ライフサイエンスコーパス: syncytium

1 ce viral envelope-mediated cell-cell fusion (syncytium).

2 +)-influx at active zones in the entire mini-syncytium.

3 ss needed to resolve individual sperm from a syncytium.

4 when no new cells are incorporated into the syncytium.

5 he heart to function as an electromechanical syncytium.

6 rted to change expression in the Arabidopsis syncytium.

7 icellular feeding site within roots called a syncytium.

8 enting transfating and for fusion of the PMC syncytium.

9 site of infection, a nurse cell known as the syncytium.

10 e in the blastocoel and fail to join the PMC syncytium.

11 site of infection, a nurse cell known as the syncytium.

12 ells, P(1-8).p, fuse with the hyp7 epidermal syncytium.

13 ium and in cells to be incorporated into the syncytium.

14 properties of the PM in the early embryonic syncytium.

15 maintained by the fusion of myoblasts to the syncytium.

16 r bridge interconnecting daughter cells in a syncytium.

17 ins with 13 nuclear division cycles within a syncytium.

18 ry signal" from the adjacent hyp7 hypodermal syncytium.

19 that enable the myocardium to function as a syncytium.

20 ls, inappropriately fuse into a single large syncytium.

21 sase enzyme can diffuse throughout the gonad syncytium.

22 parenchymal cells tightly juxtaposed to the syncytium.

23 e AP morphology from an intact cardiomyocyte syncytium.

24 pure mESC-CM patches did not form functional syncytium.

25 these cells affects the excitability of the syncytium.

26 -regulated genes in the H. schachtii-induced syncytium.

27 ithout LDA treatment on a model of placental syncytium.

28 id load to be transmitted across the stromal syncytium.

29 iently distribute the excess K(+) across the syncytium.

30 agonists are integrated responses of the SIP syncytium.

31 primed for incorporation into the developing syncytium.

32 type of the SMC-ICC-PDGFRalpha(+) cell (SIP) syncytium.

33 e expression changes in the nematode-induced syncytium.

34 2+) or ATP were introduced to the astrocytic syncytium.

35 cytes with M bands assembled as a functional syncytium; (2) systolic twitch forces at a similar level

36 ying enzyme, are expressed in the developing syncytium and in cells to be incorporated into the syncy

37 re explicitly related to the geometry of the syncytium and kinetics of nucleocytoplasmic shuttling.

38 Using syncytium and luciferase reporter gene fusion assays, we

39 activity is required in the major hypodermal syncytium and not in the VPCs to inhibit vulval fates.

40 ised that BETL cell fate is specified in the syncytium and that cell files subsequently develop in re

41 s in part function as a coordinated cellular syncytium, and disruption of intercellular communication

42 at the pancreatic islet acts as a functional syncytium, and the whole islet [Ca2+]i response has been

43 The syncytium appears to undergo two developmental phases du

44 ks underlying gene expression control in the syncytium are poorly understood.

45 principles underlying nuclear dispersal in a syncytium are unclear.

46 ted stronger alpha-tubulin signal within the syncytium as compared to surrounding tissue.

47 mitting infection to all the nuclei within a syncytium as efficiently as the wild-type HSV-1 strain 1

48 nd hemagglutinin expression plasmids or with syncytium-based assays in Vero, Vero-SLAM, and Vero-Nect

49 onent EXOC7-H4-1 is not expressed within the syncytium but functions in defense and is under MAPK reg

50 neously developing into an electromechanical syncytium by disassembling focal adhesions at the cell-c

51 o, it remains uncertain whether a functional syncytium can be formed between donor and recipient cell

52 A single fungal syncytium can harbor thousands or millions of mobile and

53 cell expressing HCN2 could create a two-cell syncytium capable of generating sustained pacing.

54 oRNA396 (miR396) in cells giving rise to the syncytium coincides with the initiation of the syncytial

55 A fungal colony is a syncytium composed of a branched and interconnected netw

56 n culture, CD166+ cells form an autorhythmic syncytium composed of cells morphologically similar to a

57 cells, stimulating cell wall hydrolysis for syncytium development.

