ライフサイエンスコーパス: target gene

1 e RING finger 1 (MuRF1), a proatrophic FOXO1 target gene.

2 that PARG is a direct androgen receptor (AR) target gene.

3 es we then infer the Boolean function of the target gene.

4 equences did not affect transcription of the target gene.

5 ressed elevated levels of WNT16, a NF-kappaB target gene.

6 anscription initiation and elongation of its target genes.

7 ve selection of cCREs potentially regulating target genes.

8 ced MYC protein expression and regulated MYC target genes.

9 expression and epigenetic regulation of its target genes.

10 tion and degradation, thereby regulating MYC target genes.

11 us, indicating their interplay in regulating target genes.

12 ng transcriptional activation of a myriad of target genes.

13 blocking IL-17A and global inhibition of its target genes.

14 , miR-1 levels correlated inversely with its target genes.

15 between CDKN2A expression and PPARA and its target genes.

16 via regulating expression of candidate PrCa target genes.

17 nts that activate the transcription of their target genes.

18 binding and expression of a subset of Foxp3 target genes.

19 guide RNA to display synthetic molecules on target genes.

20 ity to induce the expression of TAZ-specific target genes.

21 tion factors, associated proteins, and their target genes.

22 regulator, which activates transcription of target genes.

23 on and the subsequent expression of IFNgamma target genes.

24 al schizophrenia risk variants and their cis-target genes.

25 h direct transcriptional control of effector target genes.

26 en validated and confidently linked to their target genes.

27 sion by negatively regulating translation of target genes.

28 isorders allows correlation to unanticipated target genes.

29 ationships between transcription factors and target genes.

30 NF-kB strongly limits the expression of its target genes.

31 cidate the tissue-specific role of candidate target genes.

32 -MAGMA identified neurobiologically relevant target genes.

33 elements (cCREs) and linked them to putative target genes.

34 scertain direct and indirect responsive ABI3 target genes.

35 alization of TFEB with Mediator and mRNAs of target genes.

36 in vivo and decreased the expression of Wnt target genes.

37 8 inhibited p53 DNA binding and induction of target genes.

38 ver-represented among the highest-confidence target genes.

39 odulates its ability to regulate a subset of target genes.

40 ucleus ("localization-resets") activates YAP target genes.

41 d decreases the expression of downstream Wnt target genes.

42 nation, potently attenuating the activity of target genes.

43 e-able reads to enable detection of specific target genes.

44 tinoic acid (RA)-induced enhancers and their target genes.

45 ned by transcription factors (TFs) and their target genes.

46 of ATF4, CHOP, and XBP-1 and upregulates UPR target genes.

47 ing RNAs which each cause repression of many target genes.

48 igenetically repressing the transcription of target genes.

49 sparse network of functional CRMs regulating target genes.

50 sponse elements to regulate transcription of target genes.

51 ween the transcription factors (TFs) and the target genes.

52 enin levels and expression of its downstream target genes.

53 regulator of peripheral myelination, to its target genes.

54 3K14ac levels in their 5' and 3' ends of its target genes.

55 negatively regulate the expressions of PIF1 target genes.

56 through the regulation of a large network of target genes.

57 that eRNAs can be used to identify putative target genes.

58 EZH2-mediated repression of Snail epithelial target genes.

59 EZH2 to antagonize EZH2-mediated effects at target genes.

60 and functions in repression of specific HSF1 target genes.

61 thylation to mediate epigenetic silencing of target genes.

62 une the splicing patterns of many downstream target genes.

63 nce of LDs results in hyperactivation of MLX target genes.

64 nal neurons by influencing the expression of target genes.

65 ctivators to initiate transcription of their target genes.

66 and crypt were found to express Vdr and VDR target genes.

67 decline in the expression of c-Myc-activated target genes.

68 vely, with heterogeneous distribution across targeted genes.

69 How a common BMP signal regulates diverse target genes across many neuronal subsets remains largel

70 cant RUNX1 requirement for E2A-PBX1-mediated target gene activation and leukemogenesis.

