ライフサイエンスコーパス: synthetic peptide

1 an be applied to the characterization of any synthetic peptide.

2 ompeting activity of M to its finger using a synthetic peptide.

3 thout affecting the hydrolysis of gelatin or synthetic peptide.

4 probed by permethylating a library of short synthetic peptides.

5 an 2000 ribosomal, 80 non-ribosomal and 5700 synthetic peptides.

6 acy being peptide-dependent for QconCATs and synthetic peptides.

7 sing statistical methods and a mixture of 14 synthetic peptides.

8 igh-throughput ELISA and ELISPOT analyses of synthetic peptides.

9 d short chain peptides were determined using synthetic peptides.

10 rmed by comparison to spectra generated from synthetic peptides.

11 y that greatly accelerates the production of synthetic peptides.

12 peptide can be identified by comparison with synthetic peptides.

13 tion is peptide cyclization, was tested with synthetic peptides.

14 pecificities could be studied in detail with synthetic peptides.

15 on mutants or in treatments with GLV-derived synthetic peptides.

16 d beta-Lg 40-60, was studied in detail using synthetic peptides.

17 rarchies persist even after vaccination with synthetic peptides.

18 re designed and generated as recombinant and synthetic peptides.

19 ood mononuclear cells (PBMCs) with novel Kgp synthetic peptides.

20 ng small-molecule modulators, pepducins, and synthetic peptides.

21 intermixing different NRPS modules to create synthetic peptides.

22 high throughput serological assays based on synthetic peptides.

23 ate, and propagate helical content in short, synthetic peptides.

24 oteins and a variety of complexes with short synthetic peptides.

25 ionship (QSAR) and confirmatory studies with synthetic peptides.

26 We found that a short synthetic peptide able to inhibit FOXP3/NFAT interaction

27 This study describes the use of a xeno-free synthetic peptide acrylate surface, the Corning(R) Synth

28 y animals have provided encouraging results: synthetic peptides administered to atherosclerotic mice

29 ited tethered peptide agonist-stimulated and synthetic peptide agonist-stimulated GPR56 but did not i

30 rgens, recombinant allergen derivatives, and synthetic peptides allow us to target selectively differ

31 Using recombinant domains and synthetic peptides, along with surface plasmon resonance

32 The synthetic peptide also inhibited TCR-mediated activation

33 gh biochemical assays with seed extracts and synthetic peptides, an enzyme named oligopeptidase 1 (OL

34 oating with and without peptide 15 (P-15), a synthetic peptide analog of the cell-binding domain of c

35 ere highly reactive with both the autologous synthetic peptide and the full-length Luk toxin homologu

36 etection of approximately 10ngmL(-1) for the synthetic peptides and 0.01microgmL(-1) for the humam se

37 Based on the results of synthetic peptides and a model protein, we have further

38 to be employed to many other complexes where synthetic peptides and a suitably isotope-labeled medium

39 Using synthetic peptides and mouse immunization as a model, we

40 Using synthetic peptides and native gel electrophoresis, we co

41 d chromatographic retention time between the synthetic peptides and naturally occurring peptides.

42 cacious antagonists, the field has relied on synthetic peptides and pepducins to describe protease-ac

43 American patients with peanut allergy toward synthetic peptides and recombinant allergens was assesse

44 r the external binding of various His-tagged synthetic peptides and recombinant or chemically H6-modi

45 is potentially relevant for manufacturing of synthetic peptides and recombinant proteins.

46 enes; and (4) information about a library of synthetic peptides and root and nodule phenotyping data

47 Studies using synthetic peptides and shp gene mutants indicate that th

48 ployed as readout for receptor activation by synthetic peptides and that a new, highly sensitive, non

49 E-knockout (KO) mice, validation with select synthetic peptides, and a quantitative in vivo study of

50 ncoded by U14, U90, and U95 were mapped with synthetic peptides, and HLA restriction was defined for

51 dentified four immunodominant epitopes using synthetic peptides, and mapped them on a homology-based

52 entation is particularly effective with long synthetic peptides, and we previously reported that the

53 his interplay by ANT inhibitors, ANT-derived synthetic peptides, and/or function-blocking MMP14 and A

54 Synthetic peptide applications were shown to alter root

55 detected and quantified 216 isotope-labeled synthetic peptides (AQUA peptides) spiked in HeLa human

