ライフサイエンスコーパス: synovitis

1 h the signal intensity of fluid (nonspecific synovitis).

2 eks to months and is associated with chronic synovitis.

3 poor with high rates of implant rupture and synovitis.

4 ed synovial angiogenesis without significant synovitis.

5 itis by facilitating the resolution of early synovitis.

6 assessor to be swollen, indicating definite synovitis.

7 tify the onset and progression of hemophilic synovitis.

8 itions of chronic inflammation such as in RA synovitis.

9 to complete suppression of imaging-detected synovitis.

10 ore complete suppression of imaging-detected synovitis.

11 the cartilage-pannus junction in rheumatoid synovitis.

12 y of contrast enhanced synovium representing synovitis.

13 concentrates on increasing the detection of synovitis.

14 we established a hemophilia B mouse model of synovitis.

15 , correlating strongly with the intensity of synovitis.

16 nt homeostasis in an equine in vivo model of synovitis.

17 d in the pathogenesis of experimental murine synovitis.

18 and laboratory studies had imaging-detected synovitis.

19 hyte formation, subchondral bone change, and synovitis.

20 c factors in the development of hypertrophic synovitis.

21 relevant for T cell functions in rheumatoid synovitis.

22 may help in the diagnosis of reactive carpal synovitis.

23 ologous and HLA class I-matched heterologous synovitis.

24 s tears, joint effusion, synovial cysts, and synovitis.

25 and patients without arthroscopically proved synovitis.

26 d diffuse synovitis and their absence in GC+ synovitis.

27 ated inflammation into a chronic destructive synovitis.

28 genesis is a prominent feature of rheumatoid synovitis.

29 ssion rescued AMPK activation and suppressed synovitis.

30 liferation and the development of hemophilic synovitis.

31 mote endothelial cell proliferation in acute synovitis.

32 s (OA) is characterized by macrophage-driven synovitis.

33 -induced OA by resolving macrophage-mediated synovitis.

34 proinflammatory cytokines that contribute to synovitis.

35 ced early angiogenesis in rat models of knee synovitis.

36 tions for improving our understanding of CPJ synovitis.

37 opic germinal center reactions in rheumatoid synovitis.

38 on erosion formation that was independent of synovitis.

39 itis; no erosions occurred in joints without synovitis.

40 tcome measures and therapies should focus on synovitis.

41 that characteristically appear in rheumatoid synovitis.

42 nic inflammatory condition termed hemophilic synovitis.

43 that iron plays a similar role in hemophilic synovitis.

44 ificantly reduced the severity of hemophilic synovitis.

45 ces early chondrocyte apoptosis and reactive synovitis.

46 togenic, and MRE11A reconstitution mitigated synovitis.

47 ) patients where they probably contribute to synovitis.

48 on possibly makes a major contribution to RA synovitis.

49 y conditions observed in CPPD crystal-driven synovitis.

50 for the presence of lamellated hyperintense synovitis.

51 formation in the initial complete absence of synovitis.

52 ne therapy if resistant demonstrated reduced synovitis 12 months after treatment compared with those

53 wers for the following potential findings of synovitis: (a) distention of the pisotriquetral recess b

54 SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis) is

55 rum and synovial fluid lipid levels with OA, synovitis, adipokine levels, and wound healing in a pre-

56 this antigen in the joint may contribute to synovitis after antibiotics eradicate the pathogen.

57 -chain of the FcgammaR did not show clinical synovitis after receiving K/BxN sera, erosive lesions in

58 deficient mice developed visually detectable synovitis after transfer of arthritogenic sera.

59 Synovitis also appears to play a role in osteoarthritis

60 lternatively known as pigmented villonodular synovitis), an orphan disease with unmet medical need, i

61 The chronic persistence of rheumatoid synovitis, an inflammation driven by activated T cells,

62 7 mm (mean, 3.07 mm) in the 14 patients with synovitis and 2-7 mm (mean, 3.76 mm) in the 21 patients

63 cally normal joints, MRI showed that 96% had synovitis and 46% had bone marrow edema, and US showed t

64 hologic changes observed in human hemophilic synovitis and a marked increase in synovial cell prolife

65 shows that there is a predilection for both synovitis and bone erosion formation on the radial side

66 eus, PBD155-treated mice had lower levels of synovitis and bone erosion, as well as less myeloperoxid

67 in the joint for full progression of chronic synovitis and bone erosion.

