ライフサイエンスコーパス: tautomerization

1 F also harbors enzyme activity for keto-enol tautomerization.

2 general base to promote the imine to enamine tautomerization.

3 cannot be accounted for purely by keto-enol tautomerization.

4 n indirect and unexpected route: a keto-enol tautomerization.

5 ow pK(a), as the general base in a keto-enol tautomerization.

6 H(18)O-Fe(V)=O species, and then oxo-hydroxo tautomerization.

7 including some that invoke a novel keto-enol tautomerization.

8 asic residues are not involved in dopachrome tautomerization.

9 a sequential conjugate-addition-elimination-tautomerization.

10 otein structure enforces histidine sidechain tautomerization.

11 air mismatch during transcription occurs via tautomerization.

12 yl (.C(O)CH(3) ), and then undergo keto-enol tautomerization.

13 an endo-beta-hydride elimination followed by tautomerization.

14 e that Arg51 and Arg239* are crucial for OAA tautomerization.

15 epwise transfer mechanism is dominant in the tautomerization.

16 energetic compensation for otherwise costly tautomerization.

17 bone, possibly involving a carbonyl to imine tautomerization.

18 lly underestimate the barrier to solid-state tautomerization.

19 on of SO2 , 1,4-addition, diazotization, and tautomerization.

20 r through a hydrazido(2-)/isodiazene valence tautomerization.

21 ) nanoclusters that catalyze stereoselective tautomerization.

22 t the enolate oxygen followed by a keto-enol tautomerization.

23 n the products by alkali-catalyzed keto-enol tautomerizations.

24 ramolecular transition state for the 2S, 2SH tautomerization (2TS) lies 25 (CBS-Q) to 30 kcal/mol (CC

25 formed into the pyrrole via a gold-catalyzed tautomerization, [3,3]-sigmatropic rearrangement, and cy

26 s enol, resulting from an extended keto-enol tautomerization across a benzene ring, is described.

27 MIF can be functionally dissociated from its tautomerization activity.

28 on energy was obtained for the triplet-state tautomerization affording 3.

29 g closure on the terminal diazo nitrogen and tautomerization affords a diverse set of pyrazolines in

30 2] cycloaddition, followed by enamine/imine tautomerization and aromatization.

31 intermolecular addition of water followed by tautomerization and cyclization to give 2a,c.

32 /retro-Diels-Alder reaction of 5 followed by tautomerization and elaboration of R to give silylated f

33 Enol-keto tautomerization and enzyme-mediated hydrolytic cleavage

34 rangement, oxy-Cope rearrangement, enol-keto tautomerization and finally an intramolecular carbonyl e

35 cts a proton from Ser112, thereby completing tautomerization and generating a serinate for nucleophil

36 ve a sugar enamine intermediate, which after tautomerization and hydrolysis to release ammonia yields

37 Gly(491) work in tandem to promote keto-enol tautomerization and increase the acidity of the C2 hydro

38 h a neutral nitrosoaryl radical, followed by tautomerization and intramolecular condensation between

39 These trends support the contribution of tautomerization and N3 protonation in NEIL1 excision cat

40 ue shape shifting ability that utilizes both tautomerization and protonation.

41 ce, our study provides support for glutamine tautomerization and side-chain rotation in the BLUF phot

42 other tactics such as exploiting ring-chain tautomerization and skeletal reorganization to minimize

43 s adopt a Watson-Crick-like geometry through tautomerization and/or ionization of the bases.

44 The unexpected azido-tetrazolo tautomerizations and irreversible tetrazolo transformati

45 gh Pd(II)-catalyzed aromatic C-H activation, tautomerization, and a 1,3-shift of the palladacycle-lig

46 y a sequence of intramolecular condensation, tautomerization, and decarboxylation, which led to the f

47 y orchestrated steps: addition, formylation, tautomerization, and dehydration, with CuCN catalyzing a

48 ion followed by beta-elimination of bromide, tautomerization, and in situ trapping of the resulting 1

49 tive of 8-azidoadenosine cannot undergo this tautomerization, and instead, it fragments upon photolys

50 O(4))(2), presumably to facilitate keto-enol tautomerization, and is greatly improved by the use of c

51 ental insights into the aromatic properties, tautomerization, and reactivity of porphyrins and relate

52 ith Schiff base formation, ketimine/aldimine tautomerization, and transimidation etc.

