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1 omponent (hTR), a noncoding RNA required for telomere elongation.
2 d activated by the MRX complex, resulting in telomere elongation.
3  Cdk1 at double-strand breaks also prevented telomere elongation.
4 butes to transformation independently of net telomere elongation.
5 omere length: the frequency or the extent of telomere elongation.
6 reas TR(+/-) heterozygotes were deficient in telomere elongation.
7 tivity is regulated in vivo to ensure proper telomere elongation.
8  a negative regulator of telomerase-mediated telomere elongation.
9 that human POT1 controls telomerase-mediated telomere elongation.
10  repression by the homolog may thus regulate telomere elongation.
11 unction in telomere protection as well as in telomere elongation.
12 mere length, and induced rapid and extensive telomere elongation.
13  1 released TRF1 from telomeres and promoted telomere elongation.
14 omere capping independent of its function in telomere elongation.
15 ecific collapse of retrotransposon-dependent telomere elongation.
16 -circle mechanism for telomerase-independent telomere elongation.
17 main is involved in other aspects of in vivo telomere elongation.
18  telomeric protein that negatively regulates telomere elongation.
19 omerase RNA, TLC1, by recombination-mediated telomere elongation.
20 p1p binding site led to immediate and severe telomere elongation.
21 ric terminus is not sufficient to deregulate telomere elongation.
22 e telomere-nontelomere junction and prevents telomere elongation.
23 his mechanism is also important in wild-type telomere elongation.
24 vation of telomerase-independent pathways of telomere elongation.
25 es with certain oligonucleotides resulted in telomere elongation.
26  by impairing POT1's suppression of aberrant telomere elongation.
27  DNAs, C- and G-circles, during ALT-mediated telomere elongation.
28 ich ssDNAs and C-circles during ALT-mediated telomere elongation.
29 f this shelterin bridge leads to unregulated telomere elongation.
30 mes occurs independently of the mechanism of telomere elongation.
31 ymorpha Rif1 suppresses telomerase-dependent telomere elongation.
32  in TERC stability, telomerase activity, and telomere elongation.
33 herapeutic dNTPs inhibit telomerase-mediated telomere elongation.
34 s reverse transcriptase activity and role in telomere elongation.
35 nteraction of Trt1 with Tpz1 is critical for telomere elongation.
36 rase and scaRNAs to nucleoli, and failure of telomere elongation.
37 erase subunits to telomeres and in promoting telomere elongation.
38 ates the ability of POT1(DeltaOB) to promote telomere elongation.
39 fective in the association with TRF2 induced telomere elongation.
40 rolling circle mechanism is the key event in telomere elongation.
41 n trans these two proteins induced extensive telomere elongation.
42 esis and cell proliferation pathways promote telomere elongation.
43 dition processivity of telomerase and caused telomere elongation.
44 nits form a telomerase holoenzyme capable of telomere elongation.
45  DNA damage response and telomerase-mediated telomere elongation.
46 teins or hnRNP C remain fully functional for telomere elongation.
47 t kinase Cdk1 (Cdc28) in cell-cycle-specific telomere elongation.
48 y of TRF1, resulting in telomerase-dependent telomere elongation.
49 that persistently "selfish" machinery shapes telomere elongation across Drosophila rather than comple
50 ding (OB) folds nor the telomerase-dependent telomere elongation activity mediated by the COOH-termin
51 d some other subunits of the complex induced telomere elongation and altered telomere position effect
52 e transcriptase complementary DNA results in telomere elongation and an additional 2- to 10-fold decr
53 rase catalytic subunit that is essential for telomere elongation and cell immortalization in vivo but
54 ect mechanistic link between coordination of telomere elongation and cell-cycle progression in vivo.
55  across missions, including cytokine shifts, telomere elongation and gene expression changes, as well
56 en TRF1 and telomerase inhibition to prevent telomere elongation and help maintain telomere homeostas
57 cing genes SIR3 and SIR4) result in moderate telomere elongation and improved telomeric silencing.
58 capping of telomeres, manifested by dramatic telomere elongation and increased length heterogeneity (
59 Our results identify TRF1 as a suppressor of telomere elongation and indicate that TRF1 is involved i
60     The telomeric protein Pin2/TRF1 controls telomere elongation and its expression is tightly regula
61 ddition processivity and expression level on telomere elongation and length maintenance.
