ライフサイエンスコーパス: synthetase

1 press markers, including Glast and glutamine synthetase.

2 laminoimidazolecarboxamide ribotide (SAICAR) synthetase.

3 ide synthetase-independent siderophore (NIS) synthetase.

4 omponents, establishing a minimal fuscanodin synthetase.

5 hway that is based on a nonribosomal peptide synthetase.

6 ed for the synthesis of ATP by an acetyl-CoA synthetase.

7 valine cytoplasmic-localized aminoacyl-tRNA synthetase.

8 specialized functions including beta-lactone synthetases.

9 coupled to MS, which identified alanine tRNA synthetase 1 (AARS1) as a direct substrate of METTL21C.

10 h early induction of the long-chain acyl-CoA synthetase 1 (ACSL1).

11 is synthetically lethal in argininosuccinate synthetase 1 (ASS1)-negative cancers, including mesothel

12 On the contrary, carbamoyl-phosphate synthetase 1 (CPS1), ALB, the proliferative marker ki67

13 Oligoadenylate synthetase 1 (OAS1) binds double-stranded RNA from invad

14 High expression of 2',5'-oligoadenylate synthetase 1 (OAS1), which adds AMP residues in 2',5' li

15 rthy that individuals with argininosuccinate synthetase 1 and argininosuccinate lyase deficiencies id

16 thine transcarbamylase and argininosuccinate synthetase 1 deficiencies, we did not find evidence that

17 e, cyclohydrolase and formyltetrahydrofolate synthetase 1).

18 bi-allelic variants in NADSYN1, encoding NAD synthetase 1, the final enzyme of the nicotinamide adeni

19 Acyl coenzyme A synthetase-1 (ACSL1) facilitates long-chain fatty acid (

20 ymes, the thioesterase domain of valinomycin synthetase(12), we elucidate the biosynthetic pathway by

21 irus resistance protein 2',5'-oligoadenylate synthetase 1B (OAS1B).

22 red by an allele of the 2'-5' oligoadenylate synthetase 1b gene that encodes the inactive full-length

23 d from acetate by chromatin-bound acetyl-CoA synthetase 2 (ACSS2)(2).

24 oA synthesis from acetate through acetyl-CoA synthetase 2 (ACSS2).

25 on of Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthetase 2), the gene encoding the rate-limiting enzym

26 through knockout of RNAseL and oligodenylate synthetase 3 (OAS3), but not OAS1.

27 fatty acid synthase, and long-chain acyl-CoA synthetase (3), and glucose transport genes (glucose tra

28 ught to determine whether any aminoacyl-tRNA synthetase (aaRS) utilizes BMAA as a substrate for amino

29 is the scalable discovery of aminoacyl-tRNA synthetase (aaRS)-tRNA pairs that are orthogonal in thei

30 to the cognate mitochondrial aminoacyl-tRNA synthetase (aaRS).

31 how that a second-generation amino-acyl tRNA synthetase (aaRS)/tRNA(CUA) pair for site-specific incor

32 code is maintained in part by aminoacyl-tRNA synthetases (aaRS) proofreading mechanisms that ensure c

33 lian cells, eight cytoplasmic aminoacyl-tRNA synthetases (AARS), and three non-synthetase proteins, r

34 g ribosomes, and are then re-charged by tRNA synthetases (aaRS).

35 Aminoacyl-tRNA synthetases (aaRSs) are ancient enzymes that play a fund

36 Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that catalyze

37 mong these, we identified the aminoacyl tRNA synthetases (aaRSs) as essential mediators of Myc growth

38 s with correct amino acids by aminoacyl-tRNA synthetases (aaRSs) dictates the fidelity of translation

39 Aminoacyl-tRNA synthetases (aaRSs) have long been viewed as mere housek

40 nvolved in this exclusion are aminoacyl-tRNA synthetases (aaRSs), elongation factor thermo-unstable (

41 Aminoacyl-tRNA synthetases (aaRSs), the enzymes responsible for couplin

42 y players in this process are aminoacyl-tRNA synthetases (aaRSs), which not only catalyse the attachm

43 nzyme known as the acyl-acyl carrier protein synthetase (AasS), which allows them to scavenge fatty a

44 nd provide direct evidence that the acyl-CoA synthetase ACS-7, which was previously implicated in the

45 ation in metabolism is the acetyl-coenzyme A synthetase (Acs) enzyme.

