ライフサイエンスコーパス: terminal differentiation

1 s on a balance between stem cell renewal and terminal differentiation.

2 tivator 4 (NCOA4) as a critical regulator of terminal differentiation.

3 ishing the effector program and forestalling terminal differentiation.

4 l mediator of brown adipocyte commitment and terminal differentiation.

5 s IL-27 leads to suppression of keratinocyte terminal differentiation.

6 able to profound defects in sensory receptor terminal differentiation.

7 ad, undergo unperturbed ductal outgrowth and terminal differentiation.

8 associated with transcripts abundant during terminal differentiation.

9 tor ZEB1 to repress Notch3, thereby limiting terminal differentiation.

10 ycle genes and down-regulation of markers of terminal differentiation.

11 progenitor cells and is further remodeled in terminal differentiation.

12 memory CD8(+) T cell maintenance and T cell terminal differentiation.

13 poietin-dependent cell growth while favoring terminal differentiation.

14 d a stably maintained primed state, prior to terminal differentiation.

15 Most radiated tumor cells underwent terminal differentiation.

16 -erythroid transition, but without affecting terminal differentiation.

17 CR-driven induction of genes associated with terminal differentiation.

18 rapidly proliferating cells to post-mitotic terminal differentiation.

19 icrobial systems and in many fate choices in terminal differentiation.

20 chromatin-remodeling mechanisms that enforce terminal differentiation.

21 o not undergo NCR-induced and bacA-dependent terminal differentiation.

22 astic epidermis and disruption in late stage terminal differentiation.

23 tion that is initiated in the early stage of terminal differentiation.

24 forced transition from a neoplastic state to terminal differentiation.

25 shed role in repressing neuronal genes until terminal differentiation.

26 promotes commitment of adjacent myoblasts to terminal differentiation.

27 MLL1 catalytic activity, and erythroid cell terminal differentiation.

28 al nervous system rely on Brg1 (Smarca4) for terminal differentiation.

29 verstimulation, excessive proliferation, and terminal differentiation.

30 cell type-specific transcription program for terminal differentiation.

31 hocytic leukemia (CLL) cells fail to undergo terminal differentiation.

32 pocytes and decreasing PKCdeltaI accelerated terminal differentiation.

33 ntiated, suprabasal layers, and it regulates terminal differentiation.

34 , suggesting impaired cell-cycle exit during terminal differentiation.

35 tition between these factors controls B cell terminal differentiation.

36 to post-mitotic neurons, but fail to undergo terminal differentiation.

37 f blood cell development but cannot complete terminal differentiation.

38 pathway, and coincided with progress toward terminal differentiation.

39 in RUNX1-translocated leukemia cells induced terminal differentiation.

40 romoting cell cycle exit in cells undergoing terminal differentiation.

41 t regulator of human NK cell development and terminal differentiation.

42 and the importance of Mbnl1 during erythroid terminal differentiation.

43 equally to genes that are not required until terminal differentiation.

44 new virions occurs in infected cells during terminal differentiation.

45 e cells that proliferate before the onset of terminal differentiation.

46 t myeloid-specific enhancers associated with terminal differentiation.

47 etermine the proper initiation and timing of terminal differentiation.

48 roliferation, loss of E-cadherin, and failed terminal differentiation.

49 e I transglutaminase to enhance keratinocyte terminal differentiation.

50 r development, from initial specification to terminal differentiation.

51 omoting neural stem cell cycling that delays terminal differentiation.

52 anscription factor KLF4 and are committed to terminal differentiation.

53 ensable for their proliferative activity and terminal differentiation.

54 well as the subsequent commitment to proper terminal differentiation.

55 ded from progenitor-driven expansion through terminal differentiation.

56 opulations from gastrulation to the onset of terminal differentiation.

57 both for renal MCC progenitor formation and terminal differentiation.

58 n activators of proliferative quiescence and terminal differentiation.

59 ption factors involved in the progression of terminal differentiation.

60 haracteristics and spontaneous initiation of terminal differentiation.

61 tors by promoting proliferation and blocking terminal differentiation.

