ライフサイエンスコーパス: target

1 amine pathways are an emerging pharmacologic target.

2 ompounds to the cellular localization of the target.

3 ment and a reduction in motor noise near the target.

4 host macrophages and a potential therapeutic target.

5 ver conjugates that bind to an intracellular target.

6 sporter, PfFNT, as a novel antimalarial drug target.

7 n and identify several potential therapeutic targets.

8 ipate the future location of moving auditory targets.

9 there is limited data to guide therapies and targets.

10 restriction may yield promising therapeutic targets.

11 ases (TRKs) are promising cancer therapeutic targets.

12 required for HIV-1 reactivation as druggable targets.

13 complex natural and unnatural cyclopentanoid targets.

14 h the potential to unravel novel therapeutic targets.

15 pplied to dual-parametric assays for various targets.

16 holographic 3D guidance to assist CT-guided targeting.

17 rotein substrates, often to mediate membrane targeting.

18 A leading vaccine candidate targets 30 of the > 200 emm types of GAS.

19 cells using a focused dual guide RNA library targeting 852 DDR-associated genes.

20 sis of molecular cages with novel topologies targeting a broad range of applications.

21 ging for various intrinsic reasons (e.g. low target accessibility or nature/extent of gene modificati

22 This care should include bone-targeted agents to inhibit tumour-associated osteolysis

23 nvergent adaptations in the primary toxicity target and a major detoxification enzyme.

24 (15) g of black carbon was released from the target and ejected into the atmosphere, where it circula

25 These changes are validated by targeted and global experimental analysis.

26 there is an urgent need for novel bacterial targets and antibiotics with novel modes of action.

27 standard MBT BioTargets and stainless-steel targets and may be used for different MALDI-TOF MS appli

28 Hence, we identify new therapeutic targets and putative therapeutic approaches aimed at res

29 macrophage-specific restriction factor that targets and reduces the expression of HIV Env.

30 Synoptophore cross-in-circle targets and the largest (of right or left) single-Maddox

31 holds great potential to identify novel drug targets and vaccine development.

32 industrially relevant bacteria and achieved target- and species-specific integration in a complex ba

33 tion of complex formation of a BsAb with two target antigens, cluster of differentiation 3 (CD3) and

34 The multi-target approach that is exemplified by these types of st

35 py (RPT) is emerging as a safe and effective targeted approach to treating many types of cancer.

36 The results indicate that 3D printed MALDI targets are comparable to standard MBT BioTargets and st

37 IL6 is targeted as part of treatment in adoptive cell therapy (

38 Endothelial cells and macrophages are likely targets as these cell types highly expressed 15-PGDH.

39 privation treatment and chemotherapy through targeting ASS1- and GLUT1-mediated arginolysis and glyco

40 rovide insights into choosing an appropriate target association.

41 Nevertheless, target associations can be recovered by incorporating (p

42 fMRI activity for valid and invalid trials (target at cued/un-cued location, respectively), pre- or

43 d viral pathogens and provide a new means of targeted attenuation for next-generation rotavirus vacci

44 ne therapy, suggesting an indirect stromally targeted avenue for therapy resensitization.See related

45 test cases, our work demonstrates that drug-target binding is a major predictor of bacterial respons

46 relatively small conformational changes upon target binding.

47 New, fast-acting T2-targeting biologics (already used for preventing asthma

48 gical specimens (3.5%), as compared with MRI-targeted biopsy (8.7%) and systematic biopsy (16.8%).

49 le therapeutics beyond anticoagulants and to target both thrombocytopathy and endotheliopathy.

50 vailable inhibitors of glucose transporters, targeting both GLUT1 and GLUT3.

51 from an interaction with a single essential target but rather from the multilevel control of complex

52 ssion, coupled with the ability to precisely target by genomic editing most areas of the genome, is p

53 To identify the epitopes targeted by clusters of Mtb-specific T cells, we carried

54 ccessible activity profiles and so cannot be targeted by such strategies.

