ライフサイエンスコーパス: teratogenic

1 bitor of the phosphoinositide pathway and is teratogenic.

2 onally, mycophenolic acid (MPA) products are teratogenic.

3 e mofetil, although mycophenolate mofetil is teratogenic.

4 e to exogenous retinoids during pregnancy is teratogenic.

5 t passive smoke exposure during pregnancy is teratogenic.

6 and are cytotoxic, genotoxic, mutagenic, and teratogenic.

7 ibute to a body of evidence that PAHs may be teratogenic.

8 leflunomide was found to be embryotoxic and teratogenic.

9 To assess whether some teratogenic actions of ethanol might occur via dysregula

10 P7A-NAP, a NAP variant that also blocks the teratogenic actions of ethanol, but not by I6A-NAP, whic

11 ic effect, suggesting that the antitumor and teratogenic activities of thalidomide-like drugs are dis

12 Like other examples of strain-specific teratogenic activity, the underlying nature of the diffe

13 RAP mutant, demonstrating that rapamycin has teratogenic activity.

14 that the amino acid homocysteine may be the teratogenic agent, since serum homocysteine increases in

15 (including VEGF and VEGF receptors) and many teratogenic agents (including excess D-glucose) that giv

16 ong work hours; overnight calls; exposure to teratogenic agents, such as ionizing radiation, anesthet

17 f brain also protects embryos from otherwise-teratogenic agents.

18 antisense morpholino oligonucleotides or the teratogenic alkaloid cyclopamine, in order to dissect th

19 nic effects in vertebrate embryos, while non-teratogenic analogues of valproic acid do not inhibit hi

20 ations reveal the mechanism of cyclopamine's teratogenic and antitumor activities and further suggest

21 The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ab

22 d that CRBN, a direct protein target for the teratogenic and antitumor activities of immunomodulatory

23 Aflatoxins are highly toxic, mutagenic, teratogenic and carcinogenic mycotoxins.

24 ts that sunitinib, sorafenib and TNP-470 are teratogenic and demonstrate that axitinib, pazopanib, va

25 Concerns exist about teratogenic and long-term neurodevelopmental outcomes of

26 In women, taking MPA is teratogenic and may also influence spermatogenesis.

27 combined doxylamine/pyridoxine, which is not teratogenic and may be effective in treating NVP.

28 amacogenetic component to sodium valproate's teratogenic and neurodevelopmental effects.

29 Methotrexate and leflunomide are teratogenic and should be avoided during pregnancy.

30 lex inheritance likely results from a mix of teratogenic and single gene disorders with variable expr

31 -2 signaling during embryonic development is teratogenic and suggest a possible association of COX-2

32 -dioxin (TCDD) causes a wide range of toxic, teratogenic, and carcinogenic effects.

33 ototype compound, elicit a variety of toxic, teratogenic, and carcinogenic responses in exposed anima

34 f which are cytotoxic, mutagenic, genotoxic, teratogenic, and potential carcinogens both in vitro and

35 methimazole or carbimazole--are occasionally teratogenic; and the alternative--propylthiouracil--can

36 nal zone disorganization in this widely used teratogenic animal model.

37 s limits fetal growth and, if severe, causes teratogenic anomalies.

38 e of cell specificity, and has no detectable teratogenic, antiangiogenic or neurotoxic effects at pot

39 particular, prenatal exposure to the highly teratogenic anticonvulsant valproic acid (VPA) significa

40 Phenylalanine, teratogenic anticonvulsants, and high concentrations of

41 not only confirmed that sodium valproate is teratogenic but also that it may be associated with neur

42 ants clearly understood that isotretinoin is teratogenic but had less understanding of contraceptive

43 we hypothesized that excess retinoic acid is teratogenic by inducing a longer lasting, local retinoic

44 Regarding teratogenic, carcinogenic, and immunotoxic nature of och

45 nd -independent pathways are involved in the teratogenic/carcinogenic syndrome that follows developme

46 o elucidate the pathogenic mechanisms of the teratogenic compound valproic acid.

47 Unintended exposure to teratogenic compounds can lead to various birth defects;

48 ic of embryogenesis, to identify potentially teratogenic compounds.