62 ls with the NOS inhibitor L-NAME resulted in telomere elongation and prevention of apoptosis.
63 ls and telomerase activity, with concomitant telomere elongation and reduced levels of DNA damage sig
64  dna2-defective strains are impaired in both telomere elongation and sequential 5'-CA resection.
65 es reveal and resolve multiple TPP1 roles in telomere elongation and stem cell telomere length homeos
66 enes caused a synergistic effect on aberrant telomere elongation and t-circle accumulation, suggestin
67 ation in family-matched control cells allows telomere elongation and telomere length maintenance, whi
68         Our results suggest that coupling of telomere elongation and telomere replication is a univer
69 rom the TERT promoter was evident along with telomere elongation and TERT upregulation.
70               hPOT1 mutations also result in telomere elongation and the formation of transplantable
71  TPP1 TEL patch is genetically essential for telomere elongation and thus long-term cell viability.
72 merase inhibitor PinX1, negatively regulates telomere elongation, and specifically affects mitotic pr
73  that telomeric origin firing does not cause telomere elongation, and the role of Rif1 in regulating
74 h respect to how chromosomal replication and telomere elongation are coordinated.
75 heckpoint kinase, plays an important role in telomere elongation, as cells lacking Tel1p have short t
76  separation-of-function alleles in a de novo telomere elongation assay, we found, surprisingly, that
77                 POT1 alterations cause rapid telomere elongation, ATR kinase activation, telomere fra
78 gotes, via exposure to 20% O(2) or rotenone, telomere elongation between the 8-cell and blastocyst st
79 tion to their well-characterized function in telomere elongation, both CaEst1p and CaEst2p mediate so
80          In ALT cells, telomeric RS promotes telomere elongation but above a certain threshold become
81                Telomerase inhibitor prevents telomere elongation but induces RAD51/HR, which contribu
82 proliferation can be uncoupled not only from telomere elongation, but also from other telomerase acti
83                                              Telomere elongation by BIR appears to often occur throug
84 rent way: Pif1p inhibits telomerase-mediated telomere elongation by directly removing telomerase from
85                                              Telomere elongation by human telomerase is inhibited in
86  a telomere-associated protein that inhibits telomere elongation by its binding to telomere repeats,
87 ing Zscan4 expression, a critical factor for telomere elongation by recombination.
88 propose Cdk1 activity controls the timing of telomere elongation by regulating the single-strand over
89 AS may play an important role in controlling telomere elongation by repressing HeT-A promoter activit
90                          We demonstrate that telomere elongation by tankyrase 1 requires the catalyti
91 eover, using metaphase analysis we show that telomere elongation by telomerase can significantly redu
92 , supplementation with dT alone drove robust telomere elongation by telomerase in cells, and thymidin
93    Previous studies in yeast have shown that telomere elongation by telomerase is cell cycle dependen
94  controlled by a feedback mechanism in which telomere elongation by telomerase is limited by the accu
95 nt of the TRF1 protein complex that controls telomere elongation by telomerase.
96 t the phenotype was not due to inappropriate telomere elongation by telomerase.
97 t a regulatory mechanism exists for limiting telomere elongation by telomerase.
98 nate multiple telomere activities, including telomere elongation by telomerase.
99 atures of a recombination-based mechanism of telomere elongation, called the alternative lengthening
100         Variants in TERC and TERT can impede telomere elongation causing stem cells to enter prematur
101 mosome ends examined, demonstrating that the telomere elongation characteristic of rap1-17 and rif2 s
102 -) heterozygotes had no detectable defect in telomere elongation compared to wild-type controls, wher
103        Ectopic expression of Tbx3 results in telomere elongation, consistent with a role for Zscan4 i
104  by which Elg1 and Stn1 negatively regulates telomere elongation, coordinated by SUMO.
105 nd tankyrases modulates chromatin structure, telomere elongation, DNA repair, and the transcription o
106                  We further demonstrate that telomere elongation during ICM formation is controlled b
107 by blocking telomerase assembly and disrupts telomere elongation during reprogramming.
108 ones with short telomeres were used to study telomere elongation dynamics, which differed dramaticall
109 expression of these proteins can reverse the telomere elongation effect of overexpression of the Rap1
110 the loss of RPA-mediated stimulation impairs telomere elongation, even when TPP1-POT1-mediated stimul
111 e variant repeats, we can directly visualize telomere elongation events in human cells.
