ライフサイエンスコーパス: taste bud

1 lular capillaries and tight junctions in the taste bud.

2 nto the narrow extracellular spaces within a taste bud.

3 an elegant cellular organization within the taste bud.

4 ) and GABA(B) receptors are expressed in the taste bud.

5 ying integration of new taste cells into the taste bud.

6 inappropriate targets, leading to a loss of taste buds.

7 ng corpuscular endings that appose laryngeal taste buds.

8 ecular differentiation process of endogenous taste buds.

9 for regulating TNF production and effects in taste buds.

10 nsory innervation of the remaining fungiform taste buds.

11 in regions of the tongue normally devoid of taste buds.

12 filiform and fungiform papillae, but also to taste buds.

13 xpressed in subsets of taste cells in murine taste buds.

14 esting that NTPDase2 is the dominant form in taste buds.

15 advantage of the expansion in the number of taste buds.

16 ique patterns of neuropeptide secretion from taste buds.

17 ut also in cells in the caudal brainstem and taste buds.

18 lls that support the papilla and specialized taste buds.

19 and epithelium including taste papillae and taste buds.

20 ved in the development of taste papillae and taste buds.

21 to measure transmitter release from isolated taste buds.

22 It is also expressed in adult taste buds.

23 ween papillae, and within papillae and early taste buds.

24 significantly diminished ATP secretion from taste buds.

25 at 6 dpi accelerates entry of new cells into taste buds.

26 -release machinery remains functional in DKO taste buds.

27 ilarly expressed in taste buds in WT and DKO taste buds.

28 ly also during growth and differentiation of taste buds.

29 and each target contained the same number of taste buds.

30 les in the development of taste papillae and taste buds.

31 l numbers of cells in anterior and posterior taste buds.

32 region in cavefish and later was confined to taste buds.

33 ectable by immunohistochemistry in fungiform taste buds.

34 been proposed to underlie umami detection in taste buds.

35 ATP and pannexin 1 hemichannels in mammalian taste buds.

36 hus ruling out a mesenchymal contribution to taste buds.

37 d no effect of cell-to-cell communication in taste buds.

38 e a neurotransmitter or paracrine hormone in taste buds.

39 in the supply of new taste receptor cells to taste buds.

40 o NaCl in a semi-intact preparation of mouse taste buds.

41 ractionated IR induced death of cells within taste buds.

42 or patterning and morphogenesis of tooth and taste buds.

43 und tdTomato-positive innervation within all taste buds.

44 , polymodal nociceptors, rather than through taste buds.

45 d no effect on taste-evoked ATP release from taste buds.

46 g during processing gustatory information in taste buds.

47 id oral lamina is competent to form teeth or taste buds.

48 are signals processed in sensory end organs, taste buds?

49 III taste receptor cells (TRCs), located in taste buds across the tongue and palate epithelium.

50 t GABA is an inhibitory transmitter in mouse taste buds, acting on GABA(A) and GABA(B) receptors to s

51 sodium channel was conditionally deleted in taste buds (alphaENaC knockout).

52 at specific times in development showed that taste bud amplification and eye degeneration are sensiti

53 hyperactive Shh signaling increases oral and taste bud amplification in cavefish at the expense of ey

54 ) have a nucleus in the lower quarter of the taste bud and a foot process extending to the basement m

55 r normal Shh signaling in fungiform papilla, taste bud and filiform papilla maintenance was shown by

56 lator that maintains lingual taste papillae, taste bud and progenitor cell proliferation and differen

57 due to lateral transfer of the tracer in the taste bud and taste receptor expression in sensory gangl

58 tantly, we find that P2X2 is expressed in WT taste buds and appears to function as an autocrine, posi

59 Up-regulation of TrkB transcripts in taste buds and elevated taste cell-specific TrkB phospho

60 Diverse sensory organs, including mammalian taste buds and insect chemosensory sensilla, show a mark

61 chorda tympani (CT) nerve innervates lingual taste buds and is susceptible to damage during dental an