55 We identified cell signaling molecular targets by meta-analysis of microarray data sets.

56 These findings suggest that targeting c-Myc may unlock novel strategies to combat as

57 sumption is an immune evasion mechanism, and targeting cancer methionine signalling may provide an im

58 -shaped target DNA prior to integration (the target capture complex) and two forms of the RAG strand

59 t CD2 costimulation plays a critical role in target cell killing by freshly isolated human CD8(+) T c

60 In the presence of target cell receptors, an immunocomplex was formed betwe

61 , that will allow them to be taken up by the target cells and then released in the appropriate cellul

62 cted killing activity against Env-expressing target cells but began to decline after 3 to 6 weekly do

63 te a novel viral gene expression strategy to target cells with specific miRNA expression using miRNA-

64 athogen-infected or tumorigenic cells (i.e., target cells).

65 l firing, which alters the activity of their target cerebellar nuclei cells.

66 , resembling the recruitment process for the target clinical trial, which then can be used for augmen

67 tion produced SAFs for all source region and target combinations of the 2 International Commission on

68 demonstrate a strategy to tune RNA structure-targeting compounds to the cellular localization of the

69 l to the design and optimization of cysteine-targeted covalent inhibitors.

70 anisms that could be used to therapeutically target COVID-19.

71 s pyogenes Cas9 (SpyCas9), we used both self-targeting CRISPR screening and guilt-by-association geno

72 imicking a "flipped-out" conformation of the target cytosine bypass the SNF2 domain's requirement for

73 We demonstrate the dual-targeted delivery and enhanced therapeutic effect of eHN

74 means because of the difficulty in specific targeting/delivery to the tumor site.

75 gs indicate that public health interventions targeting diabetes prevention and management would be a

76 hat brain stimulation is able to selectively target difficult-to-reach states, potentially aiding pro

77 Observers reported either the target direction (clockwise/counterclockwise from upward

78 omeostasis through its varied secretome that targets distant adipose depots, skeletal muscle, and the

79 AG engaged with transposon ends and U-shaped target DNA prior to integration (the target capture comp

80 family of DPC-specific proteases Wss1/SPRTN targets DPC protein moieties for degradation, including

81 and confirm rescue by low temperature, CFTR-targeting drugs and second-site revertant mutation R1070

82 -organism physiology and function due to off-target effects.

83 EVM proved to be a promising tool for targeted EMB because of its sensitivity and specificity

84 nd EGFR and new opportunities to effectively target endocan-EGFR regulatory axis in patients with TKI

85 2AA accumulation inhibits target enzymes with a detrimental impact on fitness.

86 The human pathogen Chlamydia trachomatis targets epithelial cells lining the genital mucosa.

87 They target eukaryotic cells using different mechanisms, but

88 We found that the target evoked N2pc onset ~20 ms earlier when the target

89 Mechanistically, targeting EZH2 promotes transition from H3K27me3 to H3K2

90 Subcellularly targeted fluorescence resonance energy transfer sensors

91 Targeting Fn-EDA in human aortic SMCs suppressed the syn

92 FAS is an attractive target for antibiotics and many inhibitors are in clinic

93 Thus, ATR is a major target for cancer therapies in homologous recombination-

94 his enzyme has also emerged as a therapeutic target for cardiovascular disease due to its ability to

95 The brain is a critical target for developmental endocrine disruption, resulting

96 ould represent a novel potential therapeutic target for DS.

97 (GPCR) considered as a promising therapeutic target for neuropsychiatric disorders; its pharmacology,

98 n loops that has not previously emerged as a target for neutralizing antibodies.

99 deling of NAc D1-MSNs and may prove a useful target for new depression therapeutics.

100 lls, identifying them as a novel therapeutic target for obesity-related asthma, a disease that is sub

101 mation, suggesting PP(i) metabolism may be a target for periodontal regenerative therapies.

102 ion and could offer a potential prophylactic target for reducing flavivirus transmission.

103 rface height can be adopted as a pre-grazing target for rotational stocking systems to optimize sheep

104 priate antimicrobial therapy is an important target for stewardship intervention.

105 clock itself has the potential for use as a target for the treatment of NAFLD.

106 somatic genomic alterations and are thus key targets for cancer chemoprevention.

107 lties in choosing the correct combination of targets for engineering increased fruit yield.

