ライフサイエンスコーパス: tensin

1 We also showed expression of tensin 1 during valve morphogenesis and describe enlarge

2 kdown of the ortholog of TNS1, which encodes tensin 1, a focal adhesion protein involved in cytoskele

3 pid accumulation of cten (tensin 4), but not tensin 1, along a fibrous intracellular network.

4 und that MSI1 directly binds to the 3'UTR of Tensin 3 (TNS3) mRNA, a negative regulator of cell migra

5 needle leads to rapid accumulation of cten (tensin 4), but not tensin 1, along a fibrous intracellul

6 Independently, Tensin-4 (TNS4) is emerging as a putative oncogene in ma

7 s ability to bind several ligands, including tensin and talin.

8 ts Rho-GAP activity, and its ability to bind tensin and talin.

9 Tensins are thought to provide a force-bearing linkage b

10 and Y701 by SRC, which down-regulates DLC1's tensin-binding and Rho-GAP activities.

11 mote rapid FA elongation and maturation into tensin-containing fibrillar FAs in the cell center.

12 hat p17 positively regulates phosphatase and tensin deleted on chromosome 10 (PTEN), AMP-activated pr

13 o Rho-GAP through DLC1 and suggests that the tensin-DLC1-RhoA signaling axis plays an important role

14 study therefore links dynamic regulation of tensin family members by EGF to Rho-GAP through DLC1 and

15 Su Hao Lo provides an introduction to the tensin family of focal adhesion proteins.

16 al adhesion molecule that is a member of the tensin family.

17 focal adhesion molecule and a member of the tensin family.

18 pecific conditional TSC1 and phosphatase and tensin homlog knock-out mice, both of which display aber

19 al cell-specific deletion of Phosphatase and tensin homolog (K14-CreER;Pten(fl/fl)) develops prostate

20 ated protein 53 (Trp53), and phosphatase and tensin homolog (Pten) allowed the generation of 3 murine

21 Loss of phosphatase and tensin homolog (PTEN) and activation of the PI3K/AKT sig

22 and nuclear translocation of phosphatase and tensin homolog (PTEN) and FOXO 3a.

23 is model was validated using phosphatase and tensin homolog (PTEN) and its ceRNA VAMP (vesicle-associ

24 Phosphatase and tensin homolog (PTEN) and mothers against decapentaplegi

25 B cells express phosphatase and tensin homolog (PTEN) and multiple isoforms of class IA

26 However, the phosphatase and tensin homolog (Pten) and neurofibromatosis 1 (Nf1) gene

27 ack loop circuit mediated by phosphatase and tensin homolog (PTEN) and PDZ and LIM domain 2 (PDLIM2).

28 on with the up-regulation of phosphatase and tensin homolog (PTEN) and suppressor of cytokine signali

29 Levels of phosphatase and tensin homolog (PTEN) and suppressor of cytokine signali

30 SCRIB interacts with phosphatase and tensin homolog (PTEN) and the expression of P305L, but n

31 and Nedd4-2 may ubiquitinate phosphatase and tensin homolog (PTEN) and thereby regulate axonal growth

32 that tumors deficient of the phosphatase and tensin homolog (PTEN) are often dependent on the p110bet

33 We identified phosphatase and tensin homolog (PTEN) as a novel target of miR-132 and d

34 ated with phosphorylation of phosphatase and tensin homolog (PTEN) at residues Ser380/Thr382/383.

35 ys cross-talk through a Hes1-phosphatase and tensin homolog (PTEN) axis during normal T-cell developm

36 The phosphatase and tensin homolog (PTEN) can function as a dual specificity

37 The tumor suppressor phosphatase and tensin homolog (PTEN) classically counteracts the PI3K/A

38 vasive adenocarcinoma in the phosphatase and tensin homolog (Pten) conditional deletion model of pros

39 protein p53 (Tp53/p53)- and phosphatase and tensin homolog (PTEN) deficiencies, and combined p53- an

40 ary tumorigenesis induced by phosphatase and tensin homolog (Pten) deletion in mice.