62 , pigment loss, increased size and number of taste buds and mechanosensory organs, and shifts in many

63 l be particularly relevant for cell types in taste buds and other tissues that can be identified only

64 Based on studies on isolated taste buds and single taste cells, we have postulated th

65 sory neurons innervating lingual and palatal taste buds and somatosensory neurons innervating the pin

66 Isolated taste cells, taste buds and strips of lingual tissue from taste papil

67 rt, we determined the targets of CGRP within taste buds and studied what effect CGRP exerts on taste

68 We isolated mouse taste buds and taste cells, conducted functional imaging

69 y degraded to adenosine within mouse vallate taste buds and that this nucleoside acts as an autocrine

70 were positioned against mouse circumvallate taste buds and the taste buds were stimulated with KCl (

71 orphogenesis, innervation and maintenance of taste buds and their stem/progenitor cells.

72 Gustatory stimuli are detected by taste buds and transmitted to the hindbrain via sensory

73 epresent only a small fraction of cells in a taste bud, and numerous ion channels with no role in sou

74 e of taste organs, the fungiform papilla and taste bud, and surrounding lingual cells.

75 ere identified in type II taste cells of the taste bud, and VIP knockout mice exhibit enhanced taste

76 organs, including teeth, taste papillae, and taste buds, and is essential for these processes to occu

77 muli are transduced by receptor cells within taste buds, and like epidermal cells, taste cells are re

78 ctionated IR mouse model to characterize how taste buds are affected.

79 Taste buds are aggregates of 50-100 polarized neuroepith

80 When intact mammalian taste buds are apically stimulated with umami tastants,

81 Taste buds are assemblies of elongated epithelial cells,

82 Cells in taste buds are closely packed, with little extracellular

83 aquatic animals like bony fishes, teeth and taste buds are colocalized one next to the other.

84 Mammalian taste buds are comprised of specialized neuroepithelial

85 Taste buds are comprised of taste cells, which are class

86 These SHH-induced ectopic taste buds are found in regions of the adult tongue prev

87 the geniculate ganglion and nerve fibers in taste buds are GFP-positive.

88 The remaining taste buds are hyperinnervated, demonstrating a disrupti

89 ement a slice preparation in which fungiform taste buds are in a relatively intact tissue environment

90 Taste buds are innervated by neurons whose cell bodies r

91 Teeth and taste buds are iteratively patterned structures that lin

92 Taste buds are minimally affected when Shh is lost from

93 However, taste buds are more sensitive to BDNF than NT-4 removal.

94 In addition, the overall number and size of taste buds are normal in Entpd2-null mice.

95 he same early developmental period, although taste buds are not formed until much later.

96 Taste buds are unusual in requiring ATP as a transmitter

97 exosomes promoted innervation of regenerated taste buds, as evidenced by elevated expressions of neur

98 ificant reductions in the number and size of taste buds, as well as in the number of taste receptor c

99 lion subpopulations separately and remaining taste buds at birth within each target field in wild-typ

100 to 4 gustatory neurons and contained 3 to 16 taste buds at birth, indicating that some taste buds rem

101 ral-pharyngeal constructive traits (jaws and taste buds) at the expense of eyes in the blind cavefish

102 etween a variety of cells located within the taste buds before signal propagation to the brain.

103 thelial progenitors shared with anteriormost taste buds, before establishing within slow-cycling cell

104 In addition to ovoid-shaped taste buds, big tube-shaped taste buds were observed in

105 is not only endogenously expressed in mouse taste buds but also in lung airway epithelial cells, whi

106 Taste receptors are expressed not only in taste buds but also in the gastrointestinal tract.

107 een thought to play a supportive role in the taste bud, but little research has been done to explore

108 ins, has been implicated in ATP release from taste buds, but it has not been evaluated for a function

109 ection eliminated all labeled innervation to taste buds, but most of the additional innervation in th

110 of this ectonucleotidase in the function of taste buds by examining gene-targeted Entpd2-null mice g

111 ted that some gut peptides are released from taste buds by prolonged application of particular taste

112 pondin can substitute for neuronal input for taste bud cell replenishment and taste bud maintenance.

