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1 c handedness as three-crossing "entanglement synthons".
2 eld (8 steps from Evans' chiral dipropionate synthon).
3 agents or toxic gases, such as CO, as the C1 synthon.
4 talysts for amine methylation using CO2 as a synthon.
5 ely completes the coordination sphere of the synthon.
6 (1)-N:eta(1)-O)-NO2 motif, derived from this synthon.
7 from 2-alkynylbenzaldehydes (1) as a common synthon.
8 The quinone can function as a (CF)(4) synthon.
9 synthon, or the alpha-keto ester homoenolate synthon.
10 eactions to the latent C(7)-C(11) dialdehyde synthon.
11 he cubane core as a masked cyclooctatetraene synthon.
12 ilylmethyl)benzotriazole (1) as a one-carbon synthon.
13 ed by unequivocal synthesis from a diltiazem synthon.
14 ivo instability of [(89)Zr]Zr-Hy(3)ADA(5)-SA synthon.
15 dinating active species as a reactive "I(+)" synthon.
16 action of nitrite with an [LCu(II)Cu(I)](3+) synthon.
17 n between styrene and a versatile benzodiyne synthon.
18 currently underutilize this versatile carbon synthon.
19 ient use of dimethyl malonate as a methylene synthon.
20 d by a short synthesis of a (+)-peloruside A synthon.
21 diverse set of oxygen-functionalized chiral synthons.
22 products are easily transformed into useful synthons.
23 ta,gamma-unsaturated alpha-keto esters as C4 synthons.
24 on of the products into valuable and complex synthons.
25 ation states, can be regarded as interesting synthons.
26 ly converted into a variety of useful olefin synthons.
27 yloxy ketones produced are polyvalent chiral synthons.
28 )-5 are densely functionalized and versatile synthons.
29 derivatized peptides that serve as valuable synthons.
30 lipid degradation into the parent metabolic synthons.
31 acid, starting from easily accessible chiral synthons.
32 nd simple imidazoles or benzimidazoles as C2 synthons.
33 -1-yl)methyl]amines 3 as 1,3-biselectrophile synthons.
34 he preparation of C-13 paclitaxel side chain synthons.
35 form the privileged trifluoromethylthiolated synthons.
36 s, which have emerged as unique three-carbon synthons.
37 ns of new organocatalysts and supramolecular synthons.
38 t tools for sustainable synthesis of complex synthons.
39 abled the consideration of lactams as useful synthons.
40 gen (X(2)) as well as trihalogen interacting synthons.
41 the practical synthesis of important chiral synthons.
42 aryl/1-heteroaryl propargylic alcohols as C2 synthons.
43 lowed the preparation of the tetrahydrofuran synthons.
44 rtant 2-pyridone analogues and arylated acid synthons.
45 urans as powerful nucleophiles and versatile synthons.
46 ndolyl)methane products, which may be useful synthons.
47 g groups for these pharmaceutically relevant synthons.
48 2S leads to a range of >99:1 er difunctional synthons.
50 lkynyl)benzene species 2 via condensation of synthon 1 with nitromethane followed by a [3 + 2] cycloa
52 tioselective and stereospecific syntheses of synthon 17 and its attachment to the five-membered ring
56 with DIBAL-H or LiAlH4 affords the versatile synthons, 2-alkyl-propane-1,3-diols or those 3-protected
58 des of D(-)-penicillamine, prepared from the synthon 3-formyl-2,2,5,5-tetramethylthiazolidine-4S-carb
59 d widespread use as masked beta-oxo carbonyl synthons 3, the possibility that 2,5-cyclohexadienones 5
60 al synthesis of d4-iPF2alpha-VI by using two synthons, (3,3,4,4-d4)-hexylphosphonium bromide 23 prepa
61 and finally, amidation to afford the ring-D synthon 45 having the proper geometry and oxidation stat
63 of the melampomagnolide-B-triazole carbamate synthon 6 with various terminal diamino- and dihydroxyal
65 ed N-donors using Pd-catalysis from a common synthon affording access to pyridinyl triazines as the 4
66 ADO (2-azaadamantane-N-oxyl) with an iron(I) synthon affords iron(II)-nitroxido complexes ((Ar) L)Fe(
67 Direct modification of the hydrogen-bond synthon after macrocyclization proceeds smoothly to furn
69 methyl-2,3-butadienoate acts as a 1,4-dipole synthon and undergoes [4 + 2] annulation with N-tosylimi
70 ine interaction is an interesting biological synthon and will allow for the future development of imp
71 We introduce unexplored, alpha-enaminone synthones and reveal the unusual functionalities of thes
72 n between diazooxindoles as electrophilic C1 synthons and 1,3-heterodienes for the construction of sp
74 s was devised employing allene ketones as C2 synthons and beta,gamma-unsaturated alpha-keto esters as
75 ces highlight the complementarity of organic synthons and boron clusters, and therefore the feasibili
76 was then labeled with (18)F using this novel synthon, and the resulting imaging probe was subjected t
77 llman acetates of acetylenic aldehydes as C4 synthons, and simple imidazoles or benzimidazoles as C2
78 ally prepared from chiral protected glycerol synthons, and the alpha-monofluoromethylene-substituted
79 interaction and can be utilized as an Fe(I) synthon ((Ar)L = 5-mesityl-1,9-(2,4,6-Ph3C6H2)dipyrrin).