46 lized acetate-activating enzymes, ACETYL-COA SYNTHETASE (ACS) in plastids and ACETATE NON-UTILIZING1

47 s-13 encodes a homolog of the human acyl-CoA synthetase ACSL1, and localizes to the mitochondrial mem

48 eshaped the TMSiPhe-specific amino-acyl tRNA synthetase active site to selectively accommodate the tr

49 AICAR and an ATP analog occupying the SAICAR synthetase active site.

50 endent DNase and cyclic oligoadenylate (cOA) synthetase activities.

51 e (Acsl1(M) (-/-)) severely reduces acyl-CoA synthetase activity and fatty acid oxidation.

52 a single essential amino acid decreased PRPP synthetase activity with a half-life of ~ 8 h, and combi

53 activity but reduced mitochondrial acyl-CoA synthetase activity with C(12).

54 chromatography, bioinformatics analyses, NAD synthetase activity, and biolayer interferometry assays,

55 ellular phosphate, which down-regulated PRPP synthetase activity.

56 at BMAA is a substrate for human alanyl-tRNA synthetase (AlaRS) and can form BMAA-tRNA(Ala) by escapi

57 8, and genes encoding cell wall carbohydrate synthetases alpha-1-3-glucan (AGS1) and beta-1,3-glucan

58 Elimination of human folypolyglutamate synthetase alters programming and plasticity of somatic

59 r posttranslational regulation of acetyl-CoA synthetase and ADP-Glc pyrophosphorylase, and increased

60 cumulation due to trichome specific acyl-CoA synthetase and enoyl-CoA hydratase genes.

61 CD9-GFP labeled cells included glutamine synthetase and glial fibrillary acidic protein positive

62 Exaiptasia glutamine synthetase and glutamate synthase transcripts concomitan

63 This bifunctional enzyme couples the NAD(+) synthetase and glutaminase activities through an ammonia

64 nd double knockouts of genes relating to PEP synthetase and PTS components.

65 cted specific interactions between the HalM2 synthetase and the leader- and core-peptide subdomains o

66 the structural cycle of nonribosomal peptide synthetases and provide insights into the production of

67 strate specificity of natural aminoacyl-tRNA synthetases and ribosomes.

68 n apparatus, including tRNAs, aminoacyl-tRNA synthetases and translation factors.

69 se pairs must be orthogonal to both the host synthetases and tRNAs and to each other.

70 enes included purA, encoding adenylsuccinate synthetase, and the cps operon required for capsule prod

71 use model (PCmas(-/-) ) by targeting CMP-Sia synthetase, and used histologic and ultrastructural anal

72 rified E. coli RNA polymerase and lysyl-tRNA synthetase are both capable of adding such 5' caps.

73 Furthermore, mutations in tRNAs and synthetases are known to drive human maladies, such as t

74 lyketide synthases and non-ribosomal peptide synthetases are molecular assembly lines that consist of

75 Aminoacyl-tRNA synthetases are predominantly cytoplasmic, but are also

76 Aminoacyl-tRNA synthetases are ubiquitous and essential enzymes for pro

77 ported that abnormalities in aminoacyl t-RNA synthetase (ARS) genes are linked to various unique leuk

78 Aminoacyl-tRNA synthetases (ARS) are ubiquitously expressed, essential

79 Aminoacyl-tRNA synthetases (ARSs) are critical for protein translation.

80 Aminoacyl-tRNA synthetases (ARSs) are essential enzymes for protein syn

81 Aminoacyl-tRNA synthetases (ARSs) are essential enzymes responsible for

82 Aminoacyl-tRNA synthetases (ARSs) are ubiquitous, ancient enzymes that

83 Aminoacyl-tRNA synthetases (ARSs) are universal enzymes that catalyze t

84 Aminoacyl-tRNA synthetases (ARSs) catalyze the attachment of specific a

85 Aminoacyl-tRNA synthetases (ARSs) function to transfer amino acids to c

86 Aminoacyl tRNA synthetases (ARSs) link specific amino acids with their

87 ion is facilitated by cognate aminoacyl-tRNA synthetases (ARSs), which bind tRNAs and ligate them to

88 ediated killing, identifying Mtb's glutamine synthetase as a collateral, rather than directly antimyc

89 Atlas, and demonstrated that high asparagine synthetase (ASNS) expression correlated with poorer surv

90 and the expression of its target asparagine synthetase (ASNS), sensitizing melanoma and pancreatic t

91 id response induces expression of asparagine synthetase (ASNS), which provides for asparagine biosynt

92 can take up asparagine, silencing asparagine synthetase (ASNS, which converts glutamine-derived nitro

93 ntified as a 4-hydroxybenzoic acid-glutamate synthetase, AtGH3.12/PBS3 influences pathogen defense re

94 -tRNA synthetase), FARSB (phenylalanine-tRNA synthetase, beta-subunit), and NPC2 (Niemann-Pick diseas

95 ic peptides inspired by nonribosomal peptide synthetase BGCs associated with the human microbiota.

