ライフサイエンスコーパス: tendon

1 d that their levels are altered in stretched tendon.

2 interfibrillar matrix in the biomechanics of tendon.

3 t pad is located posterior to the quadriceps tendon.

4 ty to target the cellular environment of the tendon.

5 ducing capacity was recorded from the distal tendon.

6 s and other extracellular matrix proteins in tendon.

7 ice via mechanical overload of the plantaris tendon.

8 totic cells were co-stained in tendinopathic tendon.

9 fascicular (glycoprotein-rich) ECM phases of tendon.

10 s and elastic energy storage in the Achilles tendon.

11 hronically tendinopathic and 8 healthy human tendons.

12 MTP joints demonstrated sheaths surrounding tendons.

13 morphological changes in bilateral patellar tendons.

14 showed a significant decrease in elderly leg tendons.

15 endons (PTT) as two representative human leg tendons.

16 lammation induces fibrosis in diseased human tendons.

17 re not often capable of directly visualizing tendons.

18 ethod to assess the impact of aging on human tendons.

19 wn to regulate TGF-beta expression in animal tendons.

20 ACL reconstruction with autologous hamstring tendons.

21 .1 (95% CI: 1.9, 5.2; P < .001) for extensor tendons.

22 at TGFbeta ligand is positively regulated in tendons.

23 difference in the rate of re-rupture of the tendon (17 [6%] of 266 in the plaster cast group vs 13 [

24 In tendons, a highly organized extracellular matrix undergo

25 isation of mechanically loaded tissues using tendon; a simple aligned biological composite, in which

26 ngs from this study identified that although tendons across the body share a common anatomical defini

27 muscle spindle afferents and Group Ib Golgi tendon afferents is critical for the normal execution of

28 Tendon and bone are attached by a transitional connectiv

29 xis-null mice are viable and have a range of tendon and bone defects in the trunk and limbs but no de

30 Sox9 is expressed in not only tendon and bone progenitor cells but also muscle progeni

31 s of individual proteins within rat Achilles tendon and its ECM phases.

32 lds to repair and regenerate ruptured native tendon and ligament (T/L) tissues is a significant engin

33 d fine tuning of the extracellular matrix by tendon and ligament stromal cells.

34 ccessful repair and regeneration of ruptured tendon and ligament tissues.

35 ncluding novel macrophage populations within tendon and skeletal muscle and underlying the mesothelia

36 Many of the genes that differed between tendons and across species are important in tissue speci

37 et of donated bodies were examined at flexor tendons and extensor tendons for the presence and course

38 ruses were detected and isolated, 83.3% from tendons and joints, 12.3% from the heart and 3.7% from i

39 Tendons and ligaments are crucial components of the musc

40 The biomechanics and mechanobiology of tendons and ligaments form the basis for understanding h

41 veral mechanical stress-related disorders in tendons and ligaments overlaps with that of chronic infl

42 Tendons and ligaments require physiological levels of me

43 une system-mediated tissue repair pathway in tendons and ligaments.

44 lasia of the cartilage and its attachment to tendons and muscle.

45 2.4 (95% CI: 1.5, 3.8; P < .001) for flexor tendons and OR of 3.1 (95% CI: 1.9, 5.2; P < .001) for e

46 sults explain why fibrosis occurs in injured tendons and present clinical challenges to enhance tendo

47 Sox9 was expressed in MTJ, tendon, and bone progenitor cells at E13 and in bone at

48 n Sox9 expression in each component (muscle, tendon, and bone) is essential for the development of th

49 ion in muscle-associated connective tissues, tendons, and bones led to hypoplasia of the cartilage an

50 uloskeletal system, which comprises muscles, tendons, and bones, is an efficient tissue complex that

51 Coordinated development of muscles, tendons, and their attachment sites ensures emergence of

52 ogenitor cells capable of fully regenerating tendons, and this process is regulated by BMP signaling.

53 by muscle anchoring to skeleton via a short tendon anlage; and second, by rapid elongation of the te

54 ms in adipose tissue, cartilage, dermis, and tendon are discussed that inspire the need to replace na

55 Tendons are an essential part of the musculoskeletal sys

56 We recently demonstrated that long tendons are formed in two stages: first, by muscle ancho

57 These tendons are functionally distinct and are also among the

58 Tendons are specialized tissues composed primarily of lo

59 l insights into the functions of muscles and tendons as an integral part of the internal driving syst

60 Conclusion Tendons at metatarsophalangeal joints are surrounded by

61 nce (EPR) spectroscopy of stretched rat tail tendon, atomistic molecular dynamics simulations and qua

62 modeling were performed on anterior tibialis tendons (ATT) and posterior tibialis tendons (PTT) as tw

63 Tendon attachment position and associated MRI findings (

64 .32), nor was a difference found for the MHG tendon attachment position in knees with DFCI (63.9 mm v

65 DFCI size and tendon attachment position were measured.

66 cortical irregularities (DFCIs) at different tendon attachment sites in youth competitive alpine skie

67 cle shapes and topographical wiring of their tendon attachments.

68 ligament (ACL) reconstruction is the use of tendon autografts and allografts.

69 We find that loss of Fgfr2 in the mouse tendon-bone interface reduces Scx expression in Scx(+)/S

70 bstantial diversity in the transcriptomes of tendons both within and across species.

71 us healing response can be safely induced in tendon by means of biophysical cues using a woven and el

72 strocnemius muscle (LHG) and adductor magnus tendon by two radiologists.

73 s in parallel to human plantar flexor muscle-tendons can reduce the metabolic cost of walking.

74 However, tendon cell activity during growth and homeostatic maint

75 onal-ECM), can modulate canonical healing B6 tendon cell behavior by inducing morphological changes a

76 tissue specification and limb morphogenesis, tendon cell biology and tenogenesis, growth factor signa

77 These studies define a heterogeneous tendon cell environment and demonstrate discrete contrib

78 The effect on tendon cell expansion is specific to the geranylgeranyla

79 In this study, we find that the mouse tendon cell fate requires continuous maintenance in vivo

80 for TGFbeta signaling in maintenance of the tendon cell fate.

81 y cellular apparatus, regulating fundamental tendon cell functions relevant to exercise-induced adapt

82 fish, we identified a new pathway regulating tendon cell induction.

83 his time, we find low amounts of homeostatic tendon cell proliferation from 3 to 20 months.

84 ation in mice, we show significant postnatal tendon cell proliferation, correlating with longitudinal

85 Repetitive stretching of tendon cells activates the AKT and mTOR pathways, which

86 h model, we genetically ablate all embryonic tendon cells and find complete regeneration of tendon st

87 ggered muscle pattern involves attraction to tendon cells and heterotypic muscle-muscle adhesion.

88 Tendon cells are heterogenous and sparsely distributed i

89 pid mediator profiles of IL-1beta-stimulated tendon cells derived from patients with shoulder tendon

90 During tendon healing, it is postulated that tendon cells drive tissue regeneration, whereas extrinsi

91 cubation of IL-1beta-treated patient-derived tendon cells in LXB4 or RvE1 up-regulated concentrations

92 chanical loading or targeted exercise causes tendon cells to increase the stiffness of the extracellu

93 cal stimuli from the extracellular matrix to tendon cells, thereby triggering cell signaling pathways

94 ing and identify a subpopulation of resident tendon cells.

95 mice, while the other cross-links typical of tendon collagen either decreased or remained the same as

96 retinoids contribute to the establishment of tendon condensations and attachment sites that precede t

97 dapted for high motor performance, and k-rat tendon could be a novel model for improving tissue engin

98 lts Macroscopically, all extensor and flexor tendons crossing MTP joints demonstrated sheaths surroun

99 all levels of collagen cross-linking in tail tendon decreased with age.

100 that overall collagen cross-linking in mouse tendon decreases with age.

