1 tudy, we developed mice deficient in BLT2 by
targeted disruption.
2 e murine Efemp1 gene was inactivated through
targeted disruption.
3 vivo, we developed Ini1 heterozygous mice by
targeted disruption.
4 ngal infections, we created skn7 mutants via
targeted disruption.
5 When we generated Ant4-deficient mice by
targeted disruption,
a significant reduction in testicul
6 Adult heterozygous mutant mice with a
targeted disruption for type III Nrg1 (Nrg1(tm1.1Lwr+/-)
7 In this study, we carried out
targeted disruption in mice of the gene for rootletin, a
8 Targeted disruption in mice of the vitamin D receptor (V
9 rties of nicotine, is blocked in mice with a
targeted disruption in the CREB gene.
10 neration and characterization of mice with a
targeted disruption in the NAPE-PLD gene [NAPE-PLD(-/-)
11 uated angiogenic phenotypes in mice carrying
targeted disruptions in genes encoding different PHD iso
12 network more vulnerable to compound natural-
targeted disruptions including cascading failures.
13 re of signaling networks and for pinpointing
targeted disruptions leading to the silencing of undesir
14 Its
targeted disruption may afford some benefit in preventin
15 es represent what we believe to be the first
targeted disruption of a gene in C. parapsilosis and sho
16 Targeted disruption of a highly conserved distal enhance
17 loit nourseothricin resistance to detect the
targeted disruption of a hygromycin B resistance conferr
18 nfirmed by analysis of a mutant generated by
targeted disruption of a PKS gene, and by functional exp
19 We demonstrated that the
targeted disruption of ABCA1 increases amyloid depositio
20 LG-2) and the Sec31A proline-rich region: 1)
targeted disruption of ALG-2/Sec31A interactions caused
21 Here we demonstrate that
targeted disruption of Ant2 in mouse liver enhances unco
22 and IFN regulatory factor 1 since mice with
targeted disruption of any of the four genes failed to a
23 stradiol-deficient or estradiol-resistant by
targeted disruption of aromatase (ArKO) or ERalpha (alph
24 Targeted disruption of ATF3 decreased the effects of eth
25 Targeted disruption of Axin2 in mice induces malformatio
26 Targeted disruption of Axin2 in mice induces skeletal de
27 BL/6 mouse CD8(+) T cells, we used mice with
targeted disruption of beta1i, beta2i, or beta5i/beta2i
28 Additionally,
targeted disruption of betacat blocked fgf18 expression
29 Boc is expressed by commissural neurons, and
targeted disruption of Boc in mouse results in the misgu
30 Mice bearing
targeted disruption of both alleles encoding AQP9 have e
31 atures with humans, we generated pigs with a
targeted disruption of both CFTR alleles.
32 Targeted disruption of both CRTC2 and CRTC3 in stromal c
33 Using cells with
targeted disruption of both the Akt1 and Akt2 genes, we
34 ed in mouse embryonic fibroblasts (MEF) with
targeted disruption of both the Mkk3 and Mkk6 genes, est
35 Using cells with
targeted disruption of both the Mkk3 and Mkk6 genes, we
36 Mice with a
targeted disruption of Brn3b (knockout Brn3b(-/-)) under
37 ype H-2b C57BL/6 (B6) mice or B6 mice with a
targeted disruption of c-Rel gene (c-Rel-/-) were used a
38 Targeted disruption of CatSperz reduces CatSper current
39 Here we show that
targeted disruption of Ccm2 in mice results in failed lu
40 s were also markedly impaired in mice with a
targeted disruption of CCR2.
41 Targeted disruption of CD39 impaired hepatocellular rege
42 Targeted disruption of Cdk2ap1 in mESCs resulted in abro
43 ion of cardiomyocyte electrophysiology after
targeted disruption of coupled myofibroblasts and by ces
44 Furthermore,
targeted disruption of Cripto expression by use of small
45 IV infection is associated with specific and
targeted disruption of critical macrophage TLR4 signalin
46 Here we show that
targeted disruption of Cstf2t in mice causes aberrant sp
47 Targeted disruption of D-Rap1 expression decreased both
48 In this report, we sought to determine if
targeted disruption of deregulated cap-dependent transla
49 Using cells with
targeted disruption of different STAT proteins and/or th
50 Here, we report expression analysis and
targeted disruption of Dmrt4 (also called DmrtA1) in the
51 Targeted disruption of Dot1l using a conditional knockou
52 Strikingly, the
targeted disruption of Dyn2 induced a dramatic four- to
53 aspase-deficient mutants were constructed by
targeted disruption of each of the two metacaspase genes
54 Targeted disruption of either mdm2 or mdm4 genes in mice
55 Surprisingly,
targeted disruption of either Stat5a or Stat5b alone als
56 tivator-like effector nucleases (TALENs) for
targeted disruption of endogenous genes and cis-acting r
57 n developed to engineer some strains via the
targeted disruption of endogenous genes and/or transgene
58 of this hypothesis, here we have shown that
targeted disruption of EphA2 in a murine model of aggres
59 CYP2J2 and CYP2C8 epoxygenases and mice with
targeted disruption of Ephx2.
60 Mice with
targeted disruption of ERM have a loss of maintenance of
61 isms, we generated Mtdh knock-out mice via a
targeted disruption of exon 3.
62 escribe that CD4(+) T cells from mice with a
targeted disruption of exons 2 and 3 of Ly108 (Ly108(Del
63 Targeted disruption of F10 and other common pathway fact
64 trations in pregnant mice can be affected by
targeted disruption of fetal H19(Delta13).
65 Here, we show that
targeted disruption of Foxe3 results in abnormal develop
66 Targeted disruption of FoxO3 also resulted in downregula
67 Targeted disruption of Gal-1-N-glycan interactions elimi
68 T cells with a
targeted disruption of GCN2 were not susceptible to IDO-
69 Osteoblast-
targeted disruption of glucocorticoid signaling signific
70 We examine the impact of
targeted disruption of growth hormone-releasing hormone
71 Here, we show that
targeted disruption of H3f3b results in a number of phen
72 Recently, it has been shown that
targeted disruption of Hap1 in mice results in early pos
73 both wild-type and mutant p53, we found that
targeted disruption of HDAC8 expression remarkably trigg
74 on phenotype in mouse embryos homozygous for
targeted disruption of Hey2 revealed an expanded AVC dom
75 Targeted disruption of HIF-2alpha in the intestine inhib
76 c-euglycemic clamp studies demonstrated that
targeted disruption of HIF1alpha in adipocytes enhanced
77 Targeted disruption of IGF-IR signaling combined with cy
78 in mice lacking IL-12, but not in mice with
targeted disruption of IL-23 or both IL-12 and IL-23.
79 null mutant (NBC1-/-) mice were prepared by
targeted disruption of its gene (Slc4a4).
80 Thus,
targeted disruption of kcne2 has revealed a novel cardia
81 Targeted disruption of Kcne2 in mice impaired thyroid io
82 The
targeted disruption of Lck gene in mice results in sever
83 ary fibrosis, respectively, in a strain with
targeted disruption of leukotriene C(4) synthase to prev
84 Others have demonstrated that the
targeted disruption of LFA-1:ICAM interactions, either b
85 Targeted disruption of Lmo4 resulted in the dysmorphogen
86 Here we report
targeted disruption of lpa(4) in mice.
87 e proapoptotic effects of a protocol causing
targeted disruption of lysosomes.
88 nterpart, mArt, and generated a mouse with a
targeted disruption of mArt.
89 Targeted disruption of matrix adhesion promotes uniform
90 y hyaluronidase and cytochalasin D displayed
targeted disruption of matrix and cytoskeletal networks,
91 ng a proteomic approach, we demonstrate that
targeted disruption of mitochondrial Hsp90 chaperone fun
92 ition of Mnk or experiments using cells with
targeted disruption of Mnk1 and Mnk2 genes.
93 ogic role of mPGES1 in the kidney, mice with
targeted disruption of mPges1 gene were studied, with a
94 Surprisingly, embryos with a
targeted disruption of Mtb died prior to the initiation
95 Here we show that
targeted disruption of murine CatSper3 or CatSper4 also
96 he in vivo relevance of OATP1B transporters,
targeted disruption of murine Slco1b2 gene was carried o
97 hese findings were confirmed using MEFs with
targeted disruption of NF-kappaB signaling, in which Rel
98 Mice with
targeted disruption of NF90 were engineered.
