ライフサイエンスコーパス: terpene

1 unds (alcohols, aldehydes, esters, acids and terpenes).

2 s or the production of industrially valuable terpenes.

3 onut oil, petroleum distillates, and diluent terpenes.

4 caprine milk for the majority of identified terpenes.

5 rings, a pattern shared by a number of other terpenes.

6 oengineering metabolic pathways for specific terpenes.

7 penoids are a relatively rare class of plant terpenes.

8 the cannabis resin are the cannabinoids and terpenes.

9 ule and utilizes both cofactors for building terpenes.

10 ed spectroscopy, even in complex mixtures of terpenes.

11 unt of four terpenes out of seven quantified terpenes.

12 the functional groups, to give polyoxidized terpenes.

13 he preparation of a great variety of natural terpenes.

14 ectively explain a diverse range of cannabis terpenes.

15 Terpenes (15.57-41.05 mg/kg), accounting for ~97% of tot

16 la consists of esters (33%), alcohols (27%), terpenes (18%) and others (21%).

17 sulfur compounds; bacuri is characterized by terpenes (41%), non-terpenic alcohols (24%), esters (15%

18 e fruit arrangement induced a degradation of terpenes, a reduced formation of reaction products from

19 nto the elaborate polycyclic ring systems of terpenes, a sequence that is often difficult to emulate

20 For others, VOC groups, such as terpenes, acids and aldehydes topped the list.

21 del also avoids food treated with one of the terpenes, after having experienced gastrointestinal mala

22 eas for acid hydrolysis the area of released terpene aglycone did not exceed 1.3% of total peak area

23 ic hydrolysis 85-91% of total peak areas was terpene aglycone, whereas for acid hydrolysis the area o

24 any grape-derived volatile compounds such as terpene alcohols and C13-norisoprenoids in wine, althoug

25 beta-damascenone but had no impact on other terpene alcohols or beta-ionone.

26 e in content of various sulfurous compounds, terpene alcohols, ketones and pyrazines was noted.

27 configuration changed during storage for the terpene alcohols.

28 emical classes such as pyrazines, aldehydes, terpenes, alcohols, esters, and ketones.

29 mined in pistachio oil and it was found that terpenes, aldehydes, and alcohols were the most abundant

30 es in virtually every natural product class: terpenes, alkaloids, prostaglandins, macrolides, and tet

31 hibition and springtail lethality tests with terpenes, alkanes, and cyclic siloxanes.

32 When starting from sterically hindered terpenes, allenylphosphonates were also easily obtained

33 The terpenes alpha-thujene, sabinene, gamma-terpinene and be

34 high-throughput method of quantifying seven terpenes (alpha-pinene, beta-pinene, beta-myrcene, 3-car

35 tic variation (but not sexual dimorphism) in terpene amounts in leaves of the dioecious shrub Bacchar

36 odular chemoenzymatic approach to synthesize terpene analogues from diphosphorylated precursors produ

37 impacts on copy numbers of genes related to terpene and benzenoid/phenylpropanoid (the main floral s

38 SANDPUMA algorithm, improved predictions for terpene and ribosomally synthesized and post-translation

39 y investigated the volatile profiles of free terpene and terpenoid of five widely grown Vitis vinifer

40 The evolution of terpene and terpenoids throughout grapevine phenological

41 Terpenes and C(13)-norisoprenids were the most affected

42 files of grape must and wine, involving e.g. terpenes and C13-norisoprenoids, occurred in musts treat

43 ounds belonging to the class of polyphenols, terpenes and capsaicinoids, interact with important path

44 ch showed the highest contents of pyrazines, terpenes and esters, while teff, buckwheat and rice flou

45 al mainly due to the higher concentration of terpenes and methoxyphenols.

46 usly hidden degradation reactions running in terpenes and natural resins exposed to artificial aging

47 Twenty-one terpenes and one ester were identified from the exhaled

48 ospheric conditions for the autooxidation of terpenes and other unsaturated hydrocarbons; it shows th

49 ce an essential oil that is rich in volatile terpenes and plays a major role in carrot aroma and flav

50 ich contained higher number and abundance of terpenes and sulfur based compounds.

