ライフサイエンスコーパス: tail flick

1 ey hair), and thermal sensitivity (hot plate/tail flick).

2 k: 70-75%; jump: 60-81%) and beta-endorphin (tail-flick: 100%; jump: 93%) analgesia elicited from the

3 the PAG significantly reduced both morphine (tail-flick: 70-75%; jump: 60-81%) and beta-endorphin (ta

4 Antinociception studies using a radiant-heat tail flick analgesia method demonstrated that lambda-car

5 hine before norBNI responded strongly in the tail-flick analgesia assay to a subsequent challenge wit

6 eptive responses to morphine measured in the tail-flick analgesia assay.

7 R agonist-induced prolactin secretion and in tail-flick analgesia in mice.

8 vitro kappa antagonism were confirmed in the tail-flick analgesia model.

9 on of these hodgkinsine stereoisomers in the tail flick and capsaicin pain models are reported.

10 antagonist, on nociceptive responses in the tail flick and formalin tests in mice.

11 el, pain sensitivity was evaluated using the tail flick and hot plate assays for thermal pain and the

12 knockout mice displayed shorter latencies on tail flick and hot plate tests for spinal and supraspina

13 ueductal gray were determined using both the tail flick and the foot withdrawal responses to noxious

14 were confirmed in the antinociceptive tests (tail-flick and acetic acid writhing) in mice, which demo

15 increased nociceptive responses on both the tail-flick and foot-withdrawal tests.

16 strength, and heat nociception, measured by tail-flick and hindlimb withdrawal tests, were not affec

17 mpound resulted in increased efficacy in the tail-flick and hot-plate assays of antinociception.

18 ), for pharmacological activity in the mouse tail-flick and hot-plate assays, and for hypothermia and

19 iled to produce antinociception in the mouse tail-flick and hot-plate assays, engender nicotine-like

20 were markedly diminished in the radiant heat tail-flick and hot-plate assays.

21 ams of CGP 35348 antagonized the increase in tail-flick and hot-plate latency produced by either dose

22 in vivo for antinociception activity in the tail-flick and hot-plate models of acute pain and for th

23 on, 5g was a nicotine antagonist in both the tail-flick and hot-plate tests, whereas 8a was an antago

24 glion neurons, and (3) no change in baseline tail-flick and hotplate reflex nocifensive responses.

25 ormalin test, and the thermal (49 degrees C) tail-flick and increasing-temperature (3 degrees C/min)

26 ine-6beta-glucuronide (M6G) analgesia on the tail-flick and jump tests differed in potency in the per

27 teral periaqueductal gray as measured by the tail-flick and jump tests in rats.

28 25 and 250 nmol and the resulting effects on tail-flick and nociceptive foot-withdrawal latencies wer

29 of a TIP39 antibody decreased sensitivity in tail-flick and paw-pressure assays.

30 dorsal root ganglion neurons, and using the tail-flick and rotarod tests in mice.

31 prevented tolerance to morphine in both the tail-flick and the formalin test.

32 degrees C hot plate, 52 degrees C warm-water tail-flick and the Hargreaves paw-withdrawal tests.

33 was evaluated for antinociception using the tail-flick and von Frey assays in mice pretreated with l

34 es to noxious thermal stimulation (hotplate, tail flick) and to persistent noxious chemical stimulati

35 plate, high- and low-intensity radiant heat tail flick, and von Frey hair assays.

36 to the positive control, Nalbuphine, in the tail-flick animal model, while compound (S)-10h was foun

37 In the present study, hot-water-immersion tail-flick antinociception assays at 52 degrees C on mic

38 hand, the mutant mice react normally in the tail flick assay and acetic acid-induced writhing tests.

39 In a tail flick assay of nociception, TAL increased response

40 gy between deltaORs and alpha2AARs using the tail flick assay of thermal nociception in mice.

41 there was no difference in the low-intensity tail flick assay.

42 times more potent than morphine in the mouse tail-flick assay (ED(50) = 0.05 mg/kg), and (-)-(1R,5R,

43 a partial agonist effect in the 55 degrees C tail-flick assay and a full agonist effect in the acetic

44 ted by the intrathecal route using the mouse tail-flick assay and binding studies.

