ライフサイエンスコーパス: tail domain

1 is independent of either kinase function or tail domain.

2 nfluenza B virus lacking the BHA cytoplasmic tail domain.

3 culin, the actin binding site resides in the tail domain.

4 ds actin filaments similarly to the vinculin tail domain.

5 o its head domain and actin filaments to its tail domain.

6 -based motif localized within the receptor C-tail domain.

7 negatively charged surfaces in the upstream tail domain.

8 e shaft domain, and a penton base-attachment tail domain.

9 ongest selective pressure on the cytoplasmic tail domain.

10 t microtubule-binding site in its C-terminal tail domain.

11 lves rapidly, particularly in its N-terminal tail domain.

12 sites of phosphorylation occur within the C-tail domain.

13 etween the kinesin-1 head and its regulatory tail domain.

14 easing the microtubule affinity of the XCTK2 tail domain.

15 ut little is known about the function of the tail domain.

16 for post-translational export of the Cox2 C-tail domain.

17 age phagocytosis via a conserved collagenous tail domain.

18 tions that are distinct from those of the H3 tail domain.

19 t least in part by the collagenous collectin tail domain.

20 cleavage site and a hirudin-like C-terminal tail domain.

21 similar to that found previously for the H3 tail domain.

22 osphorylated on two residues at its unfolded tail domain.

23 esidue region (1849-1940) of the coiled-coil tail domain.

24 n and an intrinsically disordered C-terminal tail domain.

25 that is predicted to completely alter the K1 tail domain.

26 with acidic phospholipids through its basic tail domain.

27 ine motifs found within the LMP2A N-terminal tail domain.

28 ned the interactions between Hat1 and the H4 tail domain.

29 tol 4,5-bisphosphate (PtdIns(4,5)P2)-binding tail domain.

30 otor domain fused to the MYO7B cargo-binding tail domain.

31 ently of beta-arrestins and the receptor's C-tail domain.

32 d to cause MPS in this study occurred in the tail domain.

33 b38 and regions of the Myosin Vc coiled-coil tail domain.

34 a C-terminal motor domain and an N-terminal tail domain.

35 ing up the dynamically disordered N-terminal tail domains.

36 globular head, coiled-coil rod, and globular tail domains.

37 rod" domain flanked by the flexible head and tail domains.

38 is partially redundant with the core histone tail domains.

39 ical central rod domain, flanked by head and tail domains.

40 ta have been reported for either the head or tail domains.

41 main that is flanked by non-helical head and tail domains.

42 al interactions mediated by the core histone tail domains.

43 -MMP hemopexin, transmembrane, and cytosolic tail domains.

44 to the focal adhesion targeting and vinculin tail domains.

45 were not altered by removal of core histone tail domains.

46 re specifically associated with expressed H3 tail domains.

47 interarray interactions mediated by histone tail domains.

48 ll division cycle 25), and PR (proline-rich) tail domains.

49 etween the C terminus helical and nonhelical tail domains.

50 d differentially on vinculin head (V(H)) and tail domains.

51 ly to Rab5-containing endosomes through its "tail" domain.

52 otif localized within the C-terminal tail (C-tail) domain.

53 ear localization signal (NLS) located in the tail domain [14].

54 contrast to their inhibition of ADP release, tail domains accelerate the rate of ADP binding to nucle

55 In addition, we show that the effects of H3 tail domain acetylation on UDG/APE1 activity are at the

56 oes promote some translocation of the Cox2 C-tail domain across the inner membrane and causes increas

57 ass III myosins that requires both motor and tail domain actin-binding activity and show that the act

58 lt hypothesis, where the CD loop in the beta tail domain acts to restrain the I domain in the inactiv

59 organelles through their C-terminal globular tail domain, although recent studies have also suggested

60 al 207 amino acid region containing both the tail domain and a calponin homology (CH) domain.

61 prisingly, a minimal dimeric motor lacking a tail domain and associated subunits can cause MT sliding

62 Removal of the tail domain and lysine-serine-proline (KSP) repeats of N

63 ough the disordered N-terminal 80 amino acid tail domain and mitotic-checkpoint function is dependent

64 itated by a large movement of the polymerase tail domain and tauc.

