ライフサイエンスコーパス: targeting

1 for the fidelity of cotranslational protein targeting.

2 er, protein-protein interaction, and protein targeting.

3 RISPR (Acr) proteins that inhibit CRISPR-Cas targeting.

4 ring opportunities for potential therapeutic targeting.

5 holographic 3D guidance to assist CT-guided targeting.

6 me, indicating a unique evolution of plastid targeting.

7 rotein substrates, often to mediate membrane targeting.

8 tic anti-CD40 with antiangiogenic antibodies targeting 2 proangiogenic factors, vascular endothelial

9 results further demonstrate the potential of targeting 20E signaling pathways to reduce malaria paras

10 a focused high-coverage CRISPR-Cas9 library targeting 332 members of a recently published SARS-CoV-2

11 cells using a focused dual guide RNA library targeting 852 DDR-associated genes.

12 sis of molecular cages with novel topologies targeting a broad range of applications.

13 nd yo personalize the administered activity, targeting a mean tumor-absorbed dose of more than 90 Gy

14 When targeting a single gene, the lipoMSN achieved a 54% gene

15 ould restrict the effectiveness of therapies targeting a single node of the oncogenic signaling netwo

16 marker and point to the potential utility of targeting ABCB5 to improve current GBM therapies.

17 ar-infrared fluorophore with inherent kidney-targeting ability.

18 Sunitinib malate (Sunb-malate) targeting against multiple receptor tyrosine kinases, ex

19 BG-P-TAT is a dual-targeting agent, targeting the NET function and the thyr

20 for all of the 18 policies except for those targeting alcohol and physical activity.

21 Prostate-specific membrane antigen (PSMA)-targeting alpha-radiation therapy (TAT) is an emerging t

22 ynthesis, conferring resistance to therapies targeting anabolic pathways.

23 plasmic reticulum (ER) is accompanied by the targeting and accumulation of specific hydrophobic, memb

24 Met signaling is sufficient to redirect axon targeting and disrupt the topographic map.

25 BH sites are important determinants of motor targeting and may have a similar role in the localizatio

26 have not been available, impeding antiviral targeting and understanding of the pH-dependent transiti

27 r the continued development of phage therapy targeting antibiotic-resistant bacterial infections gene

28 To this end, we propose using MMP-targeting antibodies that can achieve high specificity i

29 Our targeting approach is based on pHLIP, a unique peptide t

30 mplications of COVID-19 and suggest that NET-targeting approaches could be considered for the treatme

31 ten dengue envelope protein domain III (ED3)-targeting aptamers into a two-dimensional pattern precis

32 The only known requirements for PIC targeting are a Gram-negative cell envelope and a unique

33 privation treatment and chemotherapy through targeting ASS1- and GLUT1-mediated arginolysis and glyco

34 It is so pervasive that several projects, targeting audiences with specialized needs, have develop

35 Targeting AZM to children at highest risk of death may b

36 the Mdr2 KO phenotype, suggesting caution in targeting beta-catenin globally for all cholestatic cond

37 An inhibitor targeting beta-catenin transcriptional interactions hind

38 New, fast-acting T2-targeting biologics (already used for preventing asthma

39 vailable inhibitors of glucose transporters, targeting both GLUT1 and GLUT3.

40 n humans) and provide a strong rationale for targeting BRD2/BRD4 for disease treatment and intercepti

41 microglia in modifying developmental myelin targeting by oligodendrocytes.

42 raising the possibility for subtype-specific targeting by pharmacological means for treatment of neur

43 on for a structural understanding of how DNA targeting by TniQ-Cascade leads to downstream recruitmen

44 mutational process, whereas APOBEC signature targeting C>G is activated in the intermediate phase of

45 These findings suggest that targeting c-Myc may unlock novel strategies to combat as

46 ma cells (Hepa1-6), a promising approach for targeting cancer and metabolic disorders.

47 sumption is an immune evasion mechanism, and targeting cancer methionine signalling may provide an im

48 Targeting cancer neoantigens generated by tumor-exclusiv

49 s therefore highly attractive to combine the targeting capabilities of exosomes and the bio-orthogona

50 Therapeutic interventions targeting catabolic pathways have, however, largely fail

51 cological manipulation offers the promise of targeting catalysis-mediated signaling without grossly d

52 onoclonal and bispecific antibody constructs targeting CD19 and CD22 might further improve outcomes a

53 ion in acute models of HS through mechanisms targeting cell swelling-induced microcirculatory failure

54 We find that IL-2C targeting cells expressing IL-2 receptor beta cause an a

55 Novel therapies targeting certain aberrations, most notably BRCA1/2 muta

56 Recently, treatments with two drug classes targeting CFTR-one boosting ion-channel function (potent

57 the radiohybrid concept show equal or better targeting characteristics than the established (18)F-PSM

58 By using a proteolysis-targeting chimera (PROTAC) strategy that couples an allo

59 Using PROteolysis TArgeting Chimeras (PROTACs) to degrade proteins that ar

60 s, and 3730 repeat-associated siRNAs (mostly targeting Class I/Copia-Ivana- Copia-SIRE and LINEs elem

61 6/UFD4-UBC4/5 are shown to form an analogous targeting complex.

62 rapeutically exploited with the mitochondria-targeting compound alexidine dihydrochloride.

63 ns to create chemical assembly systems (CAS) targeting compounds and libraries sharing structural cor

64 Here, we leverage a class of known membrane-targeting compounds that we previously showed to have br

65 demonstrate a strategy to tune RNA structure-targeting compounds to the cellular localization of the

66 virus vaccines and infections, we found mAbs targeting conserved neutralizing influenza virus hemaggl

67 nd 2-4 fold accumulation compared to the non-targeting control liposomes (p < .0001), as measured by

68 Our work suggests that targeting cooperative traits is a viable solution to the

69 s pyogenes Cas9 (SpyCas9), we used both self-targeting CRISPR screening and guilt-by-association geno

70 an be more potent in killing cSCC cells than targeting CRLs or CRL4s in general by RBX1 or DDB1 deple

71 In contrast, high concentrations of self-targeting crRNAs resulted in lower acquisition that was

72 dystrophic Cx43 remodeling and suggest that targeting Cx43 may be a therapeutic strategy for prevent

73 hat domain-specific PLA(2)R1 antibody levels targeting CysR, CTLD1, and CTLD7 strongly correlate with

74 means because of the difficulty in specific targeting/delivery to the tumor site.

75 gs indicate that public health interventions targeting diabetes prevention and management would be a

76 Targeting Diaph1 or Rab5a suppressed HSC activation and

77 also operates in a cell type-specific manner targeting distinct sets of genes in human excitatory and

78 and confirm rescue by low temperature, CFTR-targeting drugs and second-site revertant mutation R1070

79 Currently, all four FDA-approved HDAC-targeting drugs are nonselective, pan-HDAC inhibitors, e

80 We explored whether currently available T2-targeting drugs can reasonably be seen as potential play

81 ts; and finally, the potential value of NAAA-targeting drugs in the treatment of human inflammatory d

82 Ectopically targeting E3 to membranes in the absence of WIPI2 is ins

83 ed with optimal clinical response in cohorts targeting either structure.

84 oach for cementum regeneration, particularly targeting ENPP1 and/or ANK.

85 Targeting epicardium-derived stromal cells (EpiSC) by sp

86 Furthermore, targeting EZH2 for depletion with DZNep strongly sensiti

87 preclinical proof-of-principle evidence for targeting EZH2 in patients with MB.

88 Mechanistically, targeting EZH2 promotes transition from H3K27me3 to H3K2

89 This particular feature is used for targeting fast-proliferating tumor cells during chemo-,

90 Targeting Fn-EDA in human aortic SMCs suppressed the syn

91 SIV infection and suggest their therapeutic targeting for promoting neuronal recovery.IMPORTANCE Bra

92 e detrimental, and agents amenable to tissue targeting for therapeutic application have been lacking.

93 Our results demonstrate that targeting FPR1 by a selective small molecule antagonist,

94 Through this polar DprA targeting function, sigma(X) mediates the timely shut-of

95 These results effectively demonstrate that targeting glutamine metabolism may be an effective appro

96 Indeed, targeting glutamine metabolism rendered checkpoint block

97 is and to screen for anti-fibrotic compounds targeting glycogen synthase kinase 3, which has a consis

98 severely limit the therapeutic potential of targeting Grb14.

