ライフサイエンスコーパス: syn-

1 703, 0.355), CycleMorph (0.705, 0.133), ANTs SyN (0.707, 0.137) and NiftyReg (0.694, 0.549).

2 ous population, with nucleotide diversity pi syn = 0.00017, tenfold lower than the autosomal region (

3 tenfold lower than the autosomal region (pi syn = 0.0017) and 12-fold lower than the Y-linked region

4 d 12-fold lower than the Y-linked region (pi syn = 0.0021).

5 d that out of the three variants, only N13-a-syn (14-140) fibrils were capable of accelerating full-l

6 Three isomeric forms with hydrides in syn (2), anti (3), and cis (4) conformations have been c

7 DH4 did not dehydrate syn-(2S,3R)-2b-ACP, syn-(2R,3S)-2c-ACP, or anti-(2S,3S)-2d-ACP generated in

8 yl 2-chloroacetoacetate to the corresponding syn-(2R,3S)-alcohol on a multigram scale using whole cel

9 de-SNAC 14, and a 40-fold advantage over the syn-(2R,3S)-diketide-SNAC 13.

10 sence of the N-acetylcysteamine thioester of syn-(2S,3R)-2-methyl-3-hydroxypentanoate (6), methylmalo

11 DH4 did not dehydrate syn-(2S,3R)-2b-ACP, syn-(2R,3S)-2c-ACP, or anti-(2S,3S)-

12 iocatalytic approach resulted in enantiopure syn-(3 R,4 S) 1,3,4-trihydroxypentan-2-ones.

13 gth seeds efficiently promoted all but N40-a-syn (41-140).

14 dy the metal-binding site of wild-type alpha-syn (48-53, VVHGVA) and its pathological mutants (H50Q a

15 Initial data in humans suggest that syn-(99m)Tc-D-MAEC has a higher clearance than that of (

16 anged from 45% (anti-(99m)Tc-L-MAEC) to 74% (syn-(99m)Tc-D-MAEC) with the 180-min urine excretion equ

17 ude mice also showed higher tumor uptake for syn [(99m)TcO]depreotide (6.58% ID/g) than for the anti

18 ng) expressing a mutated form of human alpha-Syn (A53T) in dopaminergic (DA) neurons were video-taped

19 biosensor" cell line stably expressing alpha-syn (A53T)-CFP/YFP fusion proteins to detect alpha-syn s

20 PD rhesus monkeys that express mutant alpha-syn (A53T).

21 , triplication or genetic mutations in alpha-syn (A53T, A30P and E46K) are linked to autosomal domina

22 nulated perylene bisanhydrides (ab-PBA 6 and syn-(ab)2-PBA 19) were explored as universal starting ma

23 onene-type molecules like anti-(ab)2-PBI 15, syn-(ab)2-PBI 16, and syn-(ab)2-PTE 18.

24 ike anti-(ab)2-PBI 15, syn-(ab)2-PBI 16, and syn-(ab)2-PTE 18.

25 mice were immunized with GP-alone, GP-alpha-syn (active humoral immunization), GP+RAP, or GP+RAP/alp

26 portion of tau in the frontal neocortex than SYN + AD (t(41) = 3.3, p < 0.002).

27 ed as having moderate/severe AD copathology (SYN + AD = 20) or little/no AD copathology (SYN-AD = 35)

28 (F(1, 43) = 12.8-97.2, p < 0.001); however, SYN + AD had a greater proportion of tau in the temporal

29 SYN + AD had similar severity and distribution of neocor

30 AD had higher tau than SYN + AD in all regions (F(1, 43) = 12.8-97.2, p < 0.001

31 SYN + AD performed worse than SYN-AD on a temporal lobe-

32 SYN burden was higher in SYN + AD than SYN-AD in each neocortical region (F(1, 54

33 This suggests that the syn [AF]dG opposite dA junctional alignment can be readi

34 ture of the AF-intercalated conformer with a syn-[AF]dG adduct defines for the first time the capacit

35 potentials of the Cu(2+) complex with alpha-syn (alpha-syn-Cu(2+)) and alpha-syn(1-19) were determin

36 emonstrate that C-terminally truncated alpha-Syn (alpha-SynDeltaC), enriched in the pathological alph

37 by the splice isoforms and full-length alpha-syn (alpha-synFL).