56 Synthetic peptides are an established mode of cancer vac

57 ikewise, large-scale libraries of quantified synthetic peptides are becoming available, enabling abso

58 applications, we devised a strategy in which synthetic peptides are built by assembling 7-residue nat

59 complexes generated by incubating cells with synthetic peptides are extensively intermingled on the c

60 ubunits (GalphaCT and GgammaCT), prepared as synthetic peptides, are likely to bind sequentially and

61 Using gene expression and synthetic peptide arrays on membrane support and overlay

62 ence independence was determined by blotting synthetic peptide arrays, and they have been tested for

63 nt certain limitations of traditionally used synthetic peptides as internal standards.

64 d quarter fragment of type III collagen, and synthetic peptides as substrates.

65 ive peptides including specifically designed synthetic peptides as well as biological peptides bearin

66 xamined the activity of purified CCP5 toward synthetic peptides as well as soluble alpha- and beta-tu

67 opy, we have investigated the structure of a synthetic peptide assembled into a highly packed monolay

68 This includes (a) short synthetic peptides, (b) short peptides within a defined

69 ated by its interaction with a 22-amino acid synthetic peptide based on a short sequence in the extra

70 effect was specific, since rclaudin-1 and a synthetic peptide based on the claudin-1 ECL-2 offered n

71 Peginesatide, a synthetic peptide-based erythropoiesis-stimulating agent

72 'click' covalent assembly to produce hybrid synthetic peptide-based polymers.

73 Two IgE-binding synthetic peptides: beta-CN (57-68) and beta-CN (82-93),

74 An in vitro antibacterial study of synthetic peptide BF2 against the clinical isolates of v

75 trices of either laminin, recombinant L1, or synthetic peptides binding specifically to Itgb1 s or AP

76 ulfurreducens bacterium led to the design of synthetic peptide building blocks, which self-assemble i

77 tro by assaying the deglutathionylation of a synthetic peptide by tryptophan fluorescence quenching a

78 electrochemical platform was modified with a synthetic peptide by using glutaraldehyde as cross-linki

79 is of 62 B. burgdorferi surface proteins and synthetic peptides by assessing binding of IgG and IgM t

80 onjugate the leader peptides to a variety of synthetic peptides by copper-catalyzed azide-alkyne cycl

81 ions have been the methods of choice to fold synthetic peptides by means of macrocyclization.

82 We have engineered a synthetic peptide called clavanin-MO, derived from a mar

83 Such small synthetic peptides capable of binding phosphate could be

84 e was used to couple T4 lysozyme (T4L) and a synthetic peptide catalyst responsible for the selective

85 study was to investigate the functions of a synthetic peptide, cementum protein 1-peptide1 (CEMP-1-p

86 tion based on recombinant DNA technology and synthetic peptide chemistry.

87 A synthetic peptide composing PAR1 residues 47-66, TR47, s

88 rounds of biopanning against a biotinylated synthetic peptide comprising repetitive immunogenic glut

89 Moreover, a synthetic peptide comprising the last 30 amino acids of

90 um comS mutants of strain UA159 respond to a synthetic peptide comprising the seven C-terminal residu

91 Synthetic peptides comprising these stalks potently acti

92 o traditionally used recombinant proteins or synthetic peptides, concatenated peptides (QconCATs) wer

93 ibitor and an anti-root invasion, non-lethal synthetic peptide confers resistance to plantain against

94 A series of synthetic peptide constructs containing cross-linked tTG

95 A synthetic peptide containing the conserved motif can par

96 recision of the method were evaluated with a synthetic peptide containing the cross-link.

