ライフサイエンスコーパス: synaptic bouton

1 xons, small dendrites, dendritic spines, and synaptic boutons).

2 erneurons were contacted by several types of synaptic bouton.

3 ity to rapidly boost neuropeptide content in synaptic boutons.

4 ed by collapsing the H+ gradient in type III synaptic boutons.

5 ttached functional excitatory and inhibitory synaptic boutons.

6 vesicles, indicating that they are probably synaptic boutons.

7 ires only a postsynaptic neuron and attached synaptic boutons.

8 was formed mainly by synapses with multiple synaptic boutons.

9 nsport, suggesting localization primarily in synaptic boutons.

10 types of synapses on terminal and en passant synaptic boutons.

11 arger synaptic size and increased numbers of synaptic boutons.

12 formed with abundant, highly ramified, small synaptic boutons.

13 Ns and INs mingled with dense collections of synaptic boutons.

14 isualized fusing with the plasma membrane of synaptic boutons.

15 encounters with presynaptic growth cones or synaptic boutons.

16 of DVAP-33A tightly modulates the number of synaptic boutons.

17 is dependent on fasciclin II localization at synaptic boutons.

18 ivity levels results in an altered number of synaptic boutons.

19 utamatergic NMJs, and that Wg is secreted by synaptic boutons.

20 l overexpression results in fewer and larger synaptic boutons.

21 s that traverse the lateral margin of select synaptic boutons.

22 vantage of FM1-43 as a fluorescent marker of synaptic boutons.

23 n increase in the density of GABA-containing synaptic boutons.

24 as well as formation of ectopic mossy fiber synaptic boutons.

25 presynaptic function at the level of single synaptic boutons.

26 erved using light microscopy corresponded to synaptic boutons.

27 neuronal surface with increasing numbers of synaptic boutons.

28 he soma affect neurotransmitter release from synaptic boutons.

29 ion of enlarged intraluminal vesicles within synaptic boutons.

30 dult causes shrinkage of already established synaptic boutons.

31 ile filopodia as well as in later-stabilized synaptic boutons.

32 with lysosome markers in soma, neurites and synaptic boutons.

33 s revealed that FLN90 is present surrounding synaptic boutons.

34 Fmr1 dramatically lowers DCV numbers in synaptic boutons.

35 ribution to the signalling in the individual synaptic boutons.

36 as olfactory cilia, insect antennae, or even synaptic boutons.

37 mutant larvae have also a reduced number of synaptic boutons.

38 was found within mossy fiber axons and giant synaptic boutons.

39 lity can cluster spatially within individual synaptic boutons.

40 s and the electrophysiological properties of synaptic boutons.

41 ion of p62 in neurons and muscles, and fewer synaptic boutons.

42 nd colocalize extracellularly in surrounding synaptic boutons.

43 atellite" budding from larval motor terminus synaptic boutons.

44 ger proportion of the open conformation than synaptic boutons.

45 of medial NTS found immunoreactive OT within synaptic boutons.

46 in synaptic boutons as well as the number of synaptic boutons.

47 to overgrow and prevent formation of normal synaptic boutons.

48 ansmitter release sites housed in a chain of synaptic boutons.

49 f Limk leads to stunted terminals with fewer synaptic boutons.

50 to a sparser microtubule array in axons and synaptic boutons.

51 etically with the BMP pathway, and at mutant synaptic boutons, a key component of this pathway, phosp

52 aboration (overgrowth, overbranching, excess synaptic boutons), accumulation of development-arrested

53 urprising difference in the vulnerability of synaptic boutons after axotomy, which depend on cell-typ

54 Ultrastructural analysis of synaptic boutons after hyperstimulation revealed an accu

55 Small excitatory synaptic boutons also were labeled in the MML; by contra

56 ; there is a large increase in the number of synaptic boutons, an elaboration of the synaptic branchi

57 vating Ib motoneuron increased the number of synaptic boutons and AZs it formed.

