ライフサイエンスコーパス: tether

1 tural and functional capacity to be a PM-PER tether.

2 i (COG) complex, a Golgi apparatus vesicular tether.

3 arene functionality linked by a neopentylene tether.

4 1-positive organelles using annexin A11 as a tether.

5 ones or by altering the length of the carbon tether.

6 s of alphaENaC, were identified as potential tethers.

7 with each other through localized organelle tethers.

8 sociation rate of such TCs from their L7/L12 tethers.

9 e examination of exocyst function in vesicle tethering.

10 as low activity as a result of tight nuclear tethering(14-18).

11 is base-mediated cyclization of sulfonamide-tethered 5-iodo-1,2,3-triazoles which are readily availa

12 ly conferred by their ribbon synapses, which tether a large number of vesicles at the IHC's presynapt

13 actions and by using the carbamoyl moiety to tether a plethora of productive functional groups, inclu

14 Here we tether a protein to a surface with a flexible polymer, d

15 tructure suggests how the Dsl1 complex might tether a vesicle to its target membrane by binding at on

16 utes, we further demonstrate that covalently tethering a supramolecular polymer built from PBI subuni

17 we determined key biophysical properties of tethered actin bundles such as their rigidity and filame

18 ene units, the relatively flexible porphyrin tether actively participates in the recognition process,

19 an abundant nuclear protein with RNA-to-DNA tethering activity, coordinated by two spatially distinc

20 , self-interact to form trans-oligomers that tether adjacent Golgi membranes into stacks and ribbons

21 metrical organization of the chromatin-lamin tether affects nuclear morphology and shape fluctuations

22 Installment of tethered alkynes or azides onto the terephthalic phenoli

23 se results show that U1 snRNP acts widely to tether and mobilize lncRNAs to chromatin in a transcript

24 ular accumulation and anticancer activity in tether and nontether complexes.

25 rst molecular characterization of the PM-PER tether and show it anchors peroxisomes at the mother cel

26 lization depends on the site of the covalent tether and the nature of the protein-fragment interactio

27 les for many genes, the presence of membrane-tethered and soluble forms, and a high degree of post-tr

28 mitochondrial function and ER-mitochondrial tethering and could be considered as a new therapeutic a

29 We find no evidence for transcription factor tethering and DNA-binding domain-independent action.

30 and galactose ligands required for spheroid tethering and formation.

31 Vesicle tethering and fusion are thought to occur sequentially,

32 he membrane transport machinery required for tethering and fusion of vesicles at the plasma membrane.

33 ral and spatial dynamics of exocytic vesicle tethering and fusion with the plasma membrane.

34 conserved C(2)AB domain and induces membrane tethering and hemifusion in this cell-free model.

35 vision site, involving FtsZ bundling, Z-ring tethering and membrane reshaping activities that are nee

36 omotypic fusion and vacuole protein sorting) tethering and SNARE-assembly complex, and the Rab Ypt7,

37 concentrate in the plasma membrane via lipid-tethers and hypervariable region side-chain interactions

38 of bulky stoppering ("capping") units at the tethers and subsequent cleavage of the covalent ring/thr

39 -filament" principle involving extracellular tethers and the extracellular matrix (ECM).

40 o live cells (through antibody-mediated cell tethering) and capturing cell-secreted molecules.

41 , replication, recombination, transposition, tethering, and transport.

42 e crucial for stability, DNA duplication and tethering, and/or a means of nuclear integration of the

43 ollagens in the ER lumen to COPII machinery, tethers, and ER-Golgi intermediate compartment (ERGIC) i

44 le for the regioselective cyclization of the tethered Ant-l-Kyn dipeptide to form the unusual benzaze

45 t bind MUC16, and interestingly, these MUC16-tethered antibodies are enriched for binding to certain

46 stability profiles for the same multivalent tethered antibody formats from both in vitro serum and p

47 drug conjugates, such biotransformations of tethered antibody formats usually result in degraded pro

48 In the case of engineered multivalent tethered antibody formats, proteolysis or deconjugation

49 and protein sorting (HOPS)-mediated vesicle tethering, are required for the phosphorylation of Vac17

50 ble, but they often come at the cost of long tethers, are dependent on the presence of a particular n

51 During recombination, sister chromatids are tethered as loops to a polymerized chromosome axis, whic

52 We demonstrate a v-SNARE requirement in our tethering assay and increased v-SNARE binding to exocyst

53 We use DGCR8 tethering assays and operon structure-function assays to

54 chromatin occupancy, combined with chromatin tethering assays, demonstrate that DNA-bound RELA intera

55 We found that PBs are tethered at molecular distances to the ER in human cells

56 ly implicated in lipid exchange and membrane tethering at ER-mitochondria contacts.

