ライフサイエンスコーパス: target molecule

1 hich in turn triggers hydrolysis to uncage a target molecule.

2 which the majority contain only zero or one target molecule.

3 be selectively created and integrated in the target molecule.

4 proving the stereospecific formation of the target molecule.

5 d domino reaction and ultimately yielded the target molecule.

6 ions of the aptamer chain in presence of the target molecule.

7 s interrupted and not easily accessible to a target molecule.

8 ntrol can be achieved for sensing of the new target molecule.

9 and capable of rebinding selectively to this target molecule.

10 ich can recognize and specifically bind to a target molecule.

11 folded conformation around the small neutral target molecule.

12 ynthesis of the acyclic dienyl moiety of the target molecule.

13 od that, in principle, can be applied to any target molecule.

14 ng alpha- and beta-glycoside moieties of the target molecule.

15 to match the vibrational fingerprint of the target molecule.

16 source with the electronic absorption of the target molecule.

17 nalized with DNA probes complementary to the target molecule.

18 protein in the free-energy landscape of the target molecule.

19 It is a polymerization method around the target molecule.

20 ns, including benzylic oxidation, led to the target molecule.

21 capable of selectively and tightly binding a target molecule.

22 functional decorations to reach the desired target molecule.

23 while maintaining high concentrations of the target molecule.

24 itative measure of the population profile of target molecules.

25 nriched organosilanes, an important class of target molecules.

26 eporter for the presence of nonelectroactive target molecules.

27 that can be used in the synthesis of complex target molecules.

28 magnetic field and stabilized by multivalent target molecules.

29 ification of extremely low concentrations of target molecules.

30 s hydrated form, bicarbonate (HCO3(-)), into target molecules.

31 g their affinity and specificity towards the target molecules.

32 in proportion to the chemical nature of the target molecules.

33 man fingerprint spectrum with trace level of target molecules.

34 g events between purified bacteria- and host-target molecules.

35 ementarity of base-pairing between probe and target molecules.

36 n our diversity oriented approach toward the target molecules.

37 (MIPs) for the specific recognition of NMP22 target molecules.

38 caused reduction in atherothrombosis-related target molecules.

39 ial defect in the linear deubiquitination of target molecules.

40 for the synthesis of a variety of bioactive target molecules.

41 e unreliable for samples containing very few target molecules.

42 and resolution for the detection of specific target molecules.

43 d/or binding affinity of oligonucleotides to target molecules.

44 re to afford nitriles, an important class of target molecules.

45 and can be generated against a wide array of target molecules.

46 o-recognition elements for a wide variety of target molecules.

47 e cavities to increase their affinity to the target molecules.

48 the highest imprinting effectiveness for the target molecules.

49 pler broadening due to spatial motion of the target molecules.

50 with respect to specificity and affinity for target molecules.

51 ommodities, moving away from simple fuels as target molecules.

52 to levels of low femtomolar concentration of target molecules.

53 with the removal of the carbamoyl moiety in target molecules.

54 tic alternative to access complex structural target molecules.

55 different scaffold proteins for a variety of target molecules.

56 s but also accelerated decay of short-tailed target molecules.

57 ing into their overall approach to accessing target molecules.

58 ntibodies to amplify signals of low-abundant target molecules.

59 al described herein may be extended to other target molecules.

60 e applied to the bonds between the probe and target molecules.

61 assays indicate the involvement of multiple target molecules.

62 e the development of novel immunotherapeutic target molecules.

63 seful biochemical derivatization of intended target molecules.

64 ations to mass-limited and aggregation-prone target molecules.

65 very of both activities within one precisely targeted molecule.

66 eaction to generate initial chirality in the targeted molecule.

67 inted polymers are synthetic receptors for a targeted molecule.

68 nergy profiles of eight systems for the four targeted molecules.

69 mbined with X-rays and conjugated to a tumor-targeting molecule.

70 for the first time as late-stage gametocyte-targeting molecules.

71 nd highlights the significance of HIF-1alpha-targeting molecules.

72 he genome that are inaccessible to other DNA-targeting molecules.

73 cytic C-type lectin receptors are attractive targeting molecules.

74 the lungs, and some bacteria produce neuron-targeting molecules.

75 gments with a detection limit down to 20 DNA target molecules (1.5aM range), making it suitable for a

76 etection from 1microL(-1) to 10(5)microL(-1) target molecules (20 to 2 million targets), making it su

77 the stem P1 and inhibited recognition of the target molecule 7-methylamino-7-deazaguanine (preQ 1 ).