62 utive NF-kappaB activation and impair B-cell terminal differentiation.

63 target of Glide/Gcm is known to ensure glial terminal differentiation.

64 roliferating transit-amplifying cells before terminal differentiation.

65 RB1, which is required for mitotic exit and terminal differentiation.

66 and thereafter balancing SSC renewal versus terminal differentiation.

67 and is paralleled by pleiotropic defects in terminal differentiation.

68 n through epigenetic silencing of drivers of terminal differentiation.

69 is critical for Pu.1 down-regulation during terminal differentiation.

70 through stem cell exhaustion and collective terminal differentiation.

71 nodules in which bacterial symbionts undergo terminal differentiation.

72 epidermis and cSCC, and downregulated during terminal differentiation.

73 were cocultured with B cells to induce their terminal differentiation.

74 AM repressive function is compromised during terminal differentiation, additional unknown mechanisms

75 erstood, and the factors that maintain their terminal differentiation after nephrogenesis remain larg

76 tiation pressure that causes a resistance to terminal differentiation and a defect in maintenance of

77 yoblasts lacking LAP1 demonstrated defective terminal differentiation and altered expression of muscl

78 cycle progression, culminating in defective terminal differentiation and anemia.

79 ved in later developmental events, including terminal differentiation and axon morphogenesis, are les

80 counteracted TGF-beta-mediated myofibroblast terminal differentiation and collagen contraction.

81 r CD8(+) T cells, but it also promoted their terminal differentiation and contraction; thus, fewer me

82 rophages, which require GM-CSF signaling for terminal differentiation and effective degradation of al

83 e epidermis revealed defects in keratinocyte terminal differentiation and epidermal barrier formation

84 epidermal cells display profound defects in terminal differentiation and express a subset of markers

85 The terminal differentiation and function of several intesti

86 The terminal differentiation and function of some haematopoi

87 functions emerge at CSR, persist through PC terminal differentiation and further assort memory PC fu

88 ection, CD8(+) T cells lacking Myb underwent terminal differentiation and generated fewer stem cell-l

89 l, increased functional capacity, diminished terminal differentiation and improved anti-tumour potenc

90 to regulate its involvement in keratinocyte terminal differentiation and incorporation into the corn

91 hese findings highlight a role for defective terminal differentiation and loss of Krt9/K9 expression

92 olerable in vivo and that K9 is required for terminal differentiation and maintaining the mechanical

93 livered at relatively late time points drive terminal differentiation and marked Bim-mediated contrac

94 res of adult splice isoforms that facilitate terminal differentiation and maturation of hepatocytes.

95 dinated programs of cell fate specification, terminal differentiation and morphogenesis.

96 velope-1 (Lce1) family involved in epidermal terminal differentiation and of anticancer genes such as

97 ory axis during CD8 T cell activation limits terminal differentiation and preserves memory CD8 T cell

98 during B cell activation is known to inhibit terminal differentiation and promote memory generation.

99 witch gene expression programs, resulting in terminal differentiation and the formation of a mature s

100 the role of transcriptional heterogeneity in terminal differentiation and the functional phenotype (t

101 The dynamics of phase separation governed terminal differentiation and were disrupted by human ski

102 egions revealed hyperproliferation, impaired terminal differentiation, and abnormal expression of ker

103 to activate enzymes involved in keratinocyte terminal differentiation, and at the centrosome to inhib

104 layer of epidermis, inhibition of markers of terminal differentiation, and barrier lipid abnormalitie

105 egulating ribbon heterogeneity, dopaminergic terminal differentiation, and cochlear sensitivity.

106 a result of impaired proliferation, delayed terminal differentiation, and ectopic death of chondrocy

107 ontrol thymic iNKT cell tolerance induction, terminal differentiation, and effector functions.

108 vated B cells that precedes the induction of terminal differentiation, and Hrd1 feeds into this pathw

109 eliloti is required for efficient infection, terminal differentiation, and nitrogen fixation.

110 n followed by increased apoptosis, defective terminal differentiation, and tumor formation.

