ライフサイエンスコーパス: synthase

1 of oxidative phosphorylation, complex V (ATP synthase).

2 ncorporation of haloindoles using tryptophan synthase.

3 cetyl coenzyme A carboxylase, and fatty acid synthase.

4 ll and increasing the enzyme activity of Suc synthase.

5 ulation that expresses neuronal nitric oxide synthase.

6 ctivity of the major S. aureus peptidoglycan synthase.

7 1 encodes a subunit of the mitochondrial ATP synthase.

8 1 (GALS1), which encodes a beta-1,4-galactan synthase.

9 tion via the enzyme endothelial nitric oxide synthase.

10 (HvCslF3 and HvCslF9) (1,3;1,4)-beta-glucan synthases.

11 ding the cell wall kinase Yck2 and trehalose synthases.

12 99) with a D277N substitution in beta-glucan synthase 1 (Cps1/Bgs1) was reported to arrest with an un

13 by up regulating the expression of GALACTAN SYNTHASE 1 (GALS1), which encodes a beta-1,4-galactan sy

14 (e.g. oxytocin (OXT), neuronal nitric oxide synthase 1 (NOS1), melanocortin 4-receptor (MC4R), prody

15 ate kinase, Akt Ser/Thr kinase, nitric oxide synthase 1, nitric oxide, soluble guanylate cyclase, cyc

16 Constitutive reduction of glycogen synthase-1 (GYS1) activity prevents murine LD, but the e

17 tion therapy by inhibiting 5-aminolevulinate synthase 2 (ALAS2), the first and rate-limiting enzyme i

18 Arabidopsis thaliana phloem specific SUCROSE SYNTHASE 2 (AtSUC2) promoter were developed.

19 ation-based regulation employed by human CTP synthase 2 (CTPS2).

20 f glucose transporter 2 (GLUT2) and glycogen synthase 2 (GYS2); while expression of gluconeogenic gen

21 ice that lack the gene encoding nitric oxide synthase 2 (Nos2) are susceptible to the related murine

22 nd testing MAIT cell priming in nitric oxide synthase 2 (NOS2)-deficient mice all failed to reveal an

23 we show ECs deficient in CDP-diacylglycerol synthase 2 are uniquely sensitive to increased vascular

24 reas in dermal sheath cells, hyaluronic acid synthase 2, HAS2, and PDPN increased and alpha-smooth mu

25 sion of the inflammatory marker nitric-oxide synthase 2.

26 r-alpha, interleukin-1beta, and nitric oxide synthase-2, highlighting the potential of VLA-4 as a sur

27 functionally identify differential ceramide synthase 4 protein expression as one key difference.

28 ted ethylene responses and expression of ACC Synthase 7 (ACS7), which encodes a rate-limiting enzyme

29 Here we identify cystathionine B-synthase a (cbsa), which encodes the key enzyme of the t

30 tosynthase, a 3-hydroxy-3-methylglutaryl-CoA synthase, a dehydratase, a decarboxylase and a dedicated

31 ngolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glu

32 ist analog elicited endothelial nitric oxide synthase activation to promote endothelial monolayer wou

33 ng the fall in CK flux, total CK and citrate synthase activities and the absolute activities of mitoc

34 Although complex-IV and citrate synthase activities were similar in VOE platelets vs ste

35 ynthase, and mixed beta-amyrin and friedelin synthase activities.

36 er validates similar studies that suggest FA synthase activity and FA isomer abundances are significa

37 BioSTING affords real-time detection of CDN synthase activity and inhibition.

38 Mitochondrial mass was analysed by citrate synthase activity and mitochondrial protein content by P

39 ATP synthase activity increased in only the longest establis

40 ing glycogen content, and increased glycogen synthase activity, together with increased muscle lactat

41 vel and activity, and decreased nitric oxide synthase activity.

42 thal deficits in either aPBP or SEDS/bPBP PG synthase activity.

43 convergent evolution of the derived aldehyde synthase activity.