78 With conservative estimates of relative target molecule abundance, it is revealed that filopodia

79 his device was used to detect the low weight target molecule adenosine triphosphate (ATP), a common b

80 enables to map the detected intensity of the target molecule against an external calibration curve.

81 can be used to probe the specificity of pHLA-targeting molecules, aiding the development of future re

82 ing a solid-state host matrix containing the target molecule, allowing the observation of phosphoresc

83 ters all electronic structure changes of the target molecule along the entire reaction pathway.

84 ty (4.4% RSD) for complementary nucleic acid target molecules, along with reusability.

85 s (DC), but almost all available systems use target molecules also expressed on other cells and thus

86 neous capture rates of a mixture of both the target molecule and an internal calibrator of precisely

87 nate from various precursor ions for a given target molecule and may be acquired at varying energies

88 ecause they allow for the rapid capture of a target molecule and the removal of non-specific interact

89 horesis (ITP) to preconcentrate and co-focus target molecules and beads into a single ITP zone.

90 Target molecules and binding epitopes must be accessible

91 lecular interaction for seven macromolecular target molecules and four small-molecule ligands.

92 pment as it interferes with the detection of target molecules and may give rise to false positive sig

93 Beneficial microbes that target molecules and pathways, such as oxidative stress,

94 idated the thrombin-directed activity of all target molecules and revealed that posttranslational sul

95 aniline and metanilic acid, commingled with target molecules and various 2D materials.

96 of CD40L into rAd5-based MERS-CoV S1 vaccine targeting molecule and molecular adjuvants not only enha

97 of principle, we chose a dendritic cell (DC)-targeting molecule and specific model antigens to genera

98 nanogate, which could selectively respond to target molecules, and control enzymatic reaction for ele

99 difficulties in identifying the appropriate target molecules, and more importantly, by the phenotypi

100 dicated that our sensor binds selectively to target molecules, and the non-specific binding where ads

101 One of them can be neutralized by SR-BI-targeting molecules, and it is critical only for wild-ty

102 Herein, interaction between DNA probes and target molecule are also investigated and result reveale

103 n binding sites that specifically identify a target molecule are essential for life science research,

104 monoterpene fragments used to construct the target molecules are also reported.

105 Current approaches for incorporating target molecules are based on multistep postfunctionaliz

106 s, reliable methods to incorporate BCPs into target molecules are in high demand, as reflected by a f

107 damage in HD neurons, and these mitochondria-targeted molecules are potential therapeutic molecules f

108 sculature has opened the possibility of PSMA-targeted molecules as generalizable cancer imaging and t

109 bserving the real-time binding events of the target molecule at nanomolar concentration levels and co

110 including the (a) selection against various target molecules; (b) modulation of protein function in

111 AB sensors provide quantitative detection of target molecules based on the rate of color change of an

112 s via desorption of the aptamer strands when target molecules bind with the aptamer.

113 change of impedance caused by the receptors-target molecules binding at the sample/electrode interfa

114 e changes in streaming current, first when a target molecule binds to the capture probes immobilized

115 The target molecules bound to the control polymer very weakl

116 rsion is used to determine the number of PSA target molecules bound to the receptors in both selectiv

117 ecific rILSA, Nluc-ABD, selectively bound to target-molecule-bound mouse IgG1 and rabbit IgG primary

118 luate the interaction between aggregates and target molecules but also offers new insight for underst

119 derivatization reactions widens the scope of targeted molecules but also clearly points out mineral m

120 enable to the preparation of the carbocyclic target molecule by suitable postrearrangement transforma

121 They bind to target molecules by folding into 3D structures that can

122 tunities to redesign synthetic strategies to target molecules by incorporating a key enzymatic step i

123 noassays to sensitively detect low-abundance target molecules by just mixing their detection antibodi

124 re polymerized in the presence of a specific target molecule called the 'template' and capable of reb

125 owever, the presence of a nitrogen atom in a target molecule can complicate its chemical synthesis be

126 ids autofluorescence and photobleaching, and target molecules can be detected specifically and sensit

127 These targeted molecules can be expressed on or drive the cell

128 cross-linker, radical initiator, along with target molecule (cephalexin) in a porogenic material.

129 the mechanisms driving bacterial sepsis, the target molecules controlling vascular leakage are still

130 he remaining single-stranded portion of each target molecule could subsequently hybridize to compleme

131 tical chemistry methods requires presence of target molecules directly at a sensing surface.