58 These markers clearly recognized puncta-like synaptic boutons and both signals were well overlapped.

59 to be concentrated in the region surrounding synaptic boutons and consequently enlarges the membrane

60 mbine single-cell dye labeling of individual synaptic boutons and counterstaining of the entire nervo

61 hat motor neuron terminals failed to develop synaptic boutons and cytoskeletal abnormalities arose, i

62 ent, we identified beag, a mutant with fewer synaptic boutons and decreased neurotransmitter release.

63 e is a significant decrease in the number of synaptic boutons and extent of synaptic arborization, as

64 strictions that normally separate individual synaptic boutons and is necessary to achieve the normal

65 pathway interfere with the formation of new synaptic boutons and lead to aberrant synaptic structure

66 PTP-NP tyrosine phosphatase, is expressed on synaptic boutons and may participate in the regulation o

67 inar distribution of the dendritic trees and synaptic boutons and the number of synapses formed by a

68 are identified as neuronal varicosities and synaptic boutons and the rods as short segments of axons

69 development; in its absence, there are fewer synaptic boutons and there is a decrease in synaptic str

70 , glia-derived miR-274 coordinates growth of synaptic boutons and tracheal branches to modulate larva

71 or tracheal cells to modulate the growth of synaptic boutons and tracheal branches, respectively.

72 on-cell-autonomously modulates the growth of synaptic boutons and tracheal branches.

73 xons were reconstructed, and the morphology, synaptic boutons, and projection pattern of each axon we

74 n vivo display axonal ER accumulation within synaptic boutons, and the membrane-embedded ER-phagy rec

75 e cells, fewer PV interneurons, and fewer PV synaptic boutons, and the ratio of granule cells to PV i

76 al processes, and inhibits Ca(2+) entry into synaptic boutons, and we can reverse this by controlled

77 d that gold particles were restricted to pre-synaptic boutons, and were present mainly on the membran

78 As the first functional synaptic boutons appeared in these cultures, numerous fi

79 epeats participate in inducing phenotypes in synaptic boutons, arbors, transmission and larval locomo

80 es in total axonal length and the density of synaptic boutons are present in layer V pyramidal neuron

81 es the formation of microtubule loops within synaptic boutons as well as the number of synaptic bouto

82 cles and reported transmission at individual synaptic boutons, as well as secretion and fusion pore '

83 II antisera labeled regions associated with synaptic boutons at both larval and adult stages.

84 unction prevents the normal proliferation of synaptic boutons at glutamatergic neuromuscular junction

85 the CNS neuropil and to a variable subset of synaptic boutons at neuromuscular junctions (NMJs).

86 rate remains to be clarified, targets SVs to synaptic boutons at rest and might be outpaced by activi

87 Loss of O-GlcNAcase affected a number of synaptic boutons at the axon terminals of larval neuromu

88 scade that stimulated the development of new synaptic boutons at the Drosophila larval neuromuscular

89 rons can rapidly induce the outgrowth of new synaptic boutons at the larval neuromuscular junction (N

90 MJs), DCAF12 is expressed presynaptically in synaptic boutons, axons, and nuclei of motor neurons.

91 led expansions revealed that they were large synaptic boutons bearing asymmetric synapses.

92 LG and which is dynamically expressed during synaptic bouton budding.

93 peptidergic vesicles are immobile in resting synaptic boutons but become mobile after seconds of stim

94 calolide B or photobleaching DCVs entering a synaptic bouton by retrograde transport.

95 atic dalphaTAT activity limits the growth of synaptic boutons by affecting dynamic, but not stable, m

96 results successfully showed that Drosophila synaptic boutons can be quantified and thus we can exami

97 morphological transition of growth cones to synaptic boutons characterizes synaptogenesis.

98 hoton imaging of cortical axons to show that synaptic boutons come and go, just like spines.

99 al relationship of 133 anterogradely labeled synaptic boutons conveying CS or US information on retro

100 Furthermore, ultrastructural analysis of synaptic boutons demonstrated the presence of multivesic

101 ated Purkinje cells with functional adherent synaptic boutons, demonstrating the presynaptic locus of

102 d' digital neurite atlas, and estimating the synaptic bouton density along the axons for a mouse brai

103 The epac1-cAMP sensor (camps) response in synaptic boutons depends on extracellular Ca(2+) and rya

104 s and show that Eps15 is required for proper synaptic bouton development and normal levels of synapti

105 Synaptic bouton development relies on an underlying netw

106 oracle, in turn, controls GluRIIA levels and synaptic bouton development.