96 RNS derived from the inducible nitric oxide synthetase, but not mitochondrial ROS, were critical for

97 ers, the hyperosmotic induction of glutamine synthetase by intron 1 is position dependent.

98 In humans and mice, lanthionine synthetase C-like 2 (LANCL2) has been characterized as t

99 gut restricted, and targets the lanthionine synthetase C-like 2 immunometabolic pathway.

100 Cysteinyl-tRNA synthetase (CARS) encodes the enzyme that charges tRNA(C

101 Aminoacyl-tRNA synthetases catalyze the attachment of cognate amino aci

102 ormed via a pathway involving methionyl-tRNA synthetase-catalyzed metabolic conversion of Hcy to Hcy-

103 S. oneidensis MR-1 encodes two cytochrome c synthetases (CcmF and SirE) and two apocytochrome c chap

104 ne (PBS), had decreased expression of chitin synthetase, CHS1, CHS2, and CHS8, and genes encoding cel

105 ates identified, CMP N-acetylneuraminic acid synthetase (Cmas) and solute carrier family 35 member A1

106 etase proteins, reside in a large multi-tRNA synthetase complex (MSC).

107 (zinc finger protein 746) and aminoacyl tRNA synthetase complex interacting multifunctional protein 2

108 rgeting individual members of the multi-tRNA synthetase complex, we were able to detect all members o

109 ies, including a megadalton-scale tRNA multi-synthetase complex.

110 tide to oxazoles and thiazoles by the McbBCD synthetase complex.

111 carrier protein, and a non-ribosomal peptide synthetase condensation domain condenses it with (1S,3R,

112 The aminoacyl-tRNA synthetases constitute the largest protein family implic

113 sterase domains of such nonribosomal peptide synthetases control the oligomerization and cyclization

114 odons due to the inability of cysteinyl-tRNA synthetase (CysRS) to discriminate against Sec.

115 f hsp90 ATPase protein 1 (Aha1), alanyl-tRNA synthetase domain containing 1 (Aarsd1), cell division c

116 omains and SAICAR bound in one of the SAICAR synthetase domains.

117 tion of Escherichia coli prolyl-transfer RNA synthetase (Ec ProRS), a member of the aminoacyl-transfe

118 ion through evasion of one but not both tRNA synthetase editing systems.

119 The prokaryotic NAD synthetase enzyme NadE catalyzes the last step of NAD(+)

120 ible phosphorylation of glutamyl-prolyl tRNA synthetase (EPRS) by S6K1 in monocytes and adipocytes re

121 rA) is shown to encode a functional peramine synthetase, establishing a precedent for distribution of

122 subfunctionalize PpzA-1 into a dedicated DKP synthetase, exemplified by the truncated variant, PpzA-2

123 ession of human MAT2A, which encodes the SAM synthetase expressed in most cells.

124 NO synthetase expression and NO synthesis are linked to alt

125 recise enhancement of hyperosmotic glutamine synthetase expression.

126 hology through the long-chain fatty acyl-CoA synthetase Faa1, independently of the RNA methylation co

127 ty acid export in cells lacking the acyl-CoA synthetases Faa1 and Faa4.