53 show how the reaction pathway and barrier of tautomerization are modified in the presence of a copper

54 ic insights governing the 4H-pyrazol-4-imine tautomerization are provided.

55 that ACMSD catalyzes oxaloacetic acid (OAA) tautomerization at a rate of 6.51 +/- 0.42 s(-1) but not

56 paramount to understanding these compounds' tautomerization behavior, which may impact their reactiv

57 hase and solvent dependent preference of the tautomerization between 2-pyridinethiol (2SH) and 2-pyri

58 fragmentation data were rationalized due to tautomerization between imine and enamine substructures.

59 The tautomerization between the metal-hydride and the ligand

60 e 3-substituents inhibited His-265-catalyzed tautomerization by 5 orders of magnitude.

61 We obtain kinetic rate constants for tautomerization by applying Bayesian inference to ultrav

62 enzimidazolones, which through acid-promoted tautomerization convert to their corresponding (Z)-isome

63 anthrol (6) equilibrium, with an enthalpy of tautomerization, Delta(t)H, of 3.8 kcal mol(-1).

64 roles of primer-template stability and base tautomerization during misincorporation.

65 The tautomerization dynamics were like those measured in A-R

66 sCO found in species of Bacilli catalyze the tautomerization ("enolization") of 2,3-diketo-5-methylth

67 Electrical control over the tautomerization equilibrium of immobilized SHQ governs t

68 applied to the electrode surface governs the tautomerization equilibrium of the immobilized ligand, p

69 of immobilized SHQ through control over the tautomerization equilibrium, to produce an electrically

70 This ligand tautomerization event is assisted by the pi-bound indole

71 f 1 and 2 is associated with a LA-associated tautomerization event, whereby H(+) shifts from the term

72 tional beta-hydride elimination in the final tautomerization event.

73 6)D(6)) calorimetric enthalpy for the 2S/2SH tautomerization favoring the thione.

74 Additionally, unique tautomerization features exhibited by 5-(4-nitrophenylaz

75 is initiated by general acid/base-catalyzed tautomerization followed by oxidation by molecular oxyge

76 ese hydrogen-bonded systems is hydrazone-azo tautomerization followed by rotation around a C-N single

77 erization via an unusual mechanism involving tautomerization followed by rotation, resulting in fast

78 Tautomerization, followed by isomerization, of the initi

79 eory in vacuo and aqueous phases) formulated tautomerization for RS-stereoisomers of ascorbic acids (

80 for the pH dependence of the open and closed tautomerization forms of PD156707 was demonstrated by an

81 l analysis support a possible role of ligand tautomerization from mono-anionic (L,X) to neutral (L,L)

82 The minimum free energy paths for the tautomerization from the wG-T to the WC-like G-T* and fr

83 Catalyst release and tautomerization gives the final beta-lactamic product.

84 at the first step of the reaction, keto-enol tautomerization, had become rate-limiting, indicating th

85 Although electronic excited-state tautomerization has been widely studied, experimental wo

86 In other words, GC tautomerization has two competing quantum effects, tunne

87 diazaquinodimethane, the product of nitrene tautomerization, has a lifetime of ca. 1 min or longer i

88 Here, we report force-induced tautomerization in a single porphycene molecule on a Cu(

89 6-carboxylic acid (DMeQUIC) is vulnerable to tautomerization in its reduced form under alkaline condi

90 orts on the slow kinetics of diketo-ketoenol tautomerization in particular solvents that allow the se

91 Tautomerization in porphycenes, constitutional isomers o

92 Due to KuQs structural features, keto-enol tautomerization in solution likely occurs, leading to th

93 To investigate the role of oxyluciferin tautomerization in the color tuning mechanism, gas-phase

94 interplay between solvent-assisted enol-keto tautomerization in the former moiety and photochromic el

95 studied the guanine-cytosine (GC) base pair tautomerization in the gas phase.

96 The results reveal the importance of initial tautomerization in the pyrazole moiety of 7-azaindazole

97 traction reaction, which enables a keto-enol tautomerization in the substrate.

98 ve nonradical pathways including a keto-enol tautomerization induced by electronic excitation of the

99 These results suggest that tautomerization-induced electronic structure changes can

100 4-hydroxyquinone-2-methide, undergoes rapid tautomerization into methyl p-quinone.

