nstrate that membrane budding results in the sustained release of platelets directly into the periphe

209 isk factors, prolonged glial activation, and sustained release of pro-inflammatory mediators in glauc

210 biodegradable polymeric microspheres for the sustained release of proteinaceous drugs.

211 MSC osteogenic differentiation in vitro and sustained release of PRP alone on a fracture defect mode

212 Sustained release of PRP along with BMP2-modified MSCs c

213 Sustained release of PRP and BMP2 demonstrated significa

214 irst study to examine the combined effect of sustained release of PRP from alginate beads on BMP2-mod

215 summary, quininib-HA microneedles allow for sustained release of quininib; are safe in vivo and quin

216 onstrated the capability of nanoemulsions in sustained release of resveratrol from dialysis bags comp

217 The nanoparticles demonstrated sustained release of rifampicin for a week with the anti

218 nked zwitterionic polymer layer leads to the sustained release of rituximab as the crosslinkers are g

219 ride-ester) (SA-PAE) provides controlled and sustained release of salicylic acid (SA) that locally re

220 The effect of sustained release of SDF-1 from PPCN (PPCN+SDF-1) versus

221 In conclusion, sustained release of SDF-1 from PPCN is a promising and

222 goal of this research was to assess whether sustained release of SDF-1, a chemokine that promotes en

223 ve vasculitis both induced a significant and sustained release of sFlt1 from monocytes, whereas anti-

224 This results in sustained release of soluble tumor necrosis factor alpha

225 Local sustained release of Sunb-malate through the SCT injecti

226 er cells through endocytosis and demonstrate sustained release of the active agent, resulting in the

227 The DDCs showed cell uptake and sustained release of the bound drugs in conditions mimic

228 high initial intratumoral concentration and sustained release of the chemotherapeutic.

229 f Dex within the beaded structure results in sustained release of the drug over the period of 28days.

230 Targeted CONs showed sustained release of the drug to the cancer cells throug

231 dy with these plasma gels indicated slow and sustained release of the drugs.

232 and biological conditions providing a slow, sustained release of the exceptionally potent free drug.

233 mer films were fabricated for the controlled sustained release of the Ga- or Zn-complexes, using an i

234 We tested whether local, sustained release of the neurotrophic factor neurotrophi

235 vealed an effective bactericidal profile and sustained release of the parent antibiotic over time.

236 Sustained release of the pGFP payload was shown over a p

237 the nanotherapeutic in mice led to slow and sustained release of the prodrug, reduced exposure of ac

238 re 'exposed-core' vaginal ring that provides sustained release of the protein microbicide candidate 5

239 The latter accordingly resulted in a more sustained release of the volatile, trans-2-hexenal, from

240 iciency (ca. 46-56%), could be prepared, and sustained release of their entrapped cargoes have been d

241 Sustained release of therapeutic levels of 9-cis-retinoi

242 platforms that facilitate the localized and sustained release of therapeutics.

243 ration in rats showed extended stability and sustained release of these ligands.

244 GA microPlates (muPLs) were realized for the sustained release of two anti-inflammatory molecules, th

245 ibrin (PRF) is a platelet concentrate having sustained release of various growth factors with regener

246 ted gene delivery system to provide safe and sustained release of various nucleic acid-based therapeu

247 In this study, we hypothesize that local sustained release of vascular endothelial growth factor

248 ent can be removed from a population through sustained release of wild-type insects.

249 neutrophil-mediated lung metastasis via the sustained release of Zileuton.

250 Reproducible, sustained releases of both dexamethasone and solid dispe

251 tes achieved high GRFT loading, and provided sustained-release of GRFT for up to 90 d.

252 -electrospun fiber (EF) composite to provide sustained-release of GRFT, and to examine its safety and

253 The resulting hydrogel provides sustained-release of protein for more than a week.

254 e randomly assigned to either CAS (verapamil sustained release) or NCAS (atenolol).