38 rmined the tumor-initiating activity of (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-di

39 ene (DB[a, l]P) is activated in cells to (+)-syn- and (-)-anti-DB[a,l]P-11, 12-diol-13,14-epoxide (DB

40 Slow adduct removal occurred for both (+)-syn- and (-)-anti-DB[a,l]PDE adducts over a time period

41 tudy, we analyzed mutagenesis induced by (+)-syn- and (-)-anti-DB[a,l]PDE at the cII transgene in Big

42 The mutational spectra of (+)-syn- and (-)-anti-DB[a,l]PDE were quite similar except f

43 E)-alkenyl neopentyl boronic esters gave (E)-syn- and (E)-anti-homoallylic alcohols, respectively, in

44 ctivity differences between the triazole 1,5-syn- and 1,4-anti-isomers showed a preference for the 1,

45 ignificantly, at frequencies of 18.5% by (+)-syn- and 18.1% by (-)-anti-DB[a,l]PDE.

46 to T transversions, which were 43.9% for (+)-syn- and 38.8% for (-)-anti-DB[a,l]PDE.

47 An efficient four-step synthesis of N-BOC-5-syn- and 5-anti-carboxymethanopyrrolidines (12 and 13) a

48 were performed on Sprague-Dawley rats using syn- and anti-(99m)Tc-L- and -D-MAEC coinjected with (13

49 The clearances of syn- and anti-(99m)Tc-L-MAEC in the rats were higher tha

50 probed the two distinct CH3CHOO conformers, syn- and anti-, both of which react readily with SO2 and

51 The regio- and stereospecific conversion of syn- and anti-1,2-amino alcohols to their respective syn

52 ric allylic boronation (AAB) gives access to syn- and anti-1,2-diols.

53 anti-1,2-amino alcohols to their respective syn- and anti-1,2-imidazolylpropylamines via treatment w

54 2 with catecholborane and LiBHEt(3) provides syn- and anti-1,3-amino alcohols with very high diastere

55 s described for asymmetric synthesis of both syn- and anti-1,3-amino alcohols.

56 syn- and anti-1-amino-3-[18F]fluoromethyl-cyclobutane-1-

57 s to form major DNA adducts through both the syn- and anti-11,12-dihydrodiol 13,14-epoxide metabolite

58 oxide, syn- and anti-4-hydroxy-2-norcarene, syn- and anti-2-hydroxy-3-norcarene, 2-oxo-3-norcarene,

59 this work are 2-norcaranone, 3-norcaranone, syn- and anti-2-norcarene oxide, syn- and anti-3-norcare

60 orcaranone, syn- and anti-2-norcarene oxide, syn- and anti-3-norcarene oxide, syn- and anti-4-hydroxy

61 rene oxide, syn- and anti-3-norcarene oxide, syn- and anti-4-hydroxy-2-norcarene, syn- and anti-2-hyd

62 removed [NBu(4) ][OTf] and gave mixtures of syn- and anti-[Mes*P(Me)CH(2) CHPh][ -TRISPHAT].x[NBu(4)

63 removed [NBu(4) ][OTf] and gave mixtures of syn- and anti-[Mes*P(Me)CH(2) CHPh][Delta-TRISPHAT].x[NB

64 lished as a viable and economical entry into syn- and anti-aldol products.

65 ereocontrol were achieved to access both the syn- and anti-aldol-type products.

66 ree-step procedure for the synthesis of both syn- and anti-alpha,beta-disubstituted beta-amino acids

67 ptanone to sulfinimines resulted in only the syn- and anti-alpha-substituted beta-amino ketones.