58 overlapped with more than one-fourth of the syncytium differentially expressed genes and are of func

59 of 278 genes was identified as specifically syncytium differentially methylated genes.

60 ls and this activation was maintained in the syncytium during all sedentary stages of nematode develo

61 of each gene family is expressed within the syncytium during the defense response.

62 ignaling pathways locally at the site of the syncytium during the resistance phase of the resistant r

63 e localized gene expression occurring at the syncytium during the resistant reaction was studied.

64 tubulin (GmTubB4) and several other genes in syncytium-enriched samples as compared to samples extrac

65 in the zebrafish embryo is a multinucleated syncytium essential for embryo development, but the mole

66 nt from where the nematode is feeding as the syncytium expands.

67 Syncytium-expressed exocyst genes function in defense wh

68 e highly upregulated in the nematode-induced syncytium (feeding cells), and deliberate manipulations

69 , Nelson Bay virus, has been shown to induce syncytium formation (34).

70 In vitro, the F-L179V virus caused increased syncytium formation (cell-cell membrane fusion) yet had

71 irus from 10 of the treated patients induced syncytium formation (SI virus) when cultured with MT2 ce

72 hemifusion, cytoplasmic content mixing, and syncytium formation ability of the wild-type SER virus F

73 The XC cell line undergoes extensive syncytium formation after infection with ecotropic murin

74 V94A and MV F V94G viruses induce extensive syncytium formation and are relatively, or almost comple

75 ally inactivates RhoA, inhibited RSV-induced syncytium formation and cell-to-cell fusion, although si

76 ly increased membrane fusion, as measured by syncytium formation and content mixing.

77 /-) but not WT MEF cells displayed extensive syncytium formation and cytopathic effect (CPE) followin

78 ed levels of surface S protein could promote syncytium formation and direct cell-to-cell spread of th

79 ion mutant is hyperfusogenic as monitored by syncytium formation and in a quantitative fusion assay a

80 ults suggest that the HD is involved in both syncytium formation and in determining p10 transport and

81 of furin cleavability by APMV-7 resulted in syncytium formation and increased virus yield in vitro b

82 teraction with A56/K2 suppresses spontaneous syncytium formation and possibly "fuse-back" superinfect

83 restingly, the L161M mutant showed increased syncytium formation and promoted fusion at lower tempera

84 Here, we report that in both syncytium formation and viral entry assays, removal of m

85 (NiV-F) envelope glycoproteins mediate both syncytium formation and viral entry.

86 mRNA and protein synthesis, but it inhibited syncytium formation and virus assembly/release.

87 Syncytium formation and virus yield of the Fcs-5B virus

88 CAT-1 receptors, these results suggest that syncytium formation as well as altered host range may be

89 ant ability after trypsin cleavage to induce syncytium formation at pH 5.1; however, neither the chim

90 T gondii C-18 efficiently blocked syncytium formation between human T cells and effector c

91 s virus morphology, cell-to-cell fusion, and syncytium formation but is dispensable for the efficient

92 sites, and tunicamycin treatment suppressed syncytium formation by R(+) Env in those cells.

93 ycosylation is required for XC cell-specific syncytium formation by the R(+) Env protein.

94 Disruption of trophoblast syncytium formation consequently leads to developmental

95 Sequencing and mutagenesis demonstrated that syncytium formation could be attributed to a single amin

96 ound via various assays that viral entry and syncytium formation depend on the viral origin of the gl

97 enhanced lipid mixing, calcein transfer, and syncytium formation even in the presence of the long SER

98 ected HCC cell lines, resulting in extensive syncytium formation followed by cell death.

99 Finally, the mechanism of epidermal syncytium formation following JNK hyperactivation and wo

100 plex (EFC) and that the EFC is necessary for syncytium formation furnishes a strong connection betwee

101 (PRN) Abs, mainly IgG2a, that also inhibited syncytium formation in CD150(+) B95-8 cells.

