ライフサイエンスコーパス: teichoic acid

1 lycan) and lipid III (precursor of cell wall teichoic acid).

2 cine (concentrations of cross-links and wall teichoic acids).

3 D-alanyl ester residues between LTA and wall teichoic acid.

4 ntity of capsular polysaccharide rather than teichoic acid.

5 arked reduction in the amounts of glucose on teichoic acid.

6 m with less capsular polysaccharide and more teichoic acid.

7 paring the incorporation of [3H]choline into teichoic acid.

8 s due to differences in cell wall-associated teichoic acid.

9 e had 2.1- to 3.8-fold more immunodetectable teichoic acid.

10 lently bound to the phosphorylcholine of the teichoic acid.

11 to the septum in a manner dependent on wall teichoic acid.

12 peptidoglycan and a covalently attached wall teichoic acid.

13 ocess of choline decoration of S. pneumoniae teichoic acid.

14 n hydrolase and decreased expression of wall-teichoic acids.

15 ved binding areas specific for attachment to teichoic acids.

16 the dlt operon controlling d-alanylation of teichoic acids.

17 tive system responsible for D-alanylation of teichoic acids.

18 hree-component conjugates in which cell wall teichoic acid (a common antigen capable of T cell activa

19 bone of the partially glycosylated cell wall teichoic acid, a minor Ldb17 cell envelope component.

20 dification of N-acetylmuramic acid with wall teichoic acid, a ribitol-phosphate polymer tethered to m

21 combinant GP12 using chemically defined wall teichoic acid analogs.

22 m with more capsular polysaccharide and less teichoic acid and an avirulent form with less capsular p

23 zed with anionic glycopolymers, such as wall teichoic acid and capsular polysaccharide (CP).

24 hosphorylcholine residues from the cell wall teichoic acid and lipoteichoic acid.

25 charide biosyntheses with those facilitating teichoic acid and N-linked glycan transport.

26 Teichoic acids and acidic capsular polysaccharides are m

27 toxic as 16:1Delta9 in a strain lacking wall teichoic acids and led to growth arrest and enhanced rel

28 lower amounts of C polysaccharide (cell wall teichoic acid) and in this study were shown to have a hi

29 ein), ywnJ, the dlt operon (D-alanylation of teichoic acids), and the pss ybfM psd operon (phosphatid

30 d thus simultaneously inhibit peptidoglycan, teichoic acid, and polysaccharide capsule biosynthesis.

31 the synthesis of cell wall anionic polymer, teichoic acid, and teichuronic acid, respectively, in Ba

32 ppendages to the phage, digest the cell wall teichoic acids, and bind irreversibly to the host, respe

33 doglycan, lipopolysaccharide, glycoproteins, teichoic acids, and capsular polysaccharides, as well as

34 ynthesis, reduction of ester-linked D-Ala in teichoic acids, and reduction of peptidoglycan cross-lin

35 change in the structure and/or metabolism of teichoic acids appears to be an important component of t

36 Unique to Gram-positive bacteria, wall teichoic acids are anionic glycopolymers cross-stitched

37 Wall teichoic acids are cell wall polymers that maintain the

38 polysaccharide did not affect the amount of teichoic acid as measured by a capture enzyme-linked imm

39 sal colonization have implicated capsule and teichoic acid as staphylococcal surface factors that pro

40 pecies Listeria innocua was found to express teichoic acid-associated surface antigens that were othe

41 fective in the synthesis of polyribitol wall teichoic acid attached to the cell wall envelope, displa

42 can modification, and choline-mediated (lipo)teichoic-acid attachment contribute to the high selectiv

43 ross-reactive opsonic antibodies bind to the teichoic acid backbone.

44 al inhibition of both peptidoglycan and wall teichoic acid biosyntheses in S. aureus.

45 The demonstration of regulated wall teichoic acid biosynthesis has implications for cell env

46 catalyzes the synthesis of CDP-glycerol for teichoic acid biosynthesis in certain Gram-positive bact

47 Downregulation of teichoic acid biosynthesis in the chloride transporter m

48 biosynthetic pathway that is associated with teichoic acid biosynthesis, as well as operons for five

49 d intermediates involved in peptidoglycan or teichoic acid biosynthesis.

50 tion mutants suggest the involvement of wall teichoic acid but not of staphylococcal protein A.