111 new light on the way iterative divisions and terminal differentiation are coordinately regulated in a

112 Cell-lineage commitment and terminal differentiation are disrupted, leading to a sig

113 Remarkably, these alterations and defective terminal differentiation are reversed upon depletion of

114 sible signals mediate tissue integration and terminal differentiation as well.

115 een shown to have phenotypes associated with terminal differentiation, as well as both cytokine and p

116 ere seen in the repressed expression of late/terminal differentiation-associated uroplakin 3a gene ex

117 ion together to halt root growth and promote terminal differentiation at least in part in a transcrip

118 e a previously undescribed block during late terminal differentiation at the orthochromatic erythrobl

119 When cell cycle withdrawal accompanies terminal differentiation, biosynthesis and cellular grow

120 genome become open for transcription during terminal differentiation, blocking the action of a promi

121 widely believed that perinatal cardiomyocyte terminal differentiation blocks cytokinesis, thereby cau

122 es TG activity in keratinocytes committed to terminal differentiation by direct induction of TG1 expr

123 ate to promote DNA replication and erythroid terminal differentiation by preventing E2F2-mediated abe

124 imuli trigger a common outcome-initiation of terminal differentiation-by activating different signali

125 erturbed molecular checkpoints on the way to terminal differentiation can cause aberrant persistence

126 After birth cardiomyocytes undergo terminal differentiation, characterized by binucleation

127 We show that during terminal differentiation, chromatin closes at a set of p

128 To evaluate how Notch influences terminal differentiation, cord blood-derived NK cells or

129 ipheral neuropathy in mice, characterized by terminal differentiation defects in myelinating and non-

130 tional glia-specific deletion in mice led to terminal differentiation defects that were highly remini

131 t EPB defects including altered keratinocyte terminal differentiation, delayed skin barrier developme

132 TAM terminal differentiation depends on the transcriptional

133 f the cross talk between cell cycle exit and terminal differentiation during metamorphosis.

134 ssed by immunohistochemistry and RT-qPCR for terminal differentiation (E-cadherin, high molecular wei

135 (2) There is little control over the cells' terminal differentiation, e.g., a graft intended to repl

136 lsion by orthochromatic erythoblasts late in terminal differentiation (enucleation), but the mechanis

137 e most potent and broad immune response, but terminal differentiation, exhaustion, and apoptosis in t

138 the immunomodulatory cytokine IL-10 and the terminal-differentiation factor BLIMP-1.

139 Significant down-regulation of terminal differentiation (FLG and FLG2), lipid synthesis

140 Terminal differentiation (FLG2 and LCE5A), tight junctio

141 atinocytes showed a significant reduction in terminal differentiation gene and protein expression, si

142 IL-2 drives terminal differentiation, generating cells that are poor

143 ifferentiated and up-regulate both early and terminal differentiation genes associated with HCs, incl

144 Altered expression of several terminal differentiation genes associated with the deriv

145 Our analysis revealed that many terminal differentiation genes receive direct transcript

146 onal properties of a neuron are specified by terminal differentiation genes, which are controlled by

147 ferentiation by transcriptionally activating terminal differentiation genes.

148 , it induced expression of a large number of terminal differentiation genes.

149 also show that in addition to promoting IFE terminal differentiation, GRHL3 is essential for suppres

150 thropoiesis is well studied, its role during terminal differentiation has been difficult to functiona

151 the same transcription factors that initiate terminal differentiation in a developing organism.

152 genetic mechanism that may control timing of terminal differentiation in developing photoreceptors.

153 duction of apoptosis, cell-cycle arrest, and terminal differentiation in DNMT3A-mutant cell lines in

154 Further, we observed marked enhancement of terminal differentiation in HPV16(tg/+);Krt17(-/-)cervic

155 ation combined with induction of cancer cell terminal differentiation in human melanoma cells identif

156 phenotypes of virulence, mutation rate, and terminal differentiation in multicellular bacteria.

157 eover, transient expression of TIG3 leads to terminal differentiation in normal keratinocytes and apo

158 or Blimp1 plays crucial roles in controlling terminal differentiation in several lineages.