41 is associated with increased phosphatase and tensin homolog (PTEN) expression, which inhibits Src, an

42 ell types, and cells lacking phosphatase and tensin homolog (PTEN) function were relatively resistant

43 Mutations in the human phosphatase and tensin homolog (PTEN) gene cause PTEN hamartoma tumor sy

44 of-function mutations in the phosphatase and tensin homolog (PTEN) gene, a negative regulator of mTOR

45 n which the tumor suppressor phosphatase and tensin homolog (PTEN) has been deactivated.

46 A reduction in phosphatase and tensin homolog (PTEN) has been shown to be involved in a

47 Germline mutations in phosphatase and tensin homolog (PTEN) have been recently reported in 23%

48 sion of the tumor suppressor phosphatase and tensin homolog (PTEN) in 248 primary DLBCL patient sampl

49 Deletion of phosphatase and tensin homolog (PTEN) in adult CNS neurons promotes rege

50 presses the tumor-suppressor phosphatase and tensin homolog (PTEN) in both RMS and normal muscle.

51 n levels of tumor suppressor phosphatase and tensin homolog (PTEN) in drug-induced gingival overgrowt

52 we investigated the role of phosphatase and tensin homolog (PTEN) in genome-wide transcriptional reg

53 strated that genetic loss of phosphatase and tensin homolog (PTEN) in mammary fibroblasts induces an

54 ted that genetic deletion of phosphatase and tensin homolog (PTEN) in mouse corticospinal neurons rea

55 loss of the PI3K antagonist phosphatase and tensin homolog (PTEN) in myeloid cells renders APCs towa

56 tion of the tumor suppressor phosphatase and tensin homolog (Pten) in retinal ganglion cells (RGCs),

57 increased GPCRs and elevated phosphatase and tensin homolog (PTEN) in the LDN subset.

58 MV-associated miR221 targets phosphatase and tensin homolog (PTEN) in the recipient cells, followed b

59 ditional genetic deletion of phosphatase and tensin homolog (PTEN) in the sensorimotor cortex of neon

60 cause the lipid phosphatase, phosphatase and tensin homolog (PTEN) inhibits Akt, we generated a mouse

61 t that UVB exposure triggers phosphatase and tensin homolog (PTEN) interaction with wild-type (WT), b

62 Phosphatase and tensin homolog (PTEN) is a critical negative regulator o

63 Phosphatase and tensin homolog (PTEN) is a dual phosphatase that counter

64 The tumor suppressor phosphatase and tensin homolog (PTEN) is a key inhibitor of the protein

65 Phosphatase and tensin homolog (PTEN) is a major negative regulator of n

66 Phosphatase and tensin homolog (PTEN) is a negative regulator of the pho

67 Phosphatase and tensin homolog (PTEN) is a phosphoinositide lipid phosph

68 Phosphatase and tensin homolog (PTEN) is a tumor suppressor and a guardi

69 nd that the tumor suppressor phosphatase and tensin homolog (PTEN) is an important regulator of the h

70 en when the tumor suppressor phosphatase and tensin homolog (PTEN) is deleted to enhance intrinsic gr

71 vity of the tumor suppressor phosphatase and tensin homolog (PTEN) is enhanced by the presence of its

72 Phosphatase and tensin homolog (PTEN) is one of the molecular pathways i

73 Phosphatase and tensin homolog (PTEN) is one of the most frequently muta

74 of chromosomal instability, phosphatase and tensin homolog (PTEN) loss, and E2F3 transcription facto

75 y on liver tumors induced by phosphatase and tensin homolog (Pten) loss.

76 ilizing the tumor-suppressor phosphatase and tensin homolog (PTEN) mRNA via a mechanism that is indep

77 oson mutagenesis screen in a phosphatase and tensin homolog (Pten) mutant mice and identified 12 cand

78 Phosphatase and tensin homolog (PTEN) negatively regulates downstream pr

79 the controlling function of phosphatase and tensin homolog (PTEN) over HIF-1alpha expression and CSC

80 Inhibition of the phosphatase and tensin homolog (PTEN) pathway reversed quiescence by ind

81 n a twofold reduction of the phosphatase and TENsin homolog (PTEN) phosphatase expression and modulat

82 he miR-17-92 cluster reduced phosphatase and tensin homolog (PTEN) proteins and elevated phosphorylat

83 We find here, using the phosphatase and tensin homolog (PTEN) pseudogene as a model system, that

84 bition of negative regulator phosphatase and tensin homolog (PTEN) resulted in increased pDC numbers

85 en the 5-HT(2C)R and protein phosphatase and tensin homolog (PTEN) serves as a regulatory mechanism t

86 though the lipid phosphatase phosphatase and tensin homolog (PTEN) suppresses Akt activity, the contr

87 from a point mutation in the phosphatase and tensin homolog (PTEN) tumor suppressor protein.

88 mice haplodeficient for the phosphatase and tensin homolog (Pten) tumor-suppressor gene.

89 Moreover, deletion of phosphatase and tensin homolog (Pten) upregulated mTORC2 activity and en

90 e phosphatase 1B (PTP1B) and phosphatase and tensin homolog (PTEN) were found in hepatocytes treated

91 and further inactivation of phosphatase and tensin homolog (PTEN) yields GBM.

92 Phosphatase and tensin homolog (PTEN)(shRNA) negatively regulated PAX2 e

93 ther enhanced by deletion of phosphatase and tensin homolog (PTEN), a mechanistic target of rapamycin

94 brain and mTORC1, along with Phosphatase and tensin homolog (Pten), a negative regulator of PI3K.

95 ccurs is by silencing of the phosphatase and tensin homolog (PTEN), a tumor suppressor and major anta

96 represses the expression of phosphatase and tensin homolog (PTEN), a tumor suppressor gene, by recru

97 Phosphatase and tensin homolog (PTEN), a tumor suppressor that antagoniz

98 Somatic loss of phosphatase and tensin homolog (PTEN), a tumor suppressor that counterac

99 ding to a lipid phosphatase, phosphatase and tensin homolog (PTEN), aiding in the maintenance of PTEN

100 horylation, higher levels of phosphatase and tensin homolog (PTEN), and diminished Akt phosphorylatio

101 in-binding protein 2 (WBP2), phosphatase and tensin homolog (PTEN), and p62 proteins by WWP2 suggests

102 n phosphatase 2A (PP2A), and phosphatase and tensin homolog (PTEN), are commonly inactivated in prost

103 vels of the tumor suppressor phosphatase and tensin homolog (PTEN), both directly and indirectly by d

104 g the tumor-suppressor genes phosphatase and tensin homolog (PTEN), cyclin dependent kinase inhibitor

105 me that dephosphorylates it, phosphatase and tensin homolog (PTEN), is an important tumor suppressor.

106 Three other (phosphatase and tensin homolog (PTEN), myristoylated alanine-rich protei

107 f the tumor suppressor gene, phosphatase and tensin homolog (PTEN), occurs in 10% of melanoma specime

108 sible for PIP3 signaling: 3' phosphatase and tensin homolog (PTEN), phosphatidylinositol 3-kinase (PI

109 1 transcriptionally silences phosphatase and tensin homolog (PTEN), resulting in AKT activation, whic

110 xidation and deactivation of phosphatase and tensin homolog (PTEN), resulting in upregulation of PtdI

111 oma tumor suppressor protein phosphatase and tensin homolog (PTEN), suggesting that STAT3 regulates i

112 by directly down-regulating phosphatase and tensin homolog (PTEN), thereby promoting phosphorylation

113 Silencing phosphatase and tensin homolog (PTEN), which facilitates early to late e

114 (2+)-mediated degradation of phosphatase and tensin homolog (PTEN), which impaired intercellular junc

115 lated AKT, and downregulates phosphatase and tensin homolog (PTEN), which is involved in suppressing

116 Expression of the phosphatase and tensin homolog (PTEN), which is one of the direct target

117 Phosphatase and tensin homolog (PTEN), which negatively regulates tumori

118 regulate the activity of the phosphatase and tensin homolog (PTEN), which plays a critical role in ne

119 astoma, promotes invasion in phosphatase and tensin homolog (PTEN)-competent and PTEN-deficient gliob

120 found maximum expression in phosphatase and tensin homolog (PTEN)-deficient PCa.