68 ion at subsite +1 by Y298 and H243, enabling syn- and anti-beta-elimination, respectively.

69 E olefins without isolation or separation of syn- and anti-beta-silyl alkoxides.

70 e to an aryl aldehyde generated a mixture of syn- and anti-beta-silyl alkoxides.

71 ucts obtained by the reaction of the racemic syn- and anti-BgCDEs with calf thymus DNA and with purin

72 e larger Criegee intermediates, (CH3 )2 COO, syn- and anti-CH2 C(CH3 )C(H)OO on the water droplet sur

73 simulations examine the dynamic behavior of syn- and anti-CH3 CHOO at the air-water interface.

74 simplest Criegee intermediate (CH2 OO), both syn- and anti-CH3 CHOO remain inert towards reaction wit

75 The direct infrared detection of syn- and anti-CH3CHOO should prove useful for field meas

76 we report the transient infrared spectrum of syn- and anti-CH3CHOO, produced from CH3CHI + O2 in a fl

77 ure variation reveals that 1 reacts from its syn- and anti-conformations in competition with trapping

78 The structure reveals both the syn- and anti-conformations of template 8-oxoG in the co

79 RNAP II, the modeling studies show that both syn- and anti-conformations of the 1,N(2)-epsilon G are

80 e reaction aimed at preparing functionalized syn- and anti-cryptophanes (Brotin J.

81 ymidine upon 350 nm irradiation forming both syn- and anti-cyclobutane adducts (17 and 18), which are

82 The syn- and anti-diastereoisomeric forms of the reported st

83 l the selectivity and the switch between the syn- and anti-diastereomers are based on different activ

84 zed by ruthenium and iridium that occur with syn- and anti-diastereoselectivity, respectively, were u

85 ive cyclization to give 2,3,6-trisubstituted syn- and anti-dihydropyranones in good yields.

86 nesis in mouse skin, we have found that both syn- and anti-DMBADE are active tumor initiators, and th

87 Previously, we showed that both the syn- and anti-DMBADE bind to the adenine (A182) at codon

88 Topical application of syn- and anti-DMBADE produced stable adducts in mouse ep

89 ethylbenz[a]anthracene-3,4-diol-1,2-epoxide (syn- and anti-DMBADE), the two metabolically formed bay-

90 of the data showed that levels of the major syn- and anti-DMBADE-deoxyadenosine adducts formed after

91 orinated products were observed for both the syn- and anti-DP which were continued throughout the dur

92 .48 +/- 0.09 and 0.79 +/- 0.12 pmols/day for syn- and anti-DP, respectively.

93 ther eliminative pathways, such as concerted syn- and anti-E2 as well as gamma-deprotonation, are exc

94 yl rings in the outmost BDT units are in the syn- and anti-fashion, are designed.

95 n satisfactory yields to provide mixtures of syn- and anti-isomers 6-9 with moderate to good diastere

96 While the syn- and anti-isomers of 1,8-dipyridylnaphthalenes inter

97 ces in the absorption characteristics of the syn- and anti-isomers of CbDI, on one hand, and CbDI vs

98 The syn- and anti-isomers of CbDIs were unambiguously charac

99 roxy ketones, 2-hydroxy-3-methylnonan-4-one (syn- and anti-ketol diastereoisomers) and 3-hydroxy-3-me

100 with acenaphthenequinone leads to the trans-syn- and anti-porphodimethenes, which in turn can be con

101 report the first example of a complementary syn- and anti-selective enolboration-aldolization of ary

102 A boron-mediated syn- and anti-stereoselective aldol reaction giving rise

103 The meso syn- and C(2)-symmetric anti-isomers of 1,8-bis(4,4'-dim

104 e samples of the main eruptive events (pre-, syn- and post caldera) offer insights into the processes

105 tion, immune modulation (through pre-, pro-, syn- and postbiotics, bacterial lysates, vaccinations, a

106 Dechlorane Plus (anti- and syn-) and alpha- and beta-tetrabromoethylcyclohexane wer

107 -shifted) conformer of both molecules to the syn (anti) conformer.