97 Here, we show that short synthetic peptides containing the HPV16 L2 retromer-bind

98 To achieve this goal, synthetic peptides containing two disulfides were studie

99 Two synthetic peptides, containing either normal or deuterat

100 The current study evaluated whether a synthetic peptide corresponding to the claudin-4 ECL-2 s

101 CaMKIID was able to phosphorylate a synthetic peptide corresponding to the cytoplasmic domai

102 Consistent with this, a synthetic peptide corresponding to the HAP2 fusion loop

103 A synthetic peptide corresponding to the helix, but not to

104 epcidin-25 IgG, and a biomimetic-based, on a synthetic peptide corresponding to the hepcidin-binding

105 We observe that a synthetic peptide corresponding to the N-terminal 20 ami

106 A synthetic peptide corresponding to this decorin region d

107 We found that a synthetic peptide corresponding to this region inhibits

108 We raised antisera against synthetic peptides corresponding to an extracellular dom

109 Furthermore, treatment with synthetic peptides corresponding to FasL(117-126) signif

110 investigate the interactions between CaM and synthetic peptides corresponding to the A and B domains

111 In this study, we show that synthetic peptides corresponding to the binding interfac

112 cH2GTP from GTP (GTP 3',8-cyclase), and that synthetic peptides corresponding to the C-terminal regio

113 rtens and removes side chain glutamates from synthetic peptides corresponding to the C-terminal regio

114 tle; all four genes are transcribed, and the synthetic peptides corresponding to the core regions are

115 Synthetic peptides corresponding to the released peptide

116 teraction of its ETS domain with a series of synthetic peptides corresponding to the SRR.

117 t protein-lipid interactions simply by using synthetic peptides, corresponding to the membrane-spanni

118 transferases (GalNAc-Ts) could glycosylate a synthetic peptide covering the IRTT sequence.

119 and age-matched controls against 141 20-mer synthetic peptides covering the entire sequence of major

120 nt of the immunosensor was conducted using a synthetic peptide, derivative from the H6PGA4 R. rickett

121 nsportan 10; the second was based on DL1a, a synthetic peptide derived from staphylococcal delta-lysi

122 HCV attachment could also be inhibited by a synthetic peptide derived from the apoE receptor-binding

123 Vaccination with J8, a conserved region synthetic peptide derived from the M-protein of GAS and

124 The synthetic peptide derived from the NSE was synthesized a

125 Here we report that a synthetic peptide derived from the stem region of ZIKV e

126 A synthetic peptide derived from this region of E-cadherin

127 In this study, we designed synthetic peptides derived from indolicidin, a naturally

128 Synthetic peptides derived from the erythrocyte-binding

129 seasonal inactivated vaccines, Flumist, and synthetic peptides derived from the H3 stalk domain.

130 e also activated by exogenous application of synthetic peptides derived from the tethered-ligand sequ

131 Synthetic peptides derived from transmembrane (TM) domai

132 Finally, the intracellular inclusion of synthetic peptide designed to block GluA1 subunit of AMP

133 We additionally performed synthetic peptide digestions with recombinant ERAP1 vari

134 Using synthetic peptide dilution series, we show that the sens

135 (CDRs) from monoclonal antibodies tested as synthetic peptides display anti-infective and antitumor

136 Synthetic peptides duplicating these segments inhibited

137 the first genetically encoded alternative to synthetic peptide encapsulation schemes for sustained de

138 stimulation of HLA-A2(+) CD8(+) T cells with synthetic peptide encompassing the H3.3K27M mutation, co

139 novel approach for expansion of hiPSCs using synthetic peptide engineered surface as a substrate to a

140 Synthetic peptide epitopes with high affinities for nAbs

141 In addition, Hamp2 synthetic peptides exhibited a clear antimicrobial activ

142 ed molecular patterns (MAMPs), including the synthetic peptides Flg22 and Elf26 corresponding to bact

143 racterization revealed that both natural and synthetic peptides fold into a canonical CSalphabeta mot

144 s a novel mechanism for the self-assembly of synthetic peptide foldamers and gives new insights into

145 nt analogs using native chemical ligation of synthetic peptides, followed by bioorthogonal fluorescen

146 of the enzyme-instructed self-assembly of a synthetic peptide for trafficking endogenous proteins, t

147 We utilized synthetic peptides for EA, EB, and a scrambled control t

148 ensional multiplexing workflow that utilizes synthetic peptides for each protein to prompt the simult

149 The fibrils are built by modifying the synthetic peptide fragment corresponding to residues 105

150 P27A is an unstructured 104mer synthetic peptide from Plasmodium falciparum trophozoite

151 half-life of peptide-MHC-II complexes using synthetic peptides from regions of the Factor VIII prote

152 ls of fibrin(ogen) fragment D complexed with synthetic peptides GPRP (knob 'A' mimetic) and GHRP (kno

153 ntegrity, and this functionality was lost in synthetic peptides harboring amino acid substitutions W8

154 erse transmembrane barrels formed from short synthetic peptides has not been demonstrated previously.

