ライフサイエンスコーパス: tetravalent

1 a nuclear waste repository render neptunium tetravalent.

2 er valence cation is divalent, trivalent, or tetravalent.

3 In a tetravalent A/C/Y/W-135-DT meningococcal conjugate vacci

4 This series of isolectins is tetravalent (A4), trivalent (A3B), divalent (A2B2), and

5 n vibrational bands are exceedingly rare for tetravalent actinide complexes and reflect the strong bo

6 ally characterized hexafluorido complex of a tetravalent actinide ion, the [UF(6) