ライフサイエンスコーパス: target of

1 r, the data indicate that HIF1alpha is not a target of 14q deletion in ccRCC and that it is not a tum

2 We identified all potential genomic targets of 25 dysregulated transcription factors and com

3 cardiovascular-renal events, and trends and targets of 4 risk factors with tailored decision support

4 precomputed orthologs to predict the direct targets of ~67% of ECF sigmas.

5 ion of carotid atherosclerosis than an LDL-C target of 90 to 110 mg/dL.

6 nding domain (RBD) is immunodominant and the target of 90% of the neutralizing activity present in SA

7 Our strategy, which entails targeting of a cytotoxic agent, through a covalent enzym

8 phisticated features optimised for precision-targeting of a wide range of cancers.

9 r data unequivocally identify PfFtsH1 as the target of actinonin and suggests that actinonin should n

10 dentified the metalloprotease TgFtsH1 as the target of actinonin in the related parasite Toxoplasma g

11 Precise targeting of activation-induced cytidine deaminase (AID)

12 ied as a biomarker and potential therapeutic target of AD.

13 find that progenitor cells are the principal targets of ageing, whereas the function of individual ma

14 The cerebellum is a target of alcoholism-related brain damage in adults, yet

15 halogenation or C-H borylation) so selective targeting of all positions is often not possible.

16 d-brain barrier permeability (BBBP), and the targeting of allosteric pockets.

17 n AML, discuss the challenges with selective targeting of AML cells, and summarize the clinical resul

18 own to regulate the trafficking and synaptic targeting of AMPARs, is required for LTP and learning an

19 Targeting of amygdala serotonin reuptake with selective

20 's (WHO) hepatitis C virus (HCV) elimination target of an 80% reduction in incidence by 2030 may be r

21 s an intricate relationship between cellular targets of an RNA quality control pathway and KSHV lytic

22 The immediate downstream targets of ANT and AIL6/PLT3 in flowers are unknown, how

23 of the mycobacterial cell envelope, and are targets of anti-tuberculosis drug ethambutol.

24 ns promote entry into cells and are the main target of antibodies.

25 showed that HMGA2 is a potential therapeutic target of anticancer and anti-obesity drugs by inhibitin

26 lead SNP located 15kB upstream of SLC5A2, a target of antidiabetic drugs.

27 ine biosynthesis enzymes represent potential targets of antifungal drugs.

28 terial populations that are not the intended target of antimicrobial therapy.

29 e D(2) receptor (D(2)R) is a key therapeutic target of antipsychotics for the treatment of schizophre

30 e identify phosphatidylserine as a molecular target of Apo-15.

31 on of BMI1, and confirmed BMI1 as the direct target of AR using gene-editing technology.

32 tes survival and is a direct transcriptional target of AR, the ability of AR to induce Bnip3 is depen

33 zed by Ro60, a ring-shaped protein that is a target of autoantibodies in patients with systemic lupus

34 or 1a (AVPR1A) sites as potential peripheral targets of AVP in the neonatal mouse.

35 nicillin-binding protein 2X (PBP2X), a major target of beta-lactam antibiotics in pathogenic bacteria

36 ay provide a new perspective for therapeutic targeting of beta-catenin.

37 component of the bacterial cell wall are the targets of beta-lactams, the most clinically successful

38 ses towards the development of NLC for brain targeting of bioactives with particular reference to its

39 various other nanocarrier systems for brain targeting of bioactives.

40 vascular changes and imply that therapeutic targeting of blood vessels may restore aged endocrine ti

41 m parasites and human erythrocytes are prime targets of blood stage malaria vaccine development.

42 While CDK4/6 represents a downstream target of both KRAS mutation and loss of the CDKN2A tumo

43 and Kir6.2 ankyrin binding sites dysregulate targeting of both Na(+) and K(ATP) channels to the ICD,

44 ere, we report that MYC2, MYC3, and MYC4 are targets of BPM (BTB/POZ-MATH) proteins, which act as sub

45 tein of hepatitis C virus (HCV) is the major target of broadly neutralizing antibodies (bNAbs) that a

46 Therapeutic targeting of Bruton tyrosine kinase (BTK) has dramatical

47 p60-2, and these genes were also found to be targets of bZIP60.

48 ChIP identified Stat6 as a direct gene target of c-Myc in ILC2.

49 However, direct-targeting of c-Myc poses special problem because of its

50 a MAPK is a central mediator and therapeutic target of cancer-induced muscle wasting.