99 Taken together, our data suggested that targeting GRPR and NPRA may provide effective treatments

100 d by Genetic Analysis GA-map Dysbiosis test, targeting >=300 bacteria on different taxonomic levels.

101 Targeting H(2)S to the mitochondria may be of therapeuti

102 cs of the tumor microenvironment for precise targeting have been designed.

103 Therefore, targeting HDAC8 may be novel therapeutic approach for tr

104 Together, these results suggest that targeting HDL interactions with BrM represents a new str

105 S are first applied to three different gRNAs targeting HEK293 genomic DNA, resulting in a set of 55 h

106 Targeting highly conserved genomic regions make pan-fami

107 abetic interstitial fibrogenesis; therefore, targeting Hippo signaling may be a therapeutic strategy

108 the role of awake consolidation processes by targeting hippocampal interactions with lateral occipita

109 y to develop broad-spectrum antiviral agents targeting host factors.

110 Rather than targeting Hsp70 itself, here we have examined the feasib

111 ase superfamily and may open new avenues for targeting human FN3K in diabetic complications.

112 e we discuss the most recent developments in targeting IL-17 for the treatment of chronic inflammatio

113 Targeting immune suppression using checkpoint inhibition

114 nd assess the potential therapeutic value of targeting immunity in human stroke.

115 ying metabolic vulnerability for therapeutic targeting in SLC7A11(high) cancers.

116 enerated an RFX6(HA) reporter allele by gene targeting in wild-type H9 cells to precisely define RFX6

117 bile acid-based oral drug delivery for ASBT-targeting, including bile acid-based prodrugs, bile acid

118 Because of the low sensitivity, targeting individuals in non-help-seeking samples based

119 y illustrates the potential of phage therapy targeting infections such as bacterial neonatal meningit

120 enotype and will thus benefit from therapies targeting inflammation.

121 epression, and the MRI-guided method of coil targeting is not better than the standard method.

122 important therapeutic target with inhibitors targeting its methyltransferase activity under clinical

123 tural approach to inform clinical efforts in targeting KRAS-G12D tumors by immunotherapy and has gene

124 Targeting LAT1-mediated amino acid uptake is a potential

125 , reversible PTP inhibitor with an E3 ligase targeting ligand through a well-designed linker, the fir

126 receptor-mediated endocytosis by hepatocyte targeting-ligands.

127 s were available that addressed the topic of targeting lipid metabolism in PCa.

128 The targeting liposomes containing 10 mol% GM-modified lipid

129 They suggest that targeting lung macrophages to increase their phagocytic

130 o suggest that pharmacological interventions targeting lysosomal function in general, and those parti

131 Targeting MARCO or IL37 receptor (IL37R) by antibody or

132 s and suggest the need for improved polyplex targeting materials that penetrate brain extracellular m

133 Targeting Mcl-1 may be a therapeutic strategy in EAC.

134 ramework for structure-guided drug discovery targeting MCTs.

135 The Zn(II)-targeting mechanism enriches the inactive cargo in beta-

136 cally ineffective, and multi-modal therapies targeting mechanisms of immunotherapy resistance are lik

137 Selectively targeting memory Th17 cells may be a viable therapeutic

138 o reveal opportunities to reshape the TME by targeting metabolic pathways to favor immunity.

139 rch, particularly involved in drug discovery targeting metalloenzymes.

140 nd density functional theory (DFT) modeling, targeting methanol formation from CO(2)/H(2) feeds at 17

141 een limited due to the lack of cell-specific targeting methods in brain tissue or living animals.

142 This study aimed to identify AQP5-targeting miRNAs and examine their effects on breast can

143 Delivery of siRNA-peptide nanoplexes co-targeting MK2 and XPA to pre-existing p53-deficient tumo

144 sentations, additional surveillance programs targeting more diverse populations and prolonged samplin

145 These findings suggest that targeting mortalin has potential as a selective therapeu

146 We report three broadly reactive human MAbs targeting N1 NA.

147 ently-reported integrin alpha5(ITGA5) active targeting nanoparticles (uPtDs NPs) and tested their the

148 the efficacy of a protease inhibitor therapy targeting neutrophil elastase for the treatment of alpha

149 trategies utilizing agonists and antagonists targeting nucleic acid sensors to treat infectious disea

150 phisticated features optimised for precision-targeting of a wide range of cancers.

