ライフサイエンスコーパス: switching to

1 Switching to 8-week to 12-week IFN-free DAAs in prisons

2 story of glaucoma or ocular hypertension and switching to a 'PRN' injection protocol in patients suff

3 The highest-cost option of switching to a 3-dose IPV schedule only marginally decre

4 is associated with poor renal response when switching to a calcineurin inhibitor (CNI)-lowered or CN

5 This problem can be solved upon switching to a catalyst comprising a [Ru-Cl] bond, provi

6 ng of a system ranging from controlled state switching to a catastrophic break-down; signals that pre

7 We suggest that switching to a consensus reference would offer important

8 we examined their transfer of learning when switching to a contralateral hand, the second identical

9 lapse, either by restoring cooperation or by switching to a defector strategy.

10 ver consecutive trials in one context before switching to a different context.

11 Importantly, switching to a fish oil-supplemented diet induced a reco

12 The system responds by retaining or switching to a fold where (oxo)G is in syn conformation.

13 improvement of their variety of symptoms on switching to a GFD.

14 and inflammation that was irreversible upon switching to a healthy diet.

15 otility at high calcium is due to calmodulin switching to a higher affinity binding site, which leave

16 lternating pattern under control conditions, switching to a hopping activity at any frequency after r

17 -type alpha2-3-linked sialosides rather than switching to a human-like receptor specificity and highl

18 ns on' both reactivity and luminescence upon switching to a hydrated state.

19 e deficiencies caused by HFD were rescued by switching to a low fat diet for one month, suggesting a

20 Switching to a low temperature triggers the folding of t

21 r 2 d of high-fat feeding, but reduces after switching to a low-fat diet for 1 d.

22 hypocalciuria and displayed salt wasting on switching to a low-Na diet.

23 at least 80%, down-titration was defined by switching to a low/moderate-intensity statin with a prop

24 straight-forward method to induce resistive switching to a memristive device, introducing a new vers

25 We analyze the clinical impact of switching to a molecular assay with a 3-h test-turnaroun

26 Our analysis indicates that switching to a more specialized catabolism and scavengin

27 lusion, increasing auxiliary gas pressure or switching to a more volatile spray solvent also increase

28 Switching to a multiplex respiratory panel with a clinic

29 treatment-experienced individuals in RESPOND switching to a new 2DR or 3DR from 1/1/12-1/10/18 were i

30 is important to compare the risk in patients switching to a new product with that in a parallel contr

31 r omitting postoperative chemotherapy and/or switching to a noncross-resistant regimen in patients wi

32 ) management recommend heparin cessation and switching to a nonheparin anticoagulant (ie, argatroban,

33 spective why mental fatigue diminishes after switching to a novel task and explains action selection

34 Cytokines direct IgH class-switching to a particular isotype by initiation of germl

35 lation, while reducing to a smaller size and switching to a positive surface charge for efficient pen

36 ted of cell-associated hyaluronan respond by switching to a pro-catabolic metabolism that includes en

37 al that LH2 complexes undergo photoactivated switching to a quenched state, likely by a conformationa

38 gic changes in response to brain metastasis, switching to a reactive phenotype, which has the potenti

39 Therefore, we propose that, in switching to a resistive state, the nanotube oxidizes by

40 Switching to a running gait at 2.0 m.s(-1) caused fascic

41 also show the clinical benefit and safety of switching to a second TNF inhibitor without a washout pe

42 d viral load to promote adherence and timely switching to a second-line regimen.

43 Cold progressively promotes cell-autonomous switching to a silenced state.

44 d STAT3 activity, and caused VSMC phenotypic switching to a similar extent as TGFbeta1 or angiotensin

45 ed the efficacy, safety, and tolerability of switching to a single-tablet regimen containing rilpivir

46 We investigated the efficacy and safety of switching to a single-tablet regimen of darunavir, cobic

47 Switching to a Sn-based catalyst, for the first time O(2

48 can be continued in an approximate manner by switching to a spin-flip approach.