51 exposed to mutagens and are the most common target of cancer.

52 brain's endocannabinoid system, the primary target of cannabis, has been implicated in psychosis.

53 osing, biologicals, multispecific drugs, the targeting of cardiomyocyte inflammatory signaling and po

54 Biodistribution suggests successful targeting of CD8+ T-cell-rich tissues.

55 ant sources of energy, but they are also the target of cellular stress, toxin exposure, and aging-rel

56 Finally, we demonstrate selective covalent targeting of cellular Hsp90, which results in a prolonge

57 So far, viral targets of cellular immunity and factors determining suc

58 ng genetic variants in the gene locus of the target of CETP inhibitors were associated with lower ris

59 le hair cells in the cochlea are established targets of cisplatin, less is known regarding the affere

60 ve on a validation dataset consisting of 277 targets of clinical trial drug confirming that our compu

61 r structural optimization aimed at selective targeting of ClpB and/or DnaK.

62 is one of the most important and successful targets of cognitive modeling, with decades of model dev

63 ys, including complement and coagulation, as targets of coronaviruses.

64 n carbohydrate metabolism as transcriptional targets of CRZ1/GnRHL1 signaling.

65 Cas9/CRISPR-based system that allows ectopic targeting of Ctf19c-subunits.

66 or Cap-dependent translation, as a potential target of CUL3.

67 regulating protein and DNA modifications are targets of current cancer therapies.

68 Here we used genetic targeting of Cxcl13-expressing cells to define the molec

69 Selective targeting of cyst cell proliferation is an effective mea

70 ane, a monoamine transporter ligand, enables targeting of dense dopaminergic axons in the mouse stria

71 left DLPFC has been proposed as an explicit target of depression treatments, this suggest that the l

72 dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes.

73 In both species, predicted gene targets of differentially expressed miRNAs are involved

74 n the field of drug delivery is insufficient targeting of diseased tissues or cells.

75 in the ventrolateral thalamus, and putative target of DMFC in the caudate.

76 However, the natural functions and targets of DNA interference are poorly understood, and t

77 aits, which may be past and potential future targets of domestication, breeding, and selection.

78 al fear memory, and Ca(v)1.2 is a downstream target of dopamine D1-receptor (D1R) signaling, we next

79 posit that these advances in pharmacological targeting of DUBs establish the enzyme family as targeta

80 se in response to endotoxin, indicating that targeting of DVRGLL motif within MYLK-L may limit SOCE-i

81 eveals a set of genes that are likely direct targets of E proteins.

82 /EGFR signaling and serves as an alternative target of EGFR-TKI resistance in NSCLC.

83 PIT mitochondrial protein as a translational target of EIF4G2.

84 Allele-specific targeting of enCRISPRa to oncogenic TAL1 super-enhancer

85 bioactivity and can also be applied to other targets of endocrine disruption.

86 channels in smooth muscle are thought to be targets of endothelium-derived nitric oxide.

87 Selective targeting of eosinophil metabolism may be of therapeutic

88 Therapeutic targeting of epigenetic modulators offers a novel approa

89 erent therapeutic regimens and found that co-targeting of epithelial and mesenchymal cells is likely

90 ther than lungs, which is conventionally the target of erythrocyte-mediated delivery systems.

91 As such, readmission after AMI has been a target of financial penalties through Medicare.

92 or FOXL2(C134W) and identification of unique targets of FOXL2(C134W) including SLC35F2, whose express

93 ssium currents, two putative transcriptional targets of Foxp2, were not affected by the mutation.

94 ectively, these findings identify GSDMD as a target of fumarate and reveal a mechanism of action for

95 racterise physiological and pathological RNA targets of FUS.

96 inwardly-rectifying K(+) (GIRK) channels are targets of G(i/o)-protein-signaling systems that inhibit

97 receptor B-expressing (CCKBR-expressing) VMN targets of glucose-elevating parabrachial nucleus neuron

98 se findings identify mitochondria as a major target of glucotoxicity.

99 We show that CRISPR-mediated targeting of glycolysis in T cells in mice results in gl

100 g tissue plasminogen activator for on-demand targeting of GPA receptors in vivo.

101 el, nuanced modulators of the A(3)AR, a drug target of growing interest.