121 oorapoikayil et al have used phosphatase and tensin homolog (Pten)-deficient zebrafish to uncover pro

122 Phosphatase and tensin homolog (PTEN)-inactivating mutations and/or dele

123 ners of MARK2, we identified phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1), which is

124 ltiple PD models have linked Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)

125 mitochondrial damage induces Phosphatase and Tensin Homolog (PTEN)-induced Putative Kinase 1 (PINK1)

126 ion of cells lacking CnrN, a phosphatase and tensin homolog (PTEN)-like phosphatase, is not inhibited

127 nd localization, we define a phosphatase and tensin homolog (PTEN)-regulated checkpoint that retains

128 croRNAs that repress mRNA of phosphatase and tensin homolog (PTEN).

129 loss of the PI3K antagonist phosphatase and tensin homolog (PTEN).

130 otein and activity levels of phosphatase and tensin homolog (PTEN).

131 loss of the tumor suppressor phosphatase and tensin homolog (PTEN).

132 domain containing 2 (SETD2), phosphatase and tensin homolog (PTEN).

133 ene family, member A (RhoA); phosphatase and tensin homolog (PTEN); and nuclear factor-kappaB (NF-kap

134 Subsequently, phosphatase and tensin homolog (which suppresses PI3K activity) is inact

135 pathway (PIK3CD, PIK3R1, or phosphatase and tensin homolog [PTEN]) proved that both overactivation a

136 rate the inhibitory role of phosphatase with tensin homolog and Forkhead Box class O factors on megak

137 ta in the neuron inactivates phosphatase and tensin homolog and induces its transfer into the astrocy

138 d cell proliferation through phosphatase and tensin homolog and phosphoinositide 3-kinase/Akt signali

139 translational degradation of phosphatase and tensin homolog and the activation of the PI3K signaling

140 esis studies of human H-Ras, phosphatase and tensin homolog and thiopurine S-methyltransferase.

141 negatively regulated by the phosphatase and tensin homolog DAF-18/PTEN.

142 ma in vivo in the context of phosphatase and tensin homolog deficiency.

143 on of beta-catenin inhibited phosphatase and tensin homolog delete on chromosome 10 (PTEN) and promot

144 eraction of TRPC6 with lipid phosphatase and tensin homolog deleted from chromosome 10 (PTEN), a nega

145 ositol (3,4,5)-trisphosphate phosphatase and tensin homolog deleted from chromosome 10], a phosphatas

146 Tumor-suppressor genes phosphatase and tensin homolog deleted on chromosome 10 (Pten) and andro

147 Mutations in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) are impli

148 The dual-specificity phosphatase and tensin homolog deleted on chromosome 10 (PTEN) blocks PI

149 zygous germline mutations in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) experienc

150 lerosis complex 2 (TSC2) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) function

151 The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene is o

152 s and their negative regulator phosphate and tensin homolog deleted on chromosome 10 (PTEN) in mural

153 ed that the loss of LKB1 and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) induces a

154 te signaling with a specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor

155 Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a lipi

156 Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is an imp

157 tion of the tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is strong

158 Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) negativel

159 tem cells, we found that the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) overexpre

160 Tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) plays a c

161 s express significantly more phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein w

162 The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) regulates

163 The Phosphatase And Tensin Homolog Deleted On Chromosome 10 (PTEN) regulates

164 sion of the tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) through i

165 Here we demonstrate that the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor sup

166 phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor sup

167 We identify disinhibition of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a negati

168 Levels of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a phosph

169 report that the activity of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a phosph

170 ion of the tumor suppressor, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), alters t

171 eads to decreased colon cell phosphatase and tensin homolog deleted on chromosome 10 (PTEN), increase

172 The tumor-suppressor, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), was iden

173 PINK1 (phosphatase and tensin homolog deleted on chromosome 10 (PTEN)-induced k

174 -regulated in the absence of phosphatase and tensin homolog deleted on chromosome 10 (PTEN).