65 ctively associates with EBs via its specific tail domain and that this interaction is crucial for AIS

66 h an engineered peptide inserted between the tail domain and the motor head retain wild-type motor ac

67 s allowed us to construct models of both the tail domain and the pentameric complex.

68 interactions between K14's carboxy-terminal tail domain and two regions in the central alpha-helical

69 onal change that separates the KHC motor and tail domains and a local conformational change that move

70 uncated DKH894 which has lost the inhibitory tail domains and does not fold.

71 ever, the structures and interactions of the tail domains and the molecular mechanisms by which acety

72 Each enzyme is characterized by a dynamic 'tail' domain and a compact 'head' that contains Rvb1/Rvb

73 The tail domain appears to bind microtubules through nonspec

74 These effects of the tail domain are likely to be mediated by the tubulin- an

75 of a motor domain dimer in complex with its tail domain at 2.2 angstroms and compare it with a struc

76 the MYO7A transcript and truncates the MYO7A tail domain at the C-terminal FERM domain.

77 hey are homotetramers with dimeric motor and tail domains at both ends of a bipolar minifilament.

78 nd programmed to cell-autonomously enter the tail domain beginning with the 16th somite.

79 ct region between the membrane-proximal beta-tail domain (betaTD) and the ligand-binding betaA domain

80 a closed conformation, in which the head and tail domains bind to each other and mask the binding sit

81 Our data support the notion that the basic tail domains bind to nucleosomal DNA and influence the s

82 where its head domain binds to talin and its tail domain binds to filamentous actin, thus linking act

83 The cytoplasmic region of BMPRII contains a "tail" domain (BMPRII-TD) with no enzymatic activity or k

84 is trafficking requires the CXCR4 C-terminal tail domain but not the CXCR4 ubiquitination sites.

85 ependent catch bond with F-actin through its tail domain, but with lifetimes that depend strongly on

86 ifications occur, not only in the N-terminal tail domains, but also in the core domains.

87 ro repeat residues that are abundant in NF-H tail domains by Pin1 can regulate NF-H phosphorylation,

88 A H3.3 tail domain-CENH3 histone-fold domain chimera rescued vi

89 tivity of a tetrameric Cin8 lacking only the tail domains (Cin8Deltatail).

90 ys-27 to block cellular modifications of the tail domains completely abolished the association of spe

91 ease is also observed when separate head and tail domain constructs are mixed at low salt concentrati

92 Tail domains contain an alternating electrostatic repeat

93 e combination of TH1 and TH2 (TH12) of Myo1e tail domains contains the essential motif for PI(3,4,5)P

94 e we demonstrate that the Xenopus laevis Npm tail domain controls the binding of histones at its larg

95 deadbolt model, a hairpin loop in the beta3 tail domain could act as a deadbolt to restrain the disp

96 acking proteins required for export of the C-tail domain, Cox18 and Mss2.

97 unction of the EBV gB cytoplasmic C-terminal tail domain (CTD) in fusion, we used a previously constr

98 (+3 leucine) or by deleting the cytoplasmic tail domain (CTD) in the +1 leucine background.

99 However, when the C-terminal tail domain (CTD) is deleted, the majority of the protei

100 speculation, the divergent carboxyl-terminal tail domain (CTD) is dispensable, but serves to modulate

101 nt studies, we characterized a gB C-terminal tail domain (CTD) mutant truncated at amino acid 843 (gB

102 their N-terminal FERM domain and C-terminal tail domain (CTD), and an open conformation, in which th

103 a chimeric F-MLV Env with a GaLV cytoplasmic tail domain (CTD).

104 he N terminus to S6 with the mslo3 cytosolic tail domain (CTD).

105 However, when the cytoplasmic tail domains (CTDs) in the Env constructs were deleted,

106 gate the negatively charged carboxy-terminal tail domains (CTTs) of alpha- and beta-tubulins, using a

107 -binding site of T3 sigma1 is located in the tail domain, distal to the antibody epitope.