68 iographic techniques in detecting both early synovitis and bone erosion; and the value of combination

69 is may reduce pain behavior both by reducing synovitis and by preventing structural change.

70 re examined histologically for the extent of synovitis and cartilage degradation, and joint tissue sa

71 in synovium and (c) improves the severity of synovitis and cartilage degradation.

72 atment showed beneficial effects in reducing synovitis and cartilage destruction in obese mice with P

73 core at 4 and 8 wk, as well as a decrease in synovitis and CC/TAC.

74 many features of spondyloarthritis, such as synovitis and enthesitis.

75 d a significant reduction in MRI evidence of synovitis and erosions at 1 year.

76 continue to be explored as methods to detect synovitis and erosions in RA.

77 eumatic drug combinations showed they reduce synovitis and erosive damage, especially when used with

78 ess was seen in nine of the 14 patients with synovitis and five of the 21 patients without synovitis

79 performed to analyze the correlation between synovitis and focal erosion.

80 es, in this paper we show that onset of knee synovitis and focal erosions are paralleled by PLN contr

81 pful with soft tissue impingement syndromes, synovitis and fracture.

82 provided novel approaches to ligament tears, synovitis and fractures.

83 perfusion, was used to differentiate between synovitis and healthy joints (healthy joints, 1.25 +/- 0

84 te the long-term significance of subclinical synovitis and its relationship to structural outcome.

85 The severity of synovitis and joint destruction was significantly decrea

86 been especially helpful in the management of synovitis and osteoarthritis due to osteophytosis.

87 tion, post-treatment LA with persistent knee synovitis and post-LD syndrome are distinct and distingu

88 defined as a score of 0 for both grey scale synovitis and power Doppler activity.

89 e of fibroblast-like synoviocytes in chronic synovitis and rheumatoid arthritis.

90 trasound is a useful technique for assessing synovitis and structural damage especially in hand osteo

91 and progression, but a relationship between synovitis and symptoms in isolated meniscal disease has

92 Clinical disease onset comprises synovitis and systemic comorbidities affecting the vascu

93 (DMARDs), the key therapeutic agents, reduce synovitis and systemic inflammation and improve function

94 Despite degrees of synovitis and tenosynovitis comparable with those in RA,

95 h digital bone masking for the evaluation of synovitis and tenosynovitis in patients with rheumatoid

96 ement between CT and MR imaging findings for synovitis and tenosynovitis was demonstrated, which sugg

97 Synovitis and tenosynovitis were calculated based on the

98 is, with particular attention to the role of synovitis and the contributions of other joint tissues t

99 The non-disease-specific variations in synovitis and the differential responses to therapy in R

100 e was histopathological evidence of an acute synovitis and the fibres showed evidence of sensitisatio

101 as a close correlation between the degree of synovitis and the number of new erosions, with the area

102 ce of TACI+ T cells in aggregate and diffuse synovitis and their absence in GC+ synovitis.

103 ent was seen in seven of eight patients with synovitis and three of 16 patients without synovitis (P

104 was observed in six of the 14 patients with synovitis and two of the 21 patients without synovitis (

105 represent a promising model of both chronic synovitis and uveitis.

106 r understanding of the links of FAs with OA, synovitis and wound healing, and reports newly identifie

107 K/BxN serum-induced neutrophil recruitment, synovitis, and bone destruction in gamma-chain-deficient

108 y two independent readers for tenosynovitis, synovitis, and bone marrow edema.

109 Chondrocyte apoptosis, synovitis, and ectopic calcification appear to be target

110 esions, meniscal damage, meniscal extrusion, synovitis, and effusion prior to reported knee replaceme

111 relationship of bone marrow lesions (BMLs), synovitis, and effusion to frequent knee pain and severi

112 rrow lesions, meniscal morphology/extrusion, synovitis, and effusion.

113 notransferases increased, chondrocalcinosis, synovitis, and interstitial nephritis (n=1 each).