49 We show that pro-B cells undergo robust switching to a subset of immunoglobulin H (IgH) isotypes

50 onventional quantitative confirmation) after switching to a TD-ESI source from a conventional ESI sou

51 Switching to a tenofovir alafenamide-containing regimen

52 1 and SWORD-2 trials at 48 weeks showed that switching to a two-drug regimen of dolutegravir plus ril

53 Switching to a wP-priming vaccination strategy could red

54 of environmental variables on being in, and switching to, a particular state.

55 gnitive functioning in this population after switching to abacavir (ABC)/lamivudine (3TC)/DTG over 6

56 Here we report the biological event switching to activate necrosis over apoptosis.

57 rtolizumab pegol and 40 (62%) of 65 patients switching to adalimumab responded 12 weeks later by achi

58 ab seem to exhibit retinal dehydration after switching to aflibercept, whereas there was no demonstra

59 Switching to agalsidase-alfa is safe, but microalbuminur

60 Overall, 1,962 patients switching to AIs were matched to 3,874 patients continui

61 Prompt diagnosis and switching to alternative ART could reduce early mortalit

62 ineffective drugs taken and facilitate early switching to alternative medication when available.

63 Switching to alternative unboosted integrase regimens sh

64 Switching to alternative unboosted integrase regimens sh

65 g any medication, under tamoxifen, and after switching to an AI.

66 er 21 days of first-line chemotherapy, early switching to an alternate cytotoxic therapy was not effe

67 e institutions had the lowest probability of switching to an alternative center (odds ratio, 0.009; P

68 n which (i) SFPQ binds its mRNA and promotes switching to an alternative distal 3'-UTR that is target

69 The effect of switching to an alternative GBCA or using allergy skin t

70 Secondary analyses of GBCA class, switching to an alternative GBCA, and allergy skin testi

71 cular dynamics simulations display transient switching to an alternative open conformer.

72 se reward to promote choice repetition after switching to an alternative option due to a diminished i

73 studies have established that a strategy of switching to an aromatase inhibitor after 2 to 3 years o

74 ffered the choice of continuing tamoxifen or switching to an aromatase inhibitor for 10 years total a

75 The program includes PERK-dependent switching to an eIF3-dependent translation initiation me

76 conversion, no association was found between switching to an employment model and improvement in any

77 performance up to 2 years after evidence of switching to an employment model; however, beneficial ef

78 particle ICS (mean dose 710 ug), followed by switching to an equivalent dose of extra-fine particle h

79 ing a sequential IPV/OPV schedule instead of switching to an IPV-only schedule in 2005 would have kep

80 atellite cells lose reversible quiescence by switching to an irreversible pre-senescence state, cause

81 e conventional bar-shaped geometry) leads to switching to an off state while retaining the ultrahigh

82 ients who received L-T4 in tablet form after switching to an oral liquid formulation with the same L-

83 Thus, hepatic down-regulation of Ctr1 allows switching to an SCC-mediated removal of copper via kidne

84 id chromatography with positive/negative ion switching to analyze 258 metabolites (289 Q1/Q3 transiti

85 The cellular pathways involved in switching to and from the L-form state remain poorly und

86 ing phacoemulsification with PCT rather than switching to another backup IOL demanding wound enlargem

87 proved or changed within their channel or by switching to another channel.

88 may benefit from continued treatment without switching to another drug.

89 greater treatment persistence compared with switching to another injectable preparation following on

90 y-prediction error deficits by spontaneously switching to another learning mechanism.

91 hK1 inhibitor or in SphK1(-/-) mice, isotype switching to antigen-specific IgE was decreased in vivo

92 ed inappropriate therapy (P = .016), despite switching to appropriate antifungal therapy after a medi

93 Switching to aripiprazole led to improvement of non-HDL

94 n ePET is positive after two cycles of ABVD, switching to BEACOPPesc + INRT significantly improved 5-

95 es for monopolar growth initiation and later switching to bipolar growth.

96 We investigated the outcomes of switching to bivalirudin after initial administration of

97 tients who receive early treatment with UFH, switching to bivalirudin before primary percutaneous cor

98 telaprevir skin rash and anal discomfort by switching to boceprevir.

99 between 2 and 80 in the affected eye before switching to brolucizumab.

100 Switching to Bt cotton producing two or more toxins and

101 n during 12 weeks of treatment compared with switching to bupropion monotherapy.