102 cytotail mutations may additionally suppress syncytium formation in cells infected with syn HSV-1 by

103 n cultures of blood mononuclear cells and by syncytium formation in cocultures of the same with F-81

104 rLCMV/VSVG caused syncytium formation in cultured cells and grew to approx

105 e demonstrate that human RVB NSP1-1 mediates syncytium formation in cultured human cells.

106 f the respective HN and F proteins to induce syncytium formation in heterologous expression studies.

107 e 1 (HIV-1) infection and promote cytopathic syncytium formation in infected cells commence with the

108 glut-1 also markedly increased syncytium formation in MDBK cells after exposure to HTLV

109 F] mutant exhibited dramatically accelerated syncytium formation in melanoma cells caused by fusion o

110 (FIP) was shown to block MeV infections and syncytium formation in monkey kidney cell lines.

111 Syncytium formation in MT-2 cells and CCR5 or CXCR4 core

112 ved enhanced hemifusion, content mixing, and syncytium formation in SER virus F- and HN-expressing ce

113 plication rate, and did not cause observable syncytium formation in the lungs.

114 Live imaging of wound-induced syncytium formation in the pupal epidermis suggested dir

115 ociated with protease dependence and lack of syncytium formation in their respective native viruses,

116 d that TR1.3 and W102G Envs failed to elicit syncytium formation in these in vitro assays.

117 dependency on the HN attachment protein for syncytium formation in transfected cells.

118 We assessed viral coreceptor use via syncytium formation in vitro and with a modified PhenoSe

119 se motif conferred increased replication and syncytium formation in vitro.

120 pression of either form of SYNCRIP inhibited syncytium formation induced by MHV infection.

121 h occurs upon wounding, also correlated with syncytium formation induced by PINCH knockdown.

122 Syncytium formation involves the redifferentiation and f

123 Although syncytium formation is a hallmark of VZV infection, infe

124 r efficacies in blocking membrane fusion and syncytium formation mediated by measles virus (MeV).

125 brain microvessels and causes cell-specific syncytium formation of brain capillary endothelial cells

126 antibodies (MAbs), we could demonstrate that syncytium formation of the fusogenic gB/VSV-G chimera ca

127 ly GTPases established that HIV Env-mediated syncytium formation relies on Rac-1 but not on Cdc42 or

128 Inhibition of syncytium formation requires that F100G5 be present conc

129 low CD46 density but requires less CD46 for syncytium formation than MV.

130 VZV-induced syncytium formation was markedly reduced by ATG5 knockdo

131 Low-pH-induced syncytium formation was observed in cells infected with

132 Levels of surface expression and syncytium formation were substantially higher at 33 degr

133 In contrast, viral replication and syncytium formation were unaltered in cells that express

134 nstrated by the failure of low pH to trigger syncytium formation when cells were infected with vA28-H

135 te for its human MuV counterpart in inducing syncytium formation when coexpressed in different mammal

136 efficiently cell surface expressed, exhibits syncytium formation when coexpressed with GhV-G protein,

137 envelope protein (Env) in that it undergoes syncytium formation with cells expressing Env protein co

138 Evidence of syncytium formation within the aggregates included the c

139 lt in virus-cell (viral entry) or cell-cell (syncytium formation) membrane fusion.

140 d type of membrane fusion, cell-cell fusion (syncytium formation), which is linked to pathogenicity.

141 ntry into host cells and cytopathic effects (syncytium formation).

142 gK or UL20 gene cause extensive cell fusion (syncytium formation).

143 rpesvirus entry and cell-cell fusion induced syncytium formation, a characteristic of varicella-zoste

144 s not absolutely required for virus entry or syncytium formation, alteration of palmitoylated cystein

145 ly, cells expressing gH/gL showed pronounced syncytium formation, although expression of gH or gL alo

146 the gains in cleavability, replication, and syncytium formation, analysis of viral pathogenicity in

147 Coexpression of gag-pol with env restored syncytium formation, and accordingly, mutations within g

148 Infectivity, syncytium formation, and cytotoxicity of recombinant MV-

149 ession, release of infectious particles, and syncytium formation, and endogenous serine protease acti

150 all of them conferred protease independence, syncytium formation, and increased replication in cell c