57 This study revealed membrane tethers at the trans-Golgi as novel specific targets of

58 Moreover, tethering Axin to mitochondria was sufficient to recruit

59 ed by crossover recombination to establish a tether between homologous chromosomes.

60 's lipoprotein (Lpp) forms the only covalent tether between the OM and PG and is crucial for cell env

61 on artificial membranes, so-called sparsely tethered bilayer lipid membranes, reveal the structural

62 ination sphere at zirconium, imparted by the tethered bis(ureate) ligand, is crucial for the coordina

63 Mutations that detach one end of the tether but maintain overall binding severely impair this

64 ted by the displacement of micron-size beads tethered by DNA probes that are between 1 and 7 microns

65 pension feeders are attached to particles or tethered by gravity when feeding.

66 e barbed end the terminal subunit is loosely tethered by its DNase-1 loop to the third subunit, becau

67 Functional studies that tethered CaM to Ca(V)1.2 suggested that a single CaM suf

68 respond to signaling from the alpha-subunit-tethered CaM.

69 Such tethering can occur via protein interaction domains in t

70 ferences in rolling frequency, velocity, and tethering capability of cells under study.

71 Both the tethered cell and motility migration coefficient assays

72 ylate (HEMA) from a surface confined, dithio-tethered, chain transfer agent (CTA) enables the prepara

73 CTCF, RAD21, and SMC3, that are involved in tethering chromatin loops and marking domain boundaries.

74 Using a prototypical tethering complex made by STARD3 and VAP, we showed that

75 ay have functions independent of the exocyst tethering complex on the plasma membrane at the division

76 growing pollen tube tip requires the exocyst tethering complex responsible for specific targeting of

77 uires catalysis by HOPS, the vacuolar SM and tethering complex.

78 Multisubunit-tethering complexes (MTCs) are large (250 to >750 kDa),

79 Herein, we describe light-responsive tethers, containing an azobenzene photoswitch and two ma

80 ical models suggest that endocytic organelle tethering could regulate the direction of cytokine trans

81 ymmetrization of alkene-, alkyne- and allene-tethered cyclohexadienones using transition metals and c

82 Tethered cytokine-containing vesicle (CytV)-endocytic or

83 Only endocytic organelle-tethered CytVs are preferentially transported to their d

84 of CCCTC-binding factor (CTCF) and show that tethering DCP1A to one Tsix allele is sufficient to driv

85 During tethering, de novo centromeres sometimes prevail, causin

86 The behavior of the tethers depends on the geometry of the connection betwee

87 taining two aromatic rings linked by a short tether, diarylamines may exhibit atropisomerism (chirali

88 We demonstrate that bound mobility via tethered diffusion can be engineered into a synthetic ge

89 filters can be designed to take advantage of tethered diffusion to give rapid, selective transport.

90 In both current main approaches-tether-directed covalent functionalization and supramole

91 atment on functional 3D hepatocyte spheroids tethered directly on polystyrene multi-well plates, and

92 Vesicle and target membrane fusion involves tethering, docking and fusion.

93 erminal winged helix domain and a disordered tethering domain as well as a BORCS6-like domain found i

94 P toxins by sequential removal of a membrane-tethering domain, the cysteine-rich domain, and a disint

95 EBV genomes are maintained by EBNA1, which tethers EBV episomes to the host chromosomes during mito

96 zed multiple CaMs to the Ca(V) nanodomain by tethering either WT or mutant CaM that lack Ca(2+)-bindi

97 In addition, HaloTag-based covalent tethering enables examination of titin dynamics under fo

98 ation by intramolecular cyclization of ester-tethered enaminones, which can easily be synthesized fro

99 ated reductive epoxide opening reaction of N-tethered epoxy-indoles that trigger facile intramolecula

100 n exo70a2, a predicted member of the vesicle-tethering exocyst complex.

101 The tethering-facilitated DNA 'opening' of undamaged sites a

102 the exocyst complex during vesicle membrane tethering, facilitating docking and fusion.