107 he remodeling of microtubule networks during synaptic bouton development.

108 s have overgrown dendritic trees with larger synaptic boutons, developmental defects in pruning, and

109 Interestingly, the number of GABAergic synaptic boutons did not increase during this time, indi

110 ons and may participate in the regulation of synaptic bouton endocytosis.

111 acutely activate integrin signaling, induce synaptic bouton enlargement, and increase postsynaptic g

112 convergent inputs comprising interdigitated synaptic boutons evoke self-contained synaptic responses

113 s linked to the transient enlargement of the synaptic boutons, followed by a sustained increase in co

114 rozygous double mutants, displayed increased synaptic bouton formation and GluRIIA accumulation.

115 MRP; Fmr1) and mRNA-binding Staufen regulate synaptic bouton formation and glutamate receptor (GluR)

116 During new synaptic bouton formation, synapsin redistributed upon s

117 Finally, synaptic boutons from single-labeled axons of glycinergi

118 Two different markers were used to identify synaptic boutons: GFP marking with a synaptotagmin (Syt)

119 Sox6 in Pvalb(+) neurons leads to failure of synaptic bouton growth, whereas later removal in mature

120 The small size of synaptic boutons has hampered efforts to define the dyna

121 her then localized to the plasma membrane of synaptic boutons, immunolabeling for the DOR was intrace

122 , and clathrin packets also exchange between synaptic boutons in a microtubule-dependent "superpool."

123 er of synapses per neuron formed by multiple synaptic boutons in comparison to sham-MC.

124 e the ability of motor neurons to extend new synaptic boutons in correlation to muscle growth.

125 of synaptic vesicle recycling at individual synaptic boutons in hippocampal cell cultures derived fr

126 signals to be collected from populations of synaptic boutons in mouse primary visual cortex during l

127 led that PTP-NP-2 is abundantly expressed on synaptic boutons in primary neurons.

128 strongly concentrated in a subpopulation of synaptic boutons in the CNS neuropil and to a variable s

129 in somata in the inner nuclear layer and in synaptic boutons in the inner plexiform layer.

130 ger and extensive, it was chosen to quantify synaptic boutons in the neuronal culture.

131 The number of synaptic boutons in wild type neurons increased by 27% b

132 ack Endophilin fail to take up FM1-43 dye in synaptic boutons, indicating an inability to retrieve sy

133 pecially in the increased formation of fine, synaptic "bouton-like" structures, in which both TrkA an

134 nd a multinucleated muscle fibre, presenting synaptic bouton-like structures in the contact point.

135 ject from the unaffected hemisphere and form synaptic bouton-like structures in the denervated half o

136 F transection produced also a higher loss of synaptic boutons, mainly at the dendritic level.

137 zed by an increase in the number of multiple synaptic boutons (MSBs), i.e., presynaptic axon terminal

138 ry interest were synapses formed by multiple synaptic boutons (MSBs), which have recently been found

139 of miR-274 distributes broadly, including in synaptic boutons, muscle cells, and tracheal cells.

140 lar junctions (NMJs), resulting in increased synaptic bouton number and branch formation.

141 overexpression caused a dramatic increase in synaptic bouton number and changes in synapse structure.

142 overexpression of Shank result in defects in synaptic bouton number and maturation.

143 synaptic development, including controlling synaptic bouton number and the ability to bud new varico

144 strophic morphology and marked reductions in synaptic bouton numbers.

145 of microglomeruli each comprising the large synaptic bouton of a projection neuron (PN) from the ant

146 ide evidence that zinc is sequestered within synaptic boutons of a subpopulation of retinal ganglion

147 We conclude that the protein is present in synaptic boutons of axons with different neurochemical p

148 We determined that FM1-43-labeled synaptic boutons of csp mutant neuromuscular junctions f

149 esulted in a reduction of pY816 in axons and synaptic boutons of hippocampal mossy fibers, thereby im

150 unoreactivity was increased in axons but not synaptic boutons of mossy fibers in ZnT3 knockout mice t

151 ormal accumulation of mitochondria in distal synaptic boutons of NMJs.