45 ly active potent antinociceptive activity in tail-flick assay in mice, with diminished tolerance, dep

46 A warm-water (50 degrees C) tail-flick assay revealed a significant decrease in morp

47 compounds 3a-g and 4 were more potent in the tail-flick assay than the hot-plate test.

48 ater analgesia, as assayed in the warm water tail-flick assay, in NET-knock-out (-KO) mice than in wi

49 In the mouse tail-flick assay, intrathecal (i.t.) NNTA produced antin

50 nity and spinal analgesia as measured in the tail-flick assay.

51 nism and acted as a potent antagonist in the tail-flick assay.

52 teromeric opioid receptors, and in the mouse tail-flick assay.

53 annabinoid agonist CP55,940 (21) in a rodent tail-flick assay.

54 of nicotine-mediated antinociception in the tail-flick assay.

55 type to antagonize nicotine's effects in the tail-flick assay.

56 eption with an ED50 of 0.07 microg/kg in the tail-flick assay.

57 on and increased withdrawal latencies in the tail-flick assay.

58 ed in mice lacking ORL-1 receptors using the tail-flick assay.

59 ociception was measured using a radiant heat tail-flick assay; mechanical sensitivity was measured us

60 cies in the hot plate and the high-intensity tail flick assays (hypoalgesia), but there was no differ

61 harmacological manipulations utilized in our tail-flick assays on GM1-treated mice provide a novel bi

62 (1 mg/kg) (measured by warm-water-immersion tail-flick assays).

63 otency of morphine, as measured by hot-water tail-flick assays.

64 The cold-water tail-flick (CWT) test was used to measure antinociceptio

65 of locomotor (open-field task) and sensory (tail flick) function were used to assess behavioral reco

66 d for antinociceptive activity (55 degrees C tail flick) in mice.

67 00, 300, 600 microg), into the PAG increased tail flick latencies in male and female rats.

68 tar S-DHPG (0.1, 1.0, 10 mM) does not change tail flick latencies or paw withdrawal latencies to heat

69 ive to NMDA antagonism, but not hot plate or tail flick latencies, which were insensitive to NMDA ant

70 clei of the amygdala significantly increased tail-flick latencies and jump thresholds in rats.

71 he OFQ/N fragments in the amygdala increased tail-flick latencies on this measure.

72 WIN55,212-2 significantly elevated tail-flick latencies when injected into the amygdala, th

73 (ED50=30 microg) in significantly increasing tail-flick latencies with longer durations of action.

74 nd time-dependent increase in high-intensity tail-flick latencies with maximal effects observed at a

75 tagonist, did not antagonize the increase in tail flick latency (TFL) produced by microinjection of L

76 In this study, we measured tail flick latency (TFL), arterial blood gas (ABG) chemi

77 activity of compound 5b was evaluated by the tail flick latency test, giving an ED50 of 2.5 mg/kg.

78 BLA resulted in a time dependent increase in tail flick latency that was attenuated by preadministrat

79 dy, the effects of phenylephrine infusion on tail flick latency was determined before and after salin

80 Radiant heat tail flick latency, as a measure of behavioral effects,

81 ndently increased mean arterial pressure and tail flick latency, but had inconsistent effects on neur

82 or 3 mg kg(-1) d(-1) FP15 reversed increased tail-flick latency (a sign of reduced pain sensitivity);

83 or nonpaced) showed significant increases in tail-flick latency (TFL) within 5 s (time 0) after matin

84 iferative responses by 80% and elevated both tail-flick latency and plasma corticosterone when compar

85 Controls showed a pronounced elevation in tail-flick latency following presentation of 90-dB white

86 s, manifested by rapid onset of decreases in tail-flick latency for periods >3 h after drug administr

87 ng-lasting response in rats monitored by the tail-flick latency measurements.

88 antagonists by themselves did not alter the tail-flick latency or the analgesic effect of deltorphin

89 tary-adrenal (HPA) axis and antinociception (tail-flick latency) were examined.