103 al. report two crystal structures of a yeast tethering factor, the Dsl1 complex, bound with two SNARE

104 RE proteins, revealing new insights into how tethering factors bridge vesicles to target membranes, r

105 Tethering factors play a key role in chaperoning SNARE a

106 d the optomotor gaze stabilization reflex in tethered flight and quantified how head movements stabil

107 eeding modes, and it suggests that organisms tether for reasons that are not directly fluid dynamical

108 t to luciferase-based 3'-untranslated-region tethered function assays to pinpoint RBPs that regulate

109 BP level, recapitulating effects observed in tethered function assays.

110 that attach to host chromosomes through the tethering functions of EBNA1, a viral encoded sequence-s

111 Substrates with o-bromo tether further cyclized to pentannulated hydroquinolines

112 We show that lysosomal membrane-tethered GALC (GALCLAMP1) retains enzyme activity, is ab

113 We designed and synthesized lipid-tethered glycopolypeptide mimics of mucins and added the

114 ing a combination of pentaglycine linker and tethering glyphosate via its secondary amino group, conc

115 SPT16 binds nucleosomal DNA and tethers H2A-H2B through its carboxy-terminal domain by a

116 e in ADP, we conclude that attachment of the tethered head is the rate-limiting transition in the KIF

117 above ground in Mali, using nets mounted on tethered helium-filled balloons.

118 litates a diverse array of high-value olefin-tethered heteroarenes in high yields (up to 87%).

119 s, the transformation of 2-pyrones bearing a tethered, homochiral alpha-amino acid started with the r

120 VPS41, a component of the endolysosomal tethering homotypic fusion and vacuole protein sorting (

121 mpare FtsZs to other bacterial proteins with tethered IDRs.

122 tacts, and to reconstitute OSBP-VAP ER-Golgi tethering implicated in phosphatidylinositol-4-phosphate

123 The absence of a tether in the acetal unit considerably outpaces any 1,5-

124 an older subjects, may be due to optic nerve tethering in adduction.

125 describe a new function for membrane-actin tethering in controlling where and when cells initiate n

126 This study demonstrates a membrane-tethering-independent role of E-Syts in activation of CR

127 suggest that EMC4 and EMC7 act as molecular tethers, inter-connecting two intracellular compartments

128 Tethered interactions between the endoplasmic reticulum

129 This manuscript illustrates that tethering is an effective approach for the stereoselecti

130 dditionally, expression of artificial PM-PER tethers is sufficient to restore retention in inp1Delta

131 binding domains of RHA that are necessary to tether JUND-NCBP1/NCBP3 to polysomes.

132 Here we show that the kinetics of tethered kinases follow a Michaelis-Menten-like dependen

133 LMNA encodes nuclear Lamin A/C that tethers lamina-associated domains (LADs) to the nuclear

134 One tether lead to a strikingly different adduct distributio

135 N,N'-bis(4-pyridylmethyl)-1,6-hexanediamine tether ligand, are compared to a previously reported Ru(

136 a gatekeeper for the interaction between the tethered ligand and LBS.

137 dicted an interaction between Gly48 from the tethered ligand and Thr153 from the LBS.

138 ls the receptor-activating motif, termed the tethered ligand that binds intramolecularly to the recep

139 s, we determined the molecular mechanism for tethered ligand-mediated PAR4 activation.

140 4 activation by both agonist peptide and the tethered ligand.

141 by proteolysis of the N terminus to expose a tethered ligand.

142 ation of synthetic peptides derived from the tethered-ligand sequence.

143 The distinct tethered ligands formed through cleavage of PAR1 by thro

144 Thus, a tether-like protein is required to facilitate detection

145 xist in cis orientations with respect to the tethering linkage.

146 The all-carbon tether linking the P1-P3 subsites of 21 is functionalize

147 changes in scattering properties of surface-tethered lipid vesicles, the data demonstrate stepwise v

148 This insight indicates that the ER membrane tethering machinery in plant cells could play a role wit

149 The methodology of the NanoBiT tethering may help to provide structural information of

150 ntified by cryo-EM a segment in CPSF100 that tethers mCF to mPSF, and we have named it the PSF intera

151 hese methods and results point to a scaffold tethering mechanism that allows IQGAP1 to help control t

152 sion are thought to occur sequentially, with tethering mediated by the exocyst and fusion driven by a

153 , one-pot, metal free, orthogonal strapping (tethering) mediated by the recursive anion(s) derived fr

154 HOPS thus tethers membranes and recognizes each SNARE, assembling

155 piRNAs are proposed to tether MIWI2 to nascent transposable element transcripts

156 synthetic glycocalyx to investigate membrane-tethered mucins in the context of IAV binding and fusion

157 The mechanism(s) by which cell-tethered mucins modulate infection by influenza A viruse

158 s to bind cells via the sialic acids of cell-tethered mucins.