101 ff tear on the preoperative MRI and assessed tendon degeneration and composite muscle atrophy and fat

102 asured tear retraction (estimate, 3.52), and tendon degeneration grade (estimate, 1.59) and the posto

103 ars, more tendon retraction, and more severe tendon degeneration have worse clinical outcome scores 1

104 gorical grading scales (grade 0 indicates no tendon degeneration or muscle atrophy and fatty infiltra

105 er grades indicate incrementally more severe tendon degeneration or muscle atrophy and fatty infiltra

106 A expression in diseased compared to healthy tendon-derived cells.

107 drial function and proliferative capacity in tendon-derived fibroblasts, restricting their ability to

108 Incubation of IL-1beta treated AT and AR tendon-derived stromal cells in 15-epi-LXA(4) or MaR1 re

109 ted the bioactive lipid mediator profiles of tendon-derived stromal cells isolated from patients with

110 se cells with 2 of the mediators produced by tendon-derived stromal cells, 15-epi-Lipoxin A(4) (15-ep

111 Tendon development was not disrupted in mutant embryos,

112 ption factor scleraxis (Scx) is required for tendon development; however, the function of Scx is not

113 in tongue development (specifically, lingual tendon differentiation and intrinsic muscle patterning t

114 ced fibrosis during the development of human tendon disease and subsequent repair.

115 ed appetite, increased weight, restlessness, tendon disorder, and potential drug-induced liver injury

116 nflammation is poorly understood in Achilles tendon disorders.

117 he potential use of IGF1 in the treatment of tendon disorders.

118 lls in zebrafish larvae, finding that larval tendons display high regenerative capacity.

119 aw digit flexor, patellar, and supraspinatus tendons due to their divergent functions and high rates

120 Scx and S100a4 label distinct populations in tendon during homeostasis and healing, with Scx found in

121 teractions of the muscle spindle with muscle-tendon dynamics reveal how motor commands to the muscle

122 and/or other growth factors (GFs) within the tendon ECM microenvironment will provide a rational basi

123 the identification of changes in muscle and tendon elasticities.

124 For the soleus, forefoot striking decreased tendon energy storage and fiber work done while the musc

125 plantar flexor muscle mechanics and Achilles tendon energy storage have been explored during rearfoot

126 ns via organ culture, highlighted the innate tendon environment as the driver of scarless healing.

127 th a timely transfer of torque and energy by tendons, explains the decrease in the duration of muscle

128 was to investigate the potential of MRL/MpJ tendon extracellular matrix (ECM)-derived coatings to re

129 pared a soluble, low immunogenic (DNA-free), tendon extracellular matrix fraction (tECM) by urea extr

130 ng their ability to maintain biosynthesis of tendon extracellular matrix.

131 that advanced glycation end-products disrupt tendon fibroblast homeostasis and may be involved in the

132 impact of advanced glycation end-products on tendon fibroblasts to further our mechanistic understand

133 We demonstrate that tendon fibroblasts treated with advanced glycation end-p

134 Significant infiltration of tendon fibroblasts was observed within the electrospun c

135 Tendon fibroblasts were the most abundant scaffold-popul

136 were examined at flexor tendons and extensor tendons for the presence and course of tendon sheaths.

137 gue epithelium have perturbed lingual septum tendon formation and disrupted intrinsic muscle patterni

138 ere not recruited during elongation and long tendon formation was impaired.

139 ied the changes in crosslink bonding in tail tendon from 11-week-old C57Bl/6 mice at 4% physical stra

140 nscription factor scleraxis marks vertebrate tendons from early specification.

141 ur torque prediction and the absence of long tendons from experimental observations.

142 ured and compared the material properties of tendons from k-rat ankle extensor muscles to those of si

143 hese results support the hypothesis that the tendons from k-rats are specially adapted for high motor

144 ned with findings from mechanical testing of tendons from these mice, indicate that overall collagen

145 , promising therapeutic candidate to improve tendon function after acute injury.

146 y or inhibition of S100a4 signaling improves tendon function following acute injury and surgical repa

147 presence of neovascularity between the three tendon groups.

148 1 signaling is required for proper postnatal tendon growth and support the potential use of IGF1 in t

149 -inducible Cre-recombinase system and caused tendon growth in adult mice via mechanical overload of t

150 d that IGF1 signaling is required for proper tendon growth in response to mechanical loading through

151 tion, correlating with longitudinal Achilles tendon growth.