102 oral phosphate and active vitamin D, versus switching to burosumab, a fully human monoclonal antibod

103 uggests a potential mechanism for polymerase switching to bypass lesions.

104 pletely antagonized by a SOCE antagonist, by switching to Ca(2+)-free medium, and by overexpression o

105 s were transplanted either directly or after switching to central bilateral centrifugal pump, ventric

106 certolizumab pegol; 33 (58%) of 57 patients switching to certolizumab pegol and 40 (62%) of 65 patie

107 Switching to cheaper asthma drugs, using less medication

108 ning mice, plasma cholesterol was lowered by switching to chow diet and treatment with LDLR sense oli

109 Switching to CL detection, the same immunosensor exhibit

110 rogressive subcortical volume deficits after switching to clozapine despite experiencing symptomatic

111 dication use or that it is contributed to by switching to clozapine treatment.

112 enitor were meiotically unstable, frequently switching to co-dominance.

113 actin, thus facilitating Tpm conformational switching to cooperatively propagate along F-actin.

114 c enrichment of 5' capped RNAs with template switching to create sequencing libraries.

115 interquartile range, 1.1-2.3 days]) prior to switching to daptomycin.

116 We exploit this switching to demonstrate energy-efficient control of a s

117 In contrast, switching to depsipeptide substrates effectively renders

118 Data suggest that switching to dormancy not only represents a mechanism of

119 rd combination antiretroviral therapy (cART) switching to DTG + emtricitabine (FTC).

120 eeks on standard cART were randomized 1:1 to switching to DTG + FTC or to continuing cART, and 1:1 to

121 ) improved both after immediate and deferred switching to DTG overall and regardless of baseline PI/r

122 DTG-I arm and 5 (1 while on PI/r and 4 after switching to DTG) in the DTG-D arm without selection of

123 We present efficacy and safety of switching to DTG/3TC in virologically suppressed individ

124 Switching to dual therapy was associated with a signific

125 reviously demonstrated the noninferiority of switching to efavirenz (EFV) versus remaining on ritonav

126 h ritonavir-boosted lopinavir-based therapy, switching to efavirenz-based therapy compared with conti

127 udies have directly compared the outcomes of switching to either of these agents.

128 Switching to Erwinia asparaginase leads to effective asp

129 iving all prescribed PEG-ASNase doses versus switching to Erwinia but receiving all doses versus not

130 ntegrating pollinator dispersal and resource switching to estimate city-scale effects of management i

131 ment showed that the on-treatment benefit of switching to exemestane (HR, 0.60; 95% CI, 0.48 to 0.75;

132 The protective effect of switching to exemestane compared with continuing on tamo

133 all area intensively ('local search') before switching to explore a much larger area ('global search'

134 After switching to fingolimod (M0-12 vs M13-EOS), patients ini

135 tching to natalizumab is more effective than switching to fingolimod in reducing relapse rate and sho

136 by approximately 50% in the first year after switching to fingolimod treatment (44.3% to 66.0%).

137 After switching to fingolimod, numbers of new or newly enlargi

138 es including laser and anti-VEGF injections, switching to fluocinolone achieved treatment benefit.

139 re low in 10 (26%) of 39 at some time before switching to foscarnet.

140 After switching to FP/FM-pMDI, asthmatic symptoms and plural v

141 is an important barrier to ORS use and that switching to free distribution by CHWs substantially inc

142 Switching to free distribution is low-cost, easily scala

143 ibitor (PI) + 3TC/ABC regimen, the merits of switching to FTC/TDF as the NRTI backbone are unknown.

144 Switching to FTC/TDF from 3TC/ABC maintained virologic s

145 Switching to FTC/TDF showed improved NCEP thresholds for

146 By TLOVR through week 48, switching to FTC/TDF was noninferior compared to continu

147 eek study to evaluate efficacy and safety of switching to FTC/TDF.

148 Compared with persons switching to generic latanoprost, patients who continued

149 d that these variations can be suppressed by switching to growth conditions with a low V/III ratio.

150 ubjects attempted to maximize their gains by switching to habitats that possessed low competition den

151 ith remarkable antitumor activity by isotype switching to hIgG2.