44 ctivation of the sams-1 S-adenosylmethionine synthase also suppresses the drp-1 fission defect, sugge

45 ystem containing purified yeast F(1)F(0) ATP synthase, although, thermodynamically, a sufficiently hi

46 ated, as well as indole-3-glycerol phosphate synthase, an enzyme involved in the biosynthesis of l-Tr

47 , 3-deoxy-d-arabinoheptulosonate 7-phosphate synthase and chorismate synthase, were also up-regulated

48 the downregulation of the cystathionine beta-synthase and cystathionine gamma-lyase, two enzymes of t

49 hypoxia increased the activities of citrate synthase and cytochrome oxidase.

50 el for C-S bond formation in isopenicillin N synthase and indicate that kinetic control may be a key

51 nti-inflammatory (low inducible nitric oxide synthase and lower tumour necrosis factor-alpha), pro-he

52 creased activities of inducible nitric oxide synthase and NADPH oxidase 1 enzymes at myoendothelial p

53 ward screen that shows that glucosylceramide synthase and other components of the ganglioside synthet

54 sed expression of DNA sensors cyclic GMP-AMP synthase and stimulator of interferon genes in wild-type

55 activator of PG polymerization by the FtsWI synthase and thereby define an essential regulatory step

56 Short-lived memory was mediated by trehalose synthase and trehalose metabolism.

57 inflammatory markers: inducible nitric-oxide synthase and tumor necrosis factor-alpha, when cultured

58 m Pseudobutyrivibrio ruminis possesses 2 ATP synthases and 2 distinct respiratory enzymes, the ferred

59 wall growth is facilitated by peptidoglycan synthases and hydrolases and is potentially modulated by

60 Several peptidoglycan synthases and hydrolases require activation by outer-mem

61 tem, involving interaction between cellulose synthases and microfibrils, can maintain aligned cellulo

62 kade of adenosine receptors and nitric oxide synthase, and by modeling the determinants of coronary f

63 3GNT2 is the major poly-N-acetyl-lactosamine synthase, and deletion of its coding gene dramatically r

64 upeol synthase, mixed alpha- and beta-amyrin synthase, and mixed beta-amyrin and friedelin synthase a

65 encoding isoforms of AGPase, soluble starch synthase, and other starch branching enzymes were up-reg

66 ucleotide cyclases, including cyclic GMP-AMP synthase, and their involvement in STING-mediated immuni

67 ing of endothelial and neuronal nitric oxide synthase, and vascular/brain infiltration with inflammat

68 through the regulation of argininosuccinate synthase- and glucose transporter protein type 1-mediate

69 d increased levels of inducible nitric oxide synthase, another indicator of cell damage.

70 c neurons stained with neuronal nitric oxide synthase antibody and approximately 33% of neurons produ

71 However, while these CSLD polysaccharide synthases are essential, the nature of the polysaccharid

72 ntify the low expression of Bik1 (polyketide synthase) as a major bottleneck step in the pathway, and

73 ginine resynthesis enzymes argininosuccinate synthase (ASS) and ornithine transcarbamylase (OTC).

74 th the beta subunit of the mitochondrial ATP-synthase (ATP5B), which may therefore represent a conser

75 t not FX synapses, by stimulus-dependent ATP synthase beta subunit translation; this increases the ra

76 tallin with alcohol dehydrogenase or citrate synthase by applying thermal stress.

77 oton density to the crista tip where the ATP synthase can readily utilize the localized proton densit

78 e role of each regulatory cystathionine-beta-synthase (CBS) domain in the gamma1 subunit in metformin

79 ue structure known as the cystathionine-beta-synthase (CBS) domain, though the role of this domain is

80 he H(2)S-producing enzyme cystathionine beta-synthase (CBS) survive longer with reduced organ burden,

81 termined the structure of a poplar cellulose synthase CesA homotrimer that suggests a molecular basis

82 synthesized by rosette-structured cellulose synthase (CESA) complexes (CSCs).