101 major pathway involves gamma-proton removal, tautomerization into the PLP ring, followed by Michael a

102 The G-T*->G*-T tautomerization is also predicted to be slightly more th

103 Although the imine to enamine tautomerization is crucial to inhibition of the enzyme,

104 ures indicate that even at 300 K the H-shift tautomerization is entirely governed by QMT (>99.9%), wi

105 in the formation of an imine, and subsequent tautomerization is followed by intramolecular cyclizatio

106 effects strongly suggest that excited-state tautomerization is not an important nonradiative decay p

107 The wG-T->G-T* tautomerization is predicted to be endoergic in aqueous

108 This tautomerization is reversible under flash vacuum thermol

109 modeling indicates that the key amide-iminol tautomerization is the major hurdle in an otherwise ener

110 vides a direct measurement of the nanosecond tautomerization kinetics.

111 Subsequent tautomerization leads to both hydantoin enantiomers, but

112 Fe-4S cluster, and that this binding-induced tautomerization may have important mechanistic ramificat

113 eported pathways, including a water-assisted tautomerization mechanism that facilitates N2 formation

114 ely precedes product formation, ruling out a tautomerization mechanism.

115 quilibrium process, followed by irreversible tautomerization/neutralization providing the driving for

116 orporation model suggesting that G-T mispair tautomerization occurs in the ajar polymerase conformati

117 nism also involves gamma-proton removal, but tautomerization occurs through the vinyl group, followed

118 , in the open air or in water, fast 2H -> 1H tautomerization occurs.

119 Tautomerization of (poly)phenols by ODA creates non-plan

120 y)imines, readily accessible by condensation/tautomerization of (pseudo)benzylic primary amines and 2

121 ile; (iv) under lambda = 240 nm irradiation, tautomerization of 3-hydroxypropenenitrile to 3-oxopropa

122 Tautomerization of 4 and N(2)-elimination afford cyclohe

123 The synthesis and tautomerization of a "half-parent" aminosilylene and its

124 of an ortho-quinone intermediate, derived by tautomerization of a bis-benzoquinone, readily accessed

125 ttributed to an isotope effect of 5.1 on the tautomerization of a dienone intermediate to tyrosine wi

126 The isotope effect on the subsequent tautomerization of a dienone intermediate was determined

127 rimental evidence of excited-state keto-enol tautomerization of a firefly fluorophore, and it could b

128 e is generated through a surprisingly facile tautomerization of a para-quinone.

129 d by their ability to catalyze the keto-enol tautomerization of a pyruvyl moiety.

130 The thermokinetics for the tautomerization of a series of methylenedihydroacenes to

131 ct for hydroxylation by PheH being masked by tautomerization of an enedione intermediate to tyrosine.

132 ibers (length over 1000 mum), accompanied by tautomerization of cyanuric acid.

133 The LFP experiments showed no evidence for tautomerization of dG(N2-H)(.) to dG(N1-H)(.) within hun

134 ction is not observed, consistent with rapid tautomerization of enolpyruvate.

135 ments (assessing the state of ionization and tautomerization of enzyme-bound ThDP-related intermediat

136 c substrates is limited by the non-oxidative tautomerization of ethylnitroante to nitroethane at high

137 Knowledge of the state of ionization and tautomerization of heteroaromatic cofactors when enzyme-

138 is based on the dual acid-base property and tautomerization of indazole.

139 tion by direct proton transfer from acids or tautomerization of metal hydrides, resulting in the gene

140 This residue also is involved in aci-nitro tautomerization of nitroalkanes, the first example of a

141 of the nanosecond ground-state lactam-lactim tautomerization of pyridone derivatives in aqueous solut

142 ic preference to form ketones as a result of tautomerization of surface-bound enol intermediates.

143 profiles are consistent with a rate-limiting tautomerization of the 1,2-enediol of ribulose 5-phospha

144 Base-promoted tautomerization of the alkyne to its isomeric allene all

145 Exchange through tautomerization of the bases is no observed, although mo

146 son-Crick-like conformations forming through tautomerization of the bases that drive replication erro

147 There was no observed tautomerization of the diazenes to the corresponding ary

148 Tautomerization of the hydride leads to the clean format

149 ic monomer brought about by solvent, induced tautomerization of the hydrogen-bonding unit.