99 Here we report that
targeted disruption of NFPC function in RGC axons or the
100 eta production in neuroblastoma culture, and
targeted disruption of NgR expression increases transgen
101 Here we report that the
targeted disruption of Nocturnin (Ccrn4l) in mice, a gen
102 Recently
targeted disruption of Omi/HtrA2 has been found to cause
103 ebral vascular growth, we examined mice with
targeted disruption of one (heterozygous) or both (homoz
104 Targeted disruption of p300-mediated histone acetylation
105 Targeted disruption of Paneth cell lysozyme (Lyz1) prote
106 Exploring the
targeted disruption of PGE2 synthesis and signaling to o
107 Moreover,
targeted disruption of PI3K blunted the suppression of f
108 Here we show that
targeted disruption of PIP5KIgamma causes widespread dev
109 tive in embryonic fibroblasts from mice with
targeted disruption of PKC-delta (Pkc-delta(-)(/)(-)), p
110 Targeted disruption of pre-cardiac cell-matrix adhesion
111 Here we show that mouse embryos with a
targeted disruption of PRMT3 are small in size but survi
112 Methods for the
targeted disruption of protein function have revolutioni
113 Targeted disruption of protein retrotranslocation causes
114 Finally,
targeted disruption of PTCHD1-AS exon 3 recapitulated di
115 Here we show that
targeted disruption of PTEN leads to neoplastic transfor
116 In this system we find that
targeted disruption of Rb leads to little overt change i
117 In support of this,
targeted disruption of Rhox5 increased male germ cell ap
118 Targeted disruption of RIIbeta-protein kinase A (PKA) in
119 Through the
targeted disruption of RIPK1 kinase activity, which sele
120 We have generated a
targeted disruption of Sall3 in mice.
121 Mice with a
targeted disruption of Scd1 gene locus are lean and disp
122 lterations in the SAN following heterozygous-
targeted disruption of Scn5a thus closely resemble those
123 Targeted disruption of Scyl2 in mice caused perinatal le
124 Targeted disruption of selected ETS family members such
125 Consequently, the
targeted disruption of semaphorin 6D receptor-ligand int
126 Targeted disruption of signal transducer and activator o
127 oth human and mouse breast cancer cells, the
targeted disruption of Sin3 function by introduction of
128 Mice with
targeted disruption of single muscarinic acetylcholine r
129 SIRT6 deficiency, we generated mice carrying
targeted disruption of SIRT6.
130 Targeted disruption of SMS in CRC cells results in sperm
131 Targeted disruption of SOCS3 revealed embryonic lethalit
132 wever, due to the non-viability of mice with
targeted disruption of Socs3, the importance of Socs3 in
133 Our studies demonstrated that
targeted disruption of Sox4 or Sox11 in retinas caused a
134 We generated a strain of mice carrying a
targeted disruption of Stat3 gene in the liver (L-Stat3(
135 Targeted disruption of Stat3 in bulge region KSCs at the
136 ously shown that therapeutic intervention or
targeted disruption of Stat4 was effective in ameliorati
137 icated in erythroid disorders, and show that
targeted disruption of such elements results in altered
138 T cells with combined
targeted disruption of T-bet and RORgammat have defectiv
139 Targeted disruption of Tcf7l2 in mice led to severe defe
140 sociated with increased TCR avidity, whereas
targeted disruption of TCR avidity enhancement eliminate
141 a the Bmp6/Smad1,5,8 pathway using mice with
targeted disruption of Tfr2, Hfe, or both genes.
142 The
targeted disruption of TgCPC1 does not affect the invasi
143 We report that
targeted disruption of TGF-beta superfamily receptor ALK
144 gnificance of TSP3, we generated mice with a
targeted disruption of Thbs3.
145 ember in apoptosis, mice were generated with
targeted disruption of the 14-3-3tau gene.
146 We therefore characterized mice with
targeted disruption of the ABCA3 gene.
147 ogical roles of ACE2, we generated mice with
targeted disruption of the Ace2 gene.
148 null mutant (AE2(-/-)) mice were prepared by
targeted disruption of the AE2 (Slc4a2) gene.