108 for the conversion of the anti (syn) to the syn (anti) isomer at 66.2 degrees C.

109 for the conversion of the anti (syn) to the syn (anti) isomer at 71.0 degrees C.

110 of the samples, and SigmaDP concentrations (syn-+anti-DP concentrations) ranged from 0.05 to 5 pg/m3

111 ther side such that the monomer systems have syn (C(2) symmetry) and anti (C(1) symmetry) conformers

112 st buffelgrass (Pennisetum ciliare (L.) Link syn = Cenchrus ciliaris L.) genotypes reproduce by oblig

113 3-fold rotor to a 2-fold rotor with a strong syn (CH-2-C-2-O-2-CPg) preference once the donor was ion

114 moral immunization), GP+RAP, or GP+RAP/alpha-syn (combined active humoral and Treg) and analyzed usin

115 biscalix[5]arene from anti (uncomplexed) to syn (complexed).

116 d sequence (amino acids 121 to 123) of alpha-syn (CT alpha-syn) and performed immunocytochemical and

117 duced the accumulation of CT-truncated alpha-syn (CT-alpha-syn) in axons, rescued the loss of tyrosin

118 ided by anchimeric assistance and subsequent syn- exo-elimination of tetrabromonorbornane (-)-5a as t

119 tion of alpha-syn in vitro by using an alpha-syn -fragment complementation assay.

120 ypass all the photoproducts in the order cis-syn > Dewar > (6-4) > trans-syn-II.

121 was able to bypass them all in the order cis-syn > Dewar > trans-syn-II > (6-4).

122 ive stabilities: syn-anti > anti-anti > anti-syn > syn-syn.

123 This is followed by a thermal syn-->anti C14-C15 conformational relaxation to form Pfr

124 nterconversion is an indication of a C14-C15 syn-->anti conformational change.

125 mediated by the caspase, according to alpha-syn-->caspase-->ROS-->apoptosis.

126 ith mice selectively expressing human mutant SYN (hSYN(A53T)) in neurons.

127 t-translational modifications of blood alpha-syn (i.e., N-terminal acetylation).

128 e of subpopulation are Ck8+/Ck5+/Sca-1-/Ck4-/Syn- in the adult mouse AP epithelium.

129 However, the incorporation of FN(syn-) into fibrils and the deoxycholate-insoluble matrix

130 ter prolonged incubation, indicating that FN(syn-) is defective in progression of the assembly proces

131 e expressing pathogenic Ala53Thr human alpha-syn (M83 mice) that develop extensive alpha-syn patholog

132 exhibited a marked ability to reduce mBBr to syn-(methyl,methyl)bimane, an ability that was quenched

133 Here, we show that alpha-Syn-/- mice are viable and fertile, exhibit intact brain

134 oncurrent with the altered DA release, alpha-Syn-/- mice display a reduction in striatal DA and an at

135 Nigrostriatal terminals of alpha-Syn-/- mice display a standard pattern of dopamine (DA)

136 oluble p-Tau in striatum of WT but not alpha-Syn-/- mice.

137 d cells not expressing alpha-Syn or in alpha-Syn-/- mice.

138 ble homozygote knockout (alpha-dbn-/-; alpha-syn-/-) mice and examined the ability of individual mole

139 eductions in grip strength than single alpha-syn-/- mutant and wild-type.

140 mpaired than in single alpha-dbn-/- or alpha-syn-/- mutants.

141 In support of the model that decreased syn- Muv B gene activity enhances antiviral response, we

142 f detection in DNA treated directly with (+)-syn- or (-)-anti-DB[a,l]PDE or in DNA from Chinese hamst

143 s and enable selective access to either of a syn- or an anti-diastereoisomer through kinetic or therm

144 ts provides straightforward access to either syn- or anti-1,2-amino alcohols.