83 nosine monophosphate-adenosine monophosphate synthase (cGAS) and enhanced interferon signaling mediat

84 the activation of cyclic GMP-AMP (cGMP-AMP) synthase (cGAS) and generation of the cyclic dinucleotid

85 cell cytosol is sensed by the cyclic GMP-AMP synthase (cGAS) and stimulator of IFN genes (STING) path

86 Cyclic GMP-AMP synthase (cGAS) is a critical cytosolic DNA sensor that

87 Cyclic GMP-AMP synthase (cGAS) is a double-stranded DNA sensor that cat

88 Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a major responder to the pathogenic D

89 Cyclic cGMP-AMP synthase (cGAS) is a pattern recognition cytosolic DNA s

90 hosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) recognizes cytosolic foreign or damaged

91 y telomere shortening, but by cyclic GMP-AMP synthase (cGAS) recognizing cytosolic chromatin fragment

92 The enzyme cyclic GMP-AMP synthase (cGAS) senses cytosolic DNA in infected and mal

93 Cyclic-G/AMP (cGAMP) synthase (cGAS) triggers host innate immune responses ag

94 Here, we report that cGMP-AMP synthase (cGAS), a DNA sensor, is a critical regulator o

95 ubiquitinates and down-regulates the chitin synthase Chs3.

96 ans involves the sequential action of chitin synthases (CHSs) and chitin deacetylases (CDAs).

97 ion unearthed the Krebs cycle enzyme citrate synthase (CitA) as a checkpoint regulator controlling th

98 xSAM) cofactor generated from SAM by a cxSAM synthase (CmoA).

99 we identified a novel biomarker, coenzyme A synthase (COASY), whose mRNA expression was consistently

100 ll cellulose is synthesized by the cellulose synthase complex (CSC) containing CELLULOSE SYNTHASE1 (C

101 the addition of subunit j, leading to an ATP synthase complex that is coupled to the proton motive fo

102 Our data suggest how cellulose synthase complexes assemble and provide the molecular ba

103 l such a mechanism by showing that cellulose synthase complexes can interact with the trails left by

104 Supramolecular plant cellulose synthase complexes organize multiple linear glucose poly

105 ulose by guiding the trajectory of cellulose synthase complexes.

106 gate the reaction mechanism in the diterpene synthase CotB2, commencing with the substrate geranyl ge

107 ulfhydrylase (OASS), referred to as cysteine synthase (CS), synthesizes cysteine from O-acetyl serine

108 -PHOSPHATE ACYLTRANSFERASE [GPAT6] and CUTIN SYNTHASE [CUS1] mutants).

109 vity against the closely homologous cortisol synthase (CYP11B1).

110 produced by a trifunctional enzyme, siroheme synthase (CysG).

111 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (DAH7PS), at the gateway to aromatic amino acid

112 Deacetoxycephalosporin C synthase (DAOCS) is an alphaKG-dependent nonheme iron en

113 e previously reported (E)-beta-caryophyllene synthase (DcTPS01), we biochemically characterized sever

114 whereas genes encoding granule-bound starch synthase, debranching enzymes, pullulanase, and starch p

115 The 6-deoxyerythronolide B synthase (DEBS) is a prototypical assembly line polyketi

116 n diseases, at least, in those with F1Fo ATP synthase defects.

117 ography, pointing the way for future terpene synthase design.

118 ow distribution based upon the characterized synthases, DncV and Hypr GGDEFs.

119 ago in a proto-reptile by cystathionine beta-synthase duplication, cysteine lyase neofunctionalizatio

120 te (N-gamma-ADABA), the substrate of ectoine synthase (EctC).

121 Mutant strains lacking the spermine synthase-encoding gene SPS1 progressed through all stage

122 fecting the NF-kappaB-inducible nitric oxide synthase-endoplasmic reticulum stress pathway.

123 f antigen presentation, EZH2 and thymidylate synthase, enhanced DLBCL MHC-I presentation.

124 sed by dysregulated endothelial nitric-oxide synthase (eNOS) activity is linked to vascular dysfuncti

125 nd SK) channels and endothelial nitric oxide synthase (eNOS) are present in the endothelium of mesent

126 ted protein kinase (MAPK) and endothelial NO synthase (eNOS) in EA.hy926 cells treated with condition

127 e vascular beds and endothelial nitric oxide synthase (eNOS) in others.

128 cally, higher Abeta42 reduced endothelial NO synthase (eNOS), cyclic GMP (cGMP), and protein kinase G

129 kinase (AMPK), Akt, endothelial nitric oxide synthase (eNOS), nuclear factor erythroid 2-related fact

130 translation; this increases the ratio of ATP synthase enzyme to its c-subunit, enhancing ATP producti

131 as been used to determine which nitric oxide synthase enzymes are active in discrete regions of the r

132 on in the 5-enolpyruvylshikimate 3-phosphate synthase (EPSPS) gene, with minor contributions from EPS

133 t enzyme 5-enolpyruvyl-shikimate-3-phosphate synthase (EPSPs).