128 oRS), a member of the aminoacyl-transfer RNA synthetase family, has been investigated using a combine

129 pha-subunit), MARS (methionyl aminoacyl-tRNA synthetase), FARSB (phenylalanine-tRNA synthetase, beta-

130 e, we show that loss of the VLCFA-coenzyme A synthetase Fat1, which is essential for VLCFA utilizatio

131 d that the first enzyme in the pathway, PRPP synthetase, forms evolutionarily conserved filaments tha

132 specific mutations in the folylpolyglutamate synthetase (FPGS) gene, whose product catalyzes the addi

133 Folypolyglutamate synthetase (FPGS) is known to play a crucial role in the

134 the crystal structures of hsNadE and NAD(+) synthetase from M. tuberculosis (tbNadE) with synthetase

135 iction, we purified a candidate beta-lactone synthetase from Nocardia brasiliensis and reconstituted

136 Francisella encodes a NIS synthetase FslA/FigA and an ornithine decarboxylase homo

137 te reductase (HAC1), gamma-glutamyl-cysteine synthetase (gamma-ECS), phytochelatin synthase (PCS1) an

138 caused by dominant mutations in glycyl-tRNA synthetase (GARS).

139 peptides inspired by 96 nonribosomal peptide synthetase gene clusters were synthesized and screened f

140 ft, along with expression of both acetyl-CoA synthetase genes ACS1 and ACS2 We conclude that CR maxim

141 olyketide synthase and non-ribosomal peptide synthetase genes from two newly decoded genomes of Symbi

142 m of human diseases due to mutations in tRNA synthetase genes.

143 one marrow stromal cell antigen 1, glutamine synthetase [GLNA], laminin subunit beta-2, lysophospholi

144 A single peptide from the glutamine synthetase (GlnA1) enzyme was identified in 61/74 (82%)

145 E. coli HipA inactivates the glutamyl-tRNA synthetase GltX, which inhibits translation and triggers

146 phase by phosphorylating the aminoacyl-tRNA synthetases GltX and TrpS.

147 The mRNA levels of glutamine synthetase (GLUL), beta-catenin (CTNNB) and its direct t

148 We identify glutamine synthetase (GS) as an enzyme whose activity is most resp

149 mate, and the counteracting enzyme glutamine synthetase (GS) cause disturbed glutamate homeostasis an

150 Glutamine synthetase (GS) plays an essential role in metabolism by

151 protein expression and activity of glutamine synthetase (GS) were unaffected, whereas the ammonia-tra

152 ion of pericentral vein-juxtaposed glutamine synthetase (GS)(-) hepatocytes into GS(+) hepatocytes an

153 ation of beta-catenin targets like glutamine synthetase (GS), leukocyte cell-derived chemotaxin 2, Re

154 edly observed that the bacterial glutathione synthetase (GshB) is glycosylated by NleB on arginine re

155 he well-characterized class II lanthipeptide synthetase HalM2 as a model system, we have employed HDX

156 It is known that certain aminoacyl t-RNA synthetase have multiple non-canonical roles in both tra

157 olving a plasmid-encoded CysS cysteinyl-tRNA synthetase, highlighting the power of large-scale compar

158 tity element for the histidyl aminoacyl tRNA synthetase (HisRS).

159 Human lysyl-tRNA synthetase (hLysRS) is essential for aminoacylation of t

160 module, flanked by four flexible acetyl-CoA synthetase homology (ASH) domains; CoA is bound at the C

161 Here we show that the Homo sapiens NAD(+) synthetase (hsNadE) lacks substrate specificity for glut

162 ionary-related IleRS, leucyl- and valyl-tRNA synthetases (I/L/VRSs), all efficiently hydrolyze Nva-tR

163 Arabidopsis is mediated by the aspartyl tRNA synthetase IBI1, which activates priming of multiple imm

164 Isoleucyl-tRNA synthetase (IleRS) is an aminoacyl-tRNA synthetase whose

165 that in the synthetic site of isoleucyl-tRNA synthetase (IleRS), Nva and Val are activated and transf

166 Glutamine synthetase immunoreactivity was sparse like in the area

167 rt that a gene encoding a bacterial (p)ppGpp synthetase in Bacillus subtilis, sasA, exhibits high lev

168 irmed this by expression of R. pickettii NIS synthetase in Escherichia coli, resulting in rhizoferrin

169 of glutamate decarboxylase-65 and glutamine synthetase in PFC; reduced fractional anisotropy in vari

170 ia coli and Staphylococcus aureus seryl-tRNA synthetases in complex with aminoacyl adenylate analogue

171 Our classifier predicted beta-lactone synthetases in uncharacterized biosynthetic gene cluster

172 ential localization of the enzyme, glutamine synthetase, in pericentral hepatocytes, where it convert

173 the translational machinery, primarily tRNA synthetases, in response to the SF3B1 K700E mutation.