149 Here, we utilize murine models with
targeted disruption of the akt2 or the akt1 genes to dem
150 Mice with a
targeted disruption of the alpha-switch region and 5' H
151 Here we evaluated, by
targeted disruption of the APN gene, whether APN partici
152 By
targeted disruption of the Atac2 locus in mice, we demon
153 Targeted disruption of the BBSome by Bbs1 gene deletion
154 Targeted disruption of the BCL2-PARP1 interaction theref
155 Mice with a
targeted disruption of the c-Cbl gene displayed increase
156 Targeted disruption of the c-myb gene resulted in a crit
157 Here we report that mice homozygous for
targeted disruption of the Cacna2d2 gene exhibit growth
158 ressure overload stimulation were blocked by
targeted disruption of the calcineurin Abeta gene.
159 Targeted disruption of the calcium-activated chloride ch
160 Targeted disruption of the capsid motor interaction may
161 Herein, we demonstrate that the
targeted disruption of the cbp gene in mice has no effec
162 s in the doublecortin (DCX) gene in human or
targeted disruption of the cdk5 gene in mouse lead to si
163 We have shown that
targeted disruption of the Ceacam1a (MHVR) gene resultin
164 We show that
targeted disruption of the cell surface Cripto/GRP78 com
165 Swollenin was shown to promote
targeted disruption of the cellulosic structure at fiber
166 Similarly, a
targeted disruption of the circadian clock within the he
167 adian rhythms by food and light in mice with
targeted disruption of the clock gene Bmal1, which lack
168 clockworks in mammals, we determined whether
targeted disruption of the clock genes, Per1 and/or Per2
169 Mouse lines with
targeted disruption of the cocaine amphetamine-related t
170 n of a mouse with complete CPN deficiency by
targeted disruption of the CPN1 gene.
171 Mice that have a
targeted disruption of the crest gene are viable but dis
172 The
targeted disruption of the Cul7 gene in mice results in
173 Mice heterozygous for a
targeted disruption of the cystathionine beta-synthase g
174 Mice with
targeted disruption of the Darc gene (Darc(E2) ) or WT m
175 Targeted disruption of the distal enhancer led to a loss
176 In this study, we have investigated how
targeted disruption of the DNA methyltransferases Dnmt3a
177 althy control mice and PARP-1(-/-) mice with
targeted disruption of the DNA repair enzyme, poly(ADP-r
178 al gene-targeting approach, we show that the
targeted disruption of the entire E2F activator subclass
179 ice deficient in all the isoforms of Ing1 by
targeted disruption of the exon that is common for all i
180 bsorption syndrome that we developed through
targeted disruption of the first 3 coding exons of the m
181 oid hormone receptors (SMRT)(mRID1) in which
targeted disruption of the first receptor interaction do
182 Targeted disruption of the Fli1 gene results in embryoni
183 Targeted disruption of the Friend leukemia integration 1
184 ere engineered to lack the alpha4 subunit by
targeted disruption of the Gabra4 gene.
185 ck-out mouse (Gal-3KO), we demonstrated that
targeted disruption of the galectin-3 gene significantly
186 Its identity was established by
targeted disruption of the gene cluster as well as by he
187 We used mice with
targeted disruption of the gene encoding alpha-syntrophi
188 We used mice with
targeted disruption of the gene encoding alpha-syntrophi
189 Targeted disruption of the gene encoding D4Rs reduces th
190 1/2) dephosphorylation plays in vivo through
targeted disruption of the gene encoding dual-specificit
191 However, mice with
targeted disruption of the gene encoding IL-6 (IL-6-/-)
192 Targeted disruption of the gene encoding KDM1B had no ef
193 Targeted disruption of the gene in D. discoideum resulte
194 t genetic inactivation of hCDC4, by means of
targeted disruption of the gene in karyotypically stable
195 Targeted disruption of the gene that encodes ghrelin res
196 we used embryonic fibroblasts from mice with
targeted disruption of the genes encoding for both the p
197 Targeted disruption of the genes encoding mitochondrial
198 Mice with adipocyte-specific
targeted disruption of the genes encoding the HIF1 oblig
199 and survival rate were studied in mice with
targeted disruption of the genes for PTGS and PGE recept
200 tations this elicits, we generated mice with
targeted disruption of the GLUT4 glucose transporter in
201 topoietic cell-specific GPI-AP deficiency by
targeted disruption of the GPI biosynthesis gene PigA.