132 Detection of the target molecules distinguished host infection status in

133 A compound of differently sized target molecules (DNA, proteins) is channeled into the r

134 When using our approach, the target molecules do not need to be captured by two captu

135 mplate and demonstrate high affinity for the target molecule (e.g., melamine and trypsin in our publi

136 Interactions of bacteria with target molecules (e.g. antibiotics) or other microorgani

137 The presence of the targeted molecule effects a change in the reporting agen

138 ind simultaneously to different sites on the target molecule, enabling highly sensitive and specific

139 es in aqueous solution for these hydrophobic target molecules, exceeding the values of known syntheti

140 Starting with citronellal, the quest for the target molecule featured a novel bis-transannular Diels-

141 intestinal infection or IBS is adsorption of target molecules followed by removal from the body.

142 nd to represent, in an autologous setting, a target molecule for anti-tumor T cells.

143 in HUVECs and that CXCR7 may be a potential target molecule for endothelial regeneration and repair

144 function of Noxa, this could be a potential target molecule for future treatment approaches for H. p

145 C-kinase substrate (MARCKS), as a potential target molecule for IPF.

146 nine-rich C kinase substrate) as a potential target molecule for kidney cancer.

147 FAP is a new target molecule for PET imaging of various tumors.

148 The roster of current candidate target molecules for endothelial nanomedicine includes p

149 -derived CICs and to identify CIC-associated target molecules for T cell immunotherapy.

150 on of CD137 and PD1, thereby displaying more target molecules for the corresponding mAbs.

151 toolkit of frameworks for capturing specific target molecules for their structure determination.

152 pose that SM/Cer and SMPD1 are new potential target molecules for therapeutic strategies to overcome

153 families, and demonstrate that its presence targets molecules for TLR detection, while its absence e

154 n the strengths of SERS for the detection of target molecules from complex mixtures and the clinical

155 cartridge allows for selective enrichment of target molecules from larger sample volumes and removal

156 atrix of the cell wall that partially shield target molecules from the immediate environment and also

157 was able to consistently detect and quantify target molecules from the most abundant species (Atlanti

158 is nanocomposite enable simple separation of targeted molecules from a complex matrix while the silve

159 ide the chemical identity of the capture and targeted molecules from their vibrational Raman fingerpr

160 ir structure and interactions with potential target molecules have only recently been investigated in

161 The inherent properties of the target molecule help to define which of these mechanisms

162 racellular domain (NICD) and upregulation of target molecules Hey1 and Hes1.

163 ithin a few minutes for determination of the target molecule in low sample volume at disposable cost-

164 cted several research groups to work on this target molecule in search of novel antibiotics with new

165 limit of detection is 1 pM for short 27 base target molecules in a 15-min assay.

166 ely monodisperse in size and can encapsulate target molecules in a robust, well-defined manner.

167 roach can be easily adopted to monitor other target molecules in a simple, low-cost, sensitive and se

168 at form crystalline inclusion compounds with target molecules in a single-step crystallization, compl

169 ver, the technique is limited when measuring target molecules in aqueous solution by strong water abs

170 It has been applied both to identify target molecules in cell types that are important for co

171 in which effector concentrations are read by target molecules in cells.

172 its upstream regulators, and its downstream target molecules in endothelial cells.

173 vage under an O(2) atmosphere to deliver the target molecules in high yields.

174 es of some notable SLPs required for binding target molecules in hosts and how this information can b

175 A novel strategy to sense target molecules in human blood serum is achieved by imm

176 lization as well as for the concentration of target molecules in microsystems.

177 mon intermediate to accomplish eight diverse target molecules in six to eleven steps.

178 approaches can sense a very small amount of target molecules in the blood and cerebrospinal fluids s

179 Upregulation of Wnt/beta-catenin target molecules in the optic cup and stalk may underlie

180 After removing lipids which are targeted molecules in lipidomic analysis, inorganic spec

181 quently, the effects of concentration of the targeted molecules in the sample, installation position

182 Administration of GC-targeting molecules in combination with adjuvant chemo-

183 erbium into a form suitable for chelation to targeting molecules in diagnostic nuclear medicine is pr

184 By targeting molecules in pfGCs with several mutant mouse m

185 ated secondary antibodies, regardless of the target molecules, in various immunoassay formats, such a

186 physiological process of fibrogenesis; these target molecules include collagen types I, III, and IV,

187 lyze methyl transfers onto a wide variety of target molecules, including DNA and RNA.