134 which are mediated by inducible nitric oxide synthase expression and beta-cell production of nitric o

135 222 treatment enhanced dermis endothelial NO synthase expression and plasma NO levels of diabetic mic

136 the fetal liver, reduces hepatic fatty acid synthase (Fas) expression and improves glucose tolerance

137 d a detailed kinetic model of the fatty acid synthase (FAS) of Escherichia coli and paired that model

138 responsive factors, including the fatty acid synthase FASN-1, anti-microbial peptides, and genes invo

139 ijacks the lipid-modifying enzyme fatty acid synthase (FASN) for pro-viral activity.

140 Conditional deletion of fatty acid synthase (Fasn) in SGC impairs axon regeneration.

141 Recombinant orexins increased fatty acid synthase (FASN) protein levels in chicken liver, activat

142 ne in the cytoplasm (catalyzed by fatty acid synthase, FASN) and one in the mitochondria (mtFAS).

143 Fatty acid synthases (FASs) and polyketide synthases (PKSs) iterati

144 otein that is required by Type II fatty acid synthases (FASs).

145 in concentrations (-53%) and hepatic citrate synthase flux (-38%), respectively.

146 and IDSs share a conserved "alpha terpenoid synthase fold" and a trinuclear metal cluster for cataly

147 e uroS gene, encoding a uroporphyrinogen III synthase for an early step of heme biosynthesis, is cons

148 We have studied the beta-ketoacyl-CoA synthase from the high erucic feedstock Thlaspi arvense

149 Based on their sequence similarity, terpene synthases from land plants can be divided into different

150 e enzyme, 5-enolpyruvulshikimate-3-phosphate synthase, from Agrobacterium sp. strain CP4 (CP4 EPSPS),

151 Here, we inhibited F1Fo ATP synthase function in primary cultured hippocampal neuron

152 F(1)F(o) ATP synthase functions as a biological rotary generator that

153 etry-based proteomics, granular-bound starch synthase (GBSS) is the major granular protein in isolate

154 rabidopsis thaliana) in GRANULE-BOUND STARCH SYNTHASE (GBSS), encoding the enzyme responsible for amy

155 ghts into the action of GRANULE BOUND STARCH SYNTHASE (GBSS), the major glucosyltransferase that synt

156 presence of an inhibitor of glucosylceramide synthase (GCS), the enzyme responsible for generating gl

157 y isolating and sequencing type I polyketide synthase gene clusters from an Antarctic soil metagenome

158 e histone demethylase Lsd1 to the fatty acid synthase gene promoter.

159 de synthase type II or non-ribosomal peptide synthase genes within their genome.

160 A increases expression of important glycogen synthase, glucose, fatty acid and mitochondrial metaboli

161 Three homologous candidate genes, glycogen synthase (glys), atp-binding cassette transporter (atp),

162 the key glycogen synthetic enzyme, glycogen synthase (GS), we identified a substituted imidazole, (r

163 lated glycogen phosphorylase (GPa), glycogen synthase (GSa) - respectively activated and inactivated

164 e C oxidase copper chaperone (COX17) and ATP Synthase, H(+) transporting, Mitochondrial Fo Complex (A

165 ly as positive or negative regulators of the synthase has been unclear.

166 nous inhibitor and uncoupler of nitric oxide synthase, has gained attention as a risk factor for card

167 perties of a heme chaperone for inducible NO synthase, here we investigated whether heme delivery to

168 LY forms a homotetramer with a rigid citrate synthase homology (CSH) module, flanked by four flexible

169 oration between a highly reducing polyketide synthase (HRPKS, Fub1) and a nonribosomal peptide synthe

170 an extracellular mammalian N-acyl amino acid synthase/hydrolase called PM20D1 (peptidase M20 domain c

171 as a second intracellular N-acyl amino acid synthase/hydrolase.

172 hases (TPSs) and trans-isoprenyl diphosphate synthases (IDSs) are among the core enzymes for creating

173 ed by the enzyme indole-3-glycerol phosphate synthase (IGPS) starts with a condensation step in which

174 ng from decreased activity of 3-ketoacyl-ACP synthase II.