51 pecies according to chemical classes such as terpenes and sulfur compounds.

52 ntroduction of carbonyl functionalities into terpenes and terpene-derived compounds.

53 optically active, from abundantly available terpenes and terpenoid-derived precursors.

54 Quantitative chirality sensing of terpenes and terpenoids exhibiting a single double bond

55 ess and overall amount of a large variety of terpenes and terpenoids using readily available phosphin

56 y be enhanced by the presence of mixtures of terpenes and that the acquisition of new functions by te

57 When integrating total sugar, total terpenes and the cumulated heat index, it could be found

58 mines formation, as well as between volatile terpenes and the lipophilic antioxidant activity, were o

59 Terpenes and their derivatives are sustainable, renewabl

60 Terpenes and their derivatives, terpenoids, are importan

61 idize diverse compounds, including steroids, terpenes and various human drugs.

62 disparate biosynthetic machinery, alkaloid, terpene, and polyketide-producing organisms have all evo

63 s, 8 hydrocarbons, 14 carbonyl compounds, 17 terpenes, and 6 other compounds.

64 de synthetases, type 1 polyketide synthases, terpenes, and lantipeptides.

65 dehydration grapes were richer in total free terpenes, and the resulting wines contained greater amou

66 sis (PLS-DA), the purees may be allocated to terpene- and lactone-rich ('SH-5'), ester-containing ('C

67 Terpenes are a class of volatile organic hydrocarbons co

68 is, development of secretory cavities, where terpenes are both synthesized and stored, and transport

69 The health effects of terpenes are not widely known, though several studies ha

70 Terpenes are present in tobacco smoke and are used as fl

71 Terpenes are structurally diverse natural products invol

72 cyclohexene, acting as surrogate for cyclic terpenes, are followed as protonated species (CI)H(+) us

73 llustrated using the conidiogenone family of terpenes as a representative case; however, this framewo

74 We review here the status of terpenes as a specialty biofuel and discuss the potentia

75 volatile compounds, such as ethyl esters and terpenes, as well as amino acids and tyramine.

76 liverworts accumulates structurally diverse terpenes believed to serve in deterring disease and herb

77 DMS coating showed higher relative areas for terpenes (beta-citronellol, geraniol, linalool and alpha

78 n the JA-defence pathway (opr7, aos1, 2, 3), terpene biosynthesis (fps3, tps2, 3, 4, 5, 7, 9, 10), be

79 strategy inspired by the logic of two-phase terpene biosynthesis in which powerful C-C bond construc

80 Plant terpene biosynthesis is regulated at multiple levels, le

81 eranylgeranyl reductase (CHLP), an enzyme of terpene biosynthesis that supplies the hydrocarbon chain

82 Our results show that in addition to terpene biosynthesis, development of secretory cavities,

83 The pivotal enzymes for terpene biosynthesis, terpene synthases (TPSs), had been

84 nnate immunity, as well as those involved in terpene biosynthesis, while having a significant overrep

85 yme with two-domain TPSs of mono- and sesqui-terpene biosynthesis.

86 The pool of abundant chiral terpene building blocks (i.e., "chiral pool terpenes") h

87 a strategy that simplifies the synthesis of terpenes by inverting the order of nature's two-phase bi

88 streamline the synthesis of polyhydroxylated terpenes by minimizing protecting group and redox adjust

89 oducts, e.g. capsaicinoids, cannabinoids and terpenes, by highlighting challenges and opportunities i

90 d sustainable energy has identified specific terpenes capable of supplementing or replacing current p

91 A via 10 net oxidations from the ubiquitous terpene (+)-cedrol.

92 Total free terpenes changed with the berry density, while no signif

93 ings and provide a more in-depth analysis of terpene chemistry on these same plants from an experimen

94 Sesterterpenoids are a rare terpene class harboring untapped chemodiversity and bioa

95 kers have higher serum concentrations of six terpenes compared to nonusers.