113 14, CK8, and markers for type I, II, and III taste bud cells (NTPdase 2, PLC-beta2, and AADC, respect

114 Type II and III taste bud cells (TBCs) detect molecules described by hum

115 investigation on the role of type I GAD65(+) taste bud cells (TBCs) in taste-mediated physiology and

116 ion triggered Ca(2+) influx in CD36-positive taste bud cells (TBCs) purified from mouse CVP.

117 ires Fyn-Src kinase and lipid rafts in human taste bud cells (TBCs).

118 the absence of R-spondin in culture medium, taste bud cells are not generated ex vivo.

119 ther with previous reports for the origin of taste bud cells from local epithelium in postnatal mouse

120 The recent cloning of RGS21 from taste bud cells has implicated this protein in the regul

121 In the field of taste biology, taste bud cells have been described as arising from "loc

122 GLP-1 was released immediately from taste bud cells in response to sweet compounds but not t

123 stes requires the non-vesicular release from taste bud cells of ATP, which acts as a neurotransmitter

124 ls, from placode and apical papilla cells to taste bud cells only, a surrounding population of Ptch1

125 Taste bud cells regenerate throughout life.

126 ERK1/2 activation in human taste bud cells regulates fatty acid signaling and gusta

127 In response to gustatory stimulation, taste bud cells release a transmitter, ATP, that activat

128 Receptor (type II) taste bud cells secrete ATP during taste stimulation.

129 factor sonic hedgehog (Shh) and give rise to taste bud cells that differentiate around birth.

130 gs lead to a new concept about derivation of taste bud cells that include a NC origin.

131 are detected by dedicated subpopulations of taste bud cells that use distinct combinations of sensor

132 alts from other taste stimuli was deleted in taste bud cells throughout development.

133 ts of the signalling pathway used by type II taste bud cells to sense sweet, bitter and umami compoun

134 aining revealed that >80% of NaCl-responsive taste bud cells were of Type 2.

135 Here, we show that differentiation of new taste bud cells, but not progenitor proliferation, is in

136 showed NE does not appear to act on adjacent taste bud cells, or at least on receptor cells.

137 lease from sweet-, bitter- and umami-sensing taste bud cells.

138 ically in sweet/bitter/umami-sensing type II taste bud cells.

139 erent fibers and also stimulates neighboring taste bud cells.

140 ng via GCaMP3 expressed in Type 2 and Type 3 taste bud cells.

141 on of epithelial basal progenitor cells into taste bud cells.

142 Taste buds comprise four types of taste cells: three mat

143 Taste buds consist of at least three principal cell type

144 peripheral afferent nerve fibers innervating taste buds contain calcitonin gene-related peptide (CGRP

145 Taste buds contain multiple cell types with each type ex

146 Taste buds contain two types of cells that directly part

147 More than a century ago it was shown that taste buds degenerate after their innervating nerves are

148 ing a positive correlation between tooth and taste bud densities.

149 Wnt signaling couples tooth and taste bud density and BMP and Hh mediate distinct organ

150 oss cichlid species with divergent tooth and taste bud density, and were expressed in the development

151 nstrated that the morphological integrity of taste buds depends on their innervation.

152 How taste buds detect NaCl remains poorly understood.

153 ogists do not fully understand how teeth and taste buds develop from undifferentiated epithelium or h

154 in signaling centers throughout papilla and taste bud development and differentiation.

155 These studies further suggest that mammalian taste bud development is very distinct from that of othe

156 poral functions of beta-catenin in fungiform taste bud development.

157 signaling has an important role in oral and taste bud development.

158 Taste buds differentiate at birth within epithelial appe

159 followed by taste papilla morphogenesis and taste bud differentiation, but the degree to which these

160 r innervation to drive the entire program of taste bud differentiation.

161 ithelium act in concert to support continued taste bud differentiation.