90 ven twice a day for 4 days did not alter the tail-flick latency.

91 40 mg/kg, i.p.) by itself did not alter the tail-flick latency.

92 ory brainstem response (ABR) amplitudes, and tail-flick latency.

93 slightly blocked anti-nociception in a naive tail-flick model, while enhancing morphine-induced preci

94 placements displayed analgesic ED50s on the tail-flick (morphine: 1.4 microgram, M6G: 0.06 microgram

95 placements displayed analgesic ED50s on the tail-flick (morphine: 1.7 microgram, M6G: 0.1 microgram)

96 placements displayed analgesic ED50s on the tail-flick (morphine: 2.1 microgram, M6G: 0.2 microgram)

97 0 g) and antinociception was obtained on the tail flick or foot withdrawal tests.

98 lpha of saline-pretreated rats did not alter tail-flick or hot-plate latency.

99 CART was not active in the tail-flick or PPQ tests.

100 uctural modeling, in vitro profiles, and rat tail flick outcomes are disclosed and discussed.

101 hippocampal infusions had greater analgesia (tail flick, paw lick), less anxiety behavior (plus-maze,

102 began during the 50 msec after onset of the tail flick, peaked within 200 msec, and outlasted the du

103 uation of 1, 2e, and 2f sc in mice using the tail-flick procedure indicated that they are selective d

104 ring associated with the noxious heat-evoked tail flick reflex were used to classify neurons as "on-c

105 the ability of phenylephrine to inhibit the tail flick reflex.

106 of mustard oil and measuring the nociceptive tail-flick reflex in awake rats.

107 pectively, and produced an inhibition of the tail-flick reflex in normal animals.

108 The inhibition of the tail-flick reflex produced by mustard oil following spin

109 ations that eliminated the inhibition of the tail-flick reflex restored vocalization to thermal stimu

110 the hind leg produced a facilitation of the tail-flick reflex that was significantly reduced in spin

111 d mustard oil hyperalgesia and inhibited the tail-flick reflex.

112 persistently suppressed radiant heat-evoked tail flick reflexes of anesthetized rats.

113 In contrast, the increase in the tail flick response latency produced by morphine was red

114 ter of the brain results in an increased rat tail flick response to a painful stimulus.

115 e relationship between the inhibition of the tail-flick response and brain-mediated responses to noci

116 B4101 partially reversed the increase in the tail-flick response latency produced by morphine.

117 ppress multi-segmental reflexes, such as the tail-flick response.

118 gray using both the foot-withdrawal and the tail-flick responses to noxious radiant heating in light

119 an on core body temperature and nociceptive (tail flick) responses.

120 v administration as measured analgesia using tail-flick (spinal involvement) and hot-plate (supraspin

121 nociception in the hotplate; however, in the tail flick test a dose of 2 mg/kg was required for an an

122 .07 and 0.04 microg/kg, respectively, in the tail flick test and only 35 and 0% inhibition at 20 and

123 rkedly increased withdrawal latencies in the tail flick test and reduced responses to subcutaneous fo

124 Rats were tested in the tail flick test before and after microinjections of the

125 ference conditioning for reward effects, the tail flick test for nociception, and a measure of locomo

126 ad no effect on the altered responses in the tail flick test in aged rats, and in general, had no eff

127 increases in antinociceptive responses on a tail flick test in both male and female rats.

128 s (13l and 11b) showed analgesic response in tail flick test which was blocked by pretreatment with n

129 the epibatidine analogues are full agonists (tail flick test) in producing antinociception after intr

130 ) or their combination and their behavior in tail flick test, reflective of spinal antinociception an

131 produced antinociception, assessed using the tail flick test, that lasted more than 60 min.

132 Nociception was measured using the tail flick test.

133 tinociception produced by morphine using the tail flick test.

134 n the dose-response curve to morphine on the tail-flick test (a pain sensitivity assay), suggesting e

135 that CART (55-102) was without effect on the tail-flick test after i.t. injection in mice.