159 Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous epitheli

160 n the ganglionic eminences to their place of terminal differentiation in the cerebral cortex.

161 genes act to enforce cell cycle exit during terminal differentiation in the Drosophila melanogaster

162 ration protein 1 (Blimp-1) has a key role in terminal differentiation in various T-cell subtypes.

163 g colony-forming capacity (CFC) and inducing terminal differentiation in vitro.

164 promoting the transition to quiescence upon terminal differentiation in vivo.

165 nstrate that extinction of PML/RARA triggers terminal differentiation in vivo.

166 rction patients was associated with signs of terminal differentiation including an increase in killer

167 HCMV viremia lacked markers of activation or terminal differentiation including CD38, CD69, CD25, CD5

168 tercellular calcium and triggered aspects of terminal differentiation including decreased keratin-14

169 ht promote their maturation, activation, and terminal differentiation into effector cells that also e

170 ell self-renewal, meiotic recombination, and terminal differentiation into functional spermatozoa.

171 regulated PLZF expression and directed their terminal differentiation into interferon-gamma (IFN-gamm

172 ion of full-length AR (and not AR variants), terminal differentiation into luminal cells, and cell de

173 l of human cardiac precursors (CPCs) driving terminal differentiation into mature cardiomyocytes, and

174 lls to neural progenitors and their ultimate terminal differentiation into neurons, ectopic CDC42 ove

175 age 1-2, resulting in a dramatic decrease of terminal differentiation into stage 3 and severe reducti

176 Our data suggest that terminal differentiation is an important mechanism to pr

177 required, or alternatively, the induction of terminal differentiation is defective.

178 This terminal differentiation is directed by the host plant a

179 This terminal differentiation is driven by host nodule-specif

180 Preventing terminal differentiation is important in the development

181 Terminal differentiation is often associated with cell c

182 As a consequence, NSCs fail to undergo terminal differentiation, leading to prolonged neurogene

183 In melanophores, TH drives terminal differentiation, limiting final cell numbers.

184 of Corti and the vestibular organ, impaired terminal differentiation manifests as immature stereocil

185 -specific CD8(+) T cells did not express the terminal differentiation marker CD57, and fewer HDV-spec

186 ment, including the expression of prestin, a terminal differentiation marker of outer hair cells, alt

187 escent rAM population did not upregulate the terminal differentiation marker sialic acid-binding immu

188 -KO mice also lost the expression of several terminal differentiation markers (Lyve1, Stab1, Stab2, E

189 cally induces the expression of keratinocyte terminal differentiation markers in the duct luminal cel

190 hypertrophic, and has altered expression of terminal differentiation markers involucrin, loricrin, a

191 age homeostasis, chondrocyte maturation, and terminal differentiation markers were all up-regulated v

192 Using a panel of different terminal differentiation markers, including neurotransmi

193 of genetic programs that drive cells toward terminal differentiation may also promote immature and h

194 Expression of terminal differentiation measures significantly increase

195 tifies BMP2 as an effector of the astrocytic terminal differentiation mediated by SNRPN.

196 The basic two-step terminal differentiation model of the medullary thymic e

197 During terminal differentiation, most cells exit the cell cycle

198 cell) and early myogenic differentiation and terminal differentiation (myogenin and myosin heavy chai

199 -beta signaling restricted proliferation and terminal differentiation of antiviral CD4 T cells.

200 ptors loosens PML/RARA DNA binding, inducing terminal differentiation of APL cells ex vivo or in vivo

201 These molecules are required for terminal differentiation of B cells into plasma cells an

202 Affinity maturation and terminal differentiation of B-cells via the germinal cen

203 e excitatory circuit, it is required for the terminal differentiation of basket cells.

204 hemokine that signals through CCR1, promotes terminal differentiation of CCR1-positive eosinophil pre

205 ta, but not PI3K-alpha or PI3K-beta, delayed terminal differentiation of CD8(+) T cells and maintaine

206 IRF8 and IRF4 act in pre-cDCs to direct the terminal differentiation of cDC1 and cDC2 subsets in the

207 es, variability of transgene expression, and terminal differentiation of cells at the end of culture.