96 Although terpene composition represents a critical quality attrib

97 Free and glycosidically-bound terpene compounds including linalool, geraniol, nerol, c

98 Other terpene compounds such as limonene (0.11-3.58 mg/kg), te

99 howed relatively higher levels of ketone and terpene compounds with 'woody' and 'cereal-like' sensory

100 ily fitted to regression models for some key terpene compounds.

101 rall terpene yield, eight direct measures of terpene concentration and four biomass-related traits.

102 which indicates that the observed changes in terpene concentration were not transcriptionally regulat

103 Grape berry terpene concentrations may vary at different stages of b

104 In addition, the must treated by UHPH keeps terpene concentrations similar to those of the untreated

105 Terpene concentrations were 14-78% higher in smokers tha

106 Unlike terpene concentrations, the isoprene concentrations in t

107 Terpenes constitute one of the most structurally varied

108 higher temperature or roasting decreased the terpene content (~50-25% respectively), and pyrazines ap

109 tiple levels, leading to wide variability in terpene content and chemistry.

110 The average total terpene content increased five times during the alpine r

111 The terpene content of milk and cream made from milk obtaine

112 The terpene coordination is complete within 10 min and coinc

113 ulation of a specific enantiomer of a chiral terpene could be enhanced relative to the other enantiom

114 These four terpenes could be used, as indicators, to show that milk

115 structures are produced in nature by type I terpene cyclase enzymes from one single substrate.

116 d novel carbon skeleton of 1 suggests a rare terpene cyclase machinery, exemplifying the chemical div

117 , resembling pyrophosphate initiated class I terpene cyclase reaction chemistry.

118 erases from marine algae that repurposes the terpene cyclase structural fold for the N-prenylation of

119 ogue of iridoid synthase (OeISY), an unusual terpene cyclase that couples an NAD (P)H-dependent 1,4-r

120 ces of social amoebae reveal the presence of terpene cyclases (TCs) in these organisms.

121 we report that the catalytic activity of the terpene cyclases AaTPS and FgGS can be switched from cyc

122 In nature, terpene cyclases comprise the foundation of molecular bi

123 enyltransferase activity discovered in other terpene cyclases indicates that this cryptic function is

124 ns are structurally distinct from ubiquitous terpene cyclases that, instead, assemble terpenes via in

125 ry lineage, they are distinct from all other terpene cyclases, suggesting a very distant ancestor to

126 ctivity of this new family of non-canonical, terpene cyclases.

127 al magnesium (Mg(2+))-binding motif found in terpene cyclases.

128 roadly conserved among the greater family of terpene cyclases.

129 The tail-to-head terpene cyclization is arguably one of the most complex

130 Terpenes derived from the same biosynthetic pathway had

131 ate at night is impacted by the formation of terpene-derived and higher molecular weight secondary or

132 ts as a viable agronomic solution for future terpene-derived biofuels.

133 f carbonyl functionalities into terpenes and terpene-derived compounds.

134 Oleuropein, a terpene-derived glycosylated secoiridoid biosynthesized

135 total syntheses which themselves use small, terpene-derived materials as building blocks.

136 With terpene-derived substrates, similar trends in reactivity

137 oride as reactants, the synthesized monomer, terpene-diallyl maleate adduct, was prepared by D-A addi

138 The terpenes did not influence the sensorial quality of the

139 attern of polyketide phenol nucleophiles and terpene diphosphate electrophiles.

140 In contrast, a bouquet of terpenes, dominated by sesquiterpenes including beta-bar

141 tions was also very relevant; in particular, terpenes doubled (28.38-53.84 mg/kg) using whole pistach

142 Food treated with the terpenes elicited avoidance responses in the cooccurring

143 The average total terpene emission rate from the use of herbs and pepper d

144 Terpene synthases generate terpenes employing diversified carbocation chemistry, in

145 scovered, which enhance catechin production, terpene enzyme activation, and stress tolerance, importa

146 analysis, significantly differed in terms of terpenes, esters and alcohols content, thus proving that

147 tion of mixtures containing alkynes, dienes, terpenes, esters, aldehydes, and ketones.

148 This study aimed to investigate terpene evolution in grape berries from four weeks post-

149 Thus, mastic oil, as a combination of terpenes, exerts growth inhibitory effects against colon

150 Human terpene exposure can come from inhalation, diet, smoking

151 family, as well as to the synthesis of other terpene families.