188 Illustrative examples are provided for some target molecules, including terminal alkynes, strained r

189 lusively by lysozyme and not other cell wall-targeting molecules, including the peptidoglycan deacety

190 Addition of target molecule induces a change in the charge distribut

191 electronic pre-resonance conditions to image target molecules inside living cells with very high vibr

192 f miR-92 in CSCs led to higher expression of target molecules integrin alpha(V) and alpha(5) subunits

193 ed biosensors to transduce the presence of a target molecule into a dose-dependent fluorescence signa

194 ular imaging that can visualize the specific target molecules involved in immune-checkpoint pathways.

195 to the final conclusion about the AC of the target molecules is described.

196 s to the construction of fluorine-containing target molecules is important for a variety of scientifi

197 ce (SPR) based label-free detection of small targeted molecules is a great challenge and require subs

198 Additionally, none of the TNF-alpha-targeting molecules is expected to interfere with the im

199 elective detection of a low molecular weight target molecule (less than 200 Da) by aptamer-based sens

200 -radiative modes in the matrix surrounding a target molecule may also have broader applications in li

201 of binding to distinct epitopes on the same target molecule may enable fine-tuning of intracellular

202 However, as different target molecules may form positive, negative, or even io

203 These findings suggest that mitochondria-targeted molecules MitoQ and SS31 are protective against

204 e the protective effects of the mitochondria-targeted molecules MitoQ and SS31 in striatal neurons th

205 we use the beta-lactam ampicillin to predict target molecule occupancy at MIC from antimicrobial acti

206 presence in cellulosic materials makes it a target molecule of the pulp and paper industry's bleachi

207 appropriate validation, ultimately identify target molecules of diagnostic, prognostic, or therapeut

208 re-programmed sequential release of multiple target molecules of opposite solubility (hydrophobic and

209 Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormone-related peptid

210 amed vasculature because they possess intact targeting molecules of integrin beta2.

211 mechanism of adhesion by covalent bonding to target molecules on host cells that mimics that used by

212 n reaction is triggered after the capture of target molecules on the immunodevice surface.

213 the detection probes interact with the bound target molecules on the surface.

214 AgAb action paralleled the abundance of the targeted molecules on lymphoma cells as well as their HL

215 tructure of intact IgE and the impact of IgE-targeting molecules on IgE however remain elusive.

216 lin (apoCaM) often appears inert, modulating target molecules only upon conversion to its Ca(2+)-boun

217 ion, is crucial for molecular recognition of target molecules or cells.

218 tics requires molecular amplification of the target molecules or molecular signal amplification after

219 logical ability of nucleic acids to identify target molecules or silence genes involved in disease pa

220 The use of antibodies as targeting molecules or cell-penetrating tools has emerge

221 Potential novel therapies targeting molecules other than VEGF and using new drug-d

222 The quantitative analysis of target molecules over a large concentration range has be

223 The dimensions of the target molecule play a key role in the efficiency of the

224 al tool where obtaining single crystals of a target molecule presents a significant challenge and it

225 n and for the apoptotic effect of the hRpn13-targeting molecule RA190.

226 he excellent efficiency of the MIP sites for target molecule recognition.

227 reated neurons, suggesting that mitochondria-targeted molecules reduce fission activity.

228 set of receptors that have adapted to detect target molecules relating to numerous cellular pathways.

229 iting increased in vitro resistance to SR-BI-targeting molecules remain responsive to anti-SR-BI mAb

230 stationary supports for effective binding of target molecules requires understanding of the relations

231 at dsDNA react differently than ssDNA to the targeted molecules, requiring more energy to move the mo

232 dual binders, by bringing together different target molecules, restricting their conformational flexi

233 gene, capable of orchestrating a variety of target molecules, resulting in the activation of several

234 A proteomic screen for target molecules revealed that CRM1 inhibitors in neuron

235 ylboron compounds are an important family of target molecules, serving as useful intermediates, as we

236 stem has the merits of wide applicability to target molecules, small sample volume, and a low detecti

237 e same mAb for an almost unlimited number of target molecule specificities, reducing manufacturing co

238 ptasensors capable of specifically sensing a target molecule such as ATP, HIV, ochratoxin, potassium

239 is designed to detect a potpourri of complex target molecules such as cell surface antigens, allergen

240 alcium noise properties on calcium-regulated target molecules such as the ubiquitous IP(3)R.

241 gut, and interfering with gut trafficking by targeting molecules such as alpha4beta7 in IBD can lead

242 er, attempts to develop anti-chaperone drugs targeting molecules such as Hsp70 have been hampered by

243 to replace antibodies for the recognition of target molecules (such as antigens), and have been integ

244 selectivity to CRP when compared with other target molecules, such as urea or creatinine, while main

245 ghlight the broad utility of this method for target molecule synthesis and medicinal chemistry.

