ライフサイエンスコーパス: talc

1 by volume of the magnesium silicate mineral, talc.

2 articipants douched and 35%-56% used genital talc.

3 CI, 50 to 199; p = 0.004) were greater after talc.

4 duced more systemic inflammation than graded talc.

5 ant effusions received tetracycline or mixed talc.

6 86 +/- 191 versus 85 +/- 37 microm) than did talc.

7 when compared with intrapleural injection of talc.

8 after, whereas a control group received only talc.

9 nt Effusion Trial [TIME2]) comparing IPC and talc (1:1) for which 106 patients with malignant pleural

10 The higher pressure vapor-absent reaction talc = 10 angstrom phase + enstatite + coesite was also

11 inflammation (change in C-reactive protein, talc 198 SD 79.2 vs. tetracycline 74 SD 79.4 microg/L; d

12 abbits received an intrapleural injection of talc (400 mg/kg) and an intramuscular injection of triam

13 were given TGF-beta(2) (1.7 or 5.0 microg), talc (400 mg/kg), doxycycline (10 mg/kg), or buffer intr

14 g inflammation (change in isotope clearance, talc -9.26, SD 14.3 vs. tetracycline 4.10, SD 13.8 minut

15 The mechanism whereby talc achieves this effect is unknown.

16 Conventional pleurodesing agents such as talc act by inducing pleural injury, which results in ac

17 Talc also enhanced intercellular adhesion molecule-1 (IC

18 In addition, talc and disordered biopyriboles were found replacing en

19 enes), with particular diversity among viral TalC and Hsp20 sequences.

20 ight inducible protein (hli), transaldolase (talC) and ribonucleotide reductase (nrd)--are transcribe

21 y anti-TGF-beta antibody in the TGF-beta(2), talc, and control (buffer and medium) groups.

22 y decreases the inflammatory reaction to the talc, and essentially prevents a pleurodesis from develo

23 Second, 48 patients received mixed or graded talc, and gas exchange was assessed from changes in the

24 of intimate care products, including genital talc, and ovarian cancer.

25 an detect binders and fillers such as chalk, talc, and starch not revealed by traditional chromatogra

26 Talc, as an important class of clay minerals constitutin

27 Our results demonstrated that talc at a therapeutically achievable concentration (6 mi

28 s significant, as the frictional strength of talc at elevated temperatures is sufficiently low to mee

29 uids that migrate up the fault zone, and the talc commonly occurs in sheared serpentinite.

30 a, however, regarding the optimal method for talc delivery, leading to differences in practice and re

31 hermore, monitoring the metallome around the talc deposit regions (characterized by elevated levels o

32 Talc did not induce apoptosis in PMC, and glass beads di

33 he present study was designed to evaluate if talc directly effects cell death of malignant mesothelio

34 Electrophoresis of DNA isolated from talc-exposed MMC demonstrated the typical ladder pattern

35 Three confluent MMC and PMC were exposed to talc for 24, 48, and 72 h.

36 We conclude that the routine use of graded talc for pleurodesis would reduce the morbidity of this

37 p were admitted for chest tube insertion and talc for slurry pleurodesis.

38 experienced adverse events vs 7 of 54 in the talc group (OR, 4.70; 95% CI, 1.75-12.60; P = .002).

39 e in VAS score between the IPC group and the talc group of -14.0 mm (95% CI, -25.2 to -2.8 mm; P = .0

40 Twelve patients (22%) in the talc group required further pleural procedures compared

41 The talc group were admitted for chest tube insertion and ta

42 0-1 day) and 4 days (IQR, 2-6 days) for the talc group, with a difference of -3.5 days (95% CI, -4.8

43 m) and 24.4 mm (95% CI, 19.4-29.4 mm) in the talc group, with a difference of 0.16 mm (95% CI, -6.82

44 The reaction talc + H(2)O = 10 angstrom phase was observed within 20

45 perature synthesis of 10 angstrom phase from talc + H(2)O to be observed in situ in a multianvil appa

46 Here we report the discovery of talc in cuttings of serpentinite collected from the prob

47 estradiol (high E2) before i.p. injection of talc in saline or saline alone.

48 When PMC were challenged with talc in vitro, interleukin-8 (IL-8) and monocyte chemota

49 such as endometriosis or mucosal exposure to talc increase the risk for several types of cancer.

50 Furthermore, E2 suppressed talc-induced expression of JE/MCP-1 mRNA in murine macro

51 Talc-induced maximum apoptosis in MMC (39.50 +/- 2.55%,

52 Patients with mesothelioma who have talc-induced pleurodesis have a lower morbidity than do

53 The present study has demonstrated that talc induces apoptosis in MMC without affecting normal m

54 tion of triamcinolone (0.8 mg/kg) 1 d before talc instillation and weekly thereafter, whereas a contr

55 Pleurodesis with talc is an accepted method for the treatment of symptoma

56 wide variety of sclerosing agents, of which talc is considered to be the most successful.

57 We infer that the talc is forming as a result of the reaction of serpentin

58 The possibility that talc may directly affect malignant cells was not conside

59 Talc may therefore provide the connection between serpen

60 The mechanisms whereby talc mediated these effects were considered to be second

61 c inflammation than tetracycline or "graded" talc (most particles < 10 microm were removed).

62 Calcic amphibole and talc occur in thin (less than 0.3 micrometer) crosscutti

63 c and ultramafic basement which precipitates talc on mixing with seawater.