175 lyze a 3-ketoacyl-acyl carrier protein (ACP) synthase III-like reaction to produce pimeloyl-ACP with

176 The adenosine triphosphate (ATP) synthase in human mitochondria is a membrane bound assem

177 cone by first fully reconstituting the NOCAP synthase in vitro from purified protein components follo

178 onstrates that the structures of dimeric ATP synthases in a tetrameric porcine enzyme have been serio

179 ized from methionine by S-adenosylmethionine synthase; inactivation of the sams-1 S-adenosylmethionin

180 ATP synthase inhibition in myotubes triggers the ISR via a d

181 cer cells to proliferate, despite fatty acid synthase inhibition.

182 erally considered to result from thymidylate synthase inhibition.

183 d by pretreatment with the nitric oxide (NO) synthase inhibitor l-N (G)-nitro-l-arginine methyl ester

184 d the non-selective competitive nitric oxide synthase inhibitor N(G) -monomethyl-l-arginine (l-NMMA,

185 ng with this, administration of a fatty acid synthase inhibitor, cerulenin, also alleviated the patho

186 te of TVB-2640, a pharmacological fatty acid synthase inhibitor, has been shown to reduce hepatic fat

187 rt the therapeutic potential of a fatty acid synthase inhibitor, TVB-2640 in particular, in patients

188 of a novel class of anti-tuberculosis F-ATP synthase inhibitors.

189 sidase and orally-available glucosylceramide synthase inhibitors.

190 uced from arginine by inducible Nitric Oxide Synthase (iNOS) enzyme.

191 adiotherapy increased inducible nitric oxide synthase (iNOS) in the tumor tissues.

192 ficient granuloma formation and inducible NO synthase (iNOS) induction, increased dissemination of ba

193 signaling mediated by inducible nitric oxide synthase (iNOS), transforming growth factor beta (TGF-be

194 g proteins (GBPs) and inducible nitric oxide synthase (iNOS), which we found to inhibit R. parkeri.

195 ograft survival in an inducible nitric oxide synthase (iNOS)-dependent manner.

196 tion of the stimulator of the cyclic GMP-AMP synthase interferon genes (cGAS-STING) innate immune pat

197 In silico analyses revealed that 1 ATP synthase is [Formula: see text]-dependent and the other

198 However, expression of complex V (ATP synthase) is relatively low in alphaICs, even when stimu

199 odes an epidermally-expressed 3-KETOACYL-CoA SYNTHASE (KCS) belonging to a functionally uncharacteriz

200 a novel mode of eIF6 regulation by glycogen synthase kinase 3 (GSK3) that is predominantly active in

201 including phosphoinositide 3-kinase/glycogen synthase kinase 3 (PI3K/GSK3) signaling, with serum-gluc

202 s required for BRB restoration, but glycogen synthase kinase 3 alpha/beta (GSK-3alpha/beta) inhibitio

203 nce of P. gingivalis (Pg) affecting glycogen synthase kinase 3 beta (GSK-3beta)/nuclear factor (eryth

204 that CAMK4 phosphorylates GSK3beta (glycogen synthase kinase 3 beta), activates the Wnt pathway and s

205 ical downregulation of local GSK-3 (glycogen synthase kinase 3) and Akt signaling pathways, and norma

206 tor of cyclin-dependent kinases and glycogen synthase kinase 3, as a modulator of parkin recruitment.

207 r anti-fibrotic compounds targeting glycogen synthase kinase 3, which has a consistent role as a key

208 ny signaling pathways that activate glycogen synthase kinase 3beta (GSK3beta) implicated in neurodege

209 Recent evidence suggests that glycogen-synthase kinase 3beta (GSK3beta) plays a key role in mem

210 (hTau-S199-P) by the protein kinase glycogen synthase kinase 3beta (GSK3beta).

211 id kinase 1 (SGK1), an inhibitor of glycogen synthase kinase 3beta, as part of this pathway.

212 egulated protein kinase modules and glycogen synthase kinase 3beta.

213 We found that glycogen synthase kinase-3 (GSK3) is overactivated in corticolimb

214 n vitro (i.e., 100- to 250-fold) by glycogen synthase kinase-3beta (GSK-3beta) inhibition using CHIR9

215 ascular function in endothelial nitric oxide synthase knockout (eNOS(-/-) ) mice.