152 nce of vesicle exocytosis and endocytosis in synaptic boutons of rat cerebellar granule cells.

153 ty in the awake, intact brain, we imaged the synaptic boutons of retinal axons in the superior collic

154 mergence of filopodial-like protrusions from synaptic boutons of the Ib input.

155 owever, whether this cycling also happens in synaptic boutons, or axon terminals, thought to be the m

156 ansporter currents because the small size of synaptic boutons precludes direct recordings.

157 Quantitative 3D models of excitatory synaptic boutons (SBs) in L1 of the human temporal lobe

158 Here, excitatory synaptic boutons (SBs) in layer 4 (L4) of the temporal l

159 nctionally relevant structural parameters of synaptic boutons (SBs), e.g., bouton and mitochondrial v

160 We find that the synaptic boutons show both chemical synaptic structures

161 synapses also show a profound overgrowth of synaptic boutons, similar to known Drosophila endocytoti

162 ors are not due to presynaptic retraction of synaptic boutons, since other presynaptic components are

163 ns downstream of presynaptic PDK1 to control synaptic bouton size, active zone number, and synaptic f

164 ves the transformation of a growth cone into synaptic boutons specialized for transmitter release.

165 As synapses grow, existing synaptic boutons stretch apart and new boutons insert be

166 ity, ensuring synaptic health through normal synaptic bouton structure and function.

167 In addition, synaptic bouton structure at motor nerve terminals is al

168 re, small synaptic vesicles in glutamatergic synaptic boutons, studied with synaptophluorin, are as a

169 al surface and had fewer and less pronounced synaptic boutons, suggesting they prioritize efficient a

170 An analysis of 250 anterogradely labelled synaptic boutons (taken from layers 2/3) indicated that

171 Neuronal axons terminate as synaptic boutons that form stable yet plastic connection

172 rt of mitochondria to NMJs, the structure of synaptic boutons, the organization of presynaptic microt

173 umber of synaptic vesicles in an area of the synaptic bouton thought to contain the reserve vesicle p

174 strate that the UPS functions locally within synaptic boutons to acutely control levels of presynapti

175 ed feature of imac mutants is the failure of synaptic boutons to form.

176 ds beyond the perisomatic chemical GABAergic synaptic boutons to the distal AIS, lacks both sodium ch

177 endocytosis, Eps15 moves from the center of synaptic boutons to the periphery in response to synapti

178 y from its physiological interactants at the synaptic bouton toward trafficking vesicles and organell

179 s grow wider after high-frequency AP firing: synaptic boutons undergo a rapid enlargement, which is m

180 ronous release is tied to calcium entry into synaptic boutons via P/Q type calcium channels, whereas

181 the density of immunogold particles per pre-synaptic bouton were almost 50% lower than in younger ra

182 Functional synaptic boutons were identified with FM1-43-based digit

183 ly axo-spinous synapses, as well as multiple synaptic boutons were increased in the perilesion cortex

184 Horizontal patchy connections and synaptic boutons were labeled by injections of the neuro

185 , the morphological characteristics of their synaptic boutons were measured and assessed at the elect

186 Using an image analysis software Image J, synaptic boutons were quantified on the basis of the siz

187 ss than 10 axonal vesicles occurring between synaptic boutons, were stable at 30 minutes but markedly

188 ts was formed mainly by synapses with single synaptic boutons, whereas in the ischemia EC and sham EC

189 ng causes motoneuron terminals to have fewer synaptic boutons, whereas increased neuronal activity re

190 ma-motoneurons were apposed by S- and F-type synaptic boutons, whereas only alpha-motoneurons demonst

191 ifferentiation, and are restricted to type I synaptic boutons, which mediate fast, excitatory glutama

192 Evoked activity induces Wnt1/Wg release from synaptic boutons, which stimulates both a postsynaptic D

193 mutant neurons reveal enlarged and irregular synaptic boutons with dense accumulation of synaptic ves

194 c and anatomical features, such as the large synaptic boutons with which they often terminate.