64 At Day 28, all 10 rabbits that received talc only had a pleurodesis score of 3 or 4, whereas onl

65 At 4 and 24 h, TGF-beta(2), but not talc or doxycycline, induced a significant increase in V

66 at although TGF-beta was more effective than talc or doxycycline, it induced transient production of

67 of TGF-beta(2) than after administration of talc or doxycycline.

68 +/- 0.9 for TGF-beta2 versus 2.4 +/- 0.6 for talc) or at any other time points.

69 red with 3 days (2-5) for those who received talc pleurodesis (p<0.0001).

70 ersus ten (14%) of 73 patients who completed talc pleurodesis (p=0.019), as were respiratory complica

71 s no significant difference between IPCs and talc pleurodesis at relieving patient-reported dyspnea.

72 randomly assigned (1:1) to either VAT-PP or talc pleurodesis by computer-generated random numbers, s

73 Talc pleurodesis failure (24.7%) was associated with gre

74 RAGE is a potential predictive biomarker for talc pleurodesis failure despite inferiority to pleural

75 ancer progression but its role in predicting talc pleurodesis failure is unclear.

76 ural sRAGE had the most predictive value for talc pleurodesis failure, followed by HMGB1 and MMP9.

77 associated with the underlying mechanism for talc pleurodesis failure.

78 ) in the VAT-PP group and 57% (46-66) in the talc pleurodesis group (hazard ratio 1.04 [95% CI 0.76-1

79 of overall survival, and cost, of VAT-PP and talc pleurodesis in patients with malignant pleural meso

80 Talc pleurodesis is a common and effective treatment.

81 n due to malignant pleural mesothelioma, and talc pleurodesis might be preferable considering the few

82 Small-bore-catheter thoracostomy and talc pleurodesis was successful in treating malignant pl

83 We report two trials describing whether talc pleurodesis with a mean particle size of less than

84 ed 196 patients, of whom 175 (88 assigned to talc pleurodesis, 87 assigned to VAT-PP) had confirmed m

85 n of pulmonary oedema, predicting success of talc pleurodesis, asthma exacerbations, detecting chest

86 ficantly more common after VAT-PP than after talc pleurodesis, occurring in 24 (31%) of 78 patients w

87 ant tissue damage and inflammation caused by talc pleurodesis.

88 derwent small-bore-catheter thoracostomy and talc pleurodesis.

89 alc poudrage group (n = 166) received 4 g of talc poudrage during thoracoscopy while under moderate s

90 Patients randomized to the talc poudrage group (n = 166) received 4 g of talc poudr

91 ure rate was 36 of 161 patients (22%) in the talc poudrage group and 38 of 159 (24%) in the talc slur

92 th malignant pleural effusion, thoracoscopic talc poudrage, compared with talc slurry delivered via c

93 article size of less than 15 microm ("mixed" talc) produces more lung and systemic inflammation than

94 ained naturally occurring F(-) ions from the talc raw material and spiked samples containing perfluor

95 shear at depth can become localized along a talc-rich principal-slip surface within serpentinite ent

96 tudied the formation of soapstone (magnesite-talc rock) and other magnesite-bearing assemblages durin

97 dded), mottled deposits containing saponite, talc-saponite, Fe-rich mica (for example, glauconite-non

98 and given either TGF-beta(2) (1.7 microg) or talc slurry (400 mg/kg) via a chest tube.

99 pleurodesis in rabbits at a rate faster than talc slurry and all other pleurodesing agents investigat

100 , thoracoscopic talc poudrage, compared with talc slurry delivered via chest tube, resulted in no sig

101 lc poudrage group and 38 of 159 (24%) in the talc slurry group (adjusted odds ratio, 0.91 [95% CI, 0.

102 TGF-beta2 may have advantages over talc slurry in the management of recurrent pleural effus

103 ing corticosteroids at 6 h through 4 d after talc slurry than in the other groups.

104 followed by administration of 4 g of sterile talc slurry.

105 ucing excess inflammation when compared with talc slurry.

106 jection of 10 mg/kg doxycycline or 400 mg/kg talc slurry.

107 at the use of corticosteroids at the time of talc-slurry pleurodesis markedly decreases the inflammat

108 he concurrent use of steroids at the time of talc-slurry pleurodesis would influence the development

109 osed cases and 10% of unexposed noncases had talc status reassigned.

110 Talc-stimulated PMC culture supernatant showed chemotact

111 ive of this study was to investigate whether talc stimulates pleural mesothelial cells (PMC) to relea

112 The data demonstrate that talc stimulates PMC to release chemokines and express ad

113 bdominal wall tissue showed that five of six talc-treated animals given placebo expressed mRNA for th

114 Conversely, only one of five talc-treated animals that received E2 replacement expres

115 Talc-treated mice receiving low and high E2 replacement

116 65% decrease, respectively) as compared with talc-treated mice receiving placebo pellets.

117 In the first study to examine genital talc use and cervical cancer, we did not see evidence of

118 Data on genital talc use and douching were collected at enrollment and f

119 The association between recent genital talc use and incident cervical cancer was positive, but

120 The relationship between genital talc use and ovarian cancer, in particular, has been wel

121 ot observe an association between adolescent talc use and pre-baseline cervical cancer (HR 0.95, 95%

122 Differential reporting of talc use by cases and noncases likely produces positive

123 sted for exposure misclassification, genital talc use was positively associated with ovarian cancer (

124 ith ovarian cancer, but neither douching nor talc was associated with breast or uterine cancer.

125 experiments, glass beads similar in size to talc were included as control.

126 Here, we report that subducting talc, when exposed to alkaline salty water conditions, b

127 Mixed talc worsened gas exchange (oxygen gradient change, mixe