108 nderstand the complex interactions of the H3 tail domain during chromatin condensation, we have devel

109 The histone H4 tail domain facilitates inter-array interactions by cont

110 s or the disordered N-terminal 80 amino acid tail domain fail to generate stable kinetochore-microtub

111 osin sequences provides evidence that myosin tail domain features can be maintained without strict co

112 The negatively charged tail domain floats away from the anionic MT surface whil

113 lines that constitutively express ectopic H4 tail domain for biochemical purification of proteins ass

114 mulation shows the essential role of Kif15's tail domain for load storage within the Kif15-microtubul

115 binding in cGAS as well as carboxy terminal tail domain for transducing signals in STING, only recen

116 A recombinant tail domain fragment of myosin Vb attenuated the plasma

117 Remarkably, we find that removal of tail domains from a nucleosome assembled on a DNA fragme

118 ined whether the removal of the core histone tail domains from nucleosomes reconstituted with specifi

119 aches to these vesicles through its globular-tail domain (GTD) and mediates their polarized delivery

120 hibition of MyoVa function with the globular tail domain (GTD) of MyoVa protein or short hairpin RNA

121 indicate that it is the C-terminal globular tail domain (GTD) that directly inhibits the motor activ

122 s of the myosin Va or the myosin Vb globular tail domain (GTD) that gives insights into how the motor

123 In contrast, the isolated tail domain has no inhibitory effect on Dyn1/HC targetin

124 tutions and lysine acetylation within the H4 tail domain have identical effects on nucleosome array s

125 genes exhibited increased recruitment of the tail domain; however, only genes with increased occupanc

126 Our data show a role for the Capu-tail domain in assembling the actin cytoskeleton, largel

127 ing to organelles may occur via the globular tail domain in both types of motors, even though sequenc

128 the functional importance of the nonhelical tail domain in keratin molecules despite the obvious var

129 gated the role of the PTEN carboxyl-terminal tail domain in regulating its membrane targeting and cat

130 questered within a hydrophobic region in the tail domain in the absence of calcium.

131 xpression of green fluorescent protein-Myo1B tail domain in the larval gut showed that the tail domai

132 vestigates developmental features of the two tail domains in different bird groups, and analyzes them

133 es of specific regions within the individual tail domains in model chromatin complexes.

134 nal T1 domain and a conserved region in KIF5 tail domains, in which proper T1 tetramerization is cruc

135 The myo1e C-terminal tail domain includes a basic region that is required for

136 hat acetylation mimics within the histone H4 tail domain increased accessibility of the surrounding l

137 report here that removal of the core histone tail domains increases the exposure of the DNA backbone

138 xaminations of specific sites within the H2B tail domain indicate that this tail contains distinct st

139 runcation of the last 40 residues from the C-tail domain, indicating that sequence and/or structural

140 Lysine acetylation within the core histone tail domains inhibits self-association, an effect likely

141 yosin A (MyoA) and its light chain, myosin A tail domain interacting protein (MTIP), is an essential

142 tes of Plasmodium falciparum CDPK1: myosin A tail domain-interacting protein (MTIP) and glideosome-as

143 ity and includes the MyoA light chain myosin tail domain-interacting protein (MTIP) and several glide

144 ns, including the MyoA light chain, myosin A tail domain-interacting protein (MTIP).

145 Va is in a folded conformation such that the tail domain interacts with and inhibits myosin Va motor

146 found that the non-motor microtubule-binding tail domain interacts with the microtubule's E-hook tail

147 lar motors that possess a motor domain and a tail domain involved in cargo binding.

148 .0007 s-1), and the IQ motif adjacent to the tail domain (IQ3) has the fastest dissociation rate (0.5

149 n vitro assays, we demonstrate that the Hec1 tail domain is dispensable for Ska complex recruitment t

150 The Cox2 C-tail domain is exported post-translationally by the high

151 ate asymmetric motility, suggesting that the tail domain is not required for the counterclockwise tur

152 Our data suggest that the C-tail domain is recognized posttranslationally by a speci

153 e isoform of myosin VI with no insert in the tail domain is required for the polarized transport of t

154 ail domain in the larval gut showed that the tail domain is sufficient for localization of Myo1B to t