208 3-KO mice indicates that Panx3 regulates the terminal differentiation of chondrocytes by promoting va

209 ct cell type-specific levels is required for terminal differentiation of color- and motion-detecting

210 ISC proliferation and decreased capacity for terminal differentiation of daughter enteroblasts (EBs).

211 nephron to the induction and maintenance of terminal differentiation of DCTs that actively prevents

212 its downstream target KCTD1 is essential for terminal differentiation of early stage DCTs into mature

213 affect lymph node priming, but abrogated the terminal differentiation of effector TH2 cells and adapt

214 1 and Ovol2 results in expansion and blocked terminal differentiation of embryonic epidermal progenit

215 ion, EZH2 sustains AID function and prevents terminal differentiation of GC B cells, which allows ant

216 With one set of components, they inhibit terminal differentiation of germinal center B cells into

217 Cebpe-knockout mice also exhibit defects in terminal differentiation of granulocytes, a phenotype re

218 Finally, we found that PABPN1 controls the terminal differentiation of HaCaT keratinocytes by modul

219 factor 4 (KLF4) transcription factor in the terminal differentiation of hematopoietic cells to the m

220 tion, in particular 2B4 and Tim-3; precludes terminal differentiation of highly defective PD-1(hi) ef

221 , and we suggest that dopamine regulates the terminal differentiation of histamine neurons via paracr

222 rly activation and marked suppression during terminal differentiation of hMSCs.

223 Infectious HPV virions are produced during terminal differentiation of host cells.

224 3A and stabilized beta-catenin also enhanced terminal differentiation of human ERMS cells.

225 ling and inflammation through inhibiting the terminal differentiation of keratinocytes and inducing a

226 hlighted disturbed differentiation/premature terminal differentiation of keratinocytes and upregulati

227 with accelerated proliferation and impaired terminal differentiation of keratinocytes.

228 in the developing hypothalamus promotes the terminal differentiation of melanocortinergic neurons an

229 tion of Muller-specific gene expression, and terminal differentiation of MG morphological features.

230 of the miR-183/96/182 cluster in driving the terminal differentiation of multiple sensory receptor ce

231 Terminal differentiation of multipotent stem cells is ac

232 We conclude that Sox10 functions during terminal differentiation of myelinating glia, at least i

233 cid, is currently used in clinic, leading to terminal differentiation of neuroblastoma cells thus red

234 Therefore, TAOK3 controls the terminal differentiation of NOTCH2-dependent splenic cDC

235 Lineage progression and terminal differentiation of oligodendrocyte lineage cell

236 ages of OL generation, and then again during terminal differentiation of OLs.

237 sa staining confirmed the dysfunction in the terminal differentiation of osteoblasts obtained from th

238 seam cell loss occurs through inappropriate terminal differentiation of posterior daughters.

239 n, solute transporter program activation and terminal differentiation of segment populations remain p

240 To clarify its roles in the terminal differentiation of sensory receptors in vivo, w

241 sox-2 and sox-3 have selective roles in the terminal differentiation of specific neuronal cell types

242 epithelial cells by two distinct mechanisms: terminal differentiation of suprabasal cells and a spati

243 1, and TNF-alpha, the cytokines required for terminal differentiation of Th cells, decreased in the C

244 c kidney cancer, evolves from the failure of terminal differentiation of the embryonic kidney.

245 ent insights into AD reveal abnormalities in terminal differentiation of the epidermal epithelium lea

246 During terminal differentiation of the epidermal keratinocytes,

247 a potential role of vitamin A metabolism in terminal differentiation of the epidermis in humans.

248 ists of a cluster of genes important for the terminal differentiation of the epidermis.

249 f the canal occurred in a wave, triggered by terminal differentiation of the epithelium.

250 This suggests that Al-dependent terminal differentiation of the root tip is an active pr

251 lance between self-renewal of stem cells and terminal differentiation of their progeny.