71 vivo, and allows time-resolved monitoring of target gene activation and transcriptome reorganization.

72 nin protein levels and decreased betacatenin target gene activation, suggesting IPO11 facilitates bet

73 ng region of the genome and therefore, their target genes, affected cell types and regulatory mechani

74 The level of knockdown of two target genes, alpha-tubulin and mitochondrial RNA polyme

75 ted epigenetic marks were identified near RA target genes already known to be required for body axis

76 All clusters expressed the YAP1 target gene and mesothelial progenitor marker mesothelin

77 Our study identified msmb3 as an Ets1 target gene and uncovered its function in maintaining ne

78 negatively-regulated androgen receptor (AR) target gene and, therefore, may promote PCa cell surviva

79 L containing Pol III complexes bind the same target genes and assume the same functions both in vitro

80 EBV latency by driving the transcription of target genes and by interacting with the EBV lytic origi

81 nal CRISPR mutagenesis is robust across many target genes and can be efficiently employed in various

82 e ciprofloxacin-resistance mutations in drug target genes and confirmed drug resistance.

83 is known about how enhancers regulate their target genes and how enhancers and promoters communicate

84 /NuRD complex from the promoter of NF-kappaB target genes and IKK2-dependent positive regulation of M

85 ional role of Nup93 in silencing of Polycomb target genes and in spatial folding of Polycomb domains.

86 ion was associated with amplification of Myc target genes and increased expression of canonical Wnt s

87 ic acid altered the expression of PPAR-gamma target genes and increased PPAR-gamma DNA-binding activi

88 cetylation maintains the activation of Sox10 target genes and increases PNS and CNS remyelination eff

89 ake demonstrated higher transcription of AhR target genes and lower transcription of pathways implica

90 we report that mcrA is one of the VosA-VelB target genes and McrA governs the cellular and metabolic

91 novel mechanism for the transcription of Wnt target genes and regulation of tumorigenesis, with impor

92 h we identified critical microRNAs (miRNAs), target genes and regulatory motifs (miRNA-TF-gene) relat

93 r required for the recruitment of MYC to its target genes and reported the first small molecule inhib

94 s) link transcription factors (TFs) to their target genes and represent maps of potential transcripti

95 SPO2-RA in mice specifically upregulated Wnt target genes and stimulated cell proliferation in liver

96 C-miR146a inhibited expression of NF-kappaB target genes and thereby thwarted progression of dissemi

97 Thus, Arrdc3 is an insulin target gene, and ARRDC3 protein directly interacts with

98 TBXT was a KDM6A/B target gene, and chromatin changes at TBXT following KDO

99 and up-regulation of Axin2, a canonical Wnt target gene, and SRY-box transcription factor 9, a marke

100 We identified 594 miRNAs, 2197 miRNA-target genes, and 3730 repeat-associated siRNAs (mostly

101 s of expression quantitative trait loci with target genes, and confirm assigned genes or show complex

102 ensitive transcription factor functionality, target genes, and epigenetic states.

103 enetic variants, relevant cell types/states, target genes, and mechanisms by which variants can cause

104 tined branch requires induction of IRF4, MYC-target genes, and oxidative phosphorylation, with the lo

105 actions and mRNA abundance associations with target genes, and were enriched in motif-rewiring mutati

106 that drive epigenetic silencing of AP-2gamma target genes are a critical area for further research.

107 We established that Cic target genes are activated before significant downregula

108 Downstream target genes are also predicted and analyzed in the cont

109 We find that GFI1-target genes are altered sequentially, as cells go throu

110 Finally, the Boolean functions of all target genes are combined as a Boolean network.

111 ealed that 17 miRNAs and their 198 predicted target genes are differentially expressed, where the tar

112 Here, we showed HIF-1alpha target genes are enriched in TP53-mutated versus TP53-wi

113 PHF19 target genes are involved in proliferation, differentiat

114 We also discovered that formative TF target genes are marked by permissive epigenomic signatu

115 Our analyses revealed that naive TF target genes are more likely to be TFs themselves than t

116 Target genes are the porcine mitochondrial ND2 and equin

117 , BP-3 and PP had limited transactivation of target genes at 1 muM and 5 muM concentrations.