175 s not apparently affected by phosphatase and tensin homolog deleted on chromosome 10 functional statu

176 vestigated the role of PTEN (phosphatase and tensin homolog deleted on chromosome 10) during neurite

177 Deficiency in PTEN (phosphatase and tensin homolog deleted on chromosome 10) is the underlyi

178 tumor suppressor gene PTEN (phosphatase and tensin homolog deleted on chromosome 10) plays important

179 the ASD candidate gene PTEN (phosphatase and tensin homolog deleted on chromosome 10).

180 Phosphatase and tensin homolog deleted on chromosome ten (PTEN) regulate

181 on in association with PTEN (phosphatase and tensin homolog deleted on chromosome ten) accumulation,

182 clear translocation of PTEN (phosphatase and tensin homolog deleted on chromosome TEN) is a delayed s

183 lial cells exhibited reduced phosphatase and tensin homolog expression and a constitutive rise in the

184 because of relatively higher phosphatase and tensin homolog expression in the former.

185 Loss of phosphatase and tensin homolog expression was found in 16% (22/138) of c

186 Mutation of the phosphatase and tensin homolog gene in this pool of adult precursors lea

187 tively, as well as increased phosphatase and tensin homolog gene.

188 ion of the tumour-suppressor phosphatase and tensin homolog in schwannoma cells leading to increased

189 ctor receptor activation and Phosphatase and Tensin homolog inactivation are thought to promote the m

190 d NFATc1 activation, reduced phosphatase and tensin homolog levels, and increased Akt activation.

191 antagomir (Ant-21) increased phosphatase and tensin homolog levels.

192 Phosphatase and tensin homolog located on chromosome 10 (PTEN) is a tumo

193 actor Receptor elevation and Phosphatase and Tensin Homolog loss and suggest the importance of the GT

194 by germ-line mutation of the phosphatase and tensin homolog mutated on chromosome 10 (PTEN) tumor-sup

195 ns in the lipid phosphatase, phosphatase and tensin homolog on chromosome 10 (Pten).

196 Moreover, phosphate tensin homolog on chromosome 10 depletion in human kidne

197 Thus, phosphate tensin homolog on chromosome 10 is an upstream regulator

198 Conversely, PTEN (phosphatase and tensin homolog on chromosome 10) dephosphorylates PtdIns

199 Cells lacking PTEN (phosphatase and tensin homolog on chromosome 10) function were relativel

200 tations in the gene encoding phosphatase and tensin homolog on chromosome ten (PTEN) are diagnosed wi

201 Phosphatase and tensin homolog on chromosome ten (PTEN) is a tumor suppr

202 De novo phosphatase and tensin homolog on chromosome ten (PTEN) mutations are a

203 ssociated with increased Akt/phosphatase and tensin homolog proliferation/survival signals in FL-fibr

204 Low expression of phosphatase and tensin homolog showed a modest association with lower re

205 ssociated with inactivation of phosphate and tensin homolog through its protein phosphatase activity

206 ression of the miR-21 target phosphatase and tensin homolog was reduced.

207 Cells lacking phosphatase and tensin homolog were as sensitive to the drug combination

208 nd validated by re-analyzing phosphatase and tensin homolog's cross-talk pattern from The Cancer Geno

209 ve kinase protein 1; PTEN is phosphatase and tensin homolog) and the cytosolic ubiquitin ligase Parki

210 ur, had a copy loss of PTEN (phosphatase and tensin homolog) and those lesions that became refractory

211 tumour suppressor gene PTEN (phosphatase and tensin homolog) are frequent events and are associated w

212 e inositol phosphatase PTEN (phosphatase and tensin homolog) as primarily responsible for defects in

213 17-92 cluster mediated PTEN (phosphatase and tensin homolog) expression, which is a predicted target

214 experiments show that PTEN (phosphatase and tensin homolog) is a target of the miR-17-92 cluster and

215 monstrate that loss of Pten (phosphatase and tensin homolog) protein at postnatal day 8 in mice harbo

216 arker the tumor-suppressor PTEN (phosphatase tensin homolog) that degrades PIP3.