108 miR-125a-5p and L-plastin may be relevant targets for increasing in vitro platelet manufacturing a

109 lerosis, new exciting concepts and potential targets for intervention are emerging.

110 tified abundant inflammatory and immunologic targets for miR-17 and miR-548b that are known mediators

111 -independent markers of risk and even future targets for optimizing cardiovascular health.

112 biantennary galactose could represent novel targets for selective manipulation of CD11b function and

113 ino acids from human hemoglobin and are drug targets for the design of novel antimalarial agents.

114 This provides potential therapeutic targets for the treatment of EBV-associated cancers.

115 lts provide novel behavioral and brain-based targets for treatment of pediatric anxiety disorders.

116 Our results demonstrate that targeting FPR1 by a selective small molecule antagonist,

117 Through this polar DprA targeting function, sigma(X) mediates the timely shut-of

118 on muscle biopsies, while our two late DUX4 target gene expression biomarkers associate with macrosc

119 Accordingly, ChREBP target gene expression was rescued by re-expressing WT b

120 ressed elevated levels of WNT16, a NF-kappaB target gene.

121 Spatiotemporally regulated targeted gene manipulation is a common way to study the

122 ation of estrogen receptor (ESR1/ER) and its target genes (PGR, KRT8/CK8, BCL2), which are all lumina

123 ted epigenetic marks were identified near RA target genes already known to be required for body axis

124 We also discovered that formative TF target genes are marked by permissive epigenomic signatu

125 nscriptional alterations of steroid-specific target genes at 96 and 120 h post fertilization.

126 l data suggests that CALCOCO1 and ZC3H10 are target genes repressed by the HOTAIR regulatory element

127 our approach; plus, many other candidate RA target genes were found.

128 enetic variants, relevant cell types/states, target genes, and mechanisms by which variants can cause

129 actions and mRNA abundance associations with target genes, and were enriched in motif-rewiring mutati

130 among transcription factors (TFs) and their target genes, with a method able to handle both the high

131 EZH2-mediated repression of Snail epithelial target genes.

132 and functions in repression of specific HSF1 target genes.

133 tion and degradation, thereby regulating MYC target genes.

134 Indeed, targeting glutamine metabolism rendered checkpoint block

135 potency of antibodies and microbicides that target glycans on the envelope glycoproteins (Envs) of H

136 severely limit the therapeutic potential of targeting Grb14.

137 ons were 64 mg/dL (1.64 mmol/L) in the lower-target group and 106 mg/dL (2.72 mmol/L) in the higher-t

138 up and 106 mg/dL (2.72 mmol/L) in the higher-target group.

139 dicated shared features between the CHD8 and target groups that included less severe adaptive deficit

140 Targeting H(2)S to the mitochondria may be of therapeuti

141 engineered microenvironments and phagocytic targets have demonstrated how altering the actomyosin cy

142 olecules that covalently bind macromolecular targets have found widespread applications as activity-b

143 S are first applied to three different gRNAs targeting HEK293 genomic DNA, resulting in a set of 55 h

144 the role of awake consolidation processes by targeting hippocampal interactions with lateral occipita

145 cted a reward structure (ratio of points for target hits and misses) for different exploitation horiz

146 gricultural sectors achieve income gains for targeted households, but knock-on effects lead to increa

147 to apply chemoproteomic methods to assist in target identification of antimalarial drugs and highligh

148 chemical evidence that Gna1 is an antifungal target in A. fumigatus.

149 correlative networks that may eventually be targeted in a personalized approach of chronic low-grade

150 aloging and appraisal of the T-cell epitopes targeted in type 1 diabetes was completed over a decade

151 th the value-driven and physical salience of targets in a visual search task while recording response

152 point oncogenic driver genes and therapeutic targets in cancer genomes.

153 e human Y(1) receptor (hY(1)R) are promising targets in cancer therapy due to their high overexpressi

154 ue penetrant, hindering efforts to visualize targets in deep tissues.

155 pharmacological content, including molecular targets in the malaria parasite, interaction data for li

156 iple G protein-coupled receptors (GPCRs) are targets in the treatment of dementia, and the arrestins

157 s by downregulating RSK1 and MSK2 downstream targets, including CREB and ATF1.