49 ored over methimazole (MMI) due to potential teratogenic concerns with MMI.

50 servations are very important in considering teratogenic consequences of drugs aimed at inhibiting FA

51 y allow a more complete understanding of the teratogenic consequences of exposure in utero to vitamin

52 and is perturbed in a number of genetic and teratogenic contexts.

53 layed a wide range of bioactivities, such as teratogenic, cytotoxic, phytotoxic, and antibacterial ac

54 Zika virus congenital syndrome is a new teratogenic disease.

55 f embryos treated with 50 microliters of the teratogenic dose (200 mM D,L-homocysteine or 100 mM L-ho

56 To determine the effect of the teratogenic dose on the process of heart septation, embr

57 The teratogenic dose was shown to raise serum homocysteine t

58 s inspired a second wave of research on this teratogenic drug.

59 ellular phenotypes of valproic acid (VPA), a teratogenic drug.

60 isk evaluation and mitigation strategies for teratogenic drugs, Ameet Sarpatwari, Beatrice Brown and

61 ystematically identify and avoid exposure to teratogenic drugs.

62 PTU is teratogenic during late blastula, gastrulation, and neur

63 d zebrafish were continuously exposed to non-teratogenic E2 concentrations from 1 to 10 days post-fer

64 This demonstrated that thalidomide had a teratogenic effect between approximately 20 to 36 days a

65 The teratogenic effect of alcohol may depend on the genetic

66 Numerous studies have confirmed the teratogenic effect of hyperglycemia on the developing em

67 ovel mechanism whereby retinoids can exert a teratogenic effect on craniofacial morphogenesis indepen

68 We conclude that WFS may have a teratogenic effect on the developing fetus and speculate

69 approximately 45 nmol/ml, and prevented the teratogenic effect.

70 poor inhibitory activity in vivo have little teratogenic effect.

71 omain protein suggests a mechanism for viral teratogenic effects and for the tissue-specific manifest

72 The mechanisms behind these teratogenic effects are unknown, although epidemiologica

73 n of pregnancy termination if concerns about teratogenic effects arose.

74 er unmeasured familial factors before causal teratogenic effects can be suggested.

75 The only possible teratogenic effects detected included hypoplastic nails

76 Penicillamine and trientine have teratogenic effects in animals, and penicillamine has kn

77 mmation, with oncogenic effects in males and teratogenic effects in females.

78 ects in animals, and penicillamine has known teratogenic effects in humans.

79 d and trichostatin A have remarkably similar teratogenic effects in vertebrate embryos, while non-ter

80 Thus, RA- and T3 receptor-mediated teratogenic effects in Xenopus embryos occur through dis

81 The teratogenic effects of alcohol have long been publicized

82 reimplantation embryos are vulnerable to the teratogenic effects of alcohol, emphasizes the dangers o

83 rior to becoming pregnant to avoid potential teratogenic effects of antithyroid drugs during pregnanc

84 We report on the acute lethality and teratogenic effects of aquatic exposure of Silurana (Xen

85 and behavioral toxicology may testify to the teratogenic effects of bug repellant.

86 , that mediates many of the carcinogenic and teratogenic effects of certain environmental pollutants.

87 t also provide a potential mechanism for the teratogenic effects of DES on the developing reproductiv

88 es in the absence of mouse Cyp1a2 gene), the teratogenic effects of dioxin reverted to the wild-type

89 mediate many of the toxic, carcinogenic, and teratogenic effects of environmental contaminants such a

90 s that micro-RNAs (miRNAs) could mediate the teratogenic effects of ethanol in a fetal mouse cerebral

91 , rodent systems have been used to study the teratogenic effects of ethanol on vertebrate embryonic d

92 e temperature may protect offspring from the teratogenic effects of excess heat, but the mechanisms r

93 Although controversy over the teratogenic effects of lithium remains, our studies sugg

94 contribute to a better understanding of the teratogenic effects of maternal diabetes and improved co

95 ed changes in disease severity and potential teratogenic effects of medications.

