ライフサイエンスコーパス: tenascin-R

1 extracellular matrix proteins tenascin-C and tenascin-R.

2 an binds fibronectin type III domains 3-5 of tenascin-R.

3 xtracellular matrix molecules tenascin-C and tenascin-R.

4 s that phosphacan forms a tight complex with tenascin-R.

5 expressed in the nervous system, also binds tenascin-R.

6 y antigen-specific assays to be specific for tenascin-R.

7 eceptors -1, -4, and -5, homer-1 and -2, and tenascin-R.

8 in domain of versican has been shown to bind tenascin-R, an extracellular matrix protein specifically

9 om adult rat brain extracts, suggesting that tenascin-R and brevican form complexes in vivo.

10 f the same brain region, five proteoglycans, tenascin-R and NR protein neurofascin were immunostained

11 ping brain: the glycoproteins tenascin-C and tenascin-R and the chondroitin sulfate proteoglycans bre

12 phacan with the extracellular matrix protein tenascin-R and two heparin-binding proteins, amphoterin

13 We focused on aggrecan, brevican, and tenascin-R as they are especially expressed in the matur

14 We have determined that tenascin-R associated with Purkinje cell bodies and thei

15 fibronectin type III repeats 1-2 and 6-8 of tenascin-R but not to the epidermal growth factor-like d

16 The expression of tenascin-R by oligodendrocytes and small interneurons in

17 other lecticans also bind the same domain of tenascin-R by protein-protein interactions.

18 Versican and tenascin-R colocalized in OLCs, and coimmunoprecipitatio

19 cated statistical significance in the other (tenascin-R, disintegrin and metalloproteinase domain-con

20 resembled that in perineuronal nets in which tenascin-R has been localized.

21 with beta1,4-linked GalNAc-4-SO(4), whereas tenascin-R in other regions of the cerebellum does not b

22 omain of the beta2 subunit to tenascin-C and tenascin-R in vitro.

23 ough the fibronectin type III domains 3-5 of tenascin-R, independent of any carbohydrates or sulfated

24 The cellular adhesion molecule tenascin-R is a multifunctional extracellular matrix com

25 Tenascin-R is coprecipitated with brevican from adult ra

26 the PNN structural abnormalities observed in tenascin-R knockout brains.

27 and suggest that brevican is a physiological tenascin-R ligand in the adult brain.

28 ular matrix molecules such as tenascin-C and tenascin-R may play a crucial role in localizing sodium

29 y reported interactions between brevican and tenascin-R may play a functional role within the perineu

30 tion of this unique sulfated carbohydrate to tenascin-R may serve to modulate its adhesive/anti-adhes

31 sed the effect of aggrecan, brevican, and/or tenascin-R on neurite outgrowth in vitro.

32 abundance of ECM proteins brevican (BCN) and tenascin-R over the course of acquisition learning, cons

33 The 180-kDa core protein contains a tenascin-R-related molecule, consistent with recent obse

34 osed with follicular lymphoma that expressed tenascin-R suggesting a paraneoplastic origin; cancer tr

35 rotein expression of aggrecan, brevican, and tenascin-R throughout the rat brain utilizing immunohist

36 Tenascin-R (TN-R) is a member of the tenascin family of

37 f chondroitin sulfate proteoglycans (CSPGs), tenascin-R (TN-R), hyaluronan (HA), and link proteins, s

38 X (TNX), tenascin-C (TNC, or cytotactin) and tenascin-R (TN-R, or restrictin).

39 e of the purified proteins was identified as tenascin-R (TNR) by mass spectrometric analysis.

40 w that the extracellular matrix glycoprotein tenascin-R (TNR) is produced in the granule cell layer o

41 ellular matrix proteins such as aggrecan and tenascin-R (TNR).

42 absence of calcium, binding of phosphacan to tenascin-R was not affected by the absence of divalent c

43 ontaining various segments of tenascin-C and tenascin-R were purified, digested with thrombin to remo

44 an immunoreactivity colocalized with that of tenascin-R, which was also substantially codistributed w

45 ans show saturable, high affinity binding to tenascin-R with apparent dissociation constants in the 2