159 We show first that a ribosome-tethered nanobody can be used to trap GFP in the cell bo

160 molecular architectonics of cyclic dipeptide tethered naphthalimides (CDP-NIs) to evaluate their AIEg

161 detect stalled ribosomes, ubiquitylate their tethered nascent chains, and deliver the ubiquitylated n

162 sequencing showed that ecDNAs preferentially tether near chromosome ends, where they re-integrate whe

163 sent contribution, we show that the covalent tethering of a perylene bisimide (PBI)-derived supramole

164 DamID works through the tethering of a protein of interest (POI) to the Escheric

165 ir nuclease MRE11A and inefficient lysosomal tethering of AMPK due to deficiency of N-myristoyltransf

166 we demonstrate that the cell cycle-dependent tethering of BbpA is partly dependent on a developmental

167 ESCRT machinery and explains how the dynamic tethering of chromosomes to the INM is linked to the est

168 Tethering of ICF4 mutations fails to induce macroH2A dep

169 Artificial tethering of INO80 to a LacO locus enabled turnover of R

170 enzymatic domain but also from the physical tethering of kinases to their substrates.

171 nsfer to mitochondria, which was mediated by tethering of mitochondria-lysosome contact sites.

172 We propose a model whereby tethering of MIWI2 to a nascent transposable element tra

173 AIS structure are required for transport and tethering of proteasomes in the AIS region.

174 ments occur between OM proteins and PG, with tethering of the beta-barrel OM protein BbpA becoming mo

175 ribosomal subunit that could be critical for tethering of the elongating mitoribosome onto the inner-

176 ng most abundant in the stationary phase and tethering of the lipoprotein LimB similar throughout the

177 pigenomic profiling method in which antibody tethering of Tn5 to a chromatin epitope of interest prof

178 The combination of a highly stereoselective tethered olefin metathesis reaction and a Julia-Kociensk

179 sembles into a ring of treadmilling membrane-tethered oligomers.

180 attached to BioPE-DOTAP binary lipid bilayer tethered on alkane thiol molecular cushions.

181 To explore the effect of tethering on suspension feeding, we use a low-Reynolds-n

182 By engineering functional nucleic acid tethers on the constituents and the triggering strands,

183 synthetic procedures to prepare the desired tether or mask.

184 actuation strategies rely on either slow or tethered or bulky actuators (or a combination).

185 ults suggest that other FGFs may be membrane tethered or multifunctional like Pyr.

186 single molecule studies have been reliant on tethering or confinement to achieve long duration and hi

187 Here, we describe Single MOLecule Tethering or SMOLT, an amplification-free and purificati

188 ects, without limitations set by fiber optic tethers or operational lifetimes constrained by traditio

189 CHC22 complexes with ERGIC tether p115, GLUT4, and sortilin, and downregulation of

190 However, when we use a Tethered Particle Motion (TPM) assay to measure the dyna

191 recently managed the parallelization of the Tethered Particle Motion (TPM), a single molecule techni

192 omyces cerevisiae Dmc1 using single-molecule tethered particle motion experiments and in vitro bioche

193 We employ a single-molecule method known as tethered particle motion to track the formation, lifetim

194 opals formed by the self-assembly of polymer-tethered particles.

195 protein signaling through the action of the tethered-peptide agonist stalk that is occluded within t

196 However, a major shortcoming of tethered photopharmacology is the inability to obtain op

197 s have spurred the development of covalently tethered photoswitchable ligands to control neuromodulat

198 structure reveals ppGpp binding to MglA-SspA tethers PigR to promoters.