84 teps--highly improved syntheses of many C6On synthons as well as several previously undescribed produ
87 these R(P) chiral methylphosphonate linkage synthons bind RNA with significantly higher affinity tha
89 composed of a stable hexabromine interacting synthon (Br(6)) that further push the limits of our unde
90 ic labeling was achieved using the following synthons: bromo[2-(13)C]acetic acid, [(13)C]formic acid,
93 idines with dimethyl sulfoxide as the carbon synthon (CH2) using H2O2 as a mild oxidant under air.
94 tural products synthesis adopting the Chiral Synthon (Chiron) Approach and spanning nearly 50 years o
96 as published in 1989, and the supramolecular synthon concept was proposed in 1995 followed by heteros
99 ble challenge, we developed a supramolecular-synthon-driven approach to fabricate Borromean linked or
100 aves the avenue to expand the supramolecular-synthon-driven approach to other building blocks and top
101 arbonyl fluoride 2a is a particularly useful synthon due to its high yield of preparation and easy is
103 assium trinitromethanide as a 1,1-ambiphilic synthon equivalent for the construction of a benzofuran
105 peroxo-Cu compounds, using a "naked" complex synthon, [(F8)Fe(III)-(O2(2-))-Cu(II)(MeTHF)3](+) (MeTHF
106 trin (PMbetaCD) caps, to form supramolecular synthons featuring the porphyrin fluor fixed into a mask
110 TPP was successfully employed as a versatile synthon for convenient synthesis of a wide range of beta
111 on of Meldrum's acid to generate a versatile synthon for highly fluorinated alpha-phenyl acetic acid
112 keto-ketal 2, employed a dioxenyl group as a synthon for installing a corticosteroid side chain in ke
116 romethyl stereogenicity, an important chiral synthon for pharmaceutical, materials, and agrochemical
119 its reaction with dinitrogen, 4 behaves as a synthon for the 14-electron fragment [Cp*(dmpe)W]+, to g
122 e (difluoroamino)silane has promise as a new synthon for the introduction of the -NF2 group into a va
123 en achieved using a newly developed 1,3-diol synthon for the introduction of two key stereogenic cent
124 building block 9 is proposed as a universal synthon for the preparation of branched and branched cyc
128 as a novel synthetic equivalent of the S(2-) synthon for the synthesis of 2,5-disubstituted thiophene
129 The cyclopentenone unit is a very powerful synthon for the synthesis of a variety of bioactive targ
130 utyliminoborane is found to be a very useful synthon for the synthesis of a variety of functionalized
131 xadieno-oxazolidino-quinolinols, as valuable synthons for a broad range of post-photochemical transfo
133 ns enable these silicon dienes to be used as synthons for a variety of other dienes one might prepare
138 reagents are shown to be effective umpolung synthons for enantioselective additions to N-Boc-aldimin
139 reagents are shown to be effective umpolung synthons for enantioselective Michael addition to substi
143 were utilized as alternative to cyanohydrin synthons for preparation of the corresponding heteroaryl
144 4-Deoxypentenosides (4-DPs) are versatile synthons for rare or higher-order pyranosides, and they
145 ine (ManNAc6N(3)) as suitable chemoenzymatic synthons for synthesizing N-acetyl analogues of NmW CPS
147 bsequently, they were recognized as valuable synthons for the construction of a wide range of compoun
149 yfunctional intermediates serve as versatile synthons for the construction of various chiral compound
150 is of 2-halogenated cordycepins, also useful synthons for the development of additional novel C2-subs
151 opure 4-formyl-beta-lactams were deployed as synthons for the diastereoselective formation of chiral
152 0] bicyclic aziridines prove to be versatile synthons for the preparation of a diverse range of 1,2-
153 midoallyl cations are appealing three-carbon synthons for the preparation of complex amine-containing
154 g the 5-hydroxy-isoxazolidines that serve as synthons for the preparation of N,O-nucleoside analogues
155 n, the potential of H-phosphinates as useful synthons for the preparation of other organophosphorus c