162 Combined with other features of chicken taste buds, e.g., uniquely patterned array and short tur

163 at the neural crest does not supply cells to taste buds, either embryonically or postnatally, thus ru

164 neurotransmitter that has been implicated in taste buds, elicits calcium mobilization in Receptor (Ty

165 knockout mice all cell types are present in taste buds, even those cells normally expressing NTPDase

166 Previously we have shown that taste buds express various molecules involved in innate

167 oupled receptors, mGluR4 and mGluR1, and the taste bud-expressed heterodimer T1R1+T1R3.

168 Offspring also exhibited increased taste bud expression of mRNA for sweet receptor subunits

169 le knockout mice showed, however, that their taste buds fail to release ATP, suggesting the possibili

170 orm, diverts lingual epithelial cells from a taste bud fate.

171 ained candidate genes expressed in tooth and taste bud fields.

172 hosphate (cAMP), is known to be modulated in taste buds following exposure to gustatory and other sti

173 e of endogenous taste buds, however, ectopic taste buds form independently of both gustatory and soma

174 ransduced signals act in tongue, papilla and taste bud formation and maintenance, it is necessary to

175 buds and studied what effect CGRP exerts on taste bud function.

176 nally, we also defined the source of GABA in taste buds: GABA is synthesized by GAD65 in type I taste

177 ors that function as carbohydrate sensors in taste buds, gut, and pancreas.

178 ionship between placodes, papillae and adult taste buds has not been defined.

179 ids, but variants of two mGluRs expressed in taste buds have also been implicated.

180 The roles of these neurotransmitters in taste buds have not been fully elucidated.

181 Mammalian taste buds have properties of both epithelial and neuron

182 l-established nerve dependence of endogenous taste buds, however, ectopic taste buds form independent

183 ing cells in mouse circumvallate and foliate taste buds: IL-10 expression was found exclusively in th

184 e suggest that GABA may serve function(s) in taste buds in addition to synaptic inhibition.

185 nistic studies on the development of chicken taste buds in association with their feeding behaviors.

186 There is not an easy way to visualize all taste buds in chickens.

187 ct via the chorda tympani nerve to innervate taste buds in fungiform papillae.

188 to study the relationship between nerve and taste buds in fungiform papillae.

189 highly efficient method for labeling chicken taste buds in oral epithelial sheets using the molecular

190 s a modest but significant loss of fungiform taste buds in Phox2b-Cre; p75(fx/fx) mice, although ther

191 ickens, the sensory organs for taste are the taste buds in the oral cavity, of which there are ~240-3

192 geal nerve (IX), three nerves that innervate taste buds in the oral cavity, prominently occupy the gu

193 We show that taste buds in these mice are significantly larger and ha

194 of ATP secretion, are similarly expressed in taste buds in WT and DKO taste buds.

195 ical microvilli of the chemosensory cells of taste buds including the epithelium of lips and olfactor

196 BDNF also orchestrates and maintains taste bud innervation.

197 ancer treatments, disrupts taste papilla and taste bud integrity and can eliminate responses from tas

198 There is strong evidence for gut-taste bud interactions that influence taste function, be

199 s in our understanding of how the pattern of taste buds is established in embryos and discuss the cel

200 The integrity of taste buds is intimately dependent on an intact gustator

201 ate, the specific stimulus for NE release in taste buds is not well understood, and the identity of t

202 ate ganglion that are available to innervate taste buds is regulated by neurotrophin-4 (NT-4) and bra

203 T-PCR, we show the abundance of ROMK mRNA in taste buds is vallate > foliate > > palate > > fungiform

204 geniculate ganglion neurons, which innervate taste buds, is reduced by one-half.

205 In the peeled epithelial sheets, taste buds labeled with antibodies against Vimentin and

206 helial and neural supply of Shh are removed, taste buds largely disappear.

207 statory innervation, neurotrophic support of taste buds likely involves a complex set of factors.