252 latently infected B lymphocytes occurs upon terminal differentiation of these cells to plasma cells-

253 hrough inhibiting proliferation and inducing terminal differentiation of TPCs into myosin-expressing

254 re than 30 y ago for their ability to induce terminal differentiation of transformed cells.

255 i) cells to maintain proliferation and avoid terminal differentiation or programmed cell death.

256 Ts into mature DCTs, and impairment of their terminal differentiation owing to lack of KCTD1 leads to

257 These findings provide a novel view on the terminal differentiation path of slan(+) -monocytes, whi

258 be maintained and secretory cells execute a terminal differentiation program and convert into ciliat

259 lude that NeuroD2 is necessary to instruct a terminal differentiation program in basket cells that re

260 a gene regulatory network that activates the terminal differentiation program of distal segments in t

261 ich acts as a terminal selector to drive the terminal differentiation program of the cholinergic AIY

262 ptides, we show that ttx-3 also controls the terminal differentiation program of two additional, dist

263 Senescence is a terminal differentiation program that halts the growth o

264 fe cycle is tightly linked to the epithelial terminal differentiation program, with the virion-produc

265 gesting that their expression is part of the terminal differentiation program.

266 with AHR antagonists also showed an impaired terminal differentiation program.

267 as well as substantial reorganization of the terminal differentiation programs in hair follicle kerat

268 tion factors that drive neuron type-specific terminal differentiation programs in the developing nerv

269 insights into combinatorial codes that drive terminal differentiation programs in the nervous system

270 al and, later on, in selectively controlling terminal differentiation programs of specific neuron typ

271 itiation, the other in proper maintenance of terminal differentiation programs.This article has an as

272 severely impaired epidermal stratification, terminal differentiation protein expression, and stratum

273 rowth and early differentiation, rather than terminal differentiation, providing mechanistic insights

274 Here we show that during erythroid terminal differentiation, Rb plays a previously unapprec

275 tion positively contributes to signaling and terminal differentiation responses to TGFbeta activity.

276 increases stem cell self-renewal and blocks terminal differentiation, resulting in epithelial hyperp

277 At 3 months, additional signs of terminal differentiation such as increased alkaline phos

278 These include either terminal differentiation (the long-lived plasma cell) or

279 ssion of an essential mediator of neutrophil terminal differentiation, the ets transcription factor P

280 During terminal differentiation, the global protein complement

281 As a result of premature abrogation of terminal differentiation, the hair is brittle and fragil

282 ic pathway that forces commitment of CTLs to terminal differentiation, thereby restricting their memo

283 epidermis up to the granular layer where, on terminal differentiation, they progressively lose organe

284 eading to Krt8+ transitional cells and their terminal differentiation to alveolar type-1 cells.

285 We found that the TF BACH2 restrains terminal differentiation to enable generation of long-li

286 maintaining the stem cell pool and fostering terminal differentiation to establish an epithelial stem

287 gh hematopoietic specification and efficient terminal differentiation to naive CD3(+)CD8alphabeta(+)

288 present in progenitors and downregulated at terminal differentiation to promote acquisition of matur

289 Terminal differentiation to the monocytes and proliferat

290 ession, which is sufficient to induce B-cell terminal differentiation toward plasma cells.

291 The achievement of terminal differentiation ultimately requires the in vivo

292 n increased tendency of the cells to undergo terminal differentiation upon LPS stimulation.

293 obetasol) restored epidermal hyperplasia and terminal differentiation versus minimal changes with veh

294 Control of stem cell fate to either enter terminal differentiation versus returning to quiescence

295 Impaired terminal differentiation was noted in primary B cells fr

296 Terminal differentiation was then induced by activation

297 cooperate with TRbeta during human erythroid terminal differentiation, we conducted RNA-seq in human

298 newly formed muscle fibers but delayed their terminal differentiation, whereas MS275 abolished the ea

299 natal induction of SOX11 represses epidermal terminal differentiation while deficiency of Sox11 and S

300 els dropped further once NHBE cells achieved terminal differentiation, with mucociliary activity stro