156 These characteristics make them attractive synthons for the production of industrially and medicall
157 The chiral beta-borylated amides are useful synthons for the synthesis of chiral beta-hydroxylated,
162 idered inert substrates, can be harnessed as synthons for use in reactions that form C-C bonds throug
164 [5Fe-5S] cluster is the site of Fe(CO)x(CN)y synthon formation and that the limited bonding between t
165 Although it is thought that the site of synthon formation in HydG is the "dangler" Fe of a [5Fe]
166 ase the aromatic character of the squaramide synthons, giving rise to stronger intermolecular interac
167 ryl pyrazolones with maleimides as C1 and C2 synthon has been explored for the synthesis of spiro[pyr
169 carbonates of acetylenic aldehydes as handy synthons has allowed a facile synthesis of azaspirocyclo
171 tically equivalent to a cyclopent-2-en-1-one synthon having opposite donor and acceptor properties at
172 esolved including the full ligand set of the synthon, how the dangler Fe initially binds to HydG, and
173 coupling of a bromochlorin with a one-carbon synthon (hydroxymethyl tributyltin or CO) to give a 13-,
174 ch delta-acetoxy allenoate functions as a 5C-synthon in its reaction with cyclic sulfamidate imines i
176 I) fluoride provides easy access to this new synthon in robust quantitative yield for labeling a broa
179 4-(trimethylsilyl)nicotinonitrile as the key synthon in the preparation of highly substituted 2-amino
180 ucose has been identified as an efficient C1 synthon in the synthesis of benzimidazoles from o-phenyl
181 f silyl glyoxylates as dipolar glycolic acid synthons in a controlled oligomerization reaction for th
182 design focused on the use of nucleobases as synthons in a multicomponent reaction was herein proved
184 ted cyclic-1,3-diketones, which are prolific synthons in natural products and medicinal chemistry.
185 d their close analogues, which are important synthons in organic synthesis and for the preparation of
188 e chiron approach of using minimalist chiral synthons in the stereoselective synthesis of molecules w
189 y of 2-azidofucosyl (FucN3) donors, valuable synthons in the synthesis of 2-acetamido-2-deoxyfucose (
190 ominant (regularly occurring) supramolecular synthons in these crystal structures are (1) the heterom
191 nthesized as approximately 500 bp fragments (synthons) in a two-step PCR reaction and cloned using li
192 nzylamine or phenylglycine-derived chiral BP synthons incorporating a photolabile protecting group.
193 In the new approach a preformed rotaxane synthon is attached to the end of an otherwise fully for
194 s serves as the ligand platform on which the synthon is built and plays a role in both Fe(2+) binding
195 scopic analysis of HydG before and after the synthon is formed, we conclude that Cys serves as the li
198 [1-(I)2] and [1-(II)2] in which the mercury synthon is sandwiched by two molecules of the palladium
199 at the HydG product [Fe(II)(Cys)(CO)(2)(CN)] synthon is the substrate of the radical SAM enzyme HydE,
203 dition of 1-azidoadamantane to the diiron(I) synthon LRFeNNFeL R (L R = HC[C(R)N(2,6- iPr 2C 6H 3)] 2
204 was synthesized by means of the beta-lactam synthon method using 10-modified 7-(triethylsilyl)-10-de
207 beling RGD peptides through a thiol-reactive synthon, N-[2-(4-18F-fluorobenzamido)ethyl]maleimide (18
209 lorobenzoate, by introduction of a molecular synthon -O-CO- in lieu of the supramolecular synthon Br.
210 the 18-nor Grundmann type alcohol (C,D-ring synthon), obtained by oxidative degradation of vitamin D
211 highly reactive nature, have emerged as the synthon of choice during the past decade for the enantio
214 hols that are either the structural units or synthons of many important organic molecules as well as
215 tonitrile derivatives are thus umpolung-type synthons of the corresponding aryl carbonyl functionalit
216 isulfide or sulfonate ester functionalities (synthons of the eventual sulfonic acid groups) are synth
218 are assembled by combining two entanglement synthons (of the same chirality for a granny knot; of op
220 glycolic acid synthon, the glyoxylate anion synthon, or the alpha-keto ester homoenolate synthon.