152 not led to even the simplest members of this terpene family.

153 Terpenes, fatty acids and volatile phenols increased the

154 be accessed from an abundant and inexpensive terpene feedstock.

155 ural products from an abundant and renewable terpene feedstock.

156 matization of natural products, steroids and terpene feedstocks.

157 Terpenes followed by higher alcohols and esters were the

158 sed the concentration at harvest of key free terpenes for Gewurztraminer grapes such as geraniol and

159 The structural diversity of terpenes found in nature is mainly determined by terpene

160 nthases results in the enormous diversity of terpenes found in nature.

161 s to build the bridging bicyclo[4.3.1]decane terpene framework.

162 e are few examples of commercial recovery of terpenes from plants because of low yields.

163 Using terpenes from turpentine, maleic anhydride and allyl chl

164 This big hydrophobic terpene functional group affects the codon recognition p

165 thodology has been used for the synthesis of terpene furans such as mintfurane, curzerene, atractylon

166 RDI treatments down-regulated some terpene genes, which indicates that the observed changes

167 terpene building blocks (i.e., "chiral pool terpenes") has long served as a starting point for the c

168 es responsible for the chemical diversity of terpenes have yet to be described.

169 e content of several aldehydes, alcohols and terpene hydrocarbons while an increase in content of var

170 d on the individual reaction pathways of the terpenes hydroxydammarenone and abietic acid as well as

171 The main terpenes identified and semi-quantified were the monoter

172 monoterpenes, sesquiterpenes, and oxygenated terpenes in 2D space, and thus orthogonality, could be a

173 ompounds were fatty acids, their esters, and terpenes in CSF (30) and PCF (41).

174 Direct measurement of volatile terpenes in cultures of D. discoideum revealed essential

175 a development-specific function of volatile terpenes in D. discoideum.

176 Terpenes in grapes at harvest might not necessarily be s

177 ta to establish baseline exposure levels for terpenes in humans.

178 titute an important yet overlooked source of terpenes in indoor air.

179 r semi-quantitative analysis of aroma-active terpenes in liquid food matrices.

180 tudied for chemical defences in general, and terpenes in particular.

181 ue features of the biosynthetic apparatus of terpenes in plants that facilitate the production of lar

182 f monomeric and oligomeric flavan-3-ols, and terpenes in the wines.

183 s, little is known about the biosynthesis of terpenes in this crop.

184 methanol free and contained higher levels of terpenes (indicating hydrolysis of bound forms) and ferm

185 or users owing to the reaction of ozone with terpene ingredients.

186 vidence of an interaction between NtPDR1 and terpenes is lacking.

187 This set of terpenes is synthesized by multiproduct enzymes, with ei

188 Although total synthesis of such terpenes is widely studied, synthetic strategies that al

189 containing lemon essential oil incorporated terpenes (limonene, gamma-terpinene, p-cymene and alpha-

190 imple method has been found to prepare allyl terpene maleate monomer by substitution reaction at lowe

191 In this review, recent advances regarding terpene metabolic engineering are highlighted, with a sp

192 enome editing, have begun to elucidate plant terpene metabolism, and such information is useful for b

193 Correlation of TPS gene expression and terpene metabolite profiles supported the function of Dc

194 ceae) is well documented as a rich source of terpene natural products.

195 s represent a particularly prolific class of terpene natural products.

196 enes are common structural motifs in various terpene natural products.

197 occupancy, ozone addition, and cleaning with terpene, natural product, and vinegar cleaners had a muc

198 We recently characterized a gene-terpene network that is associated with artemisinin bios

199 canopy, yield, and free and glycoside-bound terpenes of the berry were investigated for three consec

200 e is known about the genetic architecture of terpene oil yield from plants.

201 rom all sorts of biomass, from carbohydrate, terpenes, or oleochemical sources.

202 , Neelum contains the highest amount of four terpenes out of seven quantified terpenes.

203 The structurally intriguing terpenes pallambins C and D have been assembled in only

204 ees Brix) led to volatile profiles richer in terpenes, particularly linalool and geraniol.