152 Switching to hormone-independent endoreplication after m

153 This finding links genotoxin induced switching to Hst3 regulation.

154 GARP/latent TGF-beta1 complexes with isotype switching to IgA production.

155 13, a cytokine involved in plasma cell class switching to IgA.

156 esponse to interleukin 4 (IL-4), hence class switching to IgE and IgG1, is not fully understood.

157 e that early Iepsilon transcription leads to switching to IgE and occurs at lower activation levels t

158 okines synergistically promoted B-cell class switching to IgE and plasma cell differentiation.

159 s determines their capacity to undergo class switching to IgE ex vivo, with the GC-derived B cells yi

160 an IgE member, are consistent with indirect switching to IgE from IgG- or IgA-expressing lineage mem

161 esponses in T cells and immunoglobulin class-switching to IgE in B cells.

162 We evaluate models for isotype switching to IgE in human subjects using immunoglobulin

163 ated with IL-4 and anti-CD40 to induce class switching to IgE in vitro, mCD23 is upregulated, and sCD

164 falling close to the threshold required for switching to IgE production.

165 aling, cell proliferation, and de novo class switching to IgE were analyzed by RT-PCR and FACS.

166 vidence of local receptor revision and class switching to IgE, and B-cell differentiation into IgE-se

167 line transcript, reflecting antibody isotype switching to IgE, measured at 6 years of age.

168 n activation of the Cepsilon locus and class switching to IgE.

169 of CD4(+) T cell responses and B cell class switching to IgE.

170 by cytokines that regulate Ig H chain class switching to IgE.

171 broader IGHV gene usage and extensive class switching to IgG and IgA subclasses with limited somatic

172 defective proliferation during activation of switching to IgG1 and IgE.

173 We found that class-switching to IgG1 biased the fate choice made by B cells

174 s and provide indirect help for B-cell class switching to IgG1 in both transnuclear and wild-type mic

175 ntly to Ag specific IgG2a and IgG2b, whereas switching to IgG1 is not affected.

176 lls alone induce T helper 2-associated class switching to IgG1, but few AFC or GC B cells express CXC

177 Frequencies of isotype switching to IgG1, IgG2b, IgG2c, and IgG3 were the same

178 rophage activation, and immunoglobulin class switching to IgG1, were enhanced in Batf3(-/-) mice resp

179 IgG4 mAb to IgG1 decreased activity, whereas switching to IgG2 markedly increased activity.

180 gD(+)CD27(+) B cells into PCs, induced class switching to IgG2, and was reproducible in cocultures wi

181 to express high levels of CXCR3, and diverse switching to IgG2a, IgG2b, with some IgG1.

182 ermines the generation of high-affinity IgG, switching to IgG2c, early memory B cells, and recall ant

183 nterparts, although they no longer underwent switching to IgG2c.

184 a higher turnover rate during activation of switching to IgG3 and IgG2b, as well as delays in CSR ki

185 Switching to IgG3 was significantly reduced in IkappaBNS

186 crosstalk impeded induction of IFN-gamma and switching to IL-10.

187 w, we use a phenomenon referred to as patchy switching to illustrate the interplay of nonlinearities,

188 isk, as was slower achievement of UMRD after switching to imatinib.

189 their characteristic quantum yield of photo-switching to imprint spatio-temporal modulations onto th

190 we propose to utilize the 90 degrees -domain switching to improve the magnetostriction of Galfenols b

191 is an opportunistic forager capable of diet switching to include a greater proportion of alternative

192 perienced more flares per person-years after switching to infliximab-abda (.92), than on the originat

193 patients (66.7%) who experienced flare after switching to infliximab-abda did so within 90 days.

194 Switching to intravitreal aflibercept appears to be an e

195 h life-history evolved through older females switching to invest in their existing (grand)offspring,

196 research is needed to evaluate the effect of switching to ISCS from the physician and surgical facili

197 ic cellular pathways and a lack of metabolic switching to ketosis resulting in a deficit in GABAergic

198 Thus lowering body weight by switching to LF diet in obese mice with heart failure is

199 acid oxidation enzymes at Wk-4 supported the switching to lipid metabolism.