221 ause of incomplete cleavage, PivCN-protected synthons performed well and allowed the generation of ol
223 proposed for Type-I X(2) interactions, Br(6)-synthon-possessing Type-I X(2) interactions exhibit a st
225 ynthesis features the use of the enantiopure synthon, prepared in a set of highly stereoselective rea
226 lationships established for three novobiocin synthons produced optimized scaffolds, which manifest mi
227 employs nitroalkenes as latent 1,2-dication synthons providing a novel access to highly useful symme
228 [PhB(tBuIm)3Fe-N(CH2CHPh)] acts as a nitride synthon, reacting with electron-poor styrenes to generat
230 ane sesquiterpenes, from a chiral, tricyclic synthon, readily available via an enzymatic resolution s
232 ch assemble via shape complementarity (shape synthons), reliably form low energy slip planes, thus fa
235 he path to alternate monocyclic and bicyclic synthons representing the basis of a myriad of bioactive
236 d omega-aminoalcohols as N-C(x)-N and N-C(y) synthons, respectively, and the Mitsunobu reaction as th
237 portantly, O -> S substitution in squaramide synthons resulted in supramolecular polymers with increa
238 pening of furan and its use as a four-carbon synthon, S(N)2 displacement of a functionalized allyl br
239 vised for preparation of the required A-ring synthons, starting from the chiral compound derived from
241 -based nanopropeller 1 by using an efficient synthon strategy involving sequential intramolecular bis
242 sors for producing useful (18)F-labeled aryl synthons, such as (18)F-labeled halomethylbenzenes, benz
243 formed by fluctuations in the supramolecular synthons, suggesting a nucleation and growth mechanism i
246 und species as an organometallic Fe(CO)2(CN) synthon that is ultimately transferred to apohydrogenase
247 ng the enantiomer of the C,D-ring side-chain synthon that leads to ent-cholesterol, the A- and B-ring
248 c products form an enzyme-bound Fe(CO)x(CN)y synthon that serves as a precursor for eventual H-cluste
249 have proved to be more synthetically useful synthons that afford crystalline polycyclic structures i
250 -methyl-5H-inden-5-o ne, C,D ring-side chain synthons that can be used for the synthesis of enantiome
251 The products of these additions are useful synthons that contain termini capable of differentiation
252 nyl-, and 2-formyl-1,4-benzodioxane, are key synthons that for the most part are never described as e
253 By initially synthesizing smaller fragments (synthons), the number of clones sequenced is low compare
254 etic equivalent to the dipolar glycolic acid synthon, the glyoxylate anion synthon, or the alpha-keto
255 We have developed a new phosphoramidite synthon--the alkynyl phosphinoamidite, which is compatib
256 d HydG may facilitate transfer of the intact synthon to its cognate acceptor for subsequent H-cluster
257 nyl acetates, exploiting disubstituted silyl synthons to afford silyl acetals and Rh-catalyzed ortho-
258 ightforward chemical design of the molecular synthons to create spontaneous polarization and to adjus
259 g and applies the concepts of supramolecular synthons to molecular systems constrained to 2D by physi
260 and diformylated azaBODIPYs are very useful synthons to prepare a wide variety of new fluorescent co
261 resulting dinuclear species were utilized as synthons to prepare bimetallic trinuclear clusters.
262 s condensed with various azomycin-containing synthons to produce chemical compounds that could chelat
264 graphite yielded the high-spin (S = 1) Co(I) synthon ((Tr)L)Co which is stabilized through an intramo
265 re synthesized using a novel phosphoramidite synthon, tris-2,2,2-[3-(4,4'-dimethoxytrityloxy) propylo
269 struction of the requisite vinyl nucleophile synthon using hydrostannylation of an alkyne was foiled
272 The preparation of a four-coordinate Co(II) synthon was achieved with the tripodal ligand, N,N',N"-[
275 this synthesis was that a relatively complex synthon was obtained from simple and inexpensive startin
277 first step in the preparation of appropriate synthons was condensation of bis(N,N-diisopropylamino)ph
281 To prepare the array, monomeric vancomycin synthons were linked through four distinct positions of
282 o- and l- erythro-pentopyranose carbohydrate synthons were prepared and further elaborated into the f
285 demonstrated by introducing phosphoramidite synthons where N-benzyloxycarbonyl (Z) protected amino a
286 es to generate synthetically useful a1,a3,d5-synthons which are prone to undergo multiple consecutive
287 vailable monoterpene (S)-carvone as a C-ring synthon, which is incorporated into the tetracyclic isos
288 importance and utility of the supramolecular synthon, which is one of the most important concepts in
289 efficiently transformed into a sesquiterpene synthon, which was converted into the corresponding brom
290 While these intermediates are convenient synthons, which are readily available from several commo
291 cognate structures may act as supramolecular synthons, which, given their chirality, may even be amen
292 the 4-position as supramolecular pai-stacked synthon with the dual functionalities of self-assembly c
293 ction of 3-alkenylpyrroles/-thiophenes as C4 synthons with 1-aryl/1-heteroaryl propargylic alcohols a
295 gonucleotides are built into 500- to 800-bp "synthons" with low error frequency by automated PCR-base
296 with an integrated 1-nm pore as an 'aperture synthon', with manganese linkers yields a vast three-dim
297 The reactions of acyl anion equivalents (d1 synthons) with carbonyl electrophiles allow for the cons
298 gioselectively modify arenes using a "diene" synthon within aromatic rings provides access to highly
299 striction enzymes allow seamless assembly of synthons without placing restrictions on the sequence be
300 pid composition of novel key alpha-enaminone synthones yields an assembly of oxazines, azaspirones, q