151 Surprisingly, these mutated GP64s induced syncytium formation, and normalized fusion activities we

152 ited viral-initiated T-cell death and T-cell syncytium formation, at which time in the HIV life cycle

153 hile DENV2-infected naive C6/36 cells showed syncytium formation, DENV2-infected wMelPop-C6/36 cells

154 TRM did not induce syncytium formation, either in vivo or in vitro.

155 ghing of apical epithelial cells, occasional syncytium formation, goblet cell hyperplasia/metaplasia,

156 The lack of syncytium formation, however, correlated with a decrease

157 5 parainfluenza virus that does not exhibit syncytium formation, in contrast to most other paramyxov

158 No mode of syncytium formation, including that induced by wounding,

159 s of these viruses for replication in vitro, syncytium formation, mean embryo death time, intracerebr

160 tions in the viral genome caused exaggerated syncytium formation, reduced VZV titers (-1.5 log10), an

161 pression significantly increased the rate of syncytium formation, revealing a novel role for IL-2 sig

162 virus leads to extensive membrane fusion and syncytium formation, suggesting that the virus may sprea

163 98-1 with trypsin reversed its properties in syncytium formation, virus production, and genome transp

164 VZV syncytium formation, which has been implicated in the pa

165 raspanins in producer cells leads to reduced syncytium formation, while downregulation has the opposi

166 Rac GTPase activity is needed for syncytium formation, while the Hippo signaling effector

167 ate the S glycoprotein during the process of syncytium formation.

168 al protein that induces cell-cell fusion and syncytium formation.

169 ect in core entry and an inability to induce syncytium formation.

170 opathic effects of rounding, detachment, and syncytium formation.

171 nforms the mechanism of cell dynamics during syncytium formation.

172 secondary to enhanced viral replication and syncytium formation.

173 tinuclear structures appeared, indicative of syncytium formation.

174 t are enriched at HIV-1 exit sites, regulate syncytium formation.

175 which are otherwise resistant to MLV-induced syncytium formation.

176 absence of detectable extracellular virus or syncytium formation.

177 protein followed by the R peptide showed any syncytium formation.

178 d F protein surface expression and increased syncytium formation.

179 ative mutant of PKCepsilon (K437R) inhibited syncytium formation.

180 inhibited R5 (but not X4) envelope-mediated syncytium formation.

181 ignaling is important for RSV replication or syncytium formation.

182 also is required for A-MuLV envelope-induced syncytium formation.

183 Anti-gH neutralizing antibodies prevented syncytium formation.

184 ll transmembrane (FAST) proteins that induce syncytium formation.

185 rions were unable to induce low-pH-triggered syncytium formation.

186 rotein, and these mutants displayed enhanced syncytium formation.

187 e expression of p10 and delayed the onset of syncytium formation.

188 UL24-betagluc yielded cytopathic effect with syncytium formation.

189 f PiT2-mediated A-MuLV envelope (R-)-induced syncytium formation.

190 ith DENV-1 or DENV-2, as detected by reduced syncytium formation.

191 mutations of this domain result in enhanced syncytium formation.

192 (SV5), is unusual in that it fails to induce syncytium formation.

193 losely related to simian virus 5, induces no syncytium formation.

194 ible for the characteristic cytopathology of syncytium formation.

195 on or mutations of the CT result in enhanced syncytium formation.

196 formation of filamentous virus particles and syncytium formation.

197 s and negatively regulate superinfection and syncytium formation.

198 n involved in HSV-1 entry and HSV-1-mediated syncytium formation.

199 pic JNK activation directly caused epidermal syncytium formation.

200 s in reduced production of progeny virus and syncytium formation.

201 nipavirus infections, which ultimately cause syncytium formation.

202 aternal interface, consistent with a role in syncytium formation.

203 luenced by the level of RSV F expression and syncytium formation.

204 o-fetal interface, consistent with a role in syncytium formation.

205 n contrast to an inhibitory effect in T-cell syncytium formation.

206 d migration and invasion, proliferation, and syncytium formation.