155 Low molecular weight synthetic peptides have been demonstrated to be effectiv

156 homotrimers of gp41, from which a number of synthetic peptides have been derived as antagonists of v

157 Synthetic peptides have been developed for therapeutic a

158 We have designed 2 synthetic peptides, HEAT_R1 and LRV_M3Delta1, based on t

159 These synthetic peptide hormones share the overall structure o

160 and oncogenicity of HAdVs, the structures of synthetic peptides identical or very similar to the aden

161 Five casein-derived synthetic peptides (Ile-Pro-Ile-Gln-Tyr, Leu-Pro-Leu-Pro

162 Cat-PAD, the first in a new class of synthetic peptide immuno-regulatory epitopes (SPIREs), w

163 Synthetic peptide immunoregulatory epitopes are a new cl

164 differences in the molecular behavior of the synthetic peptide in the presence and absence of TFA at

165 als whose T cells do not recognize the short synthetic peptide in the vaccine will be able to generat

166 Using QconCAT and synthetic peptides in parallel gives a refined focus on

167 PLB species, we co-reconstituted each of the synthetic peptides in phospholipid membranes with SERCA

168 effect has not been extensively explored in synthetic peptides in the context of supramolecular self

169 sly demonstrated that cNK-lysin and cNK-2, a synthetic peptide incorporating the core alpha-helical r

170 hosphorylation analyses of Nem1-Spo7 and its synthetic peptides indicate that both subunits of the co

171 Domain mapping using synthetic peptides indicated that the IQ motif of Ng is

172 Disruption of the Rbm38-eIF4E complex via synthetic peptides induces wild-type p53 expression, sup

173 Overall, we conclude that our synthetic peptides inhibit VEEV replication and the infl

174 Two candidate synthetic peptides inhibited VEEV replication by approxi

175 Self-assembly of designed synthetic peptides is a versatile strategy to generate f

176 The synthetic peptides Kgp12, 17, and 18 were selected based

177 (KLK7) have previously been delineated using synthetic peptide libraries of fixed length, or single p

178 cleavage sites compared to state-of-the-art synthetic peptide libraries or proteomics.

179 nzymatic technology was demonstrated for two synthetic peptide libraries that were used to screen and

180 optimized through screening and analysis of synthetic peptide libraries, ligand 1 has 7500-fold impr

181 ubstrate compatibility; incorporation into a synthetic peptide library resulted in the identification

182 Here, we extended the ProteomeTools synthetic peptide library to 550,000 tryptic peptides an

183 we performed an external correction using a synthetic peptide library with known peptide relative ab

184 of the human memory T cell response using a synthetic peptide library.

185 he predictions were confirmed with an ad-hoc synthetic peptide library.

186 etry-based antimicrobial assay revealed that synthetic peptides LL-37, hBD-3, and hBD-1 had activity

187 dation or pharmacological inhibition using a synthetic peptide (LR12) dampens myocardial inflammation

188 evaluates in vitro antimicrobial activity of synthetic peptide LyeTxI and association compound LyeTxI

189 The results indicate that the synthetic peptide m1E41920 was able to inhibit the bindi

190 Similarly, a synthetic peptide mimicking the C-terminus of the fibrin

191 sordered in the reported E2 structure, but a synthetic peptide mimicking this site forms a beta-hairp

192 We designed multiple synthetic peptides mimicking the predicted cleavage site

193 utagenesis and interference experiments with synthetic peptides mimicking transmembrane helices (TMH)

194 rization on quaternary assembly, we utilized synthetic peptide mimics, enzyme assays, molecular dynam

195 ides was characterized by infusion of a five synthetic peptide mix with zero to four phophorylation s

196 has been developed that uses the immobilized synthetic peptide, NFO4; which possesses a high binding

197 This was confirmed in experiments with a synthetic peptide of 24 aa, derived from the central par

198 A synthetic peptide of NS1 residues 305-311 could inhibit

199 atch clamp electrophysiology, we show that a synthetic peptide of the NSP4 VPD has ion channel activi

200 specific interaction was demonstrated with a synthetic peptide of the XIP, which inhibits YfkE transp