151 vascular changes and imply that therapeutic targeting of blood vessels may restore aged endocrine ti

152 Finally, we demonstrate selective covalent targeting of cellular Hsp90, which results in a prolonge

153 r structural optimization aimed at selective targeting of ClpB and/or DnaK.

154 Cas9/CRISPR-based system that allows ectopic targeting of Ctf19c-subunits.

155 Selective targeting of cyst cell proliferation is an effective mea

156 n the field of drug delivery is insufficient targeting of diseased tissues or cells.

157 posit that these advances in pharmacological targeting of DUBs establish the enzyme family as targeta

158 Allele-specific targeting of enCRISPRa to oncogenic TAL1 super-enhancer

159 Therapeutic targeting of epigenetic modulators offers a novel approa

160 We show that CRISPR-mediated targeting of glycolysis in T cells in mice results in gl

161 Targeting of HIF and its downstream targets in angiogene

162 proteins are crucial advances for antiviral targeting of influenza viruses.

163 This pathway-dependent targeting of kidney cancer arises from the fact that the

164 lla pneumophila infection blocked xenophagic targeting of L. monocytogenes by a RavZ-dependent mechan

165 vide a mechanistic framework for therapeutic targeting of ligand-dependent Hh signaling in human canc

166 Pharmacological co-targeting of MEK1/2, HDAC3, and G9a sustains PDAC tumor

167 present evidence supports screening for and targeting of modifiable risk factors for major bleeding,

168 h others in preclinical development, and the targeting of Na(V)1.9, although hampered by technical co

169 trials and household surveys, and inform the targeting of policies and prevention programming aimed a

170 ich could lead to strategies for therapeutic targeting of proteins of the NSD family.

171 generating chemical diversity for allosteric targeting of RORgammat.

172 Therefore, targeting of Septin2-mediated podosome formation is a po

173 fferences of the MA-mediated plasma membrane targeting of the B-type mouse mammary tumor virus (MMTV)

174 re by specifying the position, polarity, and targeting of these events.

175 ulations and studies in cells reveal that LD targeting of these motifs requires deeply inserted trypt

176 e variants of the NLRP1 inflammasome sensor, targeting of these pathways does not explain the lethali

177 t of peptidoglycan substrates on beta-lactam targeting of transpeptidation, and (d) demonstrate that

178 ng proteins TRAF3 and TRAF6, and that vIRF-2 targeting of USP7 regulates HHV-8 productive replication

179 onserved signaling pathways, pharmacological targeting of which substantially delays cardiomyocyte ma

180 Importantly, pharmacologic targeting of YAP reversed treatment-induced excessive co

181 Computational models for SHM targeting often model the targeting probability of a nuc

182 al factors such as the TATA-box and microRNA targeting on intrinsic or extrinsic noises and reveal ge

183 ffer from a mixed dementia, and therapeutics targeting only Alzheimer's disease-related processes may

184 al efficiency and radiation dose savings for targeting out-of-plane lesions.

185 A multiplex allele-specific PCR targeting outbreak-specific single nucleotide polymorphi

186 tor of lipid metabolism, and clinical trials targeting PCSK9 reduce cardiovascular disease.

187 fferent cell populations of the TME, such as targeting pericytes and endothelial cells for vascular n

188 Prostate-specific membrane antigen (PSMA)-targeting PET imaging is becoming the reference standard

189 ncoprotein in kidney cancer, for example, by targeting phosphatase and tensin homologue (PTEN) for pr

190 Conclusion A behavioral intervention targeting physical activity increased lower extremity mu

191 Moreover, the potential of targeting PKC with pharmacological tools to inhibit path

192 Prospective studies targeting plasma cell clones and/or fibrotic pathways ar

193 s combinatorial study of multiple transgenes targeting primary metabolism thus offers opportunities t

194 nal models for SHM targeting often model the targeting probability of a nucleotide in a motif-based f

195 Direct-acting agents, targeting protease and polymerase functionalities, repre

196 Plasmodium vivax to escape humoral immunity targeting PvDBP, the key ligand involved in reticulocyte

197 o move toward a paradigm that formulates RNA-targeting questions at the level of RNA structural subcl

198 such as gastrin-releasing peptide receptors targeting radiopharmaceuticals are small molecules with

199 aimed to discover small-molecule inhibitors targeting RANKL trimer formation.