174 ized proteins, including many aminoacyl-tRNA synthetases, in which a leaky AUG start codon is followe

175 and hybrid polyketide-non-ribosomal peptide synthetases, including those responsible for assembling

176 in and encodes a single nonribosomal peptide synthetase-independent siderophore (NIS) synthetase.

177 , has been found to be the active seryl-tRNA synthetase inhibitor component of albomycin delta(2) .

178 The glutamine synthetase inhibitor l-methionine sulfoximine abolished

179 ted the efficacy of prokaryote-specific tRNA synthetase inhibitors, indolmycin and AN3365, to mimic s

180 ynthetase from M. tuberculosis (tbNadE) with synthetase intermediate analogues.

181 An atomic-level view of the azole synthetase is a starting point for deeper understanding

182 NAD(+) synthetase is an essential enzyme of de novo and recycli

183 lly, we found that a deficiency in glutamine synthetase is an important pathogenic process for seizur

184 mbicus OmB cell line revealed that glutamine synthetase is transcriptionally regulated by hyperosmola

185 Loss of long-chain acyl-CoA synthetase isoform-1 (ACSL1) in mouse skeletal muscle (A

186 scovered genetic abnormalities in lysyl-tRNA synthetase (KARS).

187 as an inhibitor of host long-chain acyl CoA synthetases, key enzymes for glycerolipid biosynthesis,

188 The blockade of both glycogen synthetase kinase 3beta and cyclin-dependent kinase 5 is

189 The blockade of both glycogen synthetase kinase 3beta and cyclin-dependent kinase 5 pr

190 may be driven by the presence of lysyl-tRNA synthetase (KRS) in the medium.

191 nduced expression of a mutant methionyl-tRNA synthetase (L274G) enables the cell-type-specific labeli

192 yses, we identified two distinct leucyl-tRNA synthetase (LeuRS) genes within all genomes of the archa

193 Interferon-inducible human oligoadenylate synthetase-like (OASL) and its mouse ortholog, Oasl2, en

194 uch efforts, flexizymes (transfer RNA (tRNA) synthetase-like ribozymes that recognize synthetic leavi

195 olic cofactor lipoic acid by the lipoic acid synthetase, LipA, blunts macrophage activation.

196 ione peroxidase 4 overexpression or acyl-CoA synthetase long chain family member 4 depletion diminish

197 80074_23483377del, containing genes Acyl-CoA Synthetase Long Chain Family Member 5 (ACSL5) and Zinc F

198 Acyl-CoA synthetase long-chain family member 4 (ACSL4) is one of

199 d expression of 15-lipoxygenase and acyl-CoA synthetase long-chain family member 4 (enzyme that gener

200 decreased protein content of the leucyl tRNA synthetase (LRS) leucine sensor.

201 primer via an interaction between lysyl-tRNA synthetase (LysRS) and the HIV-1 Gag polyprotein.

202 Moreover, similarly disrupted lysyl-tRNA synthetase (LysRS) proteins showed reduced enzymatic act

203 n in the KARS gene, which encodes lysyl-tRNA synthetase (LysRS), a moonlight protein with a canonical

204 e implicating the multienzyme aminoacyl-tRNA synthetase (mARS) complex and its AIMp1 structural compo

205 and suggests that editing by aminoacyl-tRNA synthetases may be important for survival under starvati

206 020745.2) encoding mitochondrial alanyl-tRNA synthetase (mt-AlaRS) were first described in patients p

207 Mitochondrial aminoacyl-tRNA synthetases (mt-aaRSs) are essential components of the m

208 zymes SHMT and 5,10-methenyltetrahydrofolate synthetase (MTHFS).

209 vo functional verification of a tyrosyl-tRNA synthetase mutant for the genetic encoding of sulfotyros

210 and bi-allelic mutations in asparaginyl-tRNA synthetase (NARS1).

211 estricting the expression of the mutant tRNA synthetase, NLL-MetRS, to hippocampal neurons.

212 led significant upregulation of nitric oxide synthetase (NOS1 and NOS3) and neuroprotective genes wit

213 experimentally elusive non-ribosomal peptide synthetase (NRPS) and NRPS-polyketide synthase (PKS) hyb

214 typically catalyzed by nonribosomal peptide synthetase (NRPS) domains.

215 ipeptide from the MalG non-ribosomal peptide synthetase (NRPS) followed by reverse prenylation and a

216 is a rare example of a nonribosomal peptide synthetase (NRPS) from a higher eukaryote and contains a

217 s identified a putative nonribosomal peptide synthetase (NRPS) gene cluster (nan).