96 en together, these results indicate that the teratogenic effects of RA exposure result, in part, from

97 findings, together with previously reported teratogenic effects of selective BCR-ABL inhibitors in h

98 bryogenesis, we first screened the potential teratogenic effects of TDCPP, TCEP, TCPP, and V6 using a

99 orosis, and at least partially underlies the teratogenic effects of thalidomide on limb development.

100 lation of caspase activity is central to the teratogenic effects of thalidomide.

101 t comprehensive analysis on the toxicity and teratogenic effects of the bisphenols BPA, BPS, BPF, and

102 Together, the results demonstrate that the teratogenic effects of VPA are very likely mediated spec

103 n implicated in cardiac morphogenesis by its teratogenic effects on the heart, although its role in n

104 Finally, when these ligands were tested for teratogenic effects on zebra fish and Xenopus embryos, w

105 whether this association results from causal teratogenic effects or from confounding influences share

106 compounds were responsible for fetal cardiac teratogenic effects seen when TCE or DCE is consumed by

107 Retinoic acid, which induces teratogenic effects similarly to ethanol, also caused up

108 In addition to its well known sedative and teratogenic effects, thalidomide also possesses potent i

109 renatal exposure to Zika virus has potential teratogenic effects, with a wide spectrum of clinical pr

110 d offer a possible explanation for lithium's teratogenic effects.

111 hich the retinoids exert some of their known teratogenic effects.

112 conditions must be weighed against potential teratogenic effects.

113 d studies on the mechanism of their presumed teratogenic effects.

114 erapy, but cereblon binding can also mediate teratogenic effects.

115 sess for developmental defects and potential teratogenic effects.

116 nly prescribed antiepileptic drug with known teratogenic effects.

117 ) and 9.4 mug Se L(-1)) were in the range of teratogenic effects.

118 t toxicity, reduced fertility, or subsequent teratogenic effects.

119 e is most effective in attenuating ethanol's teratogenic effects.

120 Timing of prenatal teratogenic exposure was compared with timing of prenata

121 By 15 weeks, teratogenic exposures had occurred for 48.9% (95% CI, 48

122 ating the cellular or developmental basis of teratogenic exposures in experimental animals is an impo

123 Heterotaxy may be caused by teratogenic exposures, especially maternal diabetes.

124 me abnormalities, single gene disorders, and teratogenic exposures.

125 ologies have been linked to both genetic and teratogenic factors and to date, a definitive, commonly

126 s been demonstrated of the link between this teratogenic flavivirus and microcephaly cases.

127 13-cis-retinoic acid (RA), and it is highly teratogenic for the developing central nervous system.

128 ect and proved to be mutagenic, nephrotoxic, teratogenic, immunosuppressive, and carcinogenic.

129 The teratogenic impact of alcohol on physical growth, neurod

130 c exposure increases risk for cancers and is teratogenic in animal models.

131 nitroso compounds that have been found to be teratogenic in animal models.

132 ed to acetaldehyde, is both carcinogenic and teratogenic in humans.

133 women because marginal biotin deficiency is teratogenic in mammals.

134 Biotin deficiency is teratogenic in several mammalian species.

135 Chemotherapy is teratogenic in the early stages, but seems to be safe in

136 ith low doses of retinoic acid following the teratogenic insult rescued metanephric kidney developmen

137 ave evolved principally as a defense against teratogenic insult that permits plasticity of developmen

138 the nervous system's homeostatic response to teratogenic insult: an attempt to maintain stability des

139 equences of sporadic delamination errors and teratogenic insults.

140 s a significant overlap with those caused by teratogenic levels of retinoic acid, strongly suggesting

141 Ethanol (EtOH) is a teratogen, but its teratogenic mechanisms are not fully understood.

142 e their rapid maturation kinetics, can model teratogenic mechanisms that specifically affect early ne

143 and obesity may suggest distinct underlying teratogenic mechanisms.

144 tation, 8186 pregnancies had been exposed to teratogenic medications (25.2% [95% CI, 24.7%-25.7%] of

145 confounded by concomitant use of potentially teratogenic medications and severe underlying disease.