200 show that high-affinity vaccines targeting rare B cells capable of broadly protective ant

201 ed drugs continues, an innovative approach - targeting receptor complexes - is emerging.

202 Targeting receptor proteins, such as ligand-gated ion ch

203 Successful IGF1R targeting requires receptor downregulation, yet therapy-

204 In CALGB 40601, dual HER2-targeting resulted in significant RFS and OS benefits.

205 Targeting retinoid X receptor (RXR) has been proposed as

206 Thus, our results support targeting S100A8/A9 pathways as host-directed therapy fo

207 up-to-date account of drug discovery efforts targeting selected enzymes (MbtI, MbtA, MbtM, and PPTase

208 Targeting senescence in the BMAd or other bone marrow ce

209 the brush border using a noncanonical apical targeting sequence that maps to a previously unannotated

210 ted chloroplasts, demonstrating a functional targeting sequence.

211 binations of feature values found in the MMP-targeting sets that are distinct from those in the refer

212 e, miR-26a prevents hyperinsulinemia through targeting several critical regulators of insulin secreti

213 seems to function as a tumour suppressor by targeting several proteins, including androgen receptor

214 ding and may aid in the development of drugs targeting sheddases.

215 bitor of SHP2 with drug-like properties, and targeting SHP2 may serve as a therapeutic strategy to ov

216 phils and mast cells in asthmatic sputum and targeting Siglec-8 with an antibody is a plausible strat

217 rescent secretory cargo by adding a vacuolar targeting signal.

218 ncreased DU145 proliferation compared to non-targeting siRNA, which was in the same direction as the

219 Targeting SIRT1 by RNAi led to elevated H3 lysine 9 acet

220 Our data support a therapeutic potential of targeting Sirt3 expression in vascular dysfunction and h

221 acquisition that was mostly centered on the targeting site.

222 provide optimal muscle relaxation; however, targeting skeletal myosin is particularly challenging be

223 MDAR currents and reduced firing of dendrite-targeting somatostatin-expressing (SST) GABAergic intern

224 This seeding activity can be ameliorated by targeting specific domain or proteostatic pathway of mHT

225 Our results demonstrate that targeting specific integrin make-ups is possible and may

226 r findings suggest that health interventions targeting specific multimorbidity patterns may reduce mo

227 cceed, T cell subsets with the correct tumor-targeting specificities must be mobilized.

228 ug conjugates (ADCs), which harness the high targeting specificity of monoclonal antibodies (mAb) wit

229 seronegative for anti-SARS-CoV-2 antibodies targeting spike (S) and nucleoprotein (N).

230 rcise combined with non-invasive stimulation targeting spinal synapses further promotes functional re

231 nteric pathogen subverts repair processes by targeting stem cells during infection and preventing epi

232 ey mechanism in aortic degeneration and that targeting STING may prevent sporadic AAD development.

233 our preclinical study supports intrathecally targeting sTNFalpha as a viable strategy to broadly atte

234 y, we examine the field's success to date in targeting stressors and stress allostasis in treatments

235 Omics and drug-targeting studies revealed that PI3Ks act to reduce gluc

236 Targeting survival pathways downstream of AR could be a

237 However, targeting survivin has been challenging due to its "undr

238 al spacer acquisition machinery found in DNA-targeting systems.

239 in vitro and conventional immunosuppressants targeting T cell activation had limited effects on contr

240 inhibitors and other therapeutic strategies targeting TAMs.

241 mpared to current established landmark-based targeting techniques.

242 is study established the proof of concept of targeting TF as a new target in CAR-NK immunotherapy for

243 Targeting the actin-binding proteins LIMK1 and LIMK2 sig

244 Targeting the autophagy pathway may have therapeutic ben

245 We find that targeting the BMME with P-selectin glycoprotein ligand-1

246 rational structure-based discovery of drugs targeting the cannabinoid system.

247 We test an ASO targeting the CFTR c.3718-2477C>T mutation and show that

248 cusses potential therapeutic applications of targeting the GDF15-GFRAL pathway and lastly suggests so

249 One mAb targeting the GP2 wing, MR228, showed therapeutic protec

250 Interventions targeting the gut microbiome may be warranted to reduce

251 trafficking and the vacuolar environment by targeting the host RGS2 protein.