158 Because of the low sensitivity, targeting individuals in non-help-seeking samples based

159 Importantly, the complexity of molecular target interactions, such as protein-protein interaction

160 One of the direct SARRAH targets is NRF2, and restoration of NRF2 levels after SA

161 d that SCF(FBXW7) interacts with HsSAS-6 and targets it for ubiquitin-mediated degradation.

162 ingle residue is necessary and sufficient to target Katanin for proteasomal degradation after meiosis

163 s in transgenic Populus trichocarpa based on targeted knockdowns of specific monolignol genes.

164 tural approach to inform clinical efforts in targeting KRAS-G12D tumors by immunotherapy and has gene

165 et evoked N2pc onset ~20 ms earlier when the target location was cued than when it was not cued.

166 ffloading opportunity: an option to mark the target locations with tokens during the hiding period.

167 o suggest that pharmacological interventions targeting lysosomal function in general, and those parti

168 the current status of potential therapies to target macrophage metabolism during heart failure, inclu

169 cally ineffective, and multi-modal therapies targeting mechanisms of immunotherapy resistance are lik

170 is approach, we find that cholesterol in the target membrane enhances the efficiency of single-partic

171 Selectively targeting memory Th17 cells may be a viable therapeutic

172 We used amplicon targeted metagenomics to compare microbial communities f

173 rch, particularly involved in drug discovery targeting metalloenzymes.

174 nd density functional theory (DFT) modeling, targeting methanol formation from CO(2)/H(2) feeds at 17

175 care, the intervention group used devices to target mobility and physical activity problems, individu

176 s specific effect of lithium suggests that a targeted modulation of reward learning may be a viable a

177 ar signaling between sensory neurons and non-target motor neurons.

178 Finally, we show that LukE targets murine Darc through DR1 in vivo to cause host le

179 umber and Vegf-A expression increased in end target muscles after nerve injury and repair.

180 in (94.2%), with little to no unintended off-target mutations detected.

181 Here, a novel method for targeted near-infrared (NIR) fluorescence imaging of glu

182 on of ACh and GABA based on the postsynaptic target neuron is reflected in VIP(+)/ChAT(+) interneuron

183 This study may boost the use of non-targeted NMR methods for food control.

184 nding domain (RBD) is immunodominant and the target of 90% of the neutralizing activity present in SA

185 showed that HMGA2 is a potential therapeutic target of anticancer and anti-obesity drugs by inhibitin

186 brain's endocannabinoid system, the primary target of cannabis, has been implicated in psychosis.

187 As such, readmission after AMI has been a target of financial penalties through Medicare.

188 Melanocytes are the target of immune destruction in vitiligo and are hypothe

189 eletal SCAR/WAVE complex, a major downstream target of RAC1, in a mouse model of melanoma driven by B

190 ty and expression, and propose the mammalian target of rapamycin (mTOR) signaling pathway as a candid

191 phisticated features optimised for precision-targeting of a wide range of cancers.

192 Cas9/CRISPR-based system that allows ectopic targeting of Ctf19c-subunits.

193 posit that these advances in pharmacological targeting of DUBs establish the enzyme family as targeta

194 lla pneumophila infection blocked xenophagic targeting of L. monocytogenes by a RavZ-dependent mechan

195 h others in preclinical development, and the targeting of Na(V)1.9, although hampered by technical co

196 generating chemical diversity for allosteric targeting of RORgammat.

197 ulations and studies in cells reveal that LD targeting of these motifs requires deeply inserted trypt

198 t of peptidoglycan substrates on beta-lactam targeting of transpeptidation, and (d) demonstrate that

199 ine biosynthesis enzymes represent potential targets of antifungal drugs.

200 le hair cells in the cochlea are established targets of cisplatin, less is known regarding the affere

201 n carbohydrate metabolism as transcriptional targets of CRZ1/GnRHL1 signaling.