102 lves mutations in genes encoding the protein targets of herbicides, affecting the binding of the herb

103 Some targets of Hh signal transduction are common to the disc

104 Targeting of HIF and its downstream targets in angiogene

105 scription factor represents an "undruggable" target of high biological interest due to its central ro

106 ene, Axin2, is also a direct transcriptional target of HNF-1beta through binding to negative regulato

107 chanisms to protect their proteins, the main targets of HOCl, from HOCl-mediated damage.

108 ction of Spn-F, a downstream phosphorylation target of Ik2, greatly enhanced the mutant CHMP2B phenot

109 EGR2 is a direct target of IL-4-activated STAT6, having broad action indi

110 ithelial cells, and genetic or pharmacologic targeting of ILK reversed mitochondrial reprogramming an

111 Melanocytes are the target of immune destruction in vitiligo and are hypothe

112 n merozoite invasion and hence are important targets of immune responses.

113 ve ways to monitor lung inflammation through targeting of immunoregulatory pathways contributing to A

114 proteins are crucial advances for antiviral targeting of influenza viruses.

115 e not tolerated, can be highly successful as targets of inhibitory drugs.

116 ensors that include aptamers for detecting a target of interest.

117 ecular properties and we have utilized three targets of interest (Plasmodium falciparum, Hepatitis C

118 ession and pinpoint circulating factors as a target of intervention to restore immunity.

119 at large superspreading events should be the targets of interventions that minimize tail exposure.

120 y in cell lysates, but methods for analyzing targets of itaconation directly in living macrophages ar

121 , directly comparing the gains and losses of targets of key TFs across cell states is often not infor

122 This pathway-dependent targeting of kidney cancer arises from the fact that the

123 nse in younger mice, and highlight potential targets of kidney injury.

124 lla pneumophila infection blocked xenophagic targeting of L. monocytogenes by a RavZ-dependent mechan

125 e molecular mechanisms and novel therapeutic targets of late-onset Alzheimer's Disease (LOAD), we per

126 roteomics strategy, we identify 200 putative targets of LC3-dependent secretion.

127 vide a mechanistic framework for therapeutic targeting of ligand-dependent Hh signaling in human canc

128 cover a druggable downstream transcriptional target of LIN9.

129 ipid-based formulation resulted in efficient targeting of LPV to HIV reservoirs in mesenteric lymph a

130 ing this literature, we argue for an HbA(1c) target of <7% for most individuals, but emphasize the im

131 schemic stroke and atherosclerosis, an LDL-C target of <70 mg/dL (1.8 mmol/L) did not reduce the inci

132 tion of risk factors that could be potential targets of medical treatment to improve population healt

133 Pharmacological co-targeting of MEK1/2, HDAC3, and G9a sustains PDAC tumor

134 k disrupts siRNA production and reveals RdDM targets of methylation repatterning.

135 we have identified FOXO3 as a key downstream target of METTL3, with m(6) A modification of the FOXO3

136 tudy reporting the distinct cellular protein targets of mHAAs and mHAMs at the proteome-wide level, w

137 some function in immune evasion by selective targeting of MHC-I molecules for degradation, and provid

138 gical interventions are being devised with a target of mid to late-century implementation, at which t

139 y, these studies identify Parp-1 as a direct target of miR-124 in neuronal cells, establish miR-124 a

140 uppel-like factor 4 was found to be a direct target of miR-128 and able to modulate the methylation s

141 taining Inositol Phosphatase-1 (SHIP-1) is a target of miR-155, a pro-inflammatory factor.

142 ntrolling fibrotic responses and SHIP-1 is a target of miR-155.

143 MLL4 was identified as a direct target of miR-210, and overexpression of miR-210 inhibit

144 MyD88 has been shown to be a direct target of miR-3085-3p and may be responsible for the ear

145 clear factor kappaB (NF-kappaB), as a direct target of miR-31 establishes a functional link between o

146 nfirmed in myoblasts that EIF4G2 is a direct target of miR-379, and identified the DAPIT mitochondria

147 receptor 3 (FGFR3) was also identified as a target of miR-701-3p.

148 alysis to identify additional cardiovascular targets of miR-144, and subsequently examined the role o

149 n homolog (PTEN), which is one of the direct targets of miR-216a, was analyzed using western blot.

150 of Rab5A, Rab5C, or USP15 interferes with EL targeting of mitochondria and functionally uncouples BAX

151 present evidence supports screening for and targeting of modifiable risk factors for major bleeding,

152 Here, we discuss targets of monoclonal antibodies in mosquito sexual stag

153 sions will ultimately aid in the therapeutic targeting of mTOR in human disease.