252 d by iCP activity and the current status for targeting the iCP to elicit a therapeutic response.

253 Therapies targeting the IFN family and T-cell-activating factors m

254 These results define a therapeutic window targeting the inflammatory phase for optimal effects of

255 fectiveness of a digital health intervention targeting the intrinsic regulation of goal-directed aler

256 Targeting the MAPK pathway by combined inhibition of BRA

257 reviously engineered a synthetic DNA vaccine targeting the MERS coronavirus Spike (S) protein, the ma

258 s an urgent need to develop new therapeutics targeting the mitochondria to prevent or reverse disease

259 and with high affinity, and that antibodies targeting the N-terminal domain of ERFE that prevent ERF

260 BG-P-TAT is a dual-targeting agent, targeting the NET function and the thyrointegrin alphavb

261 for the possibility of preventing disease by targeting the parasite during the blood stage of infecti

262 All patients (100%) received prior ICIs targeting the PD-1 pathway.

263 In conclusion, although targeting the PD-1/PD-L1 pathway reinvigorates exhausted

264 s potential to achieve high selectivity when targeting the peptide substrate binding site of NTMT1/2.

265 tion, suppression of callose deposition, and targeting the plant defense regulator NPR1 and analyses

266 py with atezolizumab, a checkpoint inhibitor targeting the programmed cell death 1 (PD-1) axis, has s

267 Antibodies targeting the RSV G central conserved domain are protect

268 and GEF-dependent RAS activation (such as by targeting the scaffolding phosphatase SHP2).

269 Targeting the serotonin (5-HT) 5-HT(2C) receptor (5-HT(2

270 lso provide a template for photopharmacology targeting the ubiquitous actin cytoskeleton with precisi

271 rs at plasma membrane, cytosol, and nucleus, targeting them for degradation via the endosomal/vacuola

272 rategy in clinical exploration of cell cycle-targeting therapies in brain cancers.

273 Whether therapies targeting these mutations can eradicate premalignant cel

274 The development of molecules targeting these type-2 pathways has transformed severe a

275 ity is frequently deregulated in disease and targeting this class of proteins is a major focus of int

276 d by a lack of effective molecular therapies targeting this disease.

277 ghput, cellular NanoBRET assay was developed targeting this interaction.

278 s will help develop new treatment approaches targeting this oncogenic cascade.

279 on in cancer cells and may inform approaches targeting this oncogenic transcription factor to manage

280 Targeting this platform with anti-IL7R antibody eliminat

281 ated that some level of iron restriction (by targeting Tmprss6) would improve splenomegaly while pres

282 on, is also necessary and sufficient for its targeting to the ciliary base.

283 he mitotic kinesin-like protein 2 (MKLP2) in targeting to these distinct localizations.

284 ave shown some success, there are underlying targeting, toxicity, and immunogenicity challenges.

285 tasis, silencing TRAF3IP2 is more effective; targeting TRAF3IP2 inhibited tumor formation, regressed

286 urbing protein synthesis in a mouse liver by targeting translation elongation factor 2 (eEF2) with RN

287 drawbacks can be circumvented by CAR-T cells targeting tumour-specific driver gene mutations, such as

288 A UbV targeting Ube2D1 did not affect charging but greatly att

289 We screened an RNAi library targeting ubiquitin E3 ligases and observed that knockdo

290 ex and non-convex constraint-based models by targeting under-sampled regions of the solution space.

291 e R language are freely available on GitHub, targeting users with intermediate experience in bioinfor

292 ell-shaped relationship was found between NC targeting valency and the rate of transcytosis, where hi

293 T therapies, such as selection of ideal TCRs targeting validated epitopes with well-characterized can

294 1A) receptor-biased agonists, preferentially targeting various signaling pathways, have the potential

295 Introduction of anti-angiogenic drugs targeting vascular endothelial growth factor (VEGF) has

296 results suggest that combination treatments targeting vascular health, amyloid-beta, and tau levels

297 oach for drug delivery, bioimaging, and cell targeting was also demonstrated.

298 The significance of sensory neuron targeting was pursued subsequently by testing C2C activi

299 mics of Hgf/Met signaling to coordinate axon targeting with the developmental progression of the phar

300 ally, the paper reviews clinical efficacy of targeting with these novel MRI techniques when compared