216 Fmr1(-/y) mouse neurons, closure of the ATP synthase leak channel by mild depletion of its c-subunit

217 is cyclized by an unusual plastidial terpene synthase (LfTPS1) into the characteristic serrulatane di

218 synthase (LiGGPPS) and farnesyl diphosphate synthase (LiFPPS).

219 ynthase (LiGPPS), geranylgeranyl diphosphate synthase (LiGGPPS) and farnesyl diphosphate synthase (Li

220 ntermedia cDNAs encoding geranyl diphosphate synthase (LiGPPS), geranylgeranyl diphosphate synthase (

221 nvestigate the role of Arabidopsis cellulose synthase like-C (CSLC) proteins in XyG biosynthesis.

222 related plant species shows that a chalcone synthase-like (CHS-L) gene family has lineage-specifical

223 nerate mutations in members of the Cellulose synthase-like (Csl) gene superfamily that encode known (

224 Here, we show that a conserved starch synthase-like protein, STARCH SYNTHASE5 (SS5), regulates

225 s induced by the yeast triacylglycerol (TAG)-synthases Lro1 and Dga1 are formed at discrete ER subdom

226 ing the 60-subunit Aquifex aeolicus lumazine synthase (LuS) and the 24-subunit Helicobacter pylori fe

227 he UDP-GalNAc precursors required by the Pel synthase machinery for polymer production.

228 endent Mycobacterium tuberculosis salicylate synthase (MbtI) is a key enzyme involved in the biosynth

229 succinyl-L-homoserine by cystathionine gamma-synthase (MetB).

230 1-3 respectively encoded enzymes with lupeol synthase, mixed alpha- and beta-amyrin synthase, and mix

231 anscriptionally regulates alsS (acetolactate synthase) mRNA and enzyme levels.

232 ived 2)-like 2 (Nrf2), neuronal Nitric Oxide Synthase (nNOS) expression and nitrergic relaxation in g

233 are elevated by the activity of neuronal NO synthase (nNOS) following Ca(2+) entry through extrasyna

234 nduced dissociation of neuronal nitric oxide synthase (nNOS) from postsynaptic density 95 (PSD95) and

235 lbindin, calretinin, and neural nitric oxide synthase (nNOS).

236 response to acetylcholine, and nitric oxide synthase (NOS) activity was defined as the inverse of FB

237 r by triple labeling with CGRP, nitric oxide synthase (NOS) and calretinin (CALR) antibodies.

238 )/tetrahydrobiopterin (BH(4) )/ nitric oxide synthase (NOS) expression in primary human aortic endoth

239 We investigated the role of nitric oxide synthase (NOS) in mediating blood-brain barrier (BBB) di

240 m-dependent vasodilation due to uncoupled NO synthase (NOS).

241 st cell, it activates inducible nitric oxide synthase (NOS2) which instantly fills the phagosome with

242 uced BPD and PH via endothelial nitric oxide synthase (NOS3).

243 estingly, defense modulators such as terpene synthase, papain-like cysteine protease, serine carboxyp

244 ble for CtrA control, and functional citrate synthase paralogs cannot replace CitA in promoting S-pha

245 ecreased the expression of the peptidoglycan synthase PBP1.

246 an interaction partner of the peptidoglycan synthase PBP1a that promotes its stable accumulation at

247 t (E)FtsN binds specifically to the major PG synthase PBP1b and is sufficient to stimulate its biosyn

248 Phytochelatin synthase (PCS) is a key component of heavy metal detoxif

249 ncoding beta-ketoacyl-(acyl-carrier-protein) synthases, peroxisomal acyl-activating enzymes, ATP bind

250 hotransferase phosphatidylinositol-phosphate synthase (PIPS), an essential enzyme for mycobacterial v

251 *-domain-containing NRPS from the polyketide synthase (PKS) machinery, expanding the paradigm for the

252 ) is a prototypical assembly line polyketide synthase (PKS) that synthesizes the macrocyclic core of

253 a cryptic trans-acyl transferase polyketide synthase (PKS) was identified in the genomes of Burkhold

254 of the products of type I modular polyketide synthase (PKS) with the focus on providing a more accura

255 Engineering polyketide synthases (PKS) to produce new metabolites requires an u

256 Fatty acid synthases (FASs) and polyketide synthases (PKSs) iteratively elongate and often reduce t

257 ss the synthetic power of modular polyketide synthases (PKSs), many aspects of their biochemistry mus

258 cological inhibition of de novo sphingolipid synthases prevented diabetes in animal studies.