150 c products (e.g., o-silyl phenols) following tautomerization of the intermediate cyclohexa-2,4-dienon

151 is dinuclear reductive elimination occurs by tautomerization of the metal hydride [1-MH](+) to a liga

152 The noncatalyzed thermal tautomerization of the methylenedihydroacene in an inert

153 The enamine-imine tautomerization of the new beta,gamma-double bond and su

154 MIF also catalyzes the tautomerization of the non-naturally occurring D-isomer

155 ssible mechanisms, including the amino-imino tautomerization of the substrate base that may explain h

156 Tautomerization of the targeted anthrones occurs and aff

157 ng a zwitterionic intermediate formed by the tautomerization of the thiadiazepine ring followed by di

158 cavity adjusts to the guest via keto-to-enol tautomerization of the ureidopyrimidinone unit and as a

159 ar-cognate complex is reconciled by possible tautomerization of the wobble base pair in mRNA-tRNA.

160 opens retro-ene pathways followed by either tautomerization or Claisen rearrangement.

161 es from diverse equilibria such as keto/enol tautomerization or deprotonation equilibria of four titr

162 among many mispairing possibilities, either tautomerization or ionization of bases might allow a DNA

163 dopt Watson-Crick-like conformations through tautomerization or ionization of the bases, giving rise

164 utomerism, including a base-mediated anionic tautomerization pathway and a small activation barrier.

165 tronate were used to propose a non-oxidative tautomerization pathway, in which the enzyme catalyzes t

166 e fluorophore formation via an imine-enamine tautomerization pathway.

167 t Hsp90-mediated trans-cis isomerization via tautomerization plays an important role in subsequent Hs

168 e is subject to histidine-mediated enol-keto tautomerization prior to hydrolysis.

169 pVTZ) higher in energy than either tautomer, tautomerization probably occurs in the hydrogen bonded d

170 netic characterization and conclude that the tautomerization proceeds through a two-state concerted m

171 obtained, the latter of which results from a tautomerization process.

172 tic amines through an irreversible keto-enol tautomerization process.

173 ovel one-pot Ugi-azide/SNAr/ring-chain azido-tautomerization process.

174 bke-Blackburn-Bienayme/SNAr/ring-chain azido-tautomerization process.

175 se environmental effects, herein G-T mispair tautomerization processes are studied computationally in

176 standing of proton transfer and ring closure tautomerization processes.

177 consistent with the inherent differences in tautomerization, proton affinities, and lability.

178 Due to their polarizability and rapid tautomerization, pyridones exhibit a greater range of el

179 It is also found that the tautomerization rate is increased by vibrational excitat

180 Quantifying the tautomerization rate is paramount to understanding these

181 etical and experimental study of the initial tautomerization rate of a range of phosphinylidene compo

182 E selectivity is a sensitive function of the tautomerization rate of an alkenyl anion intermediate.

183 Initial tautomerization rates are found to decrease in the order

184 The tautomerization rates are temperature independent below

185 to a porphycene molecule, we found that the tautomerization rates could be tuned up and down in a co

186 in the neighbouring molecule influences the tautomerization reaction in a given porphycene, with pos

187 terfacial electric field-induced prototropic tautomerization reaction in acylhydrazone entities by cr

188 dence in favor of an active site facilitated tautomerization reaction is provided by the fact that th

189 addition, Y150 acts as a general acid in the tautomerization reaction of the wild-type enzyme and rep

190 y provide insight regarding a related flavin tautomerization reaction that has been proposed as a key

191 g that 4-OT may not catalyze a 1,3-keto-enol tautomerization reaction using this dienol.

192 ilylation/Tamao oxidation-diastereoselective tautomerization reaction, which achieves in a single ste

193 cts as a general acid to protonate C3 in the tautomerization reaction.

194 e Y150F mutant enzyme, replacing Y150 in the tautomerization reaction.

195 somerization reaction and the YwhB-catalyzed tautomerization reaction.

196 a mechanism for the observed YdcE-catalyzed tautomerization reaction.

197 mechanism is proposed for the MIF-catalyzed tautomerization reaction.

198 ree dienols examined, 1,3- and 1,5-keto-enol tautomerization reactions are only observed for 2-hydrox

199 control of intramolecular hydrogen-transfer (tautomerization) reactions in single molecules using sca

200 entify structural and chemical predictors of tautomerization resistance and demonstrate that they qua

201 s(pentafluorophenyl)corrole) induces valence tautomerization resulting in the formation of (tpfc(+*))

202 Zn(2+) to (TBP(8)Cz)Mn(V)(O) induces valence tautomerization, resulting in the formation of [(TBP(8)C

203 ted by QM/MM calculations, an E1 elimination-tautomerization sequence is most consistent with these f

204 phthoquinone spiroketal rearrangement, and a tautomerization sequence.