202 In the present study, mice with
targeted disruption of the growth hormone (GH) receptor
203 Mutant mice bearing a
targeted disruption of the heparan sulfate (HS) modifyin
204 sf4 gene causes cataract, and mice bearing a
targeted disruption of the hsf4 gene exhibit defects in
205 I kappa BNS in TCR triggering, we created a
targeted disruption of the I kappa BNS gene.
206 Recent studies showed that
targeted disruption of the IA-2 gene in mice resulted in
207 Anergy was prevented by
targeted disruption of the IDO gene in the DCs or by adm
208 ated in severely immunodeficient mice with a
targeted disruption of the IL2Rgammac gene have recently
209 Targeted disruption of the inhibin alpha gene (Inha(-)(/
210 Targeted disruption of the interaction between EB1 and p
211 This regulatory effect was abolished by
targeted disruption of the interactions of Ezh2 with the
212 of cancer cells, which is necessary for the
targeted disruption of the intracellular machinery, rema
213 Exploiting mice with a
targeted disruption of the Kvbeta1 gene (Kvbeta1-/-), th
214 ed for the malic enzyme metabolic pathway by
targeted disruption of the maeE or maeK gene in ABSA dem
215 Here we show using a mouse model with a
targeted disruption of the MAGL gene that MAGL is the ma
216 Here we show that mice with a
targeted disruption of the Maml1 gene have severe muscul
217 Using mice with a
targeted disruption of the Mgmt gene, we tested whether
218 sing mouse embryonic fibroblasts (MEFs) with
targeted disruption of the Mkk3 and Mkk6 genes (MKK3-/-
219 -induced apoptosis is enhanced in cells with
targeted disruption of the Mnk1 and/or Mnk2 genes, sugge
220 Targeted disruption of the mouse Hus1 cell cycle checkpo
221 Targeted disruption of the mouse Rev3L gene causes letha
222 r, we generated a knockout mouse from a gene-
targeted disruption of the murine ABCA2 gene.
223 on of each enzyme, we studied the effects of
targeted disruption of the murine CA genes, called Car5A
224 Targeted disruption of the murine gene Gp6 on a mixed 12
225 Using
targeted disruption of the murine GRP94 gene, we show th
226 Targeted disruption of the murine Iqgap2 gene resulted i
227 Targeted disruption of the murine kindlin-2 gene resulte
228 Here, we examined the effect of
targeted disruption of the murine Mlk3 gene.
229 in detail, we generated a mouse model with a
targeted disruption of the murine ortholog ClC-K2.
230 Targeted disruption of the murine suppressor of fused ge
231 ification of small organic molecules for the
targeted disruption of the NFAT-calcineurin interaction
232 -null mutant (NHE4-/-) mice were prepared by
targeted disruption of the NHE4 (Slc9a4) gene.
233 Here, we show that
targeted disruption of the novel gene Rnase10 encoding a
234 Mice carrying a
targeted disruption of the Npr1 gene (coding for guanyly
235 antioxidant response, we examined mice with
targeted disruption of the Nrf2 gene.
236 Targeted disruption of the onecut transcription factor,
237 ied its functions in epidermis of mice, with
targeted disruption of the orai1 gene, human skin sectio
238 of ORAI1 deficiency, we generated mice with
targeted disruption of the Orai1 gene.
239 eport on the characterization of mice with a
targeted disruption of the organic anion transporting po
240 Mice with
targeted disruption of the P2X(7) gene were used to eval
241 Such activation is defective in cells with
targeted disruption of the p38alpha MAPK gene, indicatin
242 Mice homozygous for
targeted disruption of the PAPPA gene were viable but 60
243 Here, we have reported that
targeted disruption of the Pbp/Pparbp gene in hepatocyte
244 Targeted disruption of the PE_PGRS47 (Rv2741) gene led t
245 These observations suggest that
targeted disruption of the peptide YY gene does not pert
246 In this study, we show that autoimmune-
targeted disruption of the pituitary-ovarian axis leads
247 euromuscular system, we examined mice with a
targeted disruption of the pro-death gene Bax.
248 eterozygous haploinsufficient mouse model by
targeted disruption of the promoter and exon 1 regions o
249 Targeted disruption of the Puralpha gene reduced NHE act
250 oxisomal membrane channel Pxmp2, mice with a
targeted disruption of the Pxmp2 gene were generated.