208 Neurons of the geniculate ganglion innervate taste buds located in two spatially distinct targets, th

209 sense of taste is mediated by multicellular taste buds located within taste papillae on the tongue.

210 Taste bud loss was not as profound in the NT-4 null mice

211 Taste bud maintenance depends on continuous replacement

212 l input for taste bud cell replenishment and taste bud maintenance.

213 generation of differentiated taste cells and taste bud maintenance.

214 usly undescribed inhibitory route within the taste bud mediated by the classic neurotransmitter GABA

215 sms in other tissues, such as CAII-PDK2L1 in taste buds, might also have similar roles to play in the

216 rming and maintaining fungiform papillae and taste buds, most likely via stage-specific autocrine and

217 including hair follicles, sebaceous glands, taste buds, nails and sweat ducts.

218 e relationship between eye size and jaw size/taste bud number, supporting a link between oral-pharyng

219 oncert, cavefish show amplified jaw size and taste bud numbers as part of a change in feeding behavio

220 istochemistry reveals no reaction product in taste buds of knockout mice, suggesting that NTPDase2 is

221 In taste buds of the circumvallate papillae, some taste rec

222 such system, the taste papillae and sensory taste buds of the mouse tongue.

223 gulatory hierarchy that configures teeth and taste buds on mammalian jaws and tongues may be an evolu

224 Fungiform papillae house taste buds on the anterior dorsal tongue.

225 (CT), which transmits taste information from taste buds on the anterior tongue to the brain, previous

226 re repeated epithelial structures that house taste buds on the anterior tongue.

227 of the chorda tympani nerve (CT; innervating taste buds on the rostral tongue) is known to initiate r

228 tion in mammals: teeth on the jaw margin and taste buds on the tongue.

229 entrations of NaCl (50-500 mm) onto isolated taste buds or cells exposes them to unphysiological (hyp

230 We observed no additional postnatal loss of taste buds or neurons in Ntf4(-/-) mice.

231 owever, did not alter the gross structure of taste buds or the expression of taste signaling molecule

232 lopment, homeostasis, and maintenance of the taste bud organ-in wounded areas of the tongue among ani

233 h that in wild type (WT) mice in vivo and in taste bud organoid experiments.

234 is required for SHH expression by endogenous taste buds, our data suggest that SHH can replace the ne

235 roups and continue to increase the number of taste buds over stages after hatch.

236 This unique sensory organ includes taste buds, papilla epithelium and lateral walls that ex

237 unted under a light microscope and many more taste buds, patterned in rosette-like clusters, were fou

238 s, sonic hedgehog (SHH) negatively regulates taste bud patterning, such that inhibition of SHH causes

239 Taste placodes comprise taste bud precursor cells, which express the secreted fa

240 rs during papilla morphogenesis also expands taste bud precursors and accelerates Type I cell differe

241 a day later within Shh(+) placodes, expands taste bud precursors directly, but enlarges papillae ind

242 SHH causes the formation of more and larger taste bud primordia, including in regions of the tongue

243 ste buds, we demonstrate that Shh-expressing taste bud progenitors are specified and produce differen

244 Shh-expressing embryonic taste placodes are taste bud progenitors, which give rise to at least two d

245 enitors form cell type-replete, onion-shaped taste buds, rather than non-taste, pseudostratified epit

246 n (5-HT) are neurotransmitters secreted from taste bud receptor (type II) and presynaptic (type III)

247 Taste bud receptor (Type II) cells have been identified

248 ATP is a transmitter secreted from taste bud receptor (Type II) cells through ATP-permeable

249 nd exosome/SIS-ECM constructs can facilitate taste bud regeneration and reinnervation with promising

250 romoted tongue lingual papillae recovery and taste bud regeneration as evidenced by increased express

251 overy of the tongue-particularly, functional taste bud regeneration-in reconstructed areas, thus seri

252 rmaceutical Ingredient (API) and oral cavity taste bud regions.

253 Taste buds release ATP to activate ionotropic purinocept

254 16 taste buds at birth, indicating that some taste buds remain even when all innervation is lost.