114 hilic inflammation in the air-pouch model of synovitis, and they show decreased joint pathology accom

115 likely play a larger role in the control of synovitis, and validated quality-of-life scores will all

116 In early RA, synovitis appears to be the primary abnormality, and bon

117 Changes in BMLs and synovitis are associated with fluctuations in knee pain

118 t tissue and bone marrow, joint effusion, or synovitis are more severe than the lesion itself.

119 molecular changes responsible for hemophilic synovitis are not known.

120 of tendon sheath and pigmented villonodular synovitis are synovial-based diseases that are generally

121 with a distant site at the SPP (in RA, mean synovitis area 162 mm2 at the CPJ versus 114 mm2 at the

122 114 mm2 at the SPP [P = 0.010]; in SpA, mean synovitis area 214 mm2 at the CPJ versus 143 mm2 at the

123 ssociated with histopathological evidence of synovitis, arthritis, and tendonitis; thus, CHIKV-induce

124 d arthritis is characterised by inflammatory synovitis, articular destruction, and accelerated athero

125 progression correlates with imaging-detected synovitis as measured by power Doppler activity.

126 were compared with arthroscopically detected synovitis as the gold standard.

127 prevented progression to chronic destructive synovitis as was noted in wild-type (wt) mice.

128 ey players in the pathogenesis of rheumatoid synovitis as well as in atherosclerosis.

129 Hepsin expression correlated with synovitis as well as tumour necrosis factor alpha expres

130 a standard dichotomous (absence/presence of synovitis) as well as a graded (absence/grade of synovit

131 The importance of contrast-enhanced MRI for synovitis assessment has been demonstrated by several st

132 ial hypertrophy, power Doppler (PD), and MRI synovitis assessments in individual joints at baseline w

133 In 21 patients, ultrasonography revealed synovitis at >/=1 tarsal joint or surrounding tendon.

134 and 26 weeks was the presence or absence of synovitis at 2 weeks (P = 0.002 and P = 0.004, respectiv

135 lete response (CR) defined as the absence of synovitis at 52 weeks.

136 nts, the presence of lamellated hyperintense synovitis at MR imaging of knee arthroplasty had a high

137 0.002]), but the differences in the areas of synovitis at these sites were not significant between th

138 ed review of paraneoplastic presentations of synovitis, bone disease, myositis, and vasculitis.

139 in the diverse pathologic changes, including synovitis, bursitis, and extracapsular changes, seen adj

140 e presence of subchondral bone marrow edema, synovitis, bursitis, or enthesitis.

141 ould reduce cartilage damage associated with synovitis but might have adverse effects on cartilage an

142 damage occurs in proportion to the level of synovitis but not in its absence.

143 there was pathological evidence of prolonged synovitis but the sensory fibres responded normally to m

144 nts were recruited upon confirmed absence of synovitis by clinical examination and musculoskeletal ul

145 gs identify a new function of TNFalpha in RA synovitis by implicating TNFalpha as a major inducer of

146 We propose that rheumatoid synovitis can be suppressed by cell-based immunotherapy

147 Rheumatoid arthritis (RA) is an autoimmune synovitis characterized by the formation of pannus and t

148 Rheumatoid arthritis (RA) is an autoimmune synovitis characterized by the presence of anticitrullin

149 traarticular FIX protein were protected from synovitis compared with mice receiving same or greater d

150 findings suggest a novel mechanism by which synovitis could develop in both degenerative joint disea

151 flammatory disease activity in patients with synovitis, demonstrating that underlying inflammatory pr

152 ranulomatous disease limited to the triad of synovitis, dermatitis, and uveitis.

153 pler imaging correlated with pain scores and synovitis detected at ultrasonography, whereas the power

154 Patients with <or=4 joints with clinical synovitis (disease duration <or=12 months) were randomiz

155 TGCT) or diffuse-type pigmented villonodular synovitis (dtPVNS), and giant cell tumor of bone (GCTB).

156 During acute synovitis, early angiogenesis may enhance inflammation b

157 e marrow lesions, meniscal damage/extrusion, synovitis, effusion, and prevalent cartilage damage in t

158 The best-performing MRI feature (synovitis/effusion) was not significantly more informati

159 Synovitis-enhanced endothelial cell proliferation was al

160 th NK1 and B2 receptors inhibited 64% of the synovitis-enhanced endothelial cell proliferation.