154 TEMENT The cannabinergic system has been the target of multiple studies to master its potential use a

155 h a function was attributed to suppressor of target of Myb protein 1 (Stm1; SERPINE1 mRNA-binding pro

156 er cells overexpressing glutaminase (GLS), a target of MYC and a key enzyme in glutaminolysis, are in

157 h others in preclinical development, and the targeting of Na(V)1.9, although hampered by technical co

158 The targeting of natural non-productive alternative splicing

159 The HIV-1 envelope protein (Env) is the target of neutralizing antibodies and the template for v

160 velope glycoprotein B (gB) serves as a major target of neutralizing antibodies.

161 omotes entry into host cells and is the main target of neutralizing antibodies.

162 results support neuraminidase as a potential target of next-generation influenza virus vaccines.

163 potential EMT-inducing gene, is a responsive target of NFkB.

164 thiol (SNO) Regulated 1 (SRG1), is a central target of NO bioactivity during plant immunity.

165 and somatic hypermutation (SHM), whereas AID targeting of non-Ig loci can generate oncogenic DNA lesi

166 heightened density of NMDARs, which are the targets of novel rapid-acting antidepressants.

167 These studies suggest that pharmacological targeting of OCT2 could be exploited to afford neuroprot

168 Under high glucose conditions, PKM2 is a target of OGA-associated acetyltransferase activity, whi

169 sis, and provide a rationale for therapeutic targeting of oncogenic MYC via AURKB inhibition.

170 tical method for global detection of protein targets of OPs.

171 In this study, we identified downstream targets of OsHOX24 under control and desiccation stress

172 viding an opportunity for specific metabolic targeting of ovarian cancer metastasis.

173 Here we identify the direct targets of PfAP2-G and demonstrate that it dynamically b

174 -genetic analysis, we isolate two functional targets of PfPP1 for egress: a HECT E3 protein-ubiquitin

175 Hoxd3 promoter is a direct target of phosphorylated (p) SMAD1, a mediator of BMP si

176 utic target in pediatric B-ALL and selective targeting of Plk1 can be achieved by the use of siRNNs.

177 terior fate formation, suggesting additional targets of PNT participate in the posterior fate determi

178 this clustering may allow identification and targeting of pockets of transmission.

179 trials and household surveys, and inform the targeting of policies and prevention programming aimed a

180 of septic shock, and its lipid A core is the target of polymyxin antibiotics(3,4).

181 expression of a peptide that mimics cellular targets of PPP2R5s robustly inhibited Vif-mediated degra

182 that cognitive dysfunction may not be useful targets of preventive interventions.

183 he results also suggest that pharmacological targeting of PRL2 could provide a novel therapeutic stra

184 consistent with their respective anatomical targets of projection outside of the BG.

185 hown to be promising agents for the specific targeting of prostate tumors.

186 ich could lead to strategies for therapeutic targeting of proteins of the NSD family.

187 eletal SCAR/WAVE complex, a major downstream target of RAC1, in a mouse model of melanoma driven by B

188 reports found that Treg have low mechanistic target of rapamycin (mTOR) activity and would be less de

189 to promote cancer growth, whereas mammalian target of rapamycin (mTOR) inhibitors like sirolimus hav

190 Signaling by the mechanistic (mammalian) target of rapamycin (mTOR) kinase is important for cell

191 through negative control of the mechanistic target of rapamycin (mTOR) pathway and independent of al

192 ty and expression, and propose the mammalian target of rapamycin (mTOR) signaling pathway as a candid

193 The mammalian Target of Rapamycin (mTOR) signaling pathway is active i

194 C), a disease with overactivated mechanistic target of rapamycin (mTOR) signaling, has demonstrated t

195 and insulin signaling intersect at mammalian target of rapamycin (mTOR), a critical node for cell pro

196 The mechanistic target of rapamycin (mTOR)-signaling pathway plays a key

197 d receptor-alpha (PPAR-alpha), and mammalian target of rapamycin (mTOR).

198 s, we demonstrate that the crosstalk between Target of Rapamycin (TOR) and Fibroblast growth factor r

199 Target of rapamycin (TOR) is a protein kinase that coord

200 ted R(N) were mitigated by inhibition of the Target of Rapamycin (TOR) kinase signaling pathway.