246 degree and distribution of labelling of the targeted molecules (termed fluxomics).

247 , thereby greatly expanding the diversity of target molecules that are readily accessible.

248 nderlie the development of immunotherapeutic target molecules that augment the function of immune eff

249 that fertoprotectants against cisplatin must target molecules that control cell death pathways in the

250 This link led us to search for targeted molecules that inhibit Fli-1.

251 namely to alpha-tocopheryl succinate, an SDH-targeting molecule that induced RIP1/PARP1-mediated necr

252 Using glucose as the target molecule, the screening of UV excitation due to p

253 By labeling a small fraction (<0.2%) of target molecules, the "tracer" DNA tracks the available

254 Proteins can bind target molecules through either induced fit or conformat

255 A origami nanoassembly, wherein binding of a target molecule to any of these probes leads to mechanoc

256 Qki5 is, thus, an interesting target molecule to combat doxorubicin-induced cardiotoxi

257 ders that recognize specific epitopes on the target molecule to exert a desired modulation of biologi

258 ll possible biosynthetic routes connecting a target molecule to its precursors.

259 signaling in the hippocampus and a possible target molecule to limit brain damage during hemorrhagic

260 molecule assays (dSimoa), that enables more target molecules to be counted through increased samplin

261 ny medical and chemical applications require target molecules to be delivered in a controlled manner

262 e of fluorochrome labelled probes allows the target molecules to be detected by measuring the fluores

263 We overexpress target molecules to infer changes in antibiotic-target b

264 heir binding specificity and affinity to the target molecules to interfere with designated molecular

265 flow, which facilitates the transport of the target molecules to the binding region located in the mi

266 nce is limited by the diffusive transport of target molecules to the surface.

267 -PSA aptamers ensured a close binding of the target molecules to the transducer surfaces.

268 ing of one (multivalent) or two (monovalent) target molecules to these elements opens the stem, enhan

269 actions between different DNA sequences with targeted molecules to rank the nucleobase sensing perfor

270 GCs or a novel generation of nonsteroidal GR-targeting molecules, to meet the increasing clinical nee

271 ular mechanism, along with the identity of a target molecule, underlying the evasion of the macrophag

272 lecular recognition of one enantiomer of the target molecule using a DNA aptamer, and the ability of

273 posites can be used to simultaneously purify target molecules using external magnetic field and produ

274 gation of an approach toward the challenging target molecules via a key guanylation step employing di

275 and blends and (ii) a lower O:C ratio in the target molecules via electrochemical decarboxylation/deo

276 the quantitative and sensitive detection of target molecules virtually impossible.

277 showed that the diastereomeric purity of the target molecule was >91 %, the highest obtained to date.

278 Solvent extraction of the target molecule was optimised and followed by subsequent

279 Specific staining and immobilization of the target molecules was achieved via a double hybridization

280 hly symmetric quaternary stereocenter of the target molecules was controlled through a matched combin

281 teractions between the cyclodextrins and the target molecule, we observe these gradients can serve to

282 Using xanthene dyes and organophosphates as target molecules, we found the transport metrics, e.g.,

283 ped liposomes for heterogeneous detection of target molecules were designed and synthesized.

284 approaches to the unusual amino acids in the target molecules were developed on the basis of a Negish

285 Therefore, target molecules were indirectly labeled by pre-hybridiz

286 ates from association of completely atomized target molecules, whereas in the late plasma, the increa

287 ical environment, while allowing coupling to target molecules, which can be biological in nature (e.g

288 ed the accumulation of detection antibody to target molecules, which dramatically enhanced the sensit

289 es enables the simultaneous detection of two target molecules, which exhibit the same affinity intera

290 ion of TGF-beta synthesis by those TNF-alpha-targeting molecules, which are able to trigger mTNF-alph

291 bling selective chemical imaging of specific target molecules, while simultaneously providing topogra

292 regarding the therapeutic potential of Nur77-targeting molecules will also be presented.

293 sitates the simultaneous binding of a single target molecule with two affinity ligands each conjugate

294 e chemical receptors that recognize and bind target molecules with a high affinity and selectivity.

295 Meanwhile, target molecules with different affinities can be adsorb

296 stoichiometric inclusion of a wide range of target molecules with full occupancy, typically without

297 are 'synthetic antibodies' that can bind to target molecules with high affinity and specificity.

298 o provide "digital" resolution of individual target molecules with high signal-to-noise ratio.

299 g diffusivity of an unknown concentration of target molecules with that of a reference solution.

300 also from asymmetric chemical bonding of the target molecules with the framework that is able to prov