218 carboxyl terminus of a nonribosomal peptide synthetase (NRPS) or as stand-alone enzymes (TbetaH(Asp)

219 re only the two-module non-ribosomal peptide synthetase (NRPS) peramine synthetase (PerA), which is e

220 such thiotemplated yet nonribosomal peptide synthetase (NRPS)-independent biosynthetic gene clusters

221 ase (HRPKS, Fub1) and a nonribosomal peptide synthetase (NRPS)-like carboxylic acid reductase (Fub8)

222 veal two single-module non-ribosomal peptide synthetases (NRPs) that incorporate the beta-keto acid a

223 Single-module nonribosomal peptide synthetases (NRPSs) and NRPS-like enzymes activate and t

224 Nonribosomal peptide synthetases (NRPSs) and NRPS-like enzymes have diverse f

225 oding the production of nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs).

226 Non-ribosomal peptide synthetases (NRPSs) are modular enzymatic machines that

227 de synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) comprise giant multidomain enzymes r

228 Nonribosomal peptide synthetases (NRPSs) generate the core peptide scaffolds

229 precursors derived from nonribosomal peptide synthetases (NRPSs) into 2,5-diketopiperazines (DKPs) is

230 popeptides assembled by nonribosomal peptide synthetases (NRPSs) that are known to display various mo

231 Nonribosomal peptide synthetases (NRPSs) underlie the biosynthesis of many na

232 e assembly lines called nonribosomal peptide synthetases (NRPSs).

233 erferon (IFN)-inducible 2'-5'-oligoadenylate synthetase (OAS) and RNase L pathway effectively suppres

234 ment occurs through the 2',5'-oligoadenylate synthetase (OAS)-RNase L pathway.

235 2'-5'-Oligoadenylate synthetases (OAS) are innate immune sensors of cytosolic

236 Oligoadenylate synthetases (OASs) are a family of interferon-inducible

237 rt the structure of the nonribosomal peptide synthetase ObiF1, highlighting the structure of the beta

238 EX to characterize a matrix of 64 orthogonal synthetase-orthogonal tRNA specificities.

239 activity of Delta(1)-pyrroline-5-carboxylate synthetase (P5CS) and decreasing proline dehydrogenase (

240 osphoribosylaminoimidazolesuccinocarboxamide synthetase (PAICS) catalyzes two essential steps in the

241 ribosomal peptide synthetase (NRPS) peramine synthetase (PerA), which is encoded by the 8.3 kb gene p

242 s shown that cladosporin inhibits lysyl-tRNA synthetase (PfKRS1).

243 ty control (QC) function of phenyalanyl-tRNA synthetase (PheRS) is required for resistantce to m-Tyr.

244 e proofreading activity of phenylalanyl-tRNA synthetase (PheRS).

245 Nonribosomal peptide synthetases produce diverse natural products using a mul

246 on in the synthetic active site, prolyl-tRNA synthetase (ProRS) misactivates and mischarges Ala and C

247 Aminoacyl t-RNA synthetase proteins are fundamentally known as the first

248 oacyl-tRNA synthetases (AARS), and three non-synthetase proteins, reside in a large multi-tRNA synthe

249 ically modifies phosphoribosyl pyrophosphate synthetase (Prs), an essential enzyme in nucleotide bios

250 using modified ribosomes and pyrrolysyl-tRNA synthetase (PylRS).

251 Pyrrolysyl-tRNA synthetase (PylRS)/(Pyl)tRNA pairs are the most widely u

252 Bacterial aminoacyl-tRNA synthetases represent attractive and validated targets f

253 how that hyperosmotic induction of glutamine synthetase represents a prominent part of this switch.

254 pressed cytoplasmic Class IIa family of tRNA synthetases required for protein translation.

255 hip between ZIKV and the host oligoadenylate synthetase-RNase L (OAS-RNase L) system, a potent antivi

256 ivation of the carboxylate anion by acyl-CoA synthetase(s), and re-esterification to the sn-2 positio

257 sphoribosylaminoimidazole succinocarboxamide synthetase (SAICARS, EC 6.3.2.6) (PAICS).

258 etabolic pathways controlled by SIN3 and SAM synthetase (SAM-S) in Drosophila melanogaster Using seve

259 le methionine catabolic genes, including SAM synthetase (Sam-S), as well as SAM levels.