118 comprehensive resource to identify candidate target genes at 139 independent breast cancer risk signa

119 nscriptional alterations of steroid-specific target genes at 96 and 120 h post fertilization.

120 cilitated a cell-type-specific activation of target genes at high levels without exogenous enhancer e

121 We find that PRC2.2 occupies polycomb target genes at low levels and that homeobox transcripti

122 The canonical Wnt target gene, Axin2, is also a direct transcriptional tar

123 ese experiments identified 200 potential ANT target genes based on their proximity to ANT binding sit

124 pression and reduced expression of the Bcl-6 target gene Bcl2.

125 ptional activation by ORE1 of its downstream target gene BIFUNCTIONAL NUCLEASE1 (BFN1).

126 uld suppress the expression of its predicted target genes (BMP2, FGF9, PAX9 and PDGFRA).

127 only accounts for cis- and trans-eQTL of the target gene but also enables efficient computation by us

128 Min/+) mice and suppressed expression of Wnt target genes but increased phosphorylation of SMAD2 and

129 -associated GLI repression complex regulates target genes by altering the acetylation status at enhan

130 AML1-ETO represses transcription of RUNX1 target genes by competitively displacing RUNX1 and recru

131 , then define lncRNA's function and specific target genes by integrating its correlated biological pa

132 CEMs) designed to activate the expression of target genes by recruiting components of the endogenous

133 Transcription factors (TFs) regulate target genes by specific interactions with DNA sequences

134 cumulation of yes-associated protein and its target gene c-Myc.

135 One of the Foxf2 target genes, Chst2, encodes a carbohydrate sulfotransfe

136 Our approach provides deep coverage of the target gene cluster, facilitating reassembly.

137 sphingosine kinase 1 (SPHK1) as a key SFMBT1 target gene contributing to its oncogenic phenotype.

138 ely clustered in genomic regions upstream of target genes, defining cis-regulatory modules that are e

139 Through targeted gene deletion and functional complementation in

140 Targeted gene deletion confirmed that (i) genes encoding

141 can induce and repress its transcription of target genes directly and some intriguing differences ex

142 ubstantial advances in developing random and targeted gene disruption methods to investigate the func

143 emory CD8 T cells using CRISPR/Cas9-mediated targeted gene disruption under the aegis of p53siRNA in

144 binding sites in the promoters of PIF Direct Target Genes (DTGs).

145 h controls a wide range of oxygen responsive target genes (eg, EPO and VEGF), certain members of the

146 Locus-specific interrogation of target genes employing functional probes such as protein

147 sregulation occurs in FSHD muscle, with DUX4 target genes enriched for those associated with inflamma

148 nscriptional dysregulation, with derepressed target gene enrichment limited to circadian processes.

149 iogenesis, and MDM2 was identified among its target genes, establishing an miR-30e-3p/TP53/MDM2 feedf

150 g, leading to constitutively elevated B2 RNA target gene expression and high Trp53 levels.

151 epressors to enhancers significantly reduces target gene expression and reduces PEL cell growth.

152 Moreover, we show that three validated DUX4 target gene expression biomarkers are not associated wit

153 on muscle biopsies, while our two late DUX4 target gene expression biomarkers associate with macrosc

154 Cell viability was determined, and target gene expression changes were evaluated by quantit

155 served lipid signaling to HIF and changes in target gene expression in developing zebrafish and adult

156 activation of both these genes, and reduced target gene expression is accompanied by a decrease in H

157 ncover a novel epigenetic basis by which HIF target gene expression is amplified in kidney cancer and

158 t to detect in FSHD muscle cells, while DUX4 target gene expression is an inconsistent biomarker for

159 ntial mechanism to synchronize the phases of target gene expression regulated by the same deadenylase

160 ibute to phenotypic variation by influencing target gene expression through chromatin loops.