152 signaling in tenocytes is required for adult tendon growth.

153 These results demonstrate that tendons harbor significant postnatal mitotic activity, a

154 oints towards the possibility that the adult tendon harbors resident tendon progenitor populations, w

155 For the first time we show that human tendon harbours at least five distinct COL1A1/2 expressi

156 surface imaging, normally mineralizing avian tendons have been studied with nanometer resolution in t

157 ntribute to organized bridging tissue during tendon healing and identify a subpopulation of resident

158 The molecular mechanisms that govern tendon healing are not well defined.

159 gnaling was maintained through all phases of tendon healing in mice, including the remodeling phase,

160 st that NF-kappaB may contribute to fibrotic tendon healing through both inflammation-dependent and i

161 During tendon healing, it is postulated that tendon cells drive

162 file of canonical NF-kappaB signaling during tendon healing.

163 e and organize into a cellular bridge during tendon healing.

164 nase (MAPK) pathways have been implicated in tendon healing.

165 lage; and second, by rapid elongation of the tendon in parallel with skeletal growth.

166 ally been treated with immobilisation of the tendon in plaster casts for several weeks.

167 rehensive atlas of the transcriptome of limb tendons in adult mice and rats using systems biology tec

168 lso provide further evidence that the use of tendons in caudal regions is beneficial from an energeti

169 rated reduced cell proliferation and smaller tendons in response to mechanical loading.

170 ved tendon tear cells, regulating markers of tendon inflammation, including podoplanin, CD90, phospho

171 lecules as potential therapeutics to resolve tendon inflammation.

172 Tendon injuries are common with poor healing potential.

173 Tendon injuries cause prolonged disability and never rec

174 Flexor tendon injuries heal with excessive scar tissue that lim

175 Treatment of tendon injuries is challenging.

176 The paucity of therapies for tendon injuries is due to our limited understanding of t

177 Acute tendon injuries often heal through a fibrotic mechanism,

178 lt fractures, osteonecrosis, ligamentous and tendon injuries, and entrapment neuropathies.

179 ice exhibit improved healing following acute tendon injuries, but the driver of this regenerative hea

180 A sheep tendon injury model characterised by a natural history o

181 in 1beta (IL-1beta) is upregulated following tendon injury.

182 Tendon is a functionally important connective tissue tha

183 Tendon is a hypocellular, matrix-rich tissue that has be

184 l location between skeletal muscle and bone, tendon is a surprisingly genetically heterogeneous tissu

185 This study indicates that tendon is a surprisingly heterogenous tissue with substa

186 most common imaging findings of disorders of tendons, labrum, and ligaments of the shoulder.

187 , effusion (20 of 40 vs 26 of 100), abductor tendon lesion (22 of 40 vs 62 of 100), or bursitis (14 o

188 tal groove in predicting long head of biceps tendon (LHBT) pathology.

189 This allows tumor, muscle, tendon, ligament or cartilage disease monitoring for the

190 he synovium but the SpA disorders target the tendon, ligament, and joint capsule skeletal anchorage p

191 The adhesion of soft connective tissues (tendons, ligaments, and cartilages) on bones in many ani

192 of adjacent anatomical structures (muscles, tendons, ligaments, and neurovascular structures) and of

193 red by the nanostructured interfaces between tendons/ligaments/cartilages and bones, we report that b

194 into the complexity of proteome dynamics in tendon, likely required to maintain tissue homeostasis.

195 activity in regulating specification of the tendon lineage.

196 librated shear wave tensiometers to evaluate tendon loading in locomotor tasks.

197 The tensiometers also detected Achilles tendon loading of 4 to 7 MPa in late swing.

198 Late swing tendon loading was not discernible in the inverse dynami

199 conventional techniques for measuring muscle-tendon loads in the human body are too invasive for use

200 haracterization of mouse skeletal muscle and tendon mechanical properties in vivo using elastography

201 his study examined how plantar flexor muscle-tendon mechanics during running differs between rearfoot

202 terns, to characterize plantar flexor muscle-tendon mechanics.