200 an effect that was reversed by subsequently switching to low glucose media.

201 al tradeoff between crop water footprint and switching to lower emissions pumping fuels.

202 ntains stable lysogeny, yet allows efficient switching to lysis.

203 to environmental changes, which may require switching to lytic conditions.

204 vidual RBCs by combining ultrarapid solution switching (to manipulate gas tension) with single-cell O

205 ing an exclusively light-triggered resistive switching to memristive devices irrespectively of the st

206 dose resulted in better disease control than switching to methotrexate alone or placebo, but no signi

207 associated cooling degree days by greening, switching to modern nonsolid cooking fuels, and anticipa

208 of staying on antipsychotic polypharmacy or switching to monotherapy.

209 usly showed that IgW VDJ can perform isotype switching to mu C regions; in this study, we found that

210 with injectable disease-modifying therapies, switching to natalizumab is more effective than switchin

211 demonstrate for the first time, that lineage switching to NE states is accompanied by key miRNA alter

212 no previous interactions, and elaborated by switching to new signals more with the unfamiliar than t

213 ations to life-cycle analyses, we found that switching to NGVs from conventional vehicles in China ha

214 whether the clinical benefits observed with switching to nilotinib are associated with improved long

215 In summary, switching to nilotinib enabled more patients with chroni

216 ved cytogenetic and molecular responses with switching to nilotinib than with imatinib dose escalatio

217 ed to investigate the safety and efficacy of switching to nilotinib vs imatinib dose escalation for p

218 matinib-based approach with selective, early switching to nilotinib.

219 influences care only for people with DTG AEs switching to NNRTI-based regimens.

220 tity of liquid consumed; by current drinkers switching to no alcohol alternatives for part of the tim

221 le of transformation in facilitating capsule switching to non-vaccine serotypes and the emergence of

222 247 genomes, we demonstrate that regulatory "switching" to nonhomologous alternatives is ubiquitous,

223 -induced inhibition of DNP dCTP synthesis by switching to NSP-mediated dCTP production.

224 y, we assessed the effects of maintaining or switching to ocrelizumab therapy on measures of disease

225 Changing background medications or switching to open-label ixekizumab Q2W, or both, was all

226 ic and demographic characteristics predicted switching to or from active commuting, whether switching

227 able on such treatment would remain so after switching to oral eliglustat, a selective inhibitor of g

228 mic voriconazole and progression of IA after switching to oral posaconazole.

229 enefits and risks for patients in ceasing or switching to other medicines.

230 y IgW VDJ can take place at the DNA level by switching to other omega or mu C regions, as well as by

231 Switching to PBO bednets could avert up to 0.5 clinical

232 ontinued to receive vedolizumab (rather than switching to placebo) were more likely to be in remissio

233 rits from the <10 nm into the 1 mum range or switching to polymeric frits with pores in the 1 to 10 m

234 s significantly greater at 24 and 48 h after switching to prasugrel versus continued therapy with tic

235 t represents task-reward associations, later switching to process tasks and rewards directly.

236 , we analyze stochastic models of phenotypic switching to provide a framework for analyzing cell-fate

237 Recent reports suggest that switching to rapamycin from calcineurin antagonists redu

238 -scaffold complex undergoes stochastic state switching to reach an active state.

239 n to the myocardium and subsequent phenotype switching to reparatory Ly6C(lo)MerTK(hi) macrophages wa

240 oring, nanopore behavior, and conformational switching to reveal membrane-binding units.

241 INTERPRETATION: Switching to rilpivirine, emtricitabine, and tenofovir a

242 INTERPRETATION: Switching to rilpivirine, emtricitabine, and tenofovir a

243 In RTR already receiving fluvastatin, switching to rosuvastatin further decreased LDL choleste

244 Switching to second-line antiretroviral therapy after 2

245 ed ART delivery by 25 percentage points, and switching to second-line ART by 1 percentage point compa

246 s to assess monitoring of first-line ART and switching to second-line ART in sub-Saharan Africa.

247 ociation with resistance and nonadherence on switching to second-line ART requires clarification.

248 frequencies and with different criteria for switching to second-line therapies.

