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1 vanced disease, successfully palliates pain, tenesmus, and bleeding.
2 estations including fever, abdominal cramps, tenesmus, and malaise.
3 ion include diarrhea, rectal pain, bleeding, tenesmus, and stricture formation.
4 stionnaires assessing symptoms such as pain, tenesmus, pruritus and anal discharge.
5                            Bowel urgency and tenesmus were identified as missing symptoms in CTCAEv5.