161 oped axial and peripheral joint disease with synovitis, enthesitis, and osteitis.

162 mined 72 tissues representing the 3 types of synovitis for BLyS and APRIL production and for expressi

163 Possible associations between synovitis for each joint and tendon and RA diagnosis at

164 The sensitivity of lamellated hyperintense synovitis for infection was 0.86-0.92 (95% confidence in

165 into autoaggressive effector cells converts synovitis from acute to chronic destructive (checkpoint

166 etween anticitrullinated protein antibodies, synovitis, genetic and environmental risk factors such a

167 In addition, the semiquantitative synovitis grade on contrast-enhanced MRI was significant

168 GC+ synovitis had the highest levels of APRIL, produced excl

169 Synovitis has now become recognized as a common and impo

170 Systematic methods for evaluating synovitis have been developed and cross-sectional evalua

171 and proliferative disorder termed hemophilic synovitis (HS).

172 which selectively engraft in areas of active synovitis/IFP fibrosis inducing SP degradation, resultin

173 e osteoarthritis with ultrasonic features of synovitis in 140 patients.

174 FMT was used to detect synovitis in all arthritic joints.

175 A predilection for synovitis in all of the MCP joints adjacent to the radia

176 rast-enhanced images were acquired to assess synovitis in all of the RA patients and in 8 of the cont

177 prevent the development of milder hemophilic synovitis in EPCR-/-FVIII-/- mice.

178 lonal antibodies markedly reduced hemophilic synovitis in FVIII-/- mice subjected to joint bleeding.

179 -enhanced MRI is essential for evaluation of synovitis in knee osteoarthritis.

180 n three patients, and pigmented villonodular synovitis in one patient.

181 Synovitis in patients with antibiotic-refractory Lyme ar

182 lows for potential therapeutic monitoring of synovitis in patients with inflammatory arthritis.

183 FMT may help detect synovitis in patients with rheumatoid arthritis.

184 with ICG provided depth-resolved imaging of synovitis in PIP joints.

185 te to the immunopathogenesis of recalcitrant synovitis in PIRRA, and a possible basis for non-inflamm

186 tention has been paid to the contribution of synovitis in posttraumatic joint injury, such as menisca

187 ay support the initiation and propagation of synovitis in RA patients.

188 evealed that treatment with CRB-15 decreased synovitis in the joints; reduced bone erosion and cartil

189 lid and reproducible technique for detecting synovitis in the knee, and is more accurate than clinica

190 ultrasonography (US) as a means of detecting synovitis in the knee, by comparing US findings with fin

191 antibiotic therapy suggests that persistent synovitis in the refractory group is not perpetuated by

192 tic therapy, months before the resolution of synovitis in the two patients with antibiotic-refractory

193 atoid arthritis (RA) patients without active synovitis in their hands exhibit different baseline ther

194 f rFVIIa partly protected against hemophilic synovitis in these mice.

195 nor IL-17R-/- BM cells developed destructive synovitis in this chronic reactivated streptococcal cell

196 e contribution of synovial tissue pathology (synovitis) in determining diverse clinical outcome/thera

197 but a small percentage have persistent knee synovitis, in some cases possibly related to the trigger

198 kines and growth factors expressed during RA synovitis, including IL-6, epidermal growth factor (EGF)

199 the complex pathways involved in rheumatoid synovitis, including mitogen-activated protein kinases,

200 In mild synovitis induced by 0.03% Carrageenan, but not in naive

201 In moderate synovitis induced by 3% kaolin and 3% carrageenan, the c

202 nistered 1 day before and up to 3 days after synovitis induction.