207 Subunit association and syncytium-forming ability of the envelope glycoproteins

208 bility and infectivity, but greatly enhanced syncytium-forming ability.

209 ker is not transferred between PMCs when the syncytium forms.

210 ent of neighboring uninfected cells into the syncytium, further amplifying the CPE.

211 on over 200-fold in the main body hypodermal syncytium, hyp 7.

212 am cells but not in the main body hypodermal syncytium (hyp7) that underlies, synthesizes, and releas

213 the VPCs do not fuse to the major hypodermal syncytium, hyp7.

214 ment, Drosophila melanogaster embryos form a syncytium, i.e., multiplying nuclei are not yet separate

215 tally perturbed cellular coupling in cardiac syncytium in vitro.

216 e coupling experiments indicate an extensive syncytium in which SNB motoneurons are coupled with each

217 Muscle cells are a syncytium in which the many nuclei are positioned to max

218 ine max) to establish its feeding structure, syncytium, in soybean roots.

219 ut consists of enteric motor neurons and SIP syncytium, including smooth muscle cells (SMCs), interst

220 neurons and postjunctional cells of the SIP syncytium, including smooth muscle cells (SMCs), interst

221 A mature syncytium incorporates as many as 200 cells into one lar

222 am cells, rather than in the main hypodermal syncytium, indicating that seam cells play the major rol

223 evidence of primary HIV-1 variants that are syncytium inducing and acutely cytopathic for CD8(+) lym

224 All discordant responders had non-syncytium-inducing (CCR5-tropic) viruses.

225 Only non-syncytium-inducing (NSI) virus was cultured from the per

226 Clear groupings of non-syncytium-inducing (NSI), CCR5-tropic (R5), and SI/CXCR4

227 We recently isolated from an infant an X4-syncytium-inducing (SI) human immunodeficiency virus typ

228 To this end, we examined the capacity of the syncytium-inducing (SI) TR1.3 and W102G MLVs to overcome

229 ype C sequences of known phenotypes (228 non-syncytium-inducing [NSI] CCR5(+) and 51 SI CXCR4(+) sequ

230 HIV1084i is an R5, non-syncytium-inducing isolate that bears all known clade C

231 s that use CCR5 as a major coreceptor and 11 syncytium-inducing isolates that use only CXCR4 or both

232 of cell fusion compared to that with the non-syncytium-inducing MLV FB29.

233 ite-specific mutagenesis determined that the syncytium-inducing phenotype of F-S MLV can be attribute

234 uses utilized CCR5 exclusively and had a non-syncytium-inducing phenotype on MT-2 cells and in primar

235 mutations associated with the host range and syncytium-inducing variants map to a key region of VRA k

236 rates of disease progression; one harbored a syncytium-inducing virus and the second was heterozygous

237 eplication capacity, and preservation of non-syncytium-inducing virus strains.

238 have higher relative fitness values than non-syncytium-inducing, CCR5-tropic HIV-1 isolates, as deter

239 Syncytium-inducing, CXCR4-tropic HIV-1 isolates did have

240 3 was examined here in comparison to the non-syncytium-inducing, nonpathogenic MLV FB29, which displa

241 leukemia virus (MLV) that induces selective syncytium induction (SI) of brain capillary endothelial

242 Syncytium induction by both F-S MLV and Spl574 is accomp

243 Syncytium induction by TR1.3 has been mapped to a single

244 nding was not affected by CA-074 Me, whereas syncytium induction was inhibited in a dose-dependent ma

245 d incorporation and to viral replication and syncytium induction, site-directed LLP mutants of a prim

246 he infection events starting with successful syncytium induction.

247 l (200 mIU/ml) but were short-lived, had low syncytium inhibition capacity, and lacked avidity matura

248 called cellularization, finally divides the syncytium into individual cells.

249 We show that diffusion within the germline syncytium is a critical control of stem cell differentia

250 The syncytium is a nurse cell formed within the roots of Gly

251 The syncytium is a unique plant root organ whose differentia

252 The syncytium is formed within the vascular bundle by partia

253 The size of each syncytium is larger in VSV-FH-infected cells at a specif

254 nclude that nematode-activated miR827 in the syncytium is necessary to suppress immune responses in o

255 cells regulate their differentiation into a syncytium is not well understood.