51 hese results indicate that the decoration of teichoic acid by the LicD enzymes is a membrane-associat

52 lycan catalyzed by OatA and D-alanylation of teichoic acids by DltABCDE.

53 Modification of teichoic acids by esterification with D-alanine and inco

54 We also established a method to isolate wall teichoic acid chains and show that the most abundant cha

55 lyzing P-choline incorporation and export of teichoic acid chains under conditions in which the nativ

56 wall, a result consistent with the apparent teichoic acid changes.

57 hermore, we show that a mAb recognizing wall teichoic acid (clone 4497) specifically localizes to a s

58 Teichoic acids come in two forms and are made by differe

59 ce for glycosylated poly(glycerol phosphate) teichoic acid compared with non-glycosylated.

60 titative (or qualitative) change in the wall teichoic acid component of resistant isolates.

61 suring the changes of peptidoglycan and wall teichoic acid compositions using solid-state NMR.

62 Thus, wall teichoic acids contribute to the structure-specific anti

63 asive serotype M1 GAS isolate led to loss of teichoic acid d-alanylation and an increase in net negat

64 Thus, teichoic acid d-alanylation may contribute in multiple w

65 e impaired in peptidoglycan O-acetylation or teichoic acid D-alanylation, resulting in increased nega

66 rotein predicted to be involved in cell wall teichoic acid deposition and a predicted MprF protein, w

67 ide gel electrophoresis for analysis of wall teichoic acid extracted from gene deletion mutants, a re

68 mes involved in bacterial lipopolysaccharide/teichoic acid formation and eukaryotic N-linked glycosyl

69 cA, which has been shown to be essential for teichoic acid glycosylation in L. monocytogenes serotype

70 s and enzymology of the biosynthesis of wall teichoic acid have been the extensively studied, however

71 B. anthracis does not elaborate wall teichoic acids; however, its genome harbors tagO and tag

72 We have studied the wall teichoic acid hydrolase activity of pure, recombinant GP

73 phage varphi29 has been implicated as a wall teichoic acid hydrolase.

74 The GP12 protein had potent wall teichoic acid hydrolytic activity in vitro and demonstra

75 r system, including (i) the d-alanylation of teichoic acids, (ii) the incorporation of lysyl-phosphat

76 Despite the central role of wall teichoic acid in S. aureus virulence, details concerning

77 lcholine (PC), a major haptenic component of teichoic acid in the S. pneumoniae cell wall, and lipote

78 n in contradiction to the prevailing view of teichoic acids in metal binding.

79 and presence of glucose substituents in the teichoic acids in the cell wall.

80 omycin and correlated with susceptibility to teichoic acid inhibitors; and 6) constitutive expression

81 ion of d-alanine (d-Ala) groups of bacterial teichoic acid is a central, yet untested, paradigm of mi

82 g a direct binding interaction with embedded teichoic acid is responsible for the added mechanism of

83 toward S. aureus when D-alanylation of (lipo)teichoic acids is limiting.

84 tion of SlpX as well as its interaction with teichoic acids lay the foundation for deciphering its ro

85 t of capsular polysaccharide rather than the teichoic acid ligand.

86 lyses indicated they were identical glycerol teichoic acid-like molecules with a carbohydrate backbon

87 rs include the peptidoglycan cell wall, wall-teichoic acids, lipoteichoic acids, and capsular polysac

88 Excess teichoic acid, LTA-0, antibodies to phosphocholine, or a

89 in abundance at the expense of lipid-linked teichoic acids (LTAs).

90 Degradation of cell wall teichoic acid occurs according to an exolytic mechanism,

91 tcA, involved in the decoration of cell wall teichoic acid of Listeria monocytogenes serotype 4b with

92 l antibody c74.22, lacked galactose from the teichoic acid of the cell wall, and were resistant to th

93 his hypothesis is based on findings that (i) teichoic acid of the pneumococcal cell wall interact wit

94 D-alanylation of (lipo) teichoic acids of S. aureus increases bacterial resistan

95 osphorylcholine (ChoP) is a component of the teichoic acids of Streptococcus pneumoniae and has been

96 nal in serotype 4b-like glycosylation of the teichoic acids of these organisms.

97 s polyanionic glycopolymers, similar to wall teichoic acids, of which they appear to be functional ho

98 Inhibition studies using teichoic acid oligomers indicated that cross-reactive op

99 y dextran, dextran sulfate, heparin, ribitol teichoic acid, or soluble low molecular weight PGN fragm

100 y to the putative polyribitol phosphate wall teichoic acid pathway in Bacillus subtilis.

