ライフサイエンスコーパス: tektin

1 e relative migration of adequately separated tektins.

2 n event prior to the divergence of the three tektins.

3 uence similarity to other proteins including tektins.

4 ficient embryos failed to up-regulate efhc1, tektin-1, and dnahc9 and could not maintain enhanced cil

5 s induced cilia motility target genes efhc1, tektin-1, and dnahc9.

6 We show that Tektin 2 (Tek2) associates with the spindle poles throug

7 s of previously annotated tektins, including tektin 4 (TEKT4), which shares 77.1% identity with its n

8 We identified Tektin 5, CCDC105, and SPACA9 as novel microtubule-assoc

9 w and shed light on the in vivo functions of Tektin 5.

10 from its cDNA (GenBank U38523), compared to tektins A (approximately 53 kDa) and B (approximately 51

11 rities are: for tektins A and C, 42/54%, for tektins A and B, 34/51%; for tektins B and C, 29/42%; fo

12 id sequence identities/similarities are: for tektins A and C, 42/54%, for tektins A and B, 34/51%; fo

13 ly 5-nm wide filament, composed of equimolar tektins A, B, and C, which interact with the nexin-dynei

14 the first mammalian (murine testis) cDNA for tektin, a protein unique to cilia, flagella, and centrio

15 f secondary structure, the segment length of tektin AB heterodimers is likely to be 16 nm.

16 able evidence, we propose that coassembly of tektin AB heterodimers with tektin C dimers produces fil

17 r a variant of it, is a prominent feature of tektins and is likely to form a functionally important p

18 To study the function of tektins and other ribbon proteins in the assembly of fla

19 The evolutionary conservation of tektins and their association with tubulin in cilia and

20 The three tektins (and the human clone) possess the exact sequence

21 onserved protein Rib45, >95% of the axonemal tektins, and >95% of the calcium-binding proteins, Rib74

22 ison with the sequence database reveals that tektins are a gene family, spanning evolution from Caeno

23 Tektins are conserved components of the flagellar proteo

24 Tektins are predicted to form extended rods composed of

25 DNA clone from mouse testis, 55/65%; and for tektin B and a partial cDNA clone from the human brain,

26 C, 42/54%, for tektins A and B, 34/51%; for tektins B and C, 29/42%; for tektin C and a partial cDNA

27 proteins (MIPs) and analyze evolution of the tektin bundle.

28 We report here the sequence of tektin C (approximately 47 kDa), predicted from its cDNA

29 B, 34/51%; for tektins B and C, 29/42%; for tektin C and a partial cDNA clone from mouse testis, 55/

30 at coassembly of tektin AB heterodimers with tektin C dimers produces filaments with overall repeats

31 Both segments of tektin C may be 24 nm long, but one may be 16 nm.

32 the onset, relative levels, and locations of tektin expression in mouse for several adult tissues and

33 Tektin expression is significant in adult brain and in t

34 There is a striking correlation of tektin expression with the known presence of either moti

35 to make several observations concerning the tektin family: (1) their common structural features, (2)

36 , and (3) their possible organization in the tektin filament polymer.

37 previously unknown MIPs, a luminal bundle of tektin filaments, and a pentameric dynein-docking comple

38 obility of sperm tail flagellar tubulins and tektins from an echinoderm and a mollusc were studied sy

39 Recent structural studies indicate that a tektin heteropolymer forms a unique protofilament of fla

40 ultiple new paralogs of previously annotated tektins, including tektin 4 (TEKT4), which shares 77.1%

41 The structural pattern of all three tektin polypeptides is similar to intermediate filament

42 Along each tektin rod cysteine residues occur with a periodicity of

43 om globular alpha and beta subunits, and the tektins, three equimolar alpha-helical proteins that for

44 a identified three of the ribbon proteins as tektins, which form coiled-coil filaments in doublet mic

45 d the separation of two normally comigrating tektins, yet minimally influenced the relative migration