199 t (CTA) enables the preparation of electrode-tethered poly(2-hydroxyethyl methacrylate) (pHEMA) brush

200 the T(1)-S(0) free energy gap of the olefin-tethered precursors and also to predict their reactiviti

201 EDGF) is a cellular factor that binds IN and tethers preintegration complexes to chromatin before int

202 n was achieved by the use of hairpin surface-tethered probes and the hybridization chain reaction was

203 olic stalk that interacts with a microtubule-tethering protein and may thus be involved in CesA local

204 ndoplasmic reticulum (ER)-lipid droplet (LD) tethering protein, as a factor required to maintain the

205 Results indicate that other tethering proteins are also important for defense.

206 The cyclopentadienyl ligand bears a tethered pyridine that binds to the metal center, result

207 kinetics can only partially predict rates of tethered reactions as product release may obscure the ra

208 in an Ir(eta(5):kappa(1)-C(5)Me(4)CH(2)pyN) tether-ring structure, as confirmed by the X-ray crystal

209 Last, we show that Y RNAs tether Ro60 to diverse effector proteins to generate spe

210 Studies in bacteria revealed that Y RNA tethers Ro60 to a ring-shaped exoribonuclease, forming a

211 performed in sensory areas of head-fixed or tethered rodents due to technical limitations of recordi

212 , but new interactions (tight attachment and tethered rotation) were also discovered for better inter

213 s favorable to be freely swimming instead of tethered since the resulting feeding flow past the cell

214 Here, we demonstrate that covalently tethered small molecule fragments can be used to stabili

215 requires Rab-family GTPases, their effector tethers, soluble N-ethylmaleimide-sensitive factor attac

216 ing that active transcription is required to tether SPEN to chromatin.

217 portant advancement in the application of 3D tethered spheroid models to high throughput drug screeni

218 ty and induction studies) of the polystyrene tethered spheroids reveal significant improvements over

219 Importantly, treatment of polystyrene tethered spheroids with vehicle and paradigm hepatotoxic

220 ICL repair requires unhooking of the tethered strands by either nuclease incision of the DNA

221 complex assembly is stabilized by a NanoBiT tethering strategy.

222 For the oxygen-tethered substrates, the reaction can proceed at room te

223 fered by Ribo-T, an engineered ribosome with tethered subunits which, while producing a desired prote

224 ) can be visualized by labeling COPI vesicle tethers such as Tip20.

225 ing between nearest neighboring units in the tethered superstructure is preserved at a temperature (3

226 Our tethering survey allows rapid assignment of the molecula

227 commonly accepted that the feeding flows of tethered suspension feeders are stronger than those of t

228 ic ribbons are macromolecular scaffolds that tether synaptic vesicles close to release sites in nonsp

229 essivity not solely by acting as a diffusive tether that maintains microtubule association, but rathe

230 that ankyrin is a long-sought intracellular tether that transmits force to TMC mechanotransduction c

231 cytoskeleton (LINC) complexes are molecular tethers that span the nuclear envelope (NE) and physical

232 uclear rim protein Amo1 has been proposed to tether the mating-type region and its boundaries to the

233 By tethering the cargo to the UBLs present on the forming a

234 ion, AKAP6 and AKAP9 form a protein platform tethering the Golgi to the nucleus.

235 d what role the linking domains play, or why tethering the MIDAS domain to the AAA ring is required f

236 Hence, tethering the MIDAS domain to the AAA ring serves to pre

237 t block DNA replication and transcription by tethering the opposing strands of DNA.

238 By mechanically tethering the plasma membrane to the cortex by enhancing

239 Tethering the SH3 domains of CD2AP or p110gamma to the m

240 The benefits of tethering the two functions of the catalyst are demonstr

241 It tethers the catalytic core to the flexibly attached C-te

242 onnections to the Tra1 module, whereas Sgf73 tethers the DUB module.

243 er, F-actin next to the plasma membrane also tethers the membrane and thus resists outgoing protrusio

244 In addition to functioning as a tether, the bacterial RNA gates access of substrates to

245 By tethering this photoswitch to a poly(ethylene glycol) st

246 ng migration and that some of these vesicles tether to and fuse with FA.

247 C. reinhardtii and C. elegans through a DNA tether to understand the molecular underpinnings of moto

248 consisting of a Trp-Trp (WW) domain flexibly tethered to a peptidyl-prolyl isomerase (PPIase) domain,

249 ent inhibitors, where two pharmacophores are tethered to a single DFOSq ligand, have better tumor upt

250 investigated when the reactive moieties are tethered to a surface.

251 methylate this residue on a nascent peptide tethered to a T domain on another module (in trans)?