205 re complex mixture of secondary metabolites (terpenes, phenolic compounds, alcohol).

206 elery include a range of volatile compounds (terpenes, phthalides and aldehydes) that contribute to i

207 and the best ways to sink existing pools of terpene precursors are discussed.

208 nalyzed the volatile dietary phytochemicals (terpenes) present in mastic oil extracted from the resin

209 cale production of natural products, such as terpenes, presents a significant scientific and technolo

210 re we report on the application of a modular terpene production platform in the characterization of t

211 ) for investigating the pathways of volatile terpene production.

212 assay for the detection of multiple volatile terpene products.

213 Terpene profile analysis showed a high frequency of appe

214 this study was to compare the fatty acid and terpene profile of ovine and caprine milk from animals r

215 parison to caprine milk that had an enriched terpene profile than ovine milk.

216 quantitative and qualitative differences in terpene profiles associated with plant sex and genotypic

217 revealed that for each grape cultivar, free terpene profiles at different E-L stages were distinctiv

218 Variations of cannabis terpene profiles contribute much to the different flavor

219 senting different cultivars with contrasting terpene profiles for clonal propagation, floral metaboli

220 of their recombinant proteins with volatile terpene profiles from DH1 and four other colored carrot

221 ndings indicated that genotypic variation in terpene profiles largely surpassed variation due to sexu

222 We characterized foliar terpene profiles of plants grown from 32 seed sources an

223 ally reported on intra-specific variation in terpene profiles, but the effects of plant sex, an impor

224 The olfactory detection threshold of this terpene reminiscent of mint was 0.9mug/L in model hydroa

225 nly 15 steps from the commercially available terpene (S)-pulegone.

226 substrates and convert them into the various terpene skeletons by catalyzing a carbocation-driven rea

227 acids, anthocyanins, saponins, carotenoids, terpenes, sugars, proteins, capsaicinoids, fatty acids,

228 , including aromatic amino acids and acyclic terpenes, suggesting a reduction of metabolic flexibilit

229 erpenoids when compared to assuming a single terpene surrogate.

230 sh revealed a total of 33 different cannabis terpene synthase (CsTPS) genes, as well as variations of

231 Here we report on a terpene synthase (DdTPS8)-cytochrome P450 (CYP521A1) gen

232 , which is cyclized by an unusual plastidial terpene synthase (LfTPS1) into the characteristic serrul

233 Four of these putative trans-IDSs exhibited terpene synthase (TPS) activity when heterologously expr

234 trans-prenyltransferase (PT) and N-terminal terpene synthase (TPS) domains.

235 Here, we describe the identification of the terpene synthase (TPS) gene family of the panicoid food

236 Here, we functionally characterized 19 terpene synthase (TPS) genes in an orange carrot (genoty

237 tative sesquiterpene synthase (M. truncatula TERPENE SYNTHASE 10 [MtTPS10]) in both developmental sta

238 ery and mechanistic analysis of golden larch terpene synthase 8 (PxaTPS8), an unusual diterpene synth

239 functionalization of a compartment-switching terpene synthase accepting a novel substrate in the plas

240 will aid the prediction and design of novel terpene synthase activities towards clean monoterpenoid

241 3) whose members have a characteristic alpha terpene synthase alpha-helical fold.

242 crystallography, pointing the way for future terpene synthase design.

243 s are produced in our system by changing the terpene synthase enzyme.

244 ortance of inherent substrate reactivity for terpene synthase enzymes is discussed, with a focus on r

245 esting a very distant ancestor to the larger terpene synthase family.