201 The mammalian Target of Rapamycin complex 1 (mTORC1) nutrient-sensing

202 e assembly and activation of the mechanistic target of rapamycin complex 1 (mTORC1) occur on the lyso

203 , can reduce the activity of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway

204 ys with inhibiting activity of the mammalian target of rapamycin complex 1 (mTORC1).

205 id kinase complex and the nutrient-regulated target of rapamycin complex 1 (TORC1) control the integr

206 Target of rapamycin complex 1 (TORC1) is a central regul

207 ng to constitutive activation of mechanistic target of rapamycin complex 1 signaling.

208 ient sensors insulin/IGF signaling (IIS) and target of rapamycin complex1 (TORC1), was investigated t

209 ion of CNI and introduction of the mammalian target of rapamycin inhibitor Sirolimus (SIR) within 4-6

210 osphorylation of proteins in the mechanistic target of rapamycin pathway were similar in control and

211 association is sensitive to mTOR (mammalian target of rapamycin) kinase activity.

212 Inhibition of mTOR (mechanistic Target Of Rapamycin) signaling by rapamycin promotes hea

213 Standard CNI-based mammalian target of rapamycin-free immunosuppression (group A, n =

214 diphosphate ribose) polymerase and mammalian-target-of-rapamycin inhibitors.

215 e chromatin accessibility regulator HMGN1, a target of recurrent DNA copy gains in leukemia, controls

216 ieving the World Health Organization's (WHO) target of reducing gonorrhea incidence by 90% during 201

217 ures from IPF patients, thus suggesting that targeting of REVERBalpha could be a viable therapeutic a

218 Pharmacological targeting of REVERBalpha inhibited myofibroblast activat

219 ting of signalless ribosomes and pre-emptive targeting of ribosomes with short nascent chains.

220 s on multiple transcript isoforms, including targets of RNA surveillance mechanisms.

221 In this study, we used TRIBE (targets of RNA-binding proteins identified by editing) a

222 generating chemical diversity for allosteric targeting of RORgammat.

223 nvolved in energy metabolism are a prominent target of ROS.

224 Moreover, combined targeting of RRM1 S559 phosphorylation and ATR triggers

225 cross health and disease to uncover putative targets of SARS-CoV-2 among tissue-resident cell subsets

226 daptations do not overlap with domestication targets of selection, suggesting that feralization occur

227 Therefore, targeting of Septin2-mediated podosome formation is a po

228 Consistently, ectopic targeting of SET to the kinetochores during metaphase hy

229 cs with SR, thereby reducing the nonspecific targeting of signalless ribosomes and pre-emptive target

230 wed that ALDH1A1 is a direct transcriptional target of SOX9, based on chromatin immunoprecipitation a

231 does not depend on growth in culture or the targeting of specific pathogens.

232 ecent evidence suggests that pharmacological targeting of specific proteins during distinct phases of

233 ommon across cancer and permits cell-surface targeting of specific therapies in preclinical and clini

234 teral parabrachial nucleus (lPBN) is a major target of spinal projection neurons conveying nociceptiv

235 eatures of the guideline in 7 crucial areas: targeting of statin dose (not low-density lipoprotein ch

236 Precise targeting of stem-directed antibody responses to the sit

237 multifactorial role as both a regulator and target of stress hormone signaling within the brain.

238 fy other colchicine site binders, a frequent target of structurally diverse small molecules.

239 Targeting of substrates to the Tat system is mediated by

240 mutations in cancer cells and are important targets of T cell-mediated anti-tumor immunity.

241 e of human ASCL1), which we show is a direct target of Tailless.

242 n enzyme and the cognate toxin is the direct target of the antitoxin: Hha/TomB (antitoxin oxidizes Cy

243 (POA) by pyrazinamidase, however, the exact target of the drug has been difficult to determine.

244 e antioxidant glutathione, and it is a known target of the environmental neurotoxin beta-methylamino-

245 merous drug discovery efforts as this is the target of the first line pro-drug isoniazid.

246 Vaccine development focuses on the principal target of the neutralizing humoral immune response, the

247 campus, a brain region that is the principal target of the serotonergic afferents along with the limb

248 TARK1 was originally identified as a target of the Xanthomonas euvesicatoria effector protein

249 fferences of the MA-mediated plasma membrane targeting of the B-type mouse mammary tumor virus (MMTV)

250 This tracer showed excellent targeting of the folate receptor beta on activated macro

251 molecular-level basis for antibody-mediated targeting of the hantaviral glycoprotein lattice.