112  cdc17-1 strains that would normally undergo telomere elongation failed to do so in the absence of te
113 s of telomeric repeats, that recombinational telomere elongation generates a repeating pattern common
114 ific changes, including decreased body mass, telomere elongation, genome instability, carotid artery
115 variants were identified in the regulator of telomere elongation helicase 1 (RTEL1) gene that encodes
116 ariant in the gene encoding for regulator of telomere elongation helicase 1 (RTEL1) that segregated w
117 h HHS, in the gene encoding the regulator of telomere elongation helicase 1 (RTEL1).
118 ere, we demonstrate that RTEL1 (regulator of telomere elongation helicase 1) has a genome-wide role i
119  reverse transcriptase], RTEL1 [regulator of telomere elongation helicase 1], and PARN [poly(A)-speci
120 , mutations in the DNA helicase Regulator of Telomere Elongation Helicase1 (RTEL1) lead to Hoyeraal-H
121 ense variants and quantified their impact on telomere elongation in a cell-based assay.
122 , recognize chromosome ends, and orchestrate telomere elongation in a highly regulated fashion.
123 c13-Est2 fusion protein to promote extensive telomere elongation in an est1-Delta strain.
124                     This result implies that telomere elongation in cdc17-1 mutants is mediated by th
125                  To investigate the cause of telomere elongation in cdc17/pol1 (DNA polymerase alpha)
126 inX1 to localize to telomeres and to inhibit telomere elongation in cells even though neither has any
127 1 binds to telomeric DNA and acts to inhibit telomere elongation in cis.
128 n of one copy of TINF2 resulted in excessive telomere elongation in clonal lines, indicating that TIN
129                     Strikingly, NBS promotes telomere elongation in conjunction with TERT in NBS fibr
130 ults demonstrate that reprogramming restores telomere elongation in DC cells despite genetic lesions
131 RF1 in vitro, and its overexpression induces telomere elongation in human cancer cells.
132 2/TRF1 protein levels and causes progressive telomere elongation in human cells.
133 r results indicate that tankyrase can induce telomere elongation in human cells.
134 er expression and positively correlated with telomere elongation in NSE than SE: three telomerase act
135 nd ZSCAN4) and Yamanaka factors might induce telomere elongation in NSE.
136  In our study, treatment with danazol led to telomere elongation in patients with telomere diseases.
137 ATR and Tel1ATM are redundantly required for telomere elongation in quiescence through the phosphoryl
138  for rapid elongation by telomerase and that telomere elongation in T. brucei is not regulated by a p
139 1 depletion caused a rapid growth arrest and telomere elongation in the absence of cell division.
140 Delta mutants, suggesting a role for Dna2 in telomere elongation in the absence of Pif1.
141 also depends on a parent-of-origin effect on telomere elongation in the early embryo.
142 ells with high levels of TERT contributes to telomere elongation in the male germline during homeosta
143 efect but are capable of promoting extensive telomere elongation in the presence of a Cdc13-Est2 fusi
144  transformed cells to escape crisis and that telomere elongation in these cells occurs in a tightly r
145 at tankyrase acts as a positive regulator of telomere elongation in vivo, apparently by inhibiting TR
146 and overexpression of the tbf1 gene leads to telomere elongation in vivo, which is dependent upon the
147  these motifs are important for catalysis of telomere elongation in vivo.
148 ts of the telomerase holoenzyme required for telomere elongation in vivo.
149     Four independent BRD4 inhibitors blocked telomere elongation, in a dose-dependent manner, in mous
150 ant versions of Cdc13 or Est1 confer similar telomere elongation, indicating that close physical prox
151 on of PIP1 or POT1 levels with shRNAs led to telomere elongation, indicating that PIP1 contributes to
152 ly ectopic expression of POT1 suppressed the telomere elongation induced by POT1(DeltaOB).
153  enhanced telomeric silencing in response to telomere elongation is associated with increased repress
154 th homeostasis in which telomerase-dependent telomere elongation is blocked by sequestration of the 3
155                                              Telomere elongation is cell-cycle regulated and requires
156 st despite the fact that the biochemistry of telomere elongation is completely different in the two m
157                                              Telomere elongation is coupled with genome replication,
158                                      Because telomere elongation is crucial for self-renewal of hPSCs
159  One of the genes that, when mutated, causes telomere elongation is ELG1, which encodes an unloader o
160       In the yeast Saccharomyces cerevisiae, telomere elongation is negatively regulated by the telom
161                                              Telomere elongation is regulated at multiple levels, inc
162                                              Telomere elongation is responsive to both the number of
163         Here, we have demonstrated that this telomere elongation is telomerase dependent.
164 g [3,4], indicating that telomerase-mediated telomere elongation is tightly regulated.