201 Synthetic peptides of each variant were tested individua

202 Importantly, synthetic peptides of FnIII(1) , FnIII(5) or FnIII(15) b

203 To test this, we used synthetic peptides of these regions of beta- and gamma-E

204 The oriented assembly of the synthetic peptides on electrode surfaces through an engi

205 he immobilization and orientation of NOF4, a synthetic peptide, onto 3-D porous chitosan supports usi

206 K8 Q70 cross-linking, in the context of synthetic peptides or intact proteins transfected into c

207 DOG), have been identified, in addition to a synthetic peptide, P19, that contains seven amino acids

208 Synthetic peptides P2 and P4 of PvTRAg38 interfered with

209 A synthetic peptide, P454, corresponding to this sequence

210 tions of MST2 SARAH domains with a series of synthetic peptides particularly designed to bind to it,

211 Here, we report that a 40-amino acid, synthetic peptide, pPorA corresponding to porin PorACj,

212 Similarly, the synthetic peptides presented here proceed from monomer t

213 inding, and quantitative binding assays with synthetic peptides presenting the HCMV- and EBV-specific

214 other functional groups to the N-termini of synthetic peptides prior to cleavage and deprotection.

215 recombinant IL-2 protein, IL-2 DNA, or IL-2 synthetic peptides prior to infection with wild-type (wt

216 ee conventional internal standard platforms (synthetic peptides, QconCAT constructs, and recombinant

217 sms of internalization have focused on small synthetic peptides rather than full-length globular home

218 nt of the BCR with an epitope-bearing 17-mer synthetic peptide readily activated OB1 B cells.

219 Novel synthetic peptides represent smart molecules for antigen

220 variable (scFv, designated 2B4) to a linear synthetic peptide representing Herceptin's heavy chain C

221 Importantly, a membrane-penetrating synthetic peptide representing the distal 20 ASIC1a NT r

222 GBV-C E2 protein and a synthetic peptide representing the inhibitory amino acid

223 Purified active CtsH sequentially cleaved a synthetic peptide representing the N terminus of the tal

224 Synthetic peptides representing the allelic forms of the

225 of recombinant Scribble PDZ domains and the synthetic peptides representing the C termini of these p

226 Synthetic peptides representing the last 10 amino acids

227 Antibodies to synthetic peptides representing the transcription factor

228 In this context, preliminary results using synthetic peptides reveal significant inhibition of subs

229 n on the T cells, and ex vivo analyses using synthetic peptides revealed a concurrent hierarchical lo

230 Experiments with deletion mutants and synthetic peptides revealed that amino acids 85-92 in l-

231 Analyses with recombinant proteins and synthetic peptides revealed that the N-terminal part of

232 es and root and nodule phenotyping data from synthetic peptide screens in planta.

233 ergent chemical ligation of four unprotected synthetic peptide segments.

234 Also in transfected cells, a synthetic peptide selectively disrupted MOR-Gal1R hetero

235 an oil-based medium, also includes a unique synthetic peptide sequence that acts as a traceable "cod

236 Inhibition experiments with synthetic peptides showed that HLA-E shares epitopes wit

237 The synthetic peptide side chain displays 10 melamine rings,

238 A synthetic peptide spanning this sequence forms amyloid-l

239 Overlapping synthetic peptides spanning B3B4 were then tested in fun

240 Submolecular mapping analysis by using synthetic peptides spanning BoNT serotype A (BoNT/A) and

241 Binding assays using synthetic peptides spanning L4 showed that PEDF selectiv

242 Overlapping synthetic peptides spanning the B1B2 region identified t

243 fied protein was calculated using a set of 7 synthetic peptides spiked into the samples.

244 .TAP1KO-HLA-C*06:02 cells, we identified the synthetic peptide SRGPVHHLL presented by HLA-C*06:02 tha

245 quantitative performance of both QconCAT and synthetic peptide standards.

246 of MuV, 41 of which were confirmed based on synthetic peptide standards.

247 sing the cell-permeable, hydrocarbon-stapled synthetic peptide stapled alpha-helical peptide derived

248 ng hiPSCs on a chemically defined, xeno-free synthetic peptide substrate, i.e. Corning Synthemax((R))

249 , the detection system has been validated on synthetic peptide substrates of Chk2, a key protein kina

250 g purified enzyme and fluorescently labeled, synthetic peptide substrates.