203 the synovium in TKA between particle-induced synovitis, infection, and nonspecific synovitis, with al

204 The four major components of RA synovitis, inflammation, immune reactivity, angiogenesis

205 Synovitis is a characteristic feature of advancing knee

206 In established OA, synovitis is associated with pain and progression, but a

207 Synovitis is being re-examined along with efforts to bet

208 Synovitis is common and is associated with progression o

209 is, we find that autoantibody-driven erosive synovitis is critically reliant on the generation of leu

210 Gouty synovitis is driven and sustained by neutrophil influx.

211 RA synovitis is highly heterogeneous with diverse cellular

212 Accurate detection of synovitis is important in both the diagnosis and outcome

213 rondlike and hypertrophied (particle-induced synovitis), lamellated and hyperintense (infection), and

214 isease characterized by chronic inflammatory synovitis leading to joint destruction and systemic bone

215 n of APRIL and BLyS in aggregate and diffuse synovitis left Ig levels unaffected and enhanced IFN-gam

216 luorescence imaging to longitudinally assess synovitis, lymphatic flow, and cell migration in lymphat

217 giogenic treatment during the acute phase of synovitis may prevent its subsequent progression.

218 The primary end point was synovitis (measured by magnetic resonance imaging [MRI])

219 gh frequency in patients with ALVAL included synovitis, mixed- or solid-type synovitis, synovial thic

220 imilar frequencies (nine of 14 patients with synovitis, nine of 21 patients without synovitis), pisot

221 t on new bone damage related to the level of synovitis; no erosions occurred in joints without synovi

222 lthy controls, and 2 groups of patients with synovitis of </=3 months' duration whose outcomes were d

223 tudy, 39 patients with early RA and clinical synovitis of the hand/wrist were randomized to receive i

224 finger (odds ratio, 14.61) in VERA group and synovitis of the radioulnar joint (odds ratio, 8.79) and

225 anced MRI is associated with measurements of synovitis on contrast-enhanced MRI.

226 fined as > or =1 swollen joint suggestive of synovitis on joint examination by a trained clinician.

227 Furthermore, BLOKS scoring of synovitis on unenhanced MRI is associated with measureme

228 ion (adjusted OR, 3.62; 95% CI: 1.34, 9.82), synovitis or effusion (adjusted OR, 3.36; 95% CI: 0.91,

229 lesions, meniscal damage and extrusion, and synovitis or effusion) to the risk of fast cartilage los

230 , the presence of high BMI, meniscal damage, synovitis or effusion, or any severe baseline MR-depicte

231 T MR imaging may be sufficient for assessing synovitis or tenosynovitis in early RA.

232 3 in 34) or tenosynovitis scores in grading synovitis or tenosynovitis in image quality and in asses

233 core (BLOKS) for the extent of infrapatellar synovitis (OR 9.05 [95% CI 1.94, 42.3] for K/L grade; OR

234 effusion (OR, 4.75; 95% CI: 2.55, 8.85), or synovitis (OR, 2.17; 95% CI: 1.33, 3.56), but not extrus

235 ondral cysts, sclerosis, joint effusion, and synovitis (P < .001).

236 bination treatment group had more grey scale synovitis (P < 0.001) but similar power Doppler activity

237 h synovitis and three of 16 patients without synovitis (P = .002).

238 ynovitis and five of the 21 patients without synovitis (P = .018).

239 synovitis and two of the 21 patients without synovitis (P = .027).

240 m (mean, 3.76 mm) in the 21 patients without synovitis (P = .193).

241 icant differences were seen in the volume of synovitis (P = 0.294), degree of flexor tenosynovitis (P

242 with disease in remission, imaging-detected synovitis persists, with power Doppler activity seen in

243 with synovitis, nine of 21 patients without synovitis), pisotriquetral bone marrow edema was seen on

244 ological findings, such as muscular atrophy, synovitis, posture-gait deterioration, and reactive bone

245 replacement, chondrocyte apoptosis at day 5, synovitis present at day 14, osteophytes, ectopic calcif

246 cell tumor (TGCT) or pigmented villonodular synovitis (PVNS) and its therapeutic implications.

247 cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) are related conditions with features of

248 a, two important physiological biomarkers of synovitis reflecting the increased metabolic demand and

249 ocyte population in patients with rheumatoid synovitis, regulate synoviocyte proliferation.

250 sponding ORs were 1.5, 1.5, and 2.4 when the synovitis score changed from 0 to 1, 2, and 3-6, respect

251 nces in steroid use, prior biologic use, and synovitis score on MRI between the R788 group and the pl

252 nd points C-reactive protein (CRP) level and synovitis score on MRI.

253 also significantly associated with the BLOKS synovitis score.