161 R performance in honey bees as queens induce target gene expression to levels comparable to those ind

162 he intersection of two promoter/enhancers to target gene expression to precise cell types.

163 Accordingly, ChREBP target gene expression was rescued by re-expressing WT b

164 Here, by studying E2FB-RBR interaction, E2F target gene expression, and epidermal cell number and sh

165 sed probability of primed cells to engage in target gene expression, correlating with the strength of

166 1300 CRM TF-binding variants associated with target gene expression, the majority of them undetected

167 inoblastoma tumor suppressor or activate E2F target gene expression.

168 CREB-responsive gene and activation of CREB target gene expression.

169 is associated with a selective effect on MYC target gene expression.

170 biomarker of FSHD status compared with DUX4 target gene expression.

171 or BMPR2 and facilitates SMAD activation and target gene expression.

172 olar apparent IC(50) values, and reduce TEAD target gene expression.

173 onstrated enhanced DNA binding and increased target gene expression.

174 molecules that regulate post-transcriptional target gene expression.

175 n are more likely associated with changes in target gene expression.

176 l widening that correlates with increased HH target gene expression.

177 Targeted gene expression (GE) profiling of 184 genes usi

178 transcription factor and its transcriptional target gene FLT3 being the most pronounced.

179 rely described RNA-binding protein, as a new target gene for oncogenic miR-106b, which was identified

180 rvationists and others to identify promising target genes for crop improvement, parasite/pest control

181 y KLF-family transcription factors as direct target genes for miR-9/9(*)-124 and show their repressio

182 The target genes for these regulators include fibroblast gro

183 It functions by disrupting a target gene, forming recessive lethal alleles, while res

184 s, yet a major challenge lies in identifying target genes from functional binding sites and reconstru

185 s gene expression is important for inferring target genes from TF chromatin immunoprecipitation follo

186 gene, integrating in a manner that preserves target gene function.

187 NUT1 downstream target genes function in cell wall biosynthesis, apoptos

188 d and the number of experimentally validated target genes has increased considerably.

189 OTAIR to recruit EZH2 on specific epithelial target genes (i.e., HNF4alpha, E-cadherin, and HNF1alpha

190 d reverse genetic analyses of homologous NS1 target genes in Arabidopsis, reveal that NS1 controls me

191 al question, given the dysregulation of HSF1 target genes in both cancer and neurodegeneration.

192 Physiological YAP target genes in cartilage include Ctgf, Cyr61 and severa

193 TAK1 blockade upregulated expression of p53 target genes in cell lines carrying wild type (wt) TP53

194 etects the tissue-specific role of candidate target genes in complex traits.

195 , can contribute to the specification of BMP target genes in efferent neuron subsets.

196 suppressed the expression of multiple Notch1 target genes in hepatic vasculature, suggesting constitu

197 ism of Pax8-mediated activation of potential target genes in inner medullary collecting duct cells.

198 ependently upregulates the expression of AhR target genes in M-MO and that the 5-HT-mediated activati

199 icient to induce activation of canonical p53 target genes in NEFs.

200 alidate these predictions for a selection of target genes in PAECs stimulated with TGF-beta, VEGF or

201 ions between transcription factors and their target genes in pathogenic Escherichia coli and Salmonel

202 sms by acquiring the ability to activate SHH target genes in response to TGF-beta.

203 s bound by regulatory proteins, can activate target genes in response to these external signals.

204 accumulate in the nucleus and activate their target genes in response to uniaxial cyclic stretch.

205 ic memory underlying the deregulation of key target genes in T2D-PTECs that may contribute to sustain

206 transcription factor locus derived from ZIC target genes in the mouse genome.