246 Mutations of residues outside of the alpha terpene synthase fold are important for acquisition of F

247 Here we report that fungi have acquired terpene synthase genes (TPSs), which encode pivotal enzy

248 Candidate terpene synthase genes for the production of 1,8-cineole

249 a HMMER search tool to identify 17 putative terpene synthase genes from M. polymorpha transcriptomes

250 Terpene synthase genes involved in the biosynthesis of t

251 n of (S)-beta-citronellol commences with the terpene synthase GES1 catalyzing the irreversible conver

252 urprising finding of an atypical class I (di)terpene synthase that acts on CPP to produce the abietan

253 ism in the promoter of the gene encoding the terpene synthase TPS2 with this QTL Biochemical characte

254 Interestingly, defense modulators such as terpene synthase, papain-like cysteine protease, serine

255 taxadiene synthase (TXS), the model class I terpene synthase, which simulates the initial catalytic

256 isogenic lines enabled the identification of terpene synthase21 (ZmTps21) on chromosome 9 as a beta-c

257 Four terpene synthases (TPS) from the TPS-a subfamily, includ

258 enes found in nature is mainly determined by terpene synthases (TPS).

259 Terpene synthases (TPSs) and trans-isoprenyl diphosphate

260 he pivotal enzymes for terpene biosynthesis, terpene synthases (TPSs), had been described only in pla

261 of a large gene family (with 20 members) for terpene synthases (TPSs).

262 -dependent cyclization cascades catalyzed by terpene synthases (TSs).

263 s, not related to previously described plant terpene synthases and only distantly so to microbial-typ

264 Based on their sequence similarity, terpene synthases from land plants can be divided into d

265 Terpene synthases generate terpenes employing diversifie

266 Class I terpene synthases generate the structural core of bioact

267 Rational engineering of terpene synthases is challenging due to a lack of correl

268 However, directed evolution of terpene synthases is hampered by the lack of a convenien

269 Substrate promiscuity of terpene synthases provides organism access to novel chem

270 Promiscuity of terpene synthases results in the enormous diversity of t

271 ata were used to identify eight putative (di)terpene synthases that were then characterized for their

272 These modified diphosphates were used with terpene synthases to produce the unnatural sesquiterpeno

273 Terpene synthases, which synthesize monoterpenes and ses

274 es these enzymes in a noncanonical family of terpene synthases.

275 ases and only distantly so to microbial-type terpene synthases.

276 patterned off of biosynthetic machinery for terpene synthesis can be used to arrive at Taxol.

277 f chemical complexity and employed two-phase terpene synthesis logic as the guiding strategy.

278 Here we implement a two-phase terpene synthesis strategy to achieve enantiospecific to

279 damental question: Could any new approach to terpene synthesis, perhaps one patterned on biosynthesis

280 lysis, including the targeting of 86 lipids, terpenes, terpenoids, alkanes and their analogues, found

281 nine ketones, five esters, eight acids, ten terpenes/terpenoids, ten furans/furanones, two pyrroles,

282 f sap was studied and a total seven selected terpenes that are alpha-pinene, alpha-phellandrene, (+)-

283 rom colored carrot cultivars identified nine terpenes that were clearly distinct among the cultivars

284 of complex natural products, including many terpenes themselves.

285 This review highlights 21st century terpene total syntheses which themselves use small, terp

286 o be responsible for the clusters, including terpenes (trans-squalene, friedelin, camphene, trans-3-p

287 particular, monomers such as carbon dioxide, terpenes, vegetable oils and carbohydrates can be used a

288 ous terpene cyclases that, instead, assemble terpenes via intramolecular rearrangements of a single s

289 Up to now, this valuable terpene was mainly manufactured from the high-boiling fr

290 The highest total concentration of free terpenes was found at 19.3 degrees Brix; however, total

291 oth synthesized and stored, and transport of terpenes were important components of terpene yield.

292 Total free and bound terpenes were more affected by grape density than by sam

293 Among thirty-one volatiles in guava powders, terpenes were predominant, even after both drying proces

294 Terpenes were the major volatile compounds (46.75%) iden

295 a-pinene (which comprised > 80% of the total terpenes) were functionally characterized as a 1,8-cineo

296 rt a disparate synthetic approach to complex terpenes whereby simple prenyl-derived chains are cycliz

297 zenes with solvent and oily odors as well as terpenes with weakly woody odors were found in cardboard

298 el insights into the genomic architecture of terpene yield and we provide candidate genes for breedin

299 iduals with 12 traits related to the overall terpene yield, eight direct measures of terpene concentr

300 ort of terpenes were important components of terpene yield.