205 form via a one-pot Diels-Alder/ring-opening/tautomerization sequence.

206 tic studies revealed a proton relay-assisted tautomerization showing the importance of external facto

207 s between the two proteins in the N-terminal tautomerization site are evident, and we provide evidenc

208 To determine the precise ionization/tautomerization states of ThDP during various stages of

209 with a p K a of 9.5 and likely catalyzes the tautomerization step by donating a proton to the enol to

210 nce supports the potential for the keto-enol tautomerization step of the aromatic Claisen rearrangeme

211 challenged by a thermodynamically favorable tautomerization step to give a more stabilized product (

212 The final tautomerization step to the acyloxime can be considered

213 be directly involved in the product-forming tautomerization step.

214 se a catalytic mechanism involving substrate tautomerization, substrate-assisted activation of water

215 d cyclization and a series of quinone-quinol tautomerizations that are followed by cycles of O2/H2O2-

216 Accompanying the tautomerization, the ionic properties of the COF can be

217 is transformation, alkylquinone 26 undergoes tautomerization to a quinone methide, which is intercept

218 ated loss of aromaticity undergoes enol-keto tautomerization to a ureidopyrimidinone moiety.

219 a highly selective pyranose to furanose ring tautomerization to access an advanced intermediate, and

220 nitrosyl group then occurs followed by rapid tautomerization to amide.

221 erized by UV/Vis and IR spectroscopy and its tautomerization to CH2SO3H observed upon irradiation wit

222 nd 2 degrees alkylazides are unstable toward tautomerization to copper(I) imine complexes [Cu](HN hor

223 d to the discovery of a likely strain-driven tautomerization to cyclohexadienone intermediates.

224 s an initial transamination step followed by tautomerization to form a stable aromatic adduct, a sche

225 on, which occurs at the Cp ring, followed by tautomerization to generate the stable Co(III)-hydride p

226 BLUF reaction model that involved glutamine tautomerization to imidic acid, accompanied by a rotatio

227 rangement of the product enamines occurs via tautomerization to imines, followed by a 1,3-trimethylsi

228 ation), degradation to undesired products or tautomerization to other isomers.

229 this reaction proceeds via rate-determining tautomerization to the allene-eneyne form followed by ve

230 so compound (R'ON --> O=NR'), and subsequent tautomerization to the more stable oxime.

231 ons tune photoisomerization and ground state tautomerizations to enable long-wavelength depopulation

232 ions then led to 13, which in turn underwent tautomerizations to give 8.

233 In the present work, we have studied the tautomerization using absorption spectroscopy in 15 diff

234 Tautomerization via formal 1,3-proton transfer in the ph

235 een different isomers induced by prototropic tautomerization was examined by (1)H nuclear magnetic re

236 Keto tautomerization was favored either in solution or in the

237 2,4-dioxo-carboxylate moiety, their solution tautomerization was investigated using both NMR and high

238 reaction product HDMF is prone to extensive tautomerization, whereas its precursor HMMF is chemicall

239 re prone to racemization driven by keto-enol tautomerization, which can lead to products with distinc

240 give 2Z-CH(3), (ii) acid-catalyzed keto-enol tautomerization, which converts 2rZ-CH(3) to 4rZ-CH(3),

241 the mono- and dianhydride undergo ring-shift tautomerization, which is in the latter case shifted tow

242 s, and fundamental mechanisms of G-T mispair tautomerization, which plays a role in a wide range of b

243 als unexpected N-oxide assistance in cascade tautomerizations, which was crucial for directing the nu

244 rated that CHMI was responsible for tri-acid tautomerization, while the protein-protein interactions

245 scopy quantifies the force needed to trigger tautomerization with submolecular spatial resolution.

246 to the thione form (1Tn) through QMT H-shift tautomerization, with a half-life of ~ 180 h, despite a

247 1,2-CHD is known to undergo a keto-enol tautomerization, with the monoenol being the primary equ

248 ervation of a double hydrogen atom transfer (tautomerization) within a single porphycene molecule on