217 rosine phosphatase-1B, PTEN (phosphatase and tensin homolog), and p85 phosphatidylinositol 3-kinase w

218 the tumor suppressor, PTEN (phosphatase and tensin homolog), is well studied in endometrial cancer,

219 tress reducing phosphatase PTEN (phosphatase tensin homolog), thereby activating PI3K (phosphoinositi

220 Akt pathway inhibitor, PTEN (phosphatase and tensin homolog), which in turn facilitates pre-TCR-induc

221 acking the phosphatase Pten (phosphatase and tensin homolog), which negatively regulates phosphoinosi

222 ional mitochondria via PTEN (phosphatase and tensin homolog)-induced putative kinase 1 (PINK1) and ta

223 so induced the expression of phosphatase and tensin homolog, a dual protein/lipid phosphatase that bl

224 tion increased expression of phosphatase and tensin homolog, a protein associated with dephosphorylat

225 We identified phosphatase and tensin homolog, a tumor suppressor, as an miR-17-92 targ

226 ignal-regulated kinases 1/2, phosphatase and tensin homolog, adenosine monophosphate-activated protei

227 Similar changes in SIRT1, phosphatase and tensin homolog, and Akt were also noted in the aorta and

228 and 2, neurofibromatosis 1, phosphatase and tensin homolog, and potentially Rett syndrome.

229 v-ras) oncogene homolog, and phosphatase and tensin homolog, demonstrating PHIP activation in triple-

230 r and liver kinase B1 (LKB1)-phosphatase and tensin homolog-AKT-dependent mechanism.

231 ate tumor involution both in phosphatase and tensin homolog-deficient (PTEN-deficient) prostate cance

232 alysis demonstrated that the phosphatase and tensin homolog-induced putative kinase 1 (PINK1)-Parkin

233 functions as a cofactor for phosphatase and tensin homolog.

234 inoistide lipid phosphatase, phosphatase and tensin homolog.

235 and with high expression of phosphatase and tensin homolog.

236 hosphatidylinositol 3-kinase/phosphatase and tensin homolog/AKT, retinoblastoma/cyclin-dependent kina

237 such as a putative role for Phosphotase and tensin homolog/phosphoinositide 3-kinase (PTEN/PI3K) as

238 M) had reduced expression of phosphatase and tensin homolog; this reduction was also observed in a po

239 Phosphatase and tensin-homolog deleted on chromosome 10 (PTEN) is a tumo

240 ing or its downstream target phosphatase-and-tensin-homolog-deleted-on-chromosome-10 (PTEN).

241 loss of the tumor-suppressor phosphatase and tensin homologue (PTEN) and overexpression of prostate-s

242 r, for example, by targeting phosphatase and tensin homologue (PTEN) for proteasomal degradation.

243 The phosphatase and tensin homologue (PTEN) gene is frequently mutated or lo

244 The tumor-suppressor phosphatase and tensin homologue (PTEN) has roles in both cellular growt

245 Phosphatase and tensin homologue (PTEN) is an extensively studied tumour

246 The activity of the phosphatase and tensin homologue (PTEN) is known to be suppressed via po

247 ay components, most commonly phosphatase and tensin homologue (PTEN) loss (by IHC) (30% of all patien

248 KT activation resulting from phosphatase and tensin homologue (PTEN) loss and EGFR-dependent PI3K act

249 Mutations in phosphatase and tensin homologue (PTEN) or genomic alterations in the ph

250 Phosphatase and tensin homologue (PTEN) protein levels are critical for

251 actor receptor 3 (FGFR3) and phosphatase and tensin homologue (PTEN) signalling pathway components (f

252 he role for mutations in the phosphatase and tensin homologue (PTEN) tumor suppressor gene and unoppo

253 in patients with pathogenic phosphatase and tensin homologue (PTEN) variants, but the frequency of c

254 s of function of the protein phosphatase and tensin homologue (PTEN), a phosphatase critically involv

255 Phosphatase and tensin homologue (PTEN), an established NEDD4 target, wa

256 target of rapamycin pathway, phosphatase and tensin homologue (PTEN), and PHLPP.