203 Close to the tendon mineralization front, calcium-rich deposits appea

204 tructural proteins within MRL/MpJ vs C57Bl/6 tendons occur synergistically to mediate the improvement

205 atrix in native (unfixed), hydrated Achilles tendon of sheep and chickens.

206 Primary tenocytes from Achilles tendon of Sprague-Dawley rats 1 week after collagenase i

207 rmore, neovascularity was more common in the tendon of the residual limb.

208 cripts were differentially regulated between tendons of a given species, and nearly 60% of the filter

209 , forepaw flexor, patellar and supraspinatus tendons of both mice and rats.

210 from patients with shoulder tendon tears and tendons of healthy volunteers to advance understanding o

211 and was easily distinguished from the flexor tendons of the hands running in the carpal tunnel.

212 contributes to the mechanical properties of tendon or whether crosslinking changes in response to st

213 njury, previous rupture of the same Achilles tendon, or being unable to complete the questionnaires.

214 feedback from muscle spindle (MS) and Golgi tendon organ (GTO) sensory end organs is critical for no

215 Golgi tendon organ feedback has been evaluated most frequently

216 nderstanding of the functional role of Golgi tendon organ feedback.

217 Force feedback from Golgi tendon organs (GTOs) has widespread intermuscular projec

218 hysiological or selective stimulus for Golgi tendon organs.

219 on and tear at the same location on the same tendon (p > 0.05, r = 0.04).

220 injuries, common traumatic and degenerative tendon pathology, abnormalities of transverse tarsal joi

221 eads to signaling that helps to shape nearby tendon precursor cells.

222 tomy, cataract surgery, meniscectomy, muscle/tendon procedures, and joint procedures) from 2011 to 20

223 ew study establishes genetic tools to ablate tendon progenitor cells in zebrafish larvae, finding tha

224 +) cells, but not nkx2.5(+) cells, increases tendon progenitor number in the perichondrium, suggestin

225 valonate pathway, causes an expansion of the tendon progenitor population.

226 ility that the adult tendon harbors resident tendon progenitor populations, which would have importan

227 eletal repair model to explore the source of tendon progenitors by fate mapping and live imaging, as

228 Collagen I is a major tendon protein whose polypeptide chains are linked by co

229 oatings derived from early-deposited MRL/MpJ tendon provisional extracellular matrix (provisional-ECM

230 ibialis tendons (ATT) and posterior tibialis tendons (PTT) as two representative human leg tendons.

231 The main safety outcome was the incidence of tendon re-rupture.

232 tic testing showed gait-difficulties, absent tendon reflexes, decreased joint-position, positive Romb

233 onal role for canonical TGFbeta signaling in tendon regeneration and offer new insights toward the di

234 Current mechanistic understanding of tendon regeneration is limited.

235 s and present clinical challenges to enhance tendon regeneration without a concurrent increase in fib

236 To develop means to augment tendon regeneration, we have previously prepared a solub

237 Using a mouse model of neonatal tendon regeneration, we identified TGFbeta signaling as

238 the cells and molecular pathways that drive tendon regeneration.

239 major molecular pathway that drives neonatal tendon regeneration.

240 nd TGFbeta-independent mechanisms underlying tendon regeneration.

241 no-canalicular network in highly mineralized tendon regions, where ~100 nm diameter canaliculi emanat

242 evaluating cell viability and expression of tendon-related proliferation markers, inflammatory media

243 e of infraspinatus muscle degeneration after tendon release involves the elimination of oxidative cha

244 ino acid levels were increased 2 weeks after tendon release, when the levels of high-energy phosphate

245 lls (Scx(Lin)) following adult murine flexor tendon repair and established the relationship between S

246 protein periostin during the late stages of tendon repair, suggesting that persistent NF-kappaB sign

247 nd polycaprolactone (PCL) patch intended for tendon repair.

248 rational basis for an ECM-based approach for tendon repair.

249 novel model for improving tissue engineered tendon replacements.