251 icity by testing the antibodies on mice with
targeted disruption of the relevant genes.
252 Targeted disruption of the retinoblastoma (Rb) tumour su
253 of RhoG, we generated mice homozygous for a
targeted disruption of the RhoG gene.
254 STAT activation is diminished in cells with
targeted disruption of the Rictor gene, whose protein pr
255 Mice with a
targeted disruption of the SCD1 isoform have reduced bod
256 in hearts from adult mice with heterozygous
targeted disruption of the Scn5a gene to clarify the rol
257 den infant death syndrome (SIDS).Mice with a
targeted disruption of the serotonin transporter (5-HTT)
258 In characterizing mice with
targeted disruption of the SerpinB2 gene, we observed an
259 Here, we report that
targeted disruption of the Slc4a5 gene encoding the elec
260 Targeted disruption of the sterol 12alpha-hydroxylase ge
261 Functionally,
targeted disruption of the STM1 gene results in rapamyci
262 age lymphoma cells rendered SYK-deficient by
targeted disruption of the syk gene.
263 espectively, in macrophages from mice with a
targeted disruption of the TBK1 gene.
264 By analyzing mice with
targeted disruption of the Tet2 catalytic domain, we sho
265 Conversely,
targeted disruption of the TG-hydrolyzing enzyme lipopro
266 VS fails to label cells lacking TgCPL due to
targeted disruption of the TgCPL gene in two different p
267 olled by adenosine, we generated mice with a
targeted disruption of the third coding exon of Cd73 to
268 tes, TPST-2-deficient mice were generated by
targeted disruption of the Tpst2 gene.
269 We have generated mice harboring a
targeted disruption of the UbC gene.
270 One of the phenotypes of mice with
targeted disruption of the uncoupling protein-2 gene (Uc
271 Targeted disruption of the Ush2a gene in mice leads to p
272 ements for YAP, we generated mice carrying a
targeted disruption of the Yap gene.
273 and a dramatic reduction of CAA occurs after
targeted disruption of the Znt3 gene in these mice.
274 Targeted disruption of these genes in exposed cells comp
275 e deficient in BLT1 and BLT2 by simultaneous
targeted disruption of these genes.
276 Moreover, we show that the
targeted disruption of these high-confidence structured
277 Targeted disruption of these labile copper stores by acu
278 Targeted disruption of this activity will increase our u
279 further assess the candidacy of Adamts16 by
targeted disruption of this gene in a rat genetic model
280 orylated beta-catenin and pSmad2 and suggest
targeted disruption of this interaction as a potential t
281 Most important, we found that a
targeted disruption of this interaction leads to an inab
282 omeostasis by studying the consequences of a
targeted disruption of this kinase.
283 RIP-B7.1 mice homozygous for
targeted disruption of TLR9, TLR3, and myeloid different
284 These results indicate that
targeted disruption of TM-TM interactions significantly
285 Targeted disruption of TSC-22 in wild-type mice enhanced
286 ion of apoptosis is diminished in cells with
targeted disruption of TSC2, a negative upstream effecto
287 CC with high penetrance using liver-specific
targeted disruption of tumor suppressors SMAD4 and PTEN.
288 Thus,
targeted disruption of tylU reduced tylosin yields by ab
289 Here we report that
targeted disruption of Ubb results in male and female in
290 Previously, we showed that
targeted disruption of Wnt5a results in over-branching o
291 Here we show using null mice produced by
targeted disruption of Zan that zonadhesin confers speci
292 Targeted disruption of Zbtb1 recapitulated the T(-)B(+)N
293 ter crescentus using a bioinformatic screen,
targeted disruptions of each histidine kinase and respon
294 Indeed, we find that mice with
targeted disruptions of each of four of these genes (Brs
295 tioned place preference, we used mice having
targeted disruptions of either the AC1 or AC8 genes or b
296 lying this trafficking, we studied mice with
targeted disruptions of either the gene that encodes the
297 rin activity of VP2 and VP3 was inhibited by
targeted disruptions of individual hydrophobic domains a
298 e the usefulness of this protocol, we report
targeted disruptions of members of the cadherin gene fam
299 esponses by electroretinography in mice with
targeted disruptions of the genes encoding them.
300 onal activities of REA in vivo, we have used
targeted disruption to delete the REA gene in mice.