101 of the pneumococcal pce gene encoding for a teichoic acid phosphorylcholine esterase (Pce), an enzym

102 biosynthetic pathway of the predominant wall teichoic acid polymer are lacking, and workers have reli

103 ith 100% confidence onto TagF, a GT-B folded teichoic acid polymerase from Staphylococcus epidermidis

104 psA-Psr (LCP) proteins are thought to attach teichoic acid polymers and capsular polysaccharides.

105 Undecaprenyl pyrophosphate and also teichoic acid precursors are bound with lower affinity a

106 ined by the accumulation of UndP-linked wall teichoic acid precursors that cannot be transferred to t

107 process presumably occurring at lipid-linked teichoic acid precursors.

108 hways have been characterized, regulation of teichoic acid production is not well understood.

109 Western blot monitoring of teichoic acid production revealed differential patterns

110 Ribitol teichoic acid (RTA) (1 microg/ml) induced a twofold incr

111 ilar technique comparing the amount of total teichoic acid showed that the transparent phenotype had

112 emonstrated that SAL inhibited production of teichoic acid, slime-associated proteins, and type 1 ant

113 aride (phosphorylcholine [PC] determinant of teichoic acid)-specific immunoglobulin (Ig) isotype resp

114 LTA-0 (or pneumococcal teichoic acid) stimulated neither CHO/CD14/TLR2 nor CHO/

115 Thus, the NMR-based description of teichoic acid structure resolves the contradictory model

116 In contrast, when the teichoic acid structure was altered by replacing choline

117 nd LicD2, enzymes responsible for loading of teichoic acid subunits with choline, are also membrane-a

118 A) synthesis while simultaneously repressing teichoic acid synthesis (TA).

119 ibed, encode genes responsible for cell wall teichoic acid synthesis in Bacillus subtilis.

120 tions, teichuronic acid is synthesized while teichoic acid synthesis is inhibited.

121 the role of Pho-P in the switch process from teichoic acid synthesis to teichuronic acid synthesis, b

122 metal transport, ferrous iron transport, and teichoic acid synthesis.

123 l tagO mutants, which are defective for wall teichoic acid synthesis.

124 line is an important bioactive adduct to the teichoic acid (TA) and lipoteichoic acid (LTA) of the su

125 Lipoteichoic acid (LTA) and wall teichoic acid (TA) isolated from the mutant were free of

126 Staphylococcus aureus contains two distinct teichoic acid (TA) polymers, lipoteichoic acid (LTA) and

127 s, whereas binding to cell walls depleted of teichoic acid (TA) was decreased.

128 Teichoic acid (TA), a crucial cell wall constituent of t

129 scribes the developments in the synthesis of teichoic acids (TA) - glycosylated poly(alditolphosphate

130 Lipoteichoic and wall teichoic acids (TA) are highly anionic cell envelope-ass

131 Teichoic acids (TA) are linear phospho-saccharidic polym

132 Teichoic acids (TAs) are anionic polymers that constitut

133 that alterations in surface polymers called teichoic acids (TAs) play a key role in penicillin-induc

134 phoretically distinct polyribitol-containing teichoic acid that we designate K-WTA.

135 ll envelope contains anionic polymers called teichoic acids that are required for cell viability.

136 nd polyanionic properties of cell wall (lipo)teichoic acids that promote attack of membrane phospholi

137 Because LytA binds to both species of teichoic acids, this change recruits the enzyme to its s

138 , additionally, no evidence for a shift from teichoic acid to teichuronic acid synthesis.

139 A in trans restored galactose and glucose on teichoic acid to wild-type levels.

140 e synthesis of the linkage unit that tethers teichoic acids to the peptidoglycan layer.

141 ng an ABC transporter similar to that of the teichoic acid translocation ATP-binding protein TagH and

142 ules, such as peptidoglycan, lipoprotein, or teichoic acid, triggering innate host immune responses t

143 e of the cell wall polymers microcapsule and teichoic acid was measured by both gas chromatography-ma

144 thesis while the incorporation of D-Ala into teichoic acids was inhibited.

145 r serotype-specific sugar substituent in the teichoic acid, was not affected.