207 have made it possible to directly modify the target genes in their native chromosomal locations, clas

208 Because NF-kappaB target genes include the STAT3-activating IL-6 family cy

209 twork as indicated by its binding to several target genes including transcription factors in rice.

210 oting beta-catenin-mediated transcription of target genes, including Myc.

211 ed SULF2-mediated induction of several STAT3 target genes, including suppressor of cytokine signaling

212 ering ATF7 activity and H3K9me2 abundance on target genes, including tRNA loci.

213 (IRF-7) is a transcription factor with many target genes, including type I interferons (IFNs).

214 xes, and is enriched at the promoters of HIF target genes, including vascular endothelial growth fact

215 g AhR nuclear localization, XRE binding, and target gene induction mediated by AhR agonists like 2,3,

216 These results demonstrate targeted gene insertion of marker-free DNA in rice using

217 uorescent imaging to screen an siRNA library targeting genes involved in cellular trafficking network

218 studied, how the Polycomb system selects its target genes is poorly understood, and whether its histo

219 Live-cell imaging coupled with targeted gene knockouts and a high-throughput RNAi assay

220 In contrast, spatial differences between BMP target genes largely collapsed when FGF and Nodal signal

221 for coronary artery disease in RA signaling target gene loci and correlation between coronary artery

222 Spatiotemporally regulated targeted gene manipulation is a common way to study the

223 ntial regulation of different subsets of p53 target genes may involve posttranslational modifications

224 Genomic information including target genes, nearby genes, nearest transcription start

225 9e-5p, resulting in the de-repression of its target gene Notch2 which is well known as an oncogene.

226 and chromatin conformation data to identify target genes of a panel of TFs.

227 The shared genes included target genes of existing antituberculous drugs including

228 is of Hnf4a mutant kidneys identified direct target genes of Hnf4a.

229 To define the physiological function and target genes of such REs, we deleted the orthologue of a

230 KLF9 and KLF6, and regulates a common set of target genes of these transcription factors.

231 ntially expressed miRNA and their regulatory target genes on prostate tumour development and progress

232 may drive pathology by direct activation of target genes or through inhibition of the homologous tra

233 ding to communal regulatory sequences of the target genes, or a combination of the aforementioned two

234 ation of estrogen receptor (ESR1/ER) and its target genes (PGR, KRT8/CK8, BCL2), which are all lumina

235 osite genomic signatures, and their putative target genes play an important role regulating SMC pheno

236 Moreover, LXR target gene products facilitated the efflux of lipid and

237 protein complex with PPM1G and NF-kappaB at target gene promoters in a stimuli-dependent manner to p

238 cells under normoxia, CHD4 enrichment at HIF target gene promoters increased RNA polymerase II loadin

239 -environments wherein clustered RFs activate target genes, providing a structural framework for relat

240 Varying levels of miR172 and/or its target gene Q (AP2L5) result in gradual transitions of g

241 (GO) enrichment analysis of salt responsive target genes related to top five selected lncRNAs showed

242 the users can search enhancers and enhancer-target gene relationships through five user-friendly, in

243 l data suggests that CALCOCO1 and ZC3H10 are target genes repressed by the HOTAIR regulatory element

244 However, the authors did not consider PAX7 target gene repression as a marker of FSHD progression.

245 We further confirm that PAX7 target gene repression associates with clinical correlat

246 We demonstrated that PAX7 target gene repression is a superior biomarker of FSHD s

247 Thus, PAX7 target gene repression is a uniquely sensitive biomarker

248 We systematically identified target genes responding to BMP and found that they have

249 pped region led to the identification of the target gene responsible for the diminutive mutant, a gen

250 portunity to pinpoint crucial regulators and target genes responsible for complex diseases.

251 the aptazyme, inserted in the 3' UTR of the target gene, resulted in rapid self-cleavage and subsequ

252 h downregulation of Col2a1 and Wnt signaling target genes, results in decreased proliferation and alt

253 omotes AM development through the miR165/166 target gene REVOLUTA.