136 ll found Delta9-THC-induced analgesia in the tail-flick test and other behavioral (licking of the abd

137 intrathecally, all produced analgesia in the tail-flick test but only 5a produced analgesia in the ho

138 blocked OFQ/N(1-17)-induced analgesia on the tail-flick test elicited from the amygdala, and whether

139 roventricular (i.c.v.) administration in the tail-flick test in mice.

140 mg/kg, i.p.) produced antinociception in the tail-flick test in sham-operated rats.

141 It is held that the tail-flick test of pain depends on a spinal reflex becau

142 knock-out mice exhibited hyperalgesia in the tail-flick test of thermal nociception.

143 70-fold more effective as antagonists in the tail-flick test versus the hot-plate procedure.

144 ve responses to noxious thermal stimulation (tail-flick test) by both types of anesthetics.

145 rophenyl analogue (5e) (AD50 = 0.0003 in the tail-flick test) was the most potent and selective analo

146 cy of tail withdrawal from radiant heat (the tail-flick test).

147 aw oedema model), analgesic (hot plate test, tail-flick test, acetic acid-induced writhing and formal

148 ema test, and the analgesic potential by the tail-flick test, acetic acid-induced writhing models, ho

149 NSAIDs are inactive in the radiant heat tail-flick test, an assay of moderate to severe pain in

150 t as well as the peak (15 min) effect on the tail-flick test, analgesia elicited by either endomorphi

151 stress-induced analgesia as detected by the tail-flick test, but decreased the potency of the opioid

152 tinociception produced by morphine using the tail-flick test, but not that using the foot-withdrawal

153 tent and long lasting antinociception in the tail-flick test, indicating that 13a was able to permeat

154 In the tail-flick test, intrathecal administration of UK 14,304

155 ayed relatively lower antinociception on the tail-flick test, resulting in significantly increased ED

156 eductions in beta-endorphin analgesia on the tail-flick test.

157 ctions of endomorphin-2, particularly on the tail-flick test.

158 , with antinociception being assessed with a tail-flick test.

159 30-60 min in naltrexone-treated rats on the tail-flick test.

160 eductions in beta-endorphin analgesia on the tail-flick test.

161 n male Swiss-Webster mice as measured by the tail-flick test.

162 tive effect of morphine determined using the tail-flick test.

163 ic interaction on the jump test, but not the tail-flick test.

164 s of nicotine-induced antinociception in the tail-flick test.

165 d antinociception in mice as measured by the tail-flick test.

166 a-endorphin analgesia in the amygdala on the tail-flick test.

167 more pronounced on the jump test than on the tail-flick test.

168 s investigated in rats with the radiant heat tail-flick test.

169 king nicotine-induced antinociception in the tail-flick test.

170 he antinociceptive effect of morphine in the tail-flick test.

171 ciception was investigated in mice using the tail-flick test.

172 ts, whereas 8a was an antagonist only in the tail-flick test.

173 OT did not produce analgesic effects in the tail-flick test.

174 en microinjected into the DRN at the time of tail-flick testing, 8-OH-DPAT also effectively prevented

175 reduce nociceptive responses in hot plate or tail flick tests of homozygous mu receptor knockout mice

176 esently studied in rats on the hot plate and tail flick tests.

177 ose-dependent analgesia in both hotplate and tail-flick tests when administered subcutaneously.

178 mal thermal nociception in the hot-plate and tail-flick tests, and had similar olfactory, auditory an

179 tinociception on both the hot plate (HP) and tail flick (TF) nociceptive tests.

180 to the amygdala results in inhibition of the tail flick (TF) reflex evoked by radiant heat.

181 e amygdala (BLA) suppresses the radiant heat tail flick (TF) reflex in anesthetized rats.

182 measuring nociception with the radiant heat tail flick (TF) test.

183 ow that facilitation of a spinal nociceptive tail-flick (TF) reflex induced by stimulation in the NGC

184 Potentiation of analgesia (tail-flick [TF] test and hotplate test) was observed onl

185 Robust thermal hyperalgesia (tail-flick, TF, and Hargreaves tests) and mechanical all

186 tagonist N-allylnormetazocine (AD(50) in the tail-flick vs morphine assay = 0.3 mg/kg).