250 This eccentricity may diminish the effect of tendon repositioning in moderate to highly myopic patien

251 atients with larger rotator cuff tears, more tendon retraction, and more severe tendon degeneration h

252 plications such as artificial cartilages and tendons, robust antifouling coatings, and hydrogel robot

253 eated non-operatively for a primary Achilles tendon rupture at the participating centres were potenti

254 rimary outcome was patient-reported Achilles tendon rupture score (ATRS) at 9 months, analysed in the

255 Patients with Achilles tendon rupture who have non-operative treatment have tra

256 patients treated non-surgically for Achilles tendon rupture.

257 onsistent with this, myofibroblasts in human tendon scar samples displayed enhanced prosurvival signa

258 kappaB activation in myofibroblasts in human tendon scar tissue.

259 Purpose To determine the anatomy of tendon sheaths of the forefoot and the relationship betw

260 tumors originated from muscle, nerve, and/or tendon sheaths, with frequent invasion into adjacent bon

261 ensor tendons for the presence and course of tendon sheaths.

262 dings, increased signal intensity of the MHG tendon showed a significant association with MHG-related

263 sing (Tppp3(+)) cell population as potential tendon stem cells.

264 o be an important factor that contributes to tendon stiffening with age and in diabetes.

265 ses with age and that this increase leads to tendon stiffening.

266 showed that the linear relationship between tendon stress and wave speed squared can be calibrated f

267 Peak tendon stresses during pushoff increased from 41 to 48 M

268 de insights into the chemical changes during tendon stretching and directly link these chemical chang

269 E1 counterregulate inflammatory processes in tendon stromal cells, supporting the role of these molec

270 ndon cells and find complete regeneration of tendon structure and pattern.

271 proinflammatory phenotype of patient-derived tendon tear cells, regulating markers of tendon inflamma

272 s moderated the proinflammatory phenotype of tendon tear stromal cells.

273 on cells derived from patients with shoulder tendon tears and healthy volunteers.

274 d cells isolated from patients with shoulder tendon tears and tendons of healthy volunteers to advanc

275 re driven by the stretched aponeuroses (flat tendons that connect the sonic muscles to the swim bladd

276 derlying transcriptional differences between tendons that may dictate their designs and properties.

277 cal properties of healing MRL/MpJ vs C57Bl/6 tendons that were isolated from systemic contributions v

278 rformed measures on four of the most studied tendons, the Achilles, forepaw flexor, patellar and supr

279 Development of tendon therapeutics has been hindered by the lack of inf

280 signs and mechanical properties of different tendons throughout the body.

281 time (UTE) MRI can acquire high signal from tendons thus enabling quantitative assessments.

282 ession of CD44 and apoptotic cell numbers in tendon tissue from patients with long head of biceps (LH

283 mechanical properties of skeletal muscle and tendon tissue, we have chosen to use this model system i

284 beta1 and BMP-2 between healthy and diseased tendon tissues and cells, advancing understanding of inf

285 s of the mechanical properties of muscle and tendon tissues.

286 ver, some species may need specially adapted tendons to support high performance motor activities, su

287 equencing data, we generated the Comparative Tendon Transcriptional Database (CTTDb) that identified

288 passive stretch of the gastrocnemius muscle-tendon units.

289 ical irregularity at the attachment sites of tendons was a frequent incidental finding on knee MRI sc

290 s that are expressed in anatomically similar tendons were different between mice and rats.

291 transcripts present in anatomically similar tendons were different between species.

292 one marrow edema, joint effusion, ligaments, tendons) were examined for an association with DFCI.

293 gnificance of these findings was explored in tendon, where we showed that BiP expression is ramped pr

294 ells of a central musculoskeletal connecting tendon, whether neighboring tissues harbor progenitors c

295 en in tissue fracture have mainly focused on tendons, which contain highly aligned bundles of collage

296 (tECM) by urea extraction of juvenile bovine tendons, which is capable of enhancing transforming grow

297 patients consisted of either a 7-mm or full tendon-width transposition of the vertical rectus muscle

298 unfixed, hydrated collagen fibrils in native tendon with a 0.1 nm depth resolution and a 10 nm latera

299 lts demonstrate complex proteome dynamics in tendon, with ~1000 fold differences in protein turnover

300 , forepaw flexor, patellar and supraspinatus tendons within either mice or rats.