155 This inhibition of ADP release by tail domains is formally analogous to the action of nucl

156 Physical linkage of the head and tail domains is required for maximal force responses.

157 Inhibition of release of ADP by tail domains is reversed by Unc-76 (FEZ1) which is a pot

158 the motor domain, but not the actin-binding tail domain, is required for stereocilia tip localizatio

159 e show that EB1 and the KIF17 autoinhibitory tail domain (KIF17-Tail) interacted competitively with t

160 d interarray interactions mediated by the H4 tail domain, known to play a predominant role in the for

161 omposed of histones lacking their N-terminal tail domains less efficiently than wild-type H3/H4 tetra

162 We found that mutating or deleting the beta3 tail domain loop has no effect on ligand binding by eith

163 lation of all four histone H4 NH(2)-terminal tail domain lysine residues is increased following DSB f

164 Interestingly, the tail domain markedly inhibits the actin-activated ATPase

165 domains works remains unclear, but kinesin-5 tail domains may be involved.

166 As acetylation of specific tail domains may encode distinct functions, we investiga

167 at the last 11 amino acids of the C-terminal tail domain mediate crosslinking by divalent ions.

168 The core histone tail domains mediate inter-nucleosomal interactions that

169 In addition, the P2 cytoplasmic tail domain mediated the constitutive interaction betwee

170 ormation of bundlelike configurations, while tail domain-mediated binding events act to stabilize the

171 contribute to furrow localization: a central tail domain mediating cortical furrow binding to heterol

172 utant, followed by those rescued with a Hec1 tail domain mutant.

173 A tail domain mutation (Val459Ile) showed milder effects o

174 characterized by a 68-residue insert in the tail domain (MVt) and correlates with hereditary idiopat

175 Metavinculin tail domain (MVT) binds actin filaments in a similar ori

176 CM mutations in the metavinculin tail domain (MVt) occur within the extra 68-residue inse

177 The myosin V globular tail domain (MyoV-GTD) interacts directly with an evolut

178 The N-terminal tail domains (NTDs) of histones play important roles in

179 tion in the Aspergillus nidulans heavy chain tail domain, nudA(F208V), which causes obvious defects i

180 93) and binds via its DUF593 to the globular tail domain of a tobacco pollen tube myosin XI.

181 These findings indicate that the cytoplasmic tail domain of BHA is important for efficient incorporat

182 Furthermore, C1q, MBL, and the tail domain of C1q were all chemoattractants for E. hist

183 on of a complex comprised of Fabp5 and the C-tail domain of Canx dictates the permeability of the mod

184 otein-protein contact with the cytoplasmic C-tail domain of Canx.

185 we have examined the role of the C-terminal tail domain of Cin8 in regulating directionality.

186 mined that GEF-H1 interaction with the rod + tail domain of cingulin was required for inactivation of

187 that shows that the C-terminal intracellular tail domain of Cx46 is essential to induce degradation o

188 -binding sites (VBS) found in the C-terminal tail domain of IpaA.

189 Furthermore, the C-terminal tail domain of keratin 8 is shown to be essential for th

190 Here we identify an essential role of the tail domain of Kip3 in mediating both its destabilizing

191 MT rescue within the bud requires the tail domain of Kip3, whereas the motor domain mediates c

192 only the second AR (AR2) binds to the cargo/tail domain of Klp64D.

193 The tail domain of lamin A directly binds 21 known partners,

194 l change also occurs in the H1' helix of the tail domain of metavinculin (MVt) upon actin binding, a

195 rms is a 68-residue insert in the C-terminal tail domain of MV (MVt).

196 strin homology domain abolish binding of the tail domain of Myo1b to PIP(2) and PIP(3) in vitro.

197 The cargo-binding tail domain of Myo1c interacted with G-actin, and the mo

198 ed proteins to demonstrate that the globular tail domain of myosin Va binds directly to an intrinsica

199 Our study focuses on the 68-residue medial tail domain of myosin-VI, which is found to contain a hi

200 proline-directed Ser/Thr residues within the tail domain of NF proteins by inhibiting the dephosphory

201 sites have been identified on the C-terminal tail domain of NF-H, with greater abundance of phosphory

202 tion and exposure of the acidic tract at the tail domain of NP.