260 Single-domain small alarmone synthetases (SASs) are RSH family members that contain t

261 During vascular development, seryl-tRNA synthetase (SerRS) regulates angiogenesis through a nove

262 BMAA is not a substrate for human seryl-tRNA synthetase (SerRS).

263 Inhibition of EPRS using a PRS (prolyl-tRNA synthetase)-specific inhibitor, halofuginone, significan

264 d decomposition in leaf by affecting sucrose synthetase (SS) and sucrose phosphate synthase (SPS) act

265 munication between two non-ribosomal peptide synthetase subunits responsible for chain release from t

266 rosin peptide substrates and the lanthionine synthetase suggests that structure diversification, rath

267 confirmed in vitro using the recombinant NIS synthetase, synthesizing rhizoferrin from putrescine and

268 of TARS2, but not cytoplasmic threonyl-tRNA synthetase TARS, for this effect demonstrates an additio

269 of an NPS-TTD-associated gene, threonyl-tRNA synthetase (TARS), found by next-generation sequencing o

270 (Thr) levels via mitochondrial threonyl-tRNA synthetase TARS2.

271 not LeuRS-I, functions as an essential tRNA synthetase that accurately charges leucine to tRNA(Leu)

272 onsible for CTA production and the thioamide synthetase that catalyzes sulfur incorporation were rece

273 d transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeability barr

274 re we present newly developed aminoacyl-tRNA synthetases that enable genetic encoding of SF(5)Phe for

275 show that in addition to ATD, threonyl-tRNA synthetase (ThrRS) can clear the error in cellular scena

276 cientific community requested aminoacyl-tRNA synthetases to be targeted in the Seattle Structural Gen

277 s use Gretchen Hagen 3 (GH3) acyl acid amido synthetases to conjugate an amino acid to a plant hormon

278 which intron 1 positively mediates glutamine synthetase transcription.

279 SPR-Cas systems, transfer RNAs (tRNAs), tRNA synthetases, tRNA-modification enzymes, translation-init

280 cated Na(v)1.5 channels using mammalian cell synthetase-tRNA technology.

281 displayed on phage using the pyrrolysyl-tRNA synthetase/tRNA pair.

282 utually orthogonal engineered aminoacyl-tRNA synthetase/tRNA pairs that suppress different nonsense/f

283 f multiple orthogonal aminoacyl-transfer RNA synthetase/tRNA pairs.

284 approach, we discover a phosphothreonyl-tRNA synthetase-tRNACUA pair and create an entirely biosynthe

285 d Saccharomyces cerevisiae tryptophanyl tRNA-synthetase (Trp-RS):suppressor tRNA pair to insert the n

286 e most common BGCs are non-ribosomal peptide synthetases, type 1 polyketide synthases, terpenes, and

287 three CMT-causing mutations in tyrosyl-tRNA synthetase (TyrRS or YARS).

288 show that a nuclear function of tyrosyl-tRNA synthetase (TyrRS) is implicated in a Drosophila model o

289 monstrated that RSV facilitates tyrosyl-tRNA synthetase (TyrRS)-dependent activation of PARP1.

290 ng methods, we disrupt uridine monophosphate synthetase (UMPS) in the pyrimidine de novo synthesis pa

291 (quinone) (DHODH) and uridine monophosphate synthetase (UMPS), as well as lactate dehydrogenase A (L

292 biosynthesis; namely, uridine monophosphate synthetase (UMPS).

293 ly reported biallelic variants in valyl-tRNA synthetase (VARS) in ten patients with a developmental e

294 ulatory sequence of O. mossambicus glutamine synthetase was investigated.

295 although metK (encoding S-adenosylmethionine synthetase) was essential in vitro, it was dispensable i

296 [TDO], arginase [ARG] 1, ARG2, inducible NO synthetase) were evaluated in PBMCs.

297 tRNA synthetase (IleRS) is an aminoacyl-tRNA synthetase whose essential function is to aminoacylate t

298 teria involves the acetylation of acetyl-CoA synthetase, whose activity must be tightly regulated to

299 hat selectively inhibit bacterial seryl-tRNA synthetases with greater than 2 orders of magnitude comp

300 ozygous for a novel mutation in tyrosyl-tRNA synthetase (YARS, c.499C > A, p.Pro167Thr) identified by