146 he S. aureus-specific mAb BC153 targets wall teichoic acid, whereas cross-reactive mAbs BC019, BC020,

147 e reduction, respectively, of glucose in the teichoic acid, whereas galactose, the other serotype-spe

148 ogen-oxygen ion pair configuration providing teichoic acid with a positive charge to repel CAMPs.

149 all negative charge by substitution of (lipo)teichoic acids with d-alanine reduces antibacterial acti

150 ia, LytR-CpsA-Psr (LCP) proteins attach wall teichoic acid (WTA) and polysaccharide capsule to peptid

151 bition of TarO, the first enzyme in the wall teichoic acid (WTA) biosynthetic pathway, decreases the

152 id II(A)(WTA), substrates in the PG and wall teichoic acid (WTA) biosynthetic pathways.

153 Wall teichoic acid (WTA) comprises a class of glycopolymers c

154 tivity of targocil, an inhibitor of the wall teichoic acid (WTA) flippase in Staphylococcus aureus.

155 ylglucosamine (GlcNAc) moieties on cell wall teichoic acid (WTA) for adsorption.

156 l phages, Podoviridae require a precise wall teichoic acid (WTA) glycosylation pattern for infection.

157 glycan, thereby promoting attachment of wall teichoic acid (WTA) in bacilli and staphylococci and cap

158 The wall teichoic acid (WTA) inhibitor tunicamycin had an 8-fold

159 olecules designed to identify bioactive wall teichoic acid (WTA) inhibitors, we identified one hit, w

160 s its surface by displaying a 'stealth' wall teichoic acid (WTA) isomer.

161 Wall teichoic acid (WTA) polymers are covalently affixed to t

162 Wall teichoic acid (WTA) polymers are covalently affixed to t

163 easoned that changes in surface-exposed wall teichoic acid (WTA) polymers of S. epidermidis, which po

164 identified an insertional mutant of the wall teichoic acid (WTA) synthesis gene tagB in E. faecalis V

165 nstrated for the well-studied system of wall teichoic acid (WTA) synthesis, a common cell wall polysa

166 enzyme in the biosynthetic pathway for wall teichoic acid (WTA) synthesis.

167 ol-linked biosynthetic intermediates of wall teichoic acid (WTA) to the peptidoglycan of Gram-positiv

168 ucose is required for the decoration of wall teichoic acid (WTA) with glucose residues and the format

169 ycan (PG) modified by the attachment of wall teichoic acid (WTA), an anionic glycopolymer that is lin

170 d in the cell membrane; the other form, wall teichoic acid (WTA), is covalently linked to the peptido

171 ) polymers, lipoteichoic acid (LTA) and wall teichoic acid (WTA), which are proposed to play redundan

172 us infection elicits antibodies against wall teichoic acid (WTA).

173 ell wall component of S. aureus, termed wall teichoic acid (WTA).

174 ymers: capsular polysaccharide (CP) and wall teichoic acid (WTA).

175 can and the phosphate-rich glycopolymer wall teichoic acid (WTA).

176 a, either bound to the peptidoglycan as wall teichoic acids (WTA) or to the membrane as lipoteichoic

177 ion of a critical virulence factor, the wall teichoic acids (WTA), within the cell envelope.

178 pneumoniae, is bound to peptidoglycan (wall teichoic acid, WTA) or to membrane glycolipids (lipoteic

179 olymers linked to either peptidoglycan (wall teichoic acids; WTA) or to membrane glycolipids (lipotei

180 inhibits C. difficile growth by binding wall teichoic acids (WTAs) and interfering with cell wall rem

181 Wall teichoic acids (WTAs) and membrane lipoteichoic acids (L

182 Wall teichoic acids (WTAs) are anionic polymers that coat the

183 Wall teichoic acids (WTAs) are major polyanionic polymer comp

184 Wall teichoic acids (WTAs) are the most abundant glycopolymer

185 Anionic glycopolymers known as wall teichoic acids (WTAs) functionalize the peptidoglycan la

186 lymer biogenesis in which cell wall-anchored teichoic acids (WTAs) increase in abundance at the expen

187 and anionic cell wall polymers such as wall teichoic acids (WTAs), is the major determinant of cell

188 Structurally diverse wall teichoic acids (WTAs), which can also be differentially

189 lpha- and beta-O-GlcNAc residues on its wall teichoic acids (WTAs).

190 zed with anionic glycopolymers known as wall teichoic acids (WTAs).

191 tionalized with anionic polymers called wall teichoic acids (WTAs).