252 oral heterogeneity and motivates therapeutic targeting of the HPCS.

253 tion of EcoRI inside the compartment enables targeting of the phage and protection of host cells.

254 ocyte responses that can result in cytolytic targeting of the tumor.

255 Therefore, identification and therapeutic targeting of the underlying pathways is a useful strateg

256 of dietary components and proportion meeting targets of the American Heart Association (AHA) 2020 con

257 for PAD enzymes in RA as both promoters and targets of the autoimmune response, as well as discussin

258 t proportion of auxin inducible genes and of targets of the AUXIN RESPONSE FACTOR 6 are regulated by

259 HIV care will be required to reach national targets of the ending the HIV epidemic initiative by 203

260 used this approach to screen for phenotypic targets of the essential mir-35-42 family.

261 FGFR4, which were both highly expressed and targets of the EWS-WT1 fusion protein.

262 This unveiled regulatory targets of the GID ligase during a metabolic switch.

263 in (GPC) and nucleoprotein (NP) are the main targets of the Lassa virus-specific T cell responses, bu

264 ifferentiation pathway of photoreceptors are targets of the miR-183 cluster, and the miR-183 cluster

265 -8) and characterized by hypermethylation of targets of the polycomb repressor complex 2 components.

266 Glycosylation, therefore, is a promising target of therapeutic interventions for presently incura

267 nto a single nanostructure, enhancing active targeting of therapeutic agents and facilitating new com

268 f novel inhibitors for many distinct protein targets of therapeutic value.

269 the size and composition of this pool are a target of therapies for primary biliary cholangitis and

270 esults confirm that DapF (Ct) is the primary target of these mDAP and l-glutamate treatments.

271 re by specifying the position, polarity, and targeting of these events.

272 ulations and studies in cells reveal that LD targeting of these motifs requires deeply inserted trypt

273 e variants of the NLRP1 inflammasome sensor, targeting of these pathways does not explain the lethali

274 pathway analysis on predicted and validated targets of these microRNAs implicated derepressed TGF-be

275 YCLIN D1, and c-MYC, which are all predicted targets of these miRNAs, and reduced lymphoma cell survi

276 computation can inform us on the sources and targets of these signals.

277 d BMP10 signalling, facilitating therapeutic targeting of this important pathway.

278 gests a high potential for subtype-selective targeting of this NR to more effectively treat patients

279 melanoma progression, suggesting therapeutic targeting of this signaling axis as a viable option for

280 Moreover, which transcripts are direct targets of this key posttranscriptional regulator is lar

281 adely propagating signals along axons to the targets of those axons.

282 chemical proteomics to identify the protein targets of three monohaloacetic acids (mHAAs) and three

283 Here, we identify Fab1 as a target of TORC1 on signaling endosomes, which are distin

284 , we suggest Gh and Sp lesions are potential targets of transcription-coupled repair.

285 , Piwi-interacting RNAs (piRNAs) to identify targets of transcriptional repression.

286 in cap-dependent translation and is the main target of translational control mechanisms.

287 t of peptidoglycan substrates on beta-lactam targeting of transpeptidation, and (d) demonstrate that

288 on and antigen-presenting cell activity is a target of Treg suppression.

289 The observed targeting of tumor lesions suggests this may be informat

290 inase D1 (Prkd1) is a direct transcriptional target of Twist1 and is not expressed in the normal mamm

291 OC-specific targeting of UBR5 strongly augments the survival benefit

292 Here, we globally identify the direct targets of UNC-3.

293 Targeting of uncontrolled self-renewal through inhibitio

294 sented data are the first to identify vIRF-2 targeting of USP7 and its role in HHV-8 biology, expandi

295 ng proteins TRAF3 and TRAF6, and that vIRF-2 targeting of USP7 regulates HHV-8 productive replication

296 These studies suggest that antigen-specific targeting of VAT-localized Treg cells could eventually b

297 and suggest that NK cell is one of the main targets of VPA, but further work is needed to ascertain

298 onserved signaling pathways, pharmacological targeting of which substantially delays cardiomyocyte ma

299 Importantly, pharmacologic targeting of YAP reversed treatment-induced excessive co

300 Notably, this signature enriched for targets of Yes-associated protein (Yap) and transcriptio