257 rmal growth factor 2 (HER2), phosphatase and tensin homologue (PTEN), and PI3K catalytic subunit (PIK

258 of the negative regulators, phosphatase and tensin homologue (PTEN), and tuberous sclerosis 1 promot

259 the PI3K pathway regulator, phosphatase and tensin homologue (Pten), which has been reported to occu

260 t the immunologic synapse by phosphatase and tensin homologue (PTEN), which increased nuclear localiz

261 In orthotopic phosphatase and tensin homologue (PTEN)-deficient glioma mouse models, m

262 int due in part to defective phosphatase and tensin homologue (PTEN).

263 diac-specific suppression of phosphatase and tensin homologue 10 (PTEN), a negative regulator of insu

264 expression, which inhibited phosphatase and tensin homologue and enhanced AKT signaling, thus endowi

265 Phosphatase and tensin homologue deleted from chromosome 10 (Pten) encod

266 of c-Abl kinase and loss of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) activit

267 role of the tumor suppressor phosphatase and tensin homologue deleted on chromosome 10 (PTEN) in the

268 enesis without affecting the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) loss re

269 eam of apo(a) attenuation of phosphatase and tensin homologue deleted on chromosome 10 activity.

270 Tumor suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) levels are fr

271 f phosphatases such as PTEN (phosphatase and tensin homologue deleted on chromosome 10), a known tumo

272 Phosphatase and tensin homologue deleted on chromosome ten (PTEN), one o

273 PTEN (phosphatase and tensin homologue deleted on chromosome TEN) is the major

274 l line derivative (VC8), and phosphatase and tensin homologue deleted on chromosome ten- (PTEN-) defi

275 Mutations in the phosphatase and tensin homologue gene are frequently detected in EMC.

276 miR-23a target and modulates phosphatase and tensin homologue itself in a miR-23a-dependent manner.

277 ephalic tissue from dopamine phosphatase and tensin homologue knock-out or control animals was then t

278 d by altered IRS-1 and PTEN (phosphatase and tensin homologue on chromosome 10) activities.

279 sed suppression of PTEN (the phosphatase and tensin homologue protein) and inhibited tumor formation

280 wn downstream targets of the phosphatase and tensin homologue protein, and their activities are up-re

281 neous manifestation of PTEN (phosphatase and tensin homologue) hamartoma-tumor syndrome.

282 we show a function of Pten (phosphatase and tensin homologue) in quiescent SCs.

283 oinositide phosphatase PTEN (phosphatase and tensin homologue) promotes axon regrowth after injury.

284 s in decreased expression of phosphatase and tensin homologue.

285 argets and revealed that the phosphatase and tensin homologue/phosphatidylinositol trisphosphate kina

286 ompanied by silencing of the phosphatase and tensin homology (PTEN) tumor suppressor.

287 represses the expression of Phosphatase and Tensin Homology (PTEN), thereby augmenting the PI3K-AKT-

288 Inactivation of phosphatase and tensin homology deleted on chromosome 10 (PTEN) is linke

289 Transient expression of tensins increases beta1-integrin activity, whereas tensi

290 ase 1 (LONP1), that degrades phosphatase and tensin-induced putative kinase 1 and blocks Parkin-media

291 C-terminal tensin-like (CTEN; TNS4) is a focal adhesion molecule th

292 cancer 1 (DLC1) by tensin3 and COOH-terminal tensin-like protein (cten) controls EGF-driven cell migr

293 s downstream migration regulators C-terminal tensin-like protein and matrix metalloproteinase 2.

294 hosphate-activated protein kinase influences tensin production to regulate alpha5beta1-integrin and f

295 e class II formin N-terminal phosphatase and tensin (PTEN) domain binds phosphoinositide-3,5-bisphosp

296 centrally located active beta1-integrin- and tensin-rich mature fibrillar adhesions, and cell spreadi

297 actin cytoskeleton; yet, direct evidence of tensin's role in mechanotransduction is lacking.

298 Accordingly, tensin silencing in AMPK-depleted fibroblasts impedes en

299 s increases beta1-integrin activity, whereas tensin silencing reduces integrin activity in fibroblast

300 , we show that the loss of AMPK up-regulates tensins, which bind beta1-integrins, supporting their ac