259 ergic neurons, reduced neuronal nitric oxide synthase production, and reduced colonic neurogenesis.

260 factor), and eNOS (endothelial nitric oxide synthase) protein contents.

261 Expression analysis of PHYTOENE SYNTHASE (PSY1) and CAROTENOID ISOMERASE (CRTISO) as wel

262 MutMap in the encoding region of Quinolinate Synthase (QS) gene required for the de novo synthesis of

263 metI gene, which encodes cystathionine gamma-synthase, regulate the expression of genes involved in m

264 at the cell periphery promotes peptidoglycan synthase relocation to midcell during cell division.

265 -2 encoding a putative auxin amido conjugate synthase, resulting in a lower free auxin concentration;

266 a loss-of-function mutation in the spermine synthase (SMS) gene.

267 e-3-phosphate dehydrogenase, calmodulin, ATP synthase, sperm equatorial segment protein 1, peroxiredo

268 However, unlike SS4 and the other starch synthases, SS5 is a noncanonical isoform that lacks cata

269 he host and leads to activation of the cGAMP synthase-stimulator of IFN genes (cGAS-STING) pathway, i

270 he DNA damage response (DDR), cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pat

271 present study, we studied the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pat

272 screen for inhibitors of the cyclic GMP-AMP synthase/stimulator of interferon genes pathway, which r

273 Strictosidine synthase (STR) catalyzes the Pictet-Spengler condensatio

274 triplet ATT codon (Ile) insertion within ATP synthase subunit 8, were unique within our assemblies.

275 The bacterial cellulose synthase subunit G (BcsG) is a predicted inner membrane-

276 Type I polyketide synthases (T1PKSs) are one of the most extensively studi

277 f proteolytic fragments of chloroplastic ATP synthase, termed inceptins.

278 somal peptide synthetases, type 1 polyketide synthases, terpenes, and lantipeptides.

279 3 is a UDP-glucose-dependent beta-1,4-glucan synthase that forms protein complexes displaying similar

280 s encoding short-chain isoprenyl diphosphate synthases that control the partitioning of precursors fo

281 Most bacteria utilize two types of synthases that polymerize glycan strands and crosslink t

282 port a bacterial ortholog to the yeast HMP-P synthase (Thi5) was necessary for HMP synthesis in Legio

283 itors of the essential bacterial thymidylate synthase ThyX in a cellular context.

284 al ion gradient is harnessed by a rotary ATP synthase to phosphorylate adenosine diphosphate to ATP.

285 modified diphosphates were used with terpene synthases to produce the unnatural sesquiterpenoid semio

286 e describe the identification of the terpene synthase (TPS) gene family of the panicoid food and bioe

287 re, we functionally characterized 19 terpene synthase (TPS) genes in an orange carrot (genotype DH1)

288 nd in nature is mainly determined by terpene synthases (TPS).

289 Terpene synthases (TPSs) and trans-isoprenyl diphosphate synthas

290 microfibrils, can maintain aligned cellulose synthase trajectories, while a microtubule guidance syst

291 porter and identified the tRNA pseudouridine synthase, TruB1.

292 basis of increased expression of thymidylate synthase (TYMS), thymidine kinase 1 (TK-1), and equilibr

293 positive for at least one of the polyketide synthase type I, polyketide synthase type II or non-ribo

294 f the polyketide synthase type I, polyketide synthase type II or non-ribosomal peptide synthase genes

295 In contrast, when ATP synthase was coreconstituted with an active proton-trans

296 losonate 7-phosphate synthase and chorismate synthase, were also up-regulated, as well as indole-3-gl

297 -1 on H2B requires NMNAT-1, a nuclear NAD(+) synthase, which directs PARP-1 catalytic activity to Glu

298 ata6 controls the expression of prostacyclin synthase, which is required for prostacyclin production

299 m in question continuously supports H(+)-ATP synthase with ADP until glucose or creatine is available

300 ectin-3, and lipocalin-like prostaglandin D2 synthase with an MRA.