251 ance cleavage of the P25K protein but not of synthetic peptides, suggesting that nucleic acids augmen

252 Such proteoforms (using synthetic peptide surrogates) act like alveolar surfacta

253 A new pregnancy derived synthetic peptide, synthetic PreImplantation Factor (sPI

254 Here, we describe a synthetic-peptide system that switches between parallel

255 g mass spectrometry, recombinant protein and synthetic peptide systems, in silico modeling, and cell

256 Allergen immunotherapy using synthetic peptide T-cell epitopes (Cat-PAD) from the maj

257 y has successfully identified a set of novel synthetic peptides targeting the BBI, and has demonstrat

258 The novel Kgp synthetic peptides tested herein are immunogenic peptide

259 wavelengths of light, attached to a helical synthetic peptide that both promotes membrane insertion

260 H) insensitive CtBP, and are replicated by a synthetic peptide that inhibits CtBP dimerization.

261 A synthetic peptide that mimics the main FN-binding sequen

262 Synthetic peptides that are selectively hydrolyzed by a

263 Furthermore, using synthetic peptides that comprise sequences in either NLG

264 Synthetic peptides that contain backbone modifications b

265 Sets of synthetic peptides that interact with the insulin recept

266 ensitized Balb/c mice upon stimulation by 18 synthetic peptides that span the full-length Met e 1.

267 Using 5 synthetic peptides that spanned the amino-terminal porti

268 residues 864 to 881 in membrane fusion, only synthetic peptides that were based on the native E2 func

269 ty and structural variability of natural and synthetic peptides, the two directions have so far not b

270 g recombinant fragments from the HMW Bx7 and synthetic peptides thereof for testing of allergic patie

271 d by native chemical ligation of the central synthetic peptide to flanking recombinant polypeptides.

272 dministration and chronic infusion of an RGD synthetic peptide to obese C57BL/6 mice improved glucose

273 epitope of which can be mimicked using short synthetic peptides to allow antigen-specific engagement

274 ross-presentation and direct presentation of synthetic peptides to CD8(+) T cells.

275 n of the MS/MS settings was performed with a synthetic peptide (TP1) cross-linked with bis[sulfosucci

276 A synthetic peptide vaccine (J8-DT) from the conserved reg

277 that are well suited for the development of synthetic peptide vaccines.

278 ivery of the N-terminal domain of VDAC1 as a synthetic peptide (VDAC1-NP) abolishes the ability of BH

279 tudy compares transferrin levels obtained by synthetic peptides versus QconCAT peptides as internal s

280 Using synthetic peptides, VesB efficiently cleaved a trypsin s

281 To screen for TcdB-derived CPPs, a panel of synthetic peptides was tested for the ability to enhance

282 Using synthetic peptides, we evaluate them by targeted proteom

283 tering length and valency of epitope-bearing synthetic peptides, we examined the properties of ligand

284 epitopes via a screen of algorithm-selected synthetic peptides, we observed that immunization of mic

285 The synthetic peptides were immobilized on the gold surface

286 r peptides, IgE ELISA inhibition assays with synthetic peptides were performed.

287 -like structural architecture assumed by the synthetic peptide which makes use of unusually remote in

288 Synthetic peptides which were designed on the basis of p

289 quencing and, where required, confirmed with synthetic peptides, which were also used to determine th

290 we documented that either adiponectin or the synthetic peptide with adiponectin properties, ADP355, s

291 Synthetic peptides with a MeCAT label which are external

292 the MAPK level were counteracted by specific synthetic peptides with amino acid sequences correspondi

293 Moreover, using synthetic peptides with selective substitutions and trun

294 rophil elastase and proteinase-3, as well as synthetic peptides with sequences derived from these nov

295 Synthetic peptides with structural modifications at diff

296 ods, and the results validated with a set of synthetic peptides with the sequence of the tryptic frag

297 Synthetic peptides with the sequence of transmembrane he

298 In this work, synthetic peptides with various sequence motifs were use

299 nvestigated for antibody response along with synthetic peptides within those regions, using in vivo p

300 permanent tags to polyhistidine segments, a synthetic peptide YPDFEDYWMKHHHHHH was used as a model.