254 In the first phase, MTX + IAST reduced synovitis scores more than MTX alone.

255 During the second phase, the synovitis scores were equivalent and a similar number of

256 MRI) scores for joint erosion, osteitis, and synovitis, scores on the Health Assessment Questionnaire

257 vitis) as well as a graded (absence/grade of synovitis) scoring system.

258 The volume of synovitis surrounding each MCP joint (divided into 8 reg

259 VAL included synovitis, mixed- or solid-type synovitis, synovial thickening, and capsular dehiscence.

260 oid arthritis is characterised by persistent synovitis, systemic inflammation, and autoantibodies (pa

261 and fingers, was performed, and presence of synovitis, tenosynovitis with or without a layered appea

262 be used to assess features of SSc, including synovitis, tenosynovitis, calcinosis, acroosteolysis, an

263 ime of carrageenan injection was followed by synovitis that persisted for 29 days.

264 r proliferation and inflammation (hemophilic synovitis) that contribute to end-stage joint degenerati

265 sions, with the area under the curve for MRI synovitis the only significant predictor of bone damage

266 ulature associated with rheumatoid arthritis synovitis, the joint affected by rheumatoid arthritis is

267 However, despite comparable degrees of synovitis, the proportion of MCP joints showing extracap

268 lage degeneration as a triggering factor for synovitis, the selected entheses included 17 that were n

269 logous BMNCs are readily available, regulate synovitis through macrophage-associated effects, and can

270 al sequence of events from joint bleeding to synovitis to arthropathy is well documented, the compone

271 In GC+ synovitis, treatment with TACI:Fc resulted in GC destruc

272 marrow edema was seen only in patients with synovitis (two of nine patients).

273 biotic treatment, leading to a proliferative synovitis typical of chronic inflammatory arthritides.

274 further tested ex vivo in human inflammatory synovitis, using collagenase-digested synovium.

275 sport are compensatory mechanisms to prevent synovitis via increased drainage of inflamed joints.

276 telet microparticles, actively contribute to synovitis via production of proinflammatory prostacyclin

277 The volume of synovitis was also greater on the radial side of the sec

278 The area of synovitis was calculated at the CPJ and SPP regions of i

279 Hemophilic synovitis was evaluated by monitoring joint bleeding, ch

280 Synovitis was found in 17 patients (39%).

281 Synovitis was induced in both radiocarpal joints of 6 ho

282 Persistence of carrageenan/FGF-2-induced synovitis was prevented by systemic administration of 3

283 A larger reduction in the area of synovitis was seen at the SPP compared with the CPJ foll

284 In patients with RA or SpA, the area of synovitis was significantly larger immediately adjacent

285 regression demonstrated that subtalar joint synovitis was the only predictive factor for abnormal su

286 int space can protect joints from hemophilic synovitis, we established a hemophilia B mouse model of

287 ke synoviocytes (FLS) to the perpetuation of synovitis, we investigated the molecular mechanisms that

288 ted kappa values for distinguishing grade of synovitis were 0.65 for inter- and 0.74 for intrareader

289 stinguishing between presence and absence of synovitis were 0.71 and 0.85, respectively (P < 0.05 for

290 tative SV), and semiquantitative measures of synovitis were also applied using both contrast-enhanced

291 curacy of these findings in the detection of synovitis were calculated.

292 Differences in CPJ and SPP synovitis were determined using calculated DEMRI paramet

293 dditionally, rabbits with chemically induced synovitis were imaged with (123)I-BTT-1023 SPECT/CT.

294 al or ligamentous tears, joint effusion, and synovitis were strongly related to increasing Kellgren-L

295 e reproduced in vivo in a rat model of acute synovitis, where transiently engrafted human IFP-MSC ind

296 n these tissues is more prominent than joint synovitis, which is common in both conditions.

297 3% carrageenan into rat knees produced acute synovitis, which was not associated with synovial angiog

298 id arthritis (RA) is a chronic, inflammatory synovitis whose pathogenesis may involve autoimmune mech

299 nduced synovitis, infection, and nonspecific synovitis, with almost perfect interobserver and intraob

300 oid arthritis (RA) is a chronic inflammatory synovitis, with destruction of juxtaarticular cartilage