252 the M domain methylate an amino acid residue tethered to a thiolation (T) domain on same NRPS module

253 trasound pulse to excite single microbubbles tethered to cell membranes, a transient pore on the cell

254 The unpaired chromosome remains tethered to centrosomes by lengthening kinetochore micro

255 vestigate the dynamics of the RBD when it is tethered to CRD that is anchored to a POPC:POPS model me

256 When SNAREs are free in solution or are tethered to distinct membranes, assembly requires cataly

257 us structural studies showed that Rad4, when tethered to DNA, could also open undamaged DNA, suggesti

258 We observed that a single CaM tethered to either the alpha or beta(2A) subunit tunes C

259 Eosinophils tethered to esophageal fibroblasts after LIGHT stimulati

260 age Reporters (RhoVR) that can be covalently tethered to genetically encoded, self-labeling enzymes.

261 bust intermolecular hydrogen bonding and are tethered to naphthalic anhydride with the ACQ (aggregati

262 Individual VP1 capsomers are tethered to one another by an extensive disulfide networ

263 bond strength of a Bronsted acidic anilinium tethered to one of the cyclopentadienyl rings.

264 sine triphosphate, or carboxyfluorescein are tethered to plasmon-resonant hollow gold nanoshells (HGN

265 saminoglycan located on the cell surface and tethered to proteoglycans such as syndecan-1.

266 When tethered to RNAs in heterologous expression systems, RDE

267 ons between E-cadherin extracellular domains tethered to supported lipid bilayers, were studied using

268 gest a difference in how chromatin loops are tethered to the chromosome axis, resulting in reduced cr

269 ion of their ethylene glycol chains that are tethered to the conjugated backbone.

270 The proximal and the distal Fabs are rigidly tethered to the Fc.

271 Varying the position at which profilin is tethered to the formin alters the elongation rate by mod

272 nsor consists of a polyethylene glycol chain tethered to the membrane surface.

273 face of gram-negative bacteria with proteins tethered to the outer membrane through a lipid anchor.

274 tron microscopy techniques and show they are tethered to the plasma membrane in a highly specialized

275 cristae and crista junctions in mitochondria tethered to the SSC in OHCs.

276 HIGH CHLOROPHYLL FLUORESCENCE244 (HCF244) is tethered to the thylakoid membrane by the OHP heterodime

277 conformations, as biosynthetic intermediates tethered to their acyl carrier proteins interact with mu

278 lone, but shows an increase in affinity when tethered to Ube2N in a disulfide-linked substrate that m

279 ablish the previously unknown interorganelle tethering to endocytic organelles as a universal solutio

280 How chromatin tethering to the INM is controlled in interphase and how

281 These conformations relied on tethering to the lamina to stretch the chromosome; detac

282 al PodJ plays an essential role in CC and LC tethering to the OP during early stages of polar growth.

283 gSpa2 interacts with FgMsb3, enabling FgMsb3 tethering to the polarisome.

284 ss-strain relationships by the physiological tethering to the surrounding cytoskeleton, extracellular

285 where components of different antibodies are tethered together to form novel amalgams, and characteri

286 The tethering together of sister chromatids by the cohesin c

287 PRi perturbation of these super-enhancers by tethering transcription repressors to enhancers signific

288 MRX is required to tether transcriptionally active loci to the nuclear pore

289 spatiotemporally regulate gene expression by tethering two chromosome loci together via functional do

290 et al., 2020 identify members of a membrane-tethered ubiquitin complex that attenuates Hedgehog sign

291 We exemplify the power of covalent tethering using the naturally occurring truncated varian

292 PvfB modification of PvfC-tethered valine was observed directly by protein NMR spe

293 cs of monomeric alpha-synuclein with surface-tethered vesicles composed of different negatively charg

294 oes not directly contact the membrane but is tethered via its C-terminal hypervariable region and car

295 dye-labeled lipids to the viral membrane, we tether virions to lipid-labeled target vesicles and use

296 If the olefin in the tether was trisubstituted (3'-methyl-2'-butenyloxy), no

297 ecular basis of cGAS inactivation by nuclear tethering, we determined the structure of mouse cGAS bou

298 COPI vesicles likely become tethered while they bud, thereby promoting efficient ret

299 , both TNF-alpha(+) and IL-2(+) vesicles can tether with endocytic organelles (lysosomes/late endosom

300 ts a model in which a single C-terminal tail tethers XLF to Ku, while allowing XLF to form interactio