256 Precise transcript distribution in the syncytium is recovered via straightforward spatiotempora

257 This three-dimensional syncytium is thought to be necessary to maintain viabili

258 a monax, at the level of cells fusing into a syncytium; it can trigger cell-cell and virus-cell fusio

259 here they are involved in the formation of a syncytium layer at the fetomaternal interface via tropho

260 inantia where the placenta lacks an extended syncytium layer but displays a heterologous cell-fusion

261 se response, the second phase is a period of syncytium maintenance (susceptible reaction) or failure

262 ecific miR396 up-regulation in the developed syncytium marks the beginning of the maintenance phase,

263 e contraction rate (CR) of the cardiomyocyte syncytium monitored by video microscopy.

264 ced titers and small plaques but differed in syncytium morphology.

265 Drosophila embryo is the process by which a syncytium of approximately 6000 nuclei is subdivided int

266 The model demonstrates that a syncytium of electrically coupled astrocytes can maintai

267 ructure and the continuity of the electrical syncytium of the adjacent myocardium.

268 to an excitable medium across the functional syncytium of the hepatic lobule, co-ordinating and ampli

269 It is believed to operate as a homogeneous syncytium of transmitter-specific cells that regulate br

270 New data reveal that cellularisation of this syncytium requires the SPATZLE protein and involves the

271 nt of high-pH-triggered receptor-independent syncytium (RIS) formation in HEK293T cells, compared to

272 erived embryoid body (EB) based cardiac cell syncytium served as a biorecognition element coupled to

273 empts to develop a multinucleate nurse cell (syncytium) serving to nourish the nematode over its 30-d

274 icrovasculature is not simply a well-coupled syncytium since we detected significant voltage dissipat

275 actor (GRF) target genes resulted in reduced syncytium size and arrested nematode development.

276 umbers of the MV receptor CD46, we evaluated syncytium size in MV- or VSV-FH-infected cells.

277 While syncytium size reached a plateau and did not increase fu

278 /cell, there was a corresponding increase in syncytium size with increases in CD46 levels in VSV-FH-i

279 ed a decrease in both nematode infection and syncytium size.

280 l fusion activity, strongly correlating with syncytium size.

281 sters of villous trophoblasts underlying the syncytium, suggesting that the receptor initiates the in

282 gans uterine seam cell (utse) is an H-shaped syncytium that connects the uterus to the body wall.

283 velop within an elaborate electro-mechanical syncytium that continuously generates and reacts to biop

284 Skeletal muscle is a multinucleated syncytium that develops and is maintained by the fusion

285 A component of the SIP syncytium that regulates smooth muscle excitability in t

286 Besides fusing into a multinuclear syncytium, the exchange surface between mother and fetus

287 flowering plants involves the formation of a syncytium through successive rounds of nuclear division

288 i remain connected to a shared cytoplasm, or syncytium, through incomplete cytokinesis.

289 cyst nematodes form a feeding site, termed a syncytium, through which the nematode obtains nutrients

290 While rodent beta cells act as a coordinated syncytium to drive insulin release, this property is une

291 , was post-transcriptionally silenced in the syncytium to permanently suppress its activity during al

292 bly increasing the coupling of cardiomyocyte syncytium to planar multiwell microelectrode arrays, res

293 ation can modulate the enteric neuromuscular syncytium to restore function, at the organ level, in a

294 in a normal nucleocytoplasmic ratio across a syncytium up to the centimeter scale.

295 constriction was blunted when the astrocytic syncytium was loaded with BAPTA (chelating intracellular

296 The integrated syncytium was responsive to the beta-adrenergic agonist

297 e mineral is subsequently transferred to the syncytium, where the spicule forms.

298 lls near the wound site fuse to form a giant syncytium, which sends lamellae under the scab to re-epi

299 rmation of a multinucleated feeding site, or syncytium, whose etiology includes massive gene expressi

300 planted cardiomyocytes can form a functional syncytium with the host myocardium.