203 cule motor and the cargo (i.e., the extended tail domain of the molecule) must be able to absorb the

204 The coiled-coil tail domain of the myosin II heavy chain mediates filame

205 The extended tail domain of these myosins consists of mechanically st

206 c domain of separase binds to the C-terminal tail domain of three homologs of the centromeric protein

207 The tail domain of vinculin (Vt) binds to acidic phospholipi

208 The tail domain of vinculin (Vt) contains determinants neces

209 The tail domain of vinculin (Vt) forms tight autoinhibitory

210 ote binding of the intracellular cytoplasmic tail domains of cadherin receptors with beta-catenin, a

211 ants carrying mutations in the head, rod, or tail domains of desmin (S46F, E245D, and T453I).

212 We found that the ectopic expression of the tail domains of each of the class VIII, but not the clas

213 e structure and interactions of the head and tail domains of epidermal keratins 1 and 10, based on al

214 Acetylation mimics within the tail domains of H2B and H4 caused the largest inhibition

215 These data suggest that the CH and tail domains of Hec1 generate essential contacts between

216 cations that lie outside of the unstructured tail domains of histones.

217 examined how the properties of the motor and tail domains of human class III myosins impact their abi

218 ned the head domain of II-A with the rod and tail domains of II-B.

219 ll cases result from mutations affecting the tail domains of keratin-10 or keratin-1, and Suzuki et a

220 that lacks the transmembrane and cytoplasmic tail domains of M2 (M2 knockout [M2KO]) is attenuated in

221 The overexpression of the rod + tail domains of paracingulin perturbs the development of

222 pared the elastic properties of the extended tail domains of processive (mouse myosin Va) and nonproc

223 Mutations in the head and tail domains of the motor protein myosin VIIA (MYO7A) ca

224 Only the tail domains of the two invertebrate CCTs were competent

225 rane binding sites within the regulatory and tail domains of this myosin.

226 vealed that several intrinsically disordered tail domains of two NP pentamers, facing each other thro

227 ooperative dissociation between the head and tail domains of vinculin with increasing temperature in

228 in vitro by disulfide derivatization of the "tail" domain of A2.

229 itical target of Aurora B is the N-terminal "tail" domain of Hec1, which is a component of the NDC80

230 The carboxyl terminal "tail" domains of the heavy and middle molecular weight m

231 -terminal RNA-binding core and a 125-residue tail domain, of which only the last 75 residues are cons

232 Tail domains only weakly inhibit the initial slow releas

233 es two dynein motor domains but not dynein's tail domain or any associated subunits.

234 followed by a transmembrane and cytoplasmic tail domains or by a glycosylphosphatidylinositol linker

235 eceptor family members, including a head and tail domain organization, multimerization that may regul

236 Previously, we demonstrated that the H3 tail domain participates in internucleosome interactions

237 Collectively these results indicate that H3 tail domain performs multiple functions during chromatin

238 ng that acetylated lysine residues on the H3 tail domain play distinct roles in regulating the initia

239 The core histone tail domains play a central role in chromatin structure

240 of specific lysines within the core histone tail domains plays a critical role in regulating chromat

241 esults indicate that acetylation of specific tail domains plays distinct roles in the regulation of c

242 ults show that the Rh1 rhodopsin cytoplasmic tail domain, positioned to interact with cytoplasmic str

243 cid substitutions, residing in both head and tail domains, predicted perturbation of protein structur

244 erines localized in the variable "head" and "tail" domain regions.

245 d serine/threonine residues of neurofilament tail-domain repeats are exclusively phosphorylated in ax

246 association of farnesylated Delta50 lamin A tail domains requires calcium.

247 We show that PTEN tail-domain residues 394-403 permit PTEN to associate wi

248 However, whether the H4 tail domains stabilize array folding via inter-nucleosom

249 In 4RL isoform, amino acids in tail domain stay mostly apart from the MT surface.

250 Surprisingly, the kinesin tail domain stimulates microtubule assembly and stabilit

251 Sequence analysis of the proximal tail domain suggests that further calmodulin binding sit

252 formation seen with mutations in the 1A and tail domains suggests that dysfunction of seemingly inta

253 Previous mutations in the beta(2)-tail domain support the importance of extension, rather

254 uction of Med15 levels, a MED subunit in the tail domain, suppressed the Nodal signaling pathway but

255 he quaternary structure of GabR is a head-to-tail domain-swap homodimer.