254 or quantifying the impact of guide RNAs on a target gene's expression in a pooled, sorting-based expr

255 spite defective transactivation of canonical target genes, SD-Foxo1 promoted IL-15-mediated CD8 T cel

256 Knockdown of these target genes sensitized cells to known ferroptosis induc

257 metric disease, emphasis should be placed in targeted gene sequencing of genes known to cause adRP, s

258 ears using an integrated approach, including targeted gene sequencing, copy-number arrays, and gene e

259 enes are differentially expressed, where the target genes showed association with cancer progression

260 Furthermore, type I-F system activates target genes specifically without off-target transcripti

261 augmented the expression of canonical Foxo1 target genes such as Il7r and Sell In contrast, an S209D

262 in WAT, driving the expression of PPARalpha target genes such as uncoupling protein 1 (Ucp1) and adr

263 GSK3 inhibitor rescued the expression of Wnt target genes suggesting that PTPRF functions upstream of

264 lso modulated transcription of canonical p53 target genes, suppressing p53-induced expression of the

265 accompanied by the downregulation of the FGF target genes tbxt/brachyury and cdx4, which mediate ante

266 tify FLIP(L) as a direct p53 transcriptional target gene that is rapidly up-regulated in response to

267 our model, we identified LGALS1 to be a GLI target gene that is up-regulated in both Gorlin tNES cel

268 Because many target genes that are activated by MYC:MAX dimers are re

269 of CRPC cells by promoting expression of AR target genes that are normally suppressed by AR-targeted

270 In addition, we identified 11 RGN downstream target genes that independently predicted longer recurre

271 We also identified potential target genes that may underlie the behavioral responses

272 thway gene signature, as well as that of MYC target genes that regulate multiple biological processes

273 interaction, causes derepression of H3K27me3-targeted genes that are involved in tumor suppression an

274 tricular zone (SVZ) have prompted strategies targeting gene therapies to these cells to enhance neuro

275 tory elements, tissue contexts and plausible target genes they affect.

276 nin signaling activates the transcription of target genes to regulate stem cells and cancer developme

277 for overexpression and silencing studies of target genes to regulate the yield of specialized metabo

278 KB, TP53 mutations based on their effects on target-gene transactivation, effects of cancer mutations

279 d by measuring significant reductions in the target gene transcript and/or protein levels.

280 oth the duration and amplitude of subsequent target gene transcription during post-embryonic developm

281 or real-time visualization of native YAP and target gene transcription dynamics, we show that a cycle

282 tes decreased Yap protein levels and blunted target gene transcription without affecting Yap transcri

283 ke place between ligand-receptor binding and target gene transcription.

284 pic expression promotes puncta formation and target gene transcription.

285 g of endogenous beta-catenin, and subsequent target gene transcription.

286 ced recruitment of HIF1alpha, leading to HIF target gene transcription.

287 he DNA-binding protein LAG-1/CSL to activate target gene transcription.

288 tool for linking these SNPs to their correct target genes under long-range regulation.

289 levels of predicted intended-target and off-target genes using reverse transcription quantitative PC

290 icant enrichment in IRT identifying the true target genes versus negative controls.

291 cent-transcription reporter knock-ins of YAP target genes, we show a strict association between these

292 Among these 125 targeted genes, we also reevaluate DNM excess in 17,426

293 neration sequencing and downstream predicted target genes were examined.

294 our approach; plus, many other candidate RA target genes were found.

295 Quantification cycle values of the target genes were normalized against reference genes and

296 Importantly, these target genes were upregulated in Rspo2-depleted explants

297 ilitates de-repression of downstream defense target genes, which involves phosphorylation, increased

298 yses showed that these three miRNAs regulate target genes, which were predominantly enriched in the g

299 erived neurotrophic factor (Bdnf) as a STAT3 target gene with newly accessible chromatin in a unique

300 among transcription factors (TFs) and their target genes, with a method able to handle both the high