146 Prescriptions for potentially teratogenic medications are frequently filled by women o

147 es, 5.8% (95% CI, 5.7%-5.8%) were exposed to teratogenic medications compared with 3.1% (95% CI, 3.0%

148 Teratogenic medications most used within the first 15 ge

149 his cross-sectional study, most exposures to teratogenic medications occurred in early pregnancy and

150 Prenatal exposure to any of 137 teratogenic medications, measured via pharmacy and medic

151 ductive options among pregnancies exposed to teratogenic medications.

152 Identification of teratogenic metabolites would allow more accurate assess

153 ftment pregnancies should be planned and the teratogenic mycophenolic acid should be replaced with az

154 se viruses serologically is vital due to the teratogenic nature of ZIKV and the potential confounding

155 Valproic acid (VPA) is among the most teratogenic of commonly prescribed anticonvulsants, incr

156 nded cardiac evaluations, filled potentially teratogenic or fetotoxic (Food and Drug Administration p

157 and, during pregnancy, 4% filled potentially teratogenic or fetotoxic cardiac-related prescriptions.

158 during pregnancy; 4 in 100 used potentially teratogenic or fetotoxic medications, and only half rece

159 lycystic kidney disease without any observed teratogenic or harmful effect.

160 was concluded that GBP was not carcinogenic, teratogenic, or mutagenic, giving a theoretical justific

161 lth effects through carcinogenic, mutagenic, teratogenic, or other toxic mechanisms.

162 genital anomaly syndromes, have Mendelian or teratogenic origins; the non-syndromic forms of orofacia

163 Teratogenic outcomes across exposures were compared by r

164 Teratogenic outcomes associated with valproic acid use r

165 eurons as an effective platform for modeling teratogenic pathways.

166 ly to the Hedgehog antagonist cyclopamine, a teratogenic plant alkaloid, which had been previously sh

167 ng an in vivo model, we have tested the anti-teratogenic potential of a potent synthetic superoxide d

168 This study was to determine the teratogenic potential of MMI and PTU using a validated X

169 The teratogenic potential of valproate in pregnancy is well

170 Zika virus in pregnancy carries severe teratogenic potential to the fetus, ranging from congeni

171 To examine its teratogenic potential, a single dose of PBO (22 - 1,800

172 oped to quantify and classify the compounds' teratogenic potential.

173 The teratogenic process is poorly understood, and vulnerable

174 It is presently unclear whether the teratogenic properties of thalidomide are connected in a

175 intercalators, but presents carcinogenic and teratogenic properties.

176 ding strategy that allowed us to compare the teratogenic response in embryos from Ahr(-/-) (null) and

177 T2D) may result in fetal exposure, but their teratogenic risk is unknown.

178 esign of cereblon-binding drugs with reduced teratogenic risk.

179 n-associated risks and understanding of ways teratogenic risks can be avoided.

180 than it helps women feel protected from the teratogenic risks of isotretinoin.

181 lex management due to physiological changes, teratogenic risks of treatments, and the need for fetal

182 Teratogenic risks were 1.3 times higher in the moderate

183 targets major pathogenic factors but carries teratogenic risks.

184 Moreover, this increased teratogenic sensitivity extends beyond dioxin, because e

185 Cyclopamine is a teratogenic steroidal alkaloid that causes cyclopia by b

186 Human epidemiologic studies and previous teratogenic studies using chick embryos and fetal rats h

187 gated the role of cereblon (CRBN), a primary teratogenic target of thalidomide, in the antimyeloma ac

188 ncy suggest that this medication may be less teratogenic than previously thought.

189 ases in which the exposure time was known, a teratogenic timetable was constructed relating affected

190 Versatile synthesis of the teratogenic, TNFalpha-modulatory, and antiangiogenic tha

191 Ethanol is teratogenic to many vertebrates.

192 at RXR-specific agonists may possess reduced teratogenic toxicity compared to RAR-specific agonists s

193 specifically targeting a prominent family of teratogenic viruses.

194 oblast organoids infected with seven diverse teratogenic viruses.

195 ors, regardless of the molecular target, are teratogenic when exposed to chicken embryos.

196 nancy, data on their fetal safety during the teratogenic window remain limited.