145 dergo highly diastereoselective reduction to syn- or anti-1,3-amino alcohols.

146 rization of the chiral phosphiranium cations syn- or anti-[Mes*P(Me)CH(2) CHPh][OTf] (Mes*=2,4,6-(t-B

147 rization of the chiral phosphiranium cations syn- or anti-[Mes*P(Me)CH(2) CHPh][OTf] (Mes*=2,4,6-(t-B

148 m cis or trans alkenes, depending upon their syn- or anti-addition mechanisms.

149 rganise both reactants, affording either the syn- or anti-adduct with high diastereo- and enantiosele

150 ried stereoselectively to produce either the syn- or anti-amino alcohol diastereomer.

151 Either syn- or anti-amino alcohol products can be obtained by t

152 isomers of the retinal cofactor with either syn- or anti-configuration, each comprising six consecut

153 that insertion is accommodated in either the syn- or anti-conformation, respectively.

154 - or (Z)-beta-trifluoromethyl enones forming syn- or anti-dihydropyranone products, respectively.

155 on of diastereomeric pairs carrying either a syn- or anti-oriented hydroxyl at C-5'.

156 With the development of substrate-controlled syn- or anti-selective reductions of alpha-fluoro ketone

157 re facilitated by a bidentate auxiliary, and syn- or anti-stereoselectivity is controlled through the

158 epending on whether the background motion is syn- or contra-directional to the target motion, the res

159 Elevated serum concentrations of beta-syn (p = 0.016), NfL (p = 0.020) or GFAP (p = 0.010) wer

160 d intravenous thrombolysis showed lower beta-syn (p = 0.029) und NfL concentrations (p = 0.0024) comp

161 CSF NFL (p<0.001), sAPPalpha (p<0.001) and a-syn (p=0.003) independently predicted diagnosis of PD ve

162 -alpha-syn (P=0.221), or oligo-phospho-alpha-syn (P=0.181).

163 e for total alpha-syn (P=0.244), oligo-alpha-syn (P=0.221), or oligo-phospho-alpha-syn (P=0.181).

164 hereas this was not the case for total alpha-syn (P=0.244), oligo-alpha-syn (P=0.221), or oligo-phosp

165 The monodeuterated aziridine syn-(p-CH(3)C(6)H(4)SO(2))NCHDCH-n-Bu (1e) reacts with e

166 neuroprotection in proteolipid protein alpha-syn (PLP-SYN) mice, a transgenic mouse model of MSA.

167 resulted in accumulation of phosphorylated a-syn (pSyn) inclusions in the substantia nigra pars compa

168 g di- or trisubstituted alkenes and anti- or syn- relative stereochemistry at the allylic and homoall

169 identification of dominantly inherited alpha-syn (SNCA) gene mutations in rare cases of familial PD.

170 ing higher luminescent and easier oxidizable syn- syn bis[1]benzothieno[1,4]thiazines.

171 kJ/mol and 115.2 (109.0) kJ/mol for the anti/syn- (syn/anti)-isomerization of 8 and 9, respectively.

172 in double knockout mice (alpha-dbn-/-; alpha-syn-/-), the synaptic phenotype (the density, the turnov

173 like combination of Li and B carbenoids and syn (thermal) elimination whereas the E isomer was obtai

174 wo internal cationic ferric hemes drives the syn- to anti-switch, as demonstrated in two ways.

175 n array of UV-induced DNA photoproducts (cis-syn-, trans-syn I- and trans-syn II CPDs, 6-4PP and Dewa

176 The stereodivergent behavior of 2,3-syn- vs 2,3-anti-alpha-methyl-beta-hydroxy aldehydes is

177 mbinant FN containing a synergy mutation, FN(syn-), was tested for its ability to form fibrils.

178 lly recognizing nonphosphorylated S129-alpha-syn (WT-alpha-syn) and noted that S129 residue is more e

179 The interaction of wild type alpha-Syn (WTS) and alpha-Syn variants (E57K, A30P, and aSyn(3