202 In both species, predicted gene targets of differentially expressed miRNAs are involved

203 receptor B-expressing (CCKBR-expressing) VMN targets of glucose-elevating parabrachial nucleus neuron

204 e molecular mechanisms and novel therapeutic targets of late-onset Alzheimer's Disease (LOAD), we per

205 heightened density of NMDARs, which are the targets of novel rapid-acting antidepressants.

206 for PAD enzymes in RA as both promoters and targets of the autoimmune response, as well as discussin

207 HIV care will be required to reach national targets of the ending the HIV epidemic initiative by 203

208 f novel inhibitors for many distinct protein targets of therapeutic value.

209 adely propagating signals along axons to the targets of those axons.

210 A multiplex allele-specific PCR targeting outbreak-specific single nucleotide polymorphi

211 he history was atypical for genes within the targeted panel.

212 d a lack of guidelines addressing the use of targeted panels versus whole-exome sequencing (WES).

213 result was pound 568.37 and pound 292.84 for targeted PCR, equating to pound 4041.76 and pound 1506.0

214 a prostate-specific membrane antigen (PSMA)-targeted PET agent, in patients with biochemically relap

215 e To determine whether imaging with the HER2-targeted PET tracer zirconium 89 ((89)Zr)-pertuzumab can

216 Enterococcus faecalis, conjugation of a Cas9-targeted plasmid was enhanced by anti-CRISPRs derived fr

217 s and highlight the potential to selectively target Plasmodium TRiC-mediated protein folding for mala

218 immune disease caused by autoantibodies that target postsynaptic proteins, primarily the acetylcholin

219 Routine environmental monitoring programs target predetermined compounds that do not reflect the c

220 s combinatorial study of multiple transgenes targeting primary metabolism thus offers opportunities t

221 inhibitors for the protein methyltransferase target PRMT5.

222 cal cross-linking and isolation by pull-down target profiling, and to rescue disease-relevant splicin

223 s spectrometry (MS) involve the digestion of target protein and employ isotope-labeled peptide intern

224 strates that in trans paired nicking retains target protein dosages in gene-edited cell populations a

225 alyze posttranslational modification of many target proteins and have been suggested to play a role i

226 In this context of targeted proteolysis research spurring the emergence of

227 such as gastrin-releasing peptide receptors targeting radiopharmaceuticals are small molecules with

228 Avr2 also targets Rcr3 paralog Pip1, which is not required for Avr

229 neric output sequences, which allows for the target recognition and signal generation regions to be d

230 hod to focus immune responses to the desired target region, in the absence of immune interference by

231 ective pathways were identified as potential targets regulated by miRNAs.

232 Small-molecule targeted RNA degradation will thus provide a general rou

233 the brush border using a noncanonical apical targeting sequence that maps to a previously unannotated

234 Development of small molecule compounds that target several cancer drivers has shown great therapeuti

235 bitor of SHP2 with drug-like properties, and targeting SHP2 may serve as a therapeutic strategy to ov

236 phils and mast cells in asthmatic sputum and targeting Siglec-8 with an antibody is a plausible strat

237 rescent secretory cargo by adding a vacuolar targeting signal.

238 yed by CYP2J2 in cardiac cells, we performed targeted silencing of CYP2J2 expression in human adult v

239 ransfer complex that differ based on whether target site DNA is annealed or dynamic.

240 m Cordoba province was mainly due to a P106S target-site mutation in the 5-enolpyruvylshikimate 3-pho

241 Both target-site resistance (TSR) and nontarget-site resistan

242 provide optimal muscle relaxation; however, targeting skeletal myosin is particularly challenging be

243 the fourfold junctions, the bimeron and the target skyrmion.

244 t sensitive to the diverse range of relevant target species.

245 r findings suggest that health interventions targeting specific multimorbidity patterns may reduce mo

246 tion of the plasma membrane once the peptide targets specific phospholipids found on the cytosolic si

247 their effects on the processing of separate target stimuli presented at different time lags.

248 and enable improved application of treat-to-target strategies.

249 y, we examine the field's success to date in targeting stressors and stress allostasis in treatments

250 en successfully applied to a large number of target structures, but requires excess quantities of sui

251 ters HuR cytosolic shuttling, regulating HuR targets such as p53, p27, Caspase-9, and BCL2.