255 ves are a source of sonic hedgehog (Shh) for taste bud renewal.

256 In mice, individual taste buds reside in fungiform papillae, which develop a

257 Mammalian taste buds respond to these diverse compounds via membra

258 We propose that in taste buds, ROMK in type I/glial-like cells may serve a

259 g chambers, permitting apical stimulation of taste buds; secreted peptides were collected from the ba

260 Taste buds (sensory structures embedded in oral epitheli

261 Each barbel carries taste buds, solitary chemosensory cells, and epithelial

262 se the CT usually regenerates to reinnervate taste buds successfully within a few weeks, a persistenc

263 as in the number of taste receptor cells per taste bud, suggesting that IL-10 plays critical roles in

264 Sonidegib treatment led to rapid loss of taste buds (TB) in both fungiform and circumvallate papi

265 n one-for-one fashion every ~20 to 50 d, and taste buds (TBs) are continuously renewed as in mammals.

266 ed tracer production and transfer within the taste buds (TBs).

267 Broiler-type, female-line males have more taste buds than other groups and continue to increase th

268 We recently identified many more taste buds than previously appreciated in chickens using

269 ique patterns of neuropeptide secretion from taste buds that are correlated with those perceptual qua

270 helium of mammalian tongue hosts most of the taste buds that transduce gustatory stimuli into neural

271 d of an epithelium that includes specialized taste buds, the basal lamina, and a lamina propria core

272 via pannexin 1 hemichannels acts within the taste bud to excite neighbouring presynaptic (Type III)

273 d aminergic transmitters function within the taste bud to modulate gustatory signaling in these perip

274 le in transmission of taste information from taste buds to nerves.

275 Moreover, applying CGRP caused taste buds to secrete serotonin (5-HT), a Presynaptic (T

276 imaging and lingual slices containing intact taste buds to test the hypothesis of purinergic signalli

277 of nerves that carry taste information from taste buds to the nucleus of the solitary tract (NST) in

278 emonstrate a new role for acetylcholine as a taste bud transmitter.

279 Activation of taste buds triggers the release of several neurotransmit

280 In murine circumvallate taste buds, Type I cells represent just over 50% of the

281 In mammals, taste buds typically contain 50-100 tightly packed taste

282 Mammalian taste buds use ATP as a neurotransmitter.

283 These findings suggest that taste buds use separate populations of taste receptor ce

284 fine the function and expression of TRPV4 in taste buds using Trpv4-deficient mice.

285 null mice, which lose neurons that innervate taste buds, we demonstrate that Shh-expressing taste bud

286 unocytochemistry, subsets of TRCs within rat taste buds were identified as expressing GABA, and its s

287 to ovoid-shaped taste buds, big tube-shaped taste buds were observed in the chicken using 2-photon m

288 NE biosensor responses evoked by stimulating taste buds were reversibly blocked by prazosin, an alpha

289 Overall, taste buds were smaller and fewer following fractionated

290 ainst mouse circumvallate taste buds and the taste buds were stimulated with KCl (50 mm) or a mixture

291 orm papillae had labeled innervation only in taste buds, whereas 43% of the fungiform papillae also h

292 sense of taste, or gustation, is mediated by taste buds, which are housed in specialized taste papill

293 tion of the CT results in a disappearance of taste buds, which can be accompanied by taste disturbanc

294 newal relies on progenitor cells adjacent to taste buds, which continually supply new cells to each b

295 between embryonic taste placodes with adult taste buds, which is independent of mesenchymal contribu

296 gustatory and chemosensory afferents inside taste buds will help explain how a coherent output is fo

297 Stimulating taste buds with forskolin (Fsk; 1 microm) + isobutylmeth

298 s an important component of the operation of taste buds with individual taste receptor cells (TRCs) c

299 Our protocol for labeling taste buds with molecular markers will factilitate futur

300 e II cells and taste-evoked ATP release from taste buds without affecting the excitability of taste c