165                     We provide evidence that telomere elongation might be the primary event that caus
166 evated mtROS in zygotes followed by impaired telomere elongation, occurred with maternal obesity or a
167 ught to be limited to the late S phase, when telomere elongation occurs.
168 r activity leading to immune suppression and telomere elongation or decreased activity causing de-dif
169           Different types of recombinational telomere elongation pathways have been identified in yea
170 over from senescence via two recombinational telomere elongation pathways.
171 validate this approach by in situ mapping of telomere elongation patterns within individual nuclei an
172 omeric sequence hampers in situ detection of telomere elongation patterns.
173                          For both genes, the telomere elongation phenotype is allele specific and app
174 sively long telomeric overhangs derived from telomere elongation processes that mostly occur during S
175 fective in regulating telomerase, leading to telomere elongation rather than the telomere shortening
176 t was recently proposed that recombinational telomere elongation (RTE) in a telomerase-deletion mutan
177  mutants lacking telomerase, recombinational telomere elongation (RTE) is induced at short telomeres
178                              Recombinational telomere elongation (RTE) known as alternate lengthening
179 ic mutations such as a specific regulator of telomere elongation (RTEL1) mutation causing isolated na
180 t cancer (MDA-MB-231), engineered for either telomere elongation/shortening, gave an increase/decreas
181 i and suggest a roll-and-spread mechanism of telomere elongation similar to that seen in previous obs
182 e lengthening of telomeres (ALT) pathway for telomere elongation, SMARCAL1 deficiency does not yield
183 n telomeric protein POT1 induces significant telomere elongation, suggesting that at least one critic
184 ssion of tankyrase 1 in the nucleus promotes telomere elongation, suggesting that tankyrase 1 regulat
185 ear overexpression leads to loss of TRF1 and telomere elongation, suggesting that tankyrase1 is a pos
186 her hand, genetic depletion of Skp1p induced telomere elongation, suggesting that this protein plays
187 tein in telomerase-positive cells results in telomere elongation, supporting the idea that hPot1 is a
188  telomeres due to a dominant mutation in the Telomere elongation (Tel) gene.
189 tion in telomerase levels blunts the natural telomere elongation that accompanies reprogramming.
190  homology-directed repair (HDR) mechanism of telomere elongation that controls proliferation in aggre
191  homology-directed repair (HDR) mechanism of telomere elongation that controls proliferation in subse
192              TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA re
193 e of RTE that results in much more extensive telomere elongation that is reminiscent of human ALT cel
194 ce of telomerase, the enzyme responsible for telomere elongation, that led to a non-canonical telomer
195 sed of Acc repeats invariably showed extreme telomere elongation, they often also initially showed pe
196 utation, whereas sexual animals only achieve telomere elongation through sexual reproduction.
197                                              Telomere elongation through telomerase enables chromosom
198 merase is a ribonucleoprotein that catalyzes telomere elongation through the addition of TTAGGG repea
199 1 appears to act upstream of TRF1, promoting telomere elongation through the removal of TRF1.
200 me domain of Rap1p also negatively regulates telomere elongation, through an unknown mechanism.
201 ifferentiation phenotype could be rescued by telomere elongation via reintroduction of Tert, via supp
202                                  Conversely, telomere elongation was induced by expression of a domin
203                                          The telomere elongation was telomerase dependent in the repl
204 nd DNA polymerase alpha that cause increased telomere elongation were unable to compensate for the lo
205  and Poz1 function as negative regulators of telomere elongation, whereas Pot1 and Tpz1 are critical
206               These differences in embryonic telomere elongation, which emerge before zygotic genome
207  a telomerase-positive cell line resulted in telomere elongation, which is typical of reduced TRF1 fu
208 ruption of this linkage leads to unregulated telomere elongation while still retaining the shelterin
209         Telomerase is a nuclear regulator of telomere elongation with recent reports suggesting a rol
210  exhibited progressive, telomerase-dependent telomere elongation without evidence of DNA damage.
211  tested whether mutations in RIF1 that cause telomere elongation would affect origin firing.

 
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