252 Taken together, these data suggest that targeted suppression of IL17RA is a promising new topica

253 ntibodies and can be employed to achieve the targeted synthesis of clinically-relevant molecules in t

254 The compounds are shown to directly target tau pre-mRNA in cells, via chemical cross-linking

255 matologic disease entities, show that common targets (TE) activated by the same drug (5-azacytidine)

256 Targeted temperature management in comatose survivors of

257 multicomponent fluorescence lifetime imaging targets that require cellular resolution and molecular s

258 RBPs identifies thousands of endogenous mRNA targets that respond to changes in RBP level, recapitula

259 ay detected 312 (92%) of the 338 respiratory targets that were detected by the ePlex RPP assay.

260 tion of the circadian system with drugs that target the clock, and that a dysfunctional clock ablates

261 We aimed to target the consistency of healthy cervix shear wave elas

262 and broadly reactive influenza vaccines that target the HA protein have suffered resistance due to de

263 Ablation targeted the neuromiocardial interface by fragmentation

264 All patients (100%) received prior ICIs targeting the PD-1 pathway.

265 In conclusion, although targeting the PD-1/PD-L1 pathway reinvigorates exhausted

266 s potential to achieve high selectivity when targeting the peptide substrate binding site of NTMT1/2.

267 tion, suppression of callose deposition, and targeting the plant defense regulator NPR1 and analyses

268 Antibodies targeting the RSV G central conserved domain are protect

269 nical disease models (e.g. stroke), vascular-targeted therapeutics, and hemodynamic data from other i

270 ecific gene expression facilitates efficient targeted therapies and treatment strategies.

271 re, we show that melanoma cells can adapt to targeted therapies through a mechanosignaling loop invol

272 nding of disease pathogenesis and ultimately targeted therapies.

273 amenable to clinical testing using available targeted therapies.

274 is no Food and Drug Administration-approved targeted therapy for advanced MCC.

275 anoma tumour growth and sensitize tumours to targeted therapy via epigenetic reprogramming.

276 -cycling state following stress (DNA damage, targeted therapy, and aging).

277 uating potential resistance mechanisms to AR-targeted therapy.

278 To better target these viruses, we examined key aspects of the vir

279 Whether therapies targeting these mutations can eradicate premalignant cel

280 enoprotective agents did not therapeutically target this elevation.

281 ity is frequently deregulated in disease and targeting this class of proteins is a major focus of int

282 isms by which these immune cells converge on target tissues, interact with fibroblasts and promote ti

283 ressed ubiquitously in the body, i.e. in non-target tissues.

284 of new pharmacologic agents that exploit or target TMPRSS6 to treat anemias and iron-related disease

285 atment, NF-kappaB can be used as a potential target to increase the treatment's outcomes.

286 suggest that IL-27 represents a therapeutic target to limit susceptibility and improve infectious ou

287 ion of the catalytic domain of TET1 to dCas9 targeted to the CDKL5 promoter using three guide RNAs ca

288 l terminals when ChR2 expression was virally targeted to the intralaminar thalamus.

289 on, is also necessary and sufficient for its targeting to the ciliary base.

290 Global conservation targets to reverse biodiversity declines and halt specie

291 tibody-Drug Conjugates (ADCs) developed as a targeted treatment approach to deliver toxins directly t

292 drawbacks can be circumvented by CAR-T cells targeting tumour-specific driver gene mutations, such as

293 biosensor enables detection of nucleic acid targets using a smartphone coupled to an appropriate opt

294 clobetasol as an important chemical tool for target validation.

295 predicted by an empirical model, agree with target values within a given level of uncertainty.

296 oach for drug delivery, bioimaging, and cell targeting was also demonstrated.

297 evidence that drives individualized HbA(1c) targets, we examine the limitations of HbA(1c), and we c

298 equivalent (P > 0.48) to bulk stool for all targets when 50 mul of FecalSwab specimen was loaded ont

299 coring approaches on the CAPRI score set (13 targets) when compared with the 37 scoring groups in CAP

300 3D Bezier curve to the basal section of each target whisker.