249 nce of confirming virological failure before switching to second-line therapy.

250 ce to clearance could be enhanced by capsule switching to serotype 4, but it was enhanced to levels l

251 During extended wake, the rapid switching to sleep-like states with short timescales can

252 ogical measures, these findings suggest that switching to straight-sided glasses may be one intervent

253 atients when PPI is necessary for treatment, switching to structurally different alternatives should

254 documented, but the contribution of capsular switching to such changes is unknown.

255 ised resources are lower than the benefit of switching to super-abundant resources.

256 ved for carbon incorporation with antagonism switching to synergism at higher doses, while the CA mod

257 Switching to TAF was associated with increases in eGFR o

258 effects of anastrozole are intolerable, then switching to tamoxifen is a good alternative.

259 ally released into toothpaste slurries after switching to TCS-free alternatives.

260 avir is used in all people on ART, including switching to tenofovir, lamivudine, and dolutegravir in

261 s and 9 admissions per month were avoided by switching to the acellular vaccine, which is a 38-fold h

262 n with MinD, suggesting it has difficulty in switching to the active form.

263 Sequential switching to the alternative HMA, clinical trials of nov

264 f a perceptual representation and suppresses switching to the alternative.

265 After column switching to the analytical column Ascentis Express C-18

266 y extended to isotope-labeled methylation by switching to the corresponding reagents CD(3)OTs or (13)

267 e their standard regimen for 52 weeks before switching to the dolutegravir plus rilpivirine combinati

268 Thus, antigenic variation is achieved by switching to the expression of a different VSG gene.

269 allowing improved matching of the stochastic switching to the frequency of environmental changes.

270 to lead to [Fe(bpp)(H2L)](ClO4)2.C3H6O (2), switching to the high-spin state while experiencing a pr

271 85B epitope and consistently induced isotype switching to the IgG2c subclass.

272 BK1 as a pivotal negative regulator of class switching to the immunoglobulin A (IgA) isotype.

273 ne transcripts and inhibited efficient class switching to the immunoglobulin G1 isotype.

274 biogenesis displays an adaptive response by switching to the incorporation of mt-tRNA(Phe) to genera

275 e by the motors with high fidelity by either switching to the intersecting microtubule or eventually

276 of aphid and experience a fitness cost when switching to the less common phenotype.

277 ity, because restoring the zero frame causes switching to the MATalpha genotype.

278 the economic and epidemiological impacts of switching to the nonavalent vaccine both for individual

279 ng biofilms, although the advantages of this switching to the organism are not well understood.

280 ors and to assess the efficacy and safety of switching to the other TNF inhibitor without a washout p

281 In case of treatment failure, switching to the other treatment arm was possible.

282 sed B cell death, low impairs antibody class switching to the pro-inflammatory IgG2c antibody isotype

283 e visual information to the same extent when switching to the second context as sensorimotor memory b

284 a high Psoriasis Area and Severity Index at switching to the second-line biologic therapy were predi

285 ounters with antigen, how they favor isotype switching to the secretory IgA isotype, and how their GC

286 the observed polarity of the voltage-biased switching to the sequence of the active and inert electr

287 Switching to the simplified regimen was associated with

288 oblematic, and synthesis was accomplished by switching to the trityl protecting group.

289 te the efficacy, safety, and tolerability of switching to this regimen compared with remaining on cof

290 l organization of the Igh locus may restrict switching to this subset of isotypes.

291 he acute psychotic state often observed with switching to this treatment.

292 for a mean (SD) of 30.9 (15.9) months after switching to tocilizumab.

293 state is required for absence seizures, and switching to tonic firing rapidly halts absences.

294 ation to intubation is deemed inappropriate, switching to total face mask can be proposed as a last r

295 Switching to total face mask, which covers the entire fa

296 aptive value of homothallism and mating-type switching to unicellular fungi.

297 imming in regions of pure splay and bend but switching to unipolar swimming in mixed splay-bend regio

298 Switching to varenicline produced less robust effects, b

299 Older birds had a lower probability of switching to Vesteralen, but over the years, the probabi

300 time the bladder is locked in storage mode, switching to voiding only when it is judged safe and/or