256 The N-terminal tail domain targets Dyn1/HC to cortical Num1 receptor si

257 We show that SEPT9 interacts with the KIF17 tail domain that associates with mLin-10/Mint1, a cargo

258 an N-terminal 'head' domain and a C-terminal tail domain that contains several predicted coiled-coils

259 er, consists of a head domain and a junction/tail domain that exhibit different functional properties

260 ding to yBre1, whereas the C-terminal acidic tail domain that is not required for a stable yBre1-yRad

261 ntramolecular interactions with the vinculin tail domain that normally clamp vinculin in an inactive

262 kinesin motor domain and a series of kinesin tail domains that can attach to their native vesicles; w

263 inesin-5, including some associated with the tail domain, that provide clues as to how spindles are a

264 in-specific insert is part of the C-terminal tail domain, the actin-binding site of both isoforms.

265 ddition to the previously suggested flexible tail domain, there is a compliant region between the mot

266 ned processivity of Kif18A, conferred by its tail domain, thus promotes concentration of Kif18A at K-

267 ide pocket is restricted upon binding of the tail domain to kinesin-1 heads.

268 gly, lysine-to-glutamine mutations in the H3 tail domain to mimic acetylation resulted in little or n

269 of the Tha4 amphipathic helix and C-terminal tail domains to form Tha4 oligomers.

270 Although this potentially allows a dimer of tail domains to interact symmetrically with a dimer of h

271 Binding of the tail domains to the heads inhibits net microtubule-stimu

272 region that links the distal calf-2 and beta-tail domains to their respective transmembrane (TM) doma

273 positioning upon removal of the core histone tail domains under physiological conditions, indicating

274 ational complexity of linker DNA and histone tail domains upon compact folding of the fiber.

275 As expected, deletion of the VCL tail domain (VCL(1-880)), which binds actin, does not no

276 rm the CDK8 submodule binds the Mediator leg/tail domain via the Med13 subunit, and this submodule-Me

277 Vinculin tail domain (VT) both binds and bundles actin filaments.

278 n is simulated either with only its vinculin tail domain (Vt), with all residues in its closed confor

279 ert that differentiates it from the vinculin tail domain (Vt).

280 ad domain (Vh) and to actin filaments at its tail domain (Vt).

281 Its tail domain, Vt, is crucial for vinculin activation and

282 nterface leads to the formation of a tail-to-tail domain wall.

283 viability of cenh3-1, but CENH3's lacking a tail domain were nonfunctional.

284 e (SSP) and G2 transmembrane and cytoplasmic tail domains were essential for correct GPC maturation a

285 v1 proteins is mediated by their cytosolic C tail domain, where we identified seven cholesterol recog

286 gers the unfolding of the protein's proximal tail domain which could drive the needed lever-arm exten

287 Diffusion is promoted by the tail domain, which also contains a second MT-binding sit

288 multiple KSP repeats in the carboxy-terminal tail domain, which are phosphorylation sites of proline-

289 at K-MT plus ends depends on its C-terminal tail domain, while the ability of Kif18A to suppress MT

290 omain 1 prevents interaction of the vinculin tail domain with actin by steric hindrance.

291 s from MYO3B in that it contains an extended tail domain with an additional actin-binding motif.

292 Calcium binds to the tail domain with an affinity KD approximately 250 muM wh

293 rane-adjacent CRAC4 and the long cytosolic C tail domain with several other CRAC motifs, which are no

294 hese residues binds directly to the globular tail domain with the same affinity as melanophilin.

295 replacing the transmembrane and cytoplasmic tail domains with a 6His tag.

296 affect the interactions of the core histone tail domains with nucleosomal DNA, redirecting the tails

297 g(2+) and Ca(2+) can replace the role of the tail domains with regard to stabilization of histone-DNA

298 mation through interaction of the C-terminal tail domains with the N-terminal motor (head) domains.

299 acement of its transmembrane and cytoplasmic tail domains with their counterparts from bovine parainf

300 only three, Mediator subunits, all from its tail domain, work as activators when fused to LexA.