255 INVEST were randomly assigned to a verapamil sustained-release- or atenolol-based strategy; blood pre

256 In addition to sustained release oral medication, the transdermal patch

257 vel polymeric platform that provides steady, sustained release over a range of precise doses.

258 eritoneal (IP) metronomic chemotherapy using sustained release paclitaxel (PTX) delivery from electro

259 The drug release showed sustained release pattern noted up to 24h.

260 Sustained-release pellets, releasing 500 nanograms/day o

261 Our findings provide a sustained release platform for local delivery of tyrosin

262 tered interleukin 12 (IL-12) encapsulated in sustained-release polymer microspheres significantly enh

263 X) 40, a non-biodegradable, non-inflammatory sustained-release polymer.

264 -vinyl acetate (ELVAX), a non-biodegradable, sustained-release polymer.

265 To assess the effect of a sustained-release preparation of bone morphogenetic prot

266 des a new approach that can be combined with sustained-release preparations to optimize delivery of a

267 Moreover, curcumin exhibited sustained release profile from crosslinked nanogels in s

268 The niosomes had sustained release profile in the simulated gastric and i

269 iding a low complement activation as well as sustained release profile with high tunability.

270 e polypill showed the intended immediate and sustained release profiles based upon the active/excipie

271 linker design (TAF 51 wt%) showed excellent sustained release profiles of the key metabolite tenofov

272 pes effectively loaded EPO-R76E and achieved sustained release, providing detectable levels of EPO-R7

273 double-blind four-period crossover study of sustained-release ranolazine 500, 1,000, or 1,500 mg, or

274 torial rapid burst response along with slow, sustained release, respectively.

275 nicline tartrate and bupropion hydrochloride sustained-release (SR) on neurobiological targets relate

276 were assigned randomly to either a verapamil sustained-release (SR)- or an atenolol-based strategy fo

277 (30 min - day 84) plasma profile of PT320, a sustained-release (SR)-Exenatide formulation under clini

278 However, the use of intravitreal of sustained-released steroid had not been mentioned to dat

279 Furthermore, we develop a slow sustained-release strategy to overcome the limited dispe

280 in situ mucoadhesive gel is a controlled and sustained release system that facilitates the absorption

281 day 8, to determine the effectiveness of the sustained release system.

282 r delivery of an anti-VEGF molecule within a sustained-release system, showing protection in a pre-cl

283 ) focused on developing oral and transdermal sustained release systems and establishing controlled dr

284 Various sustained release technologies were considered, and base

285 we demonstrate that nanoformulating 1K1 for sustained release temporally alters downstream signaling

286 es tethered to the ribbon provide a pool for sustained release that is typically fivefold greater tha

287 d increase in glycerol secretion followed by sustained release that was 40% higher than basal concent

288 Furthermore, layer 5 to layer 5 synapses sustained release throughout the duration of prolonged,

289 rties of the encapsulated compounds, provide sustained release to specific organs, "cover up" undesir

290 tenolol/hydrochlorothiazide or verapamil-SR (sustained release)/trandolapril in INVEST (INternational

291 f these novel nanotherapeutics toward future sustained release treatments via administration directly

292 oof of principle that intranasal delivery of sustained-release TRH-NPs may be neuroprotective and can

293 or proteins) allowing for formulations with sustained release tuned by the tube end-stoppers for hou

294 Vaccination with a sustained-release vehicle to enhance vaccination efficac

295 Sustained release was demonstrated, and drug loading cor

296 e of lamellar bone area for intermittent and sustained release was higher than that for the control g

297 For 5P12-RANTES, sustained release was obtained for 31 days using water v

298 easure of their ability to be formulated for sustained release, was determined using RP-HPLC at neutr

299 ddition, hydrogel delivery, which mimics low sustained release, was equally effective as gavage for B

300 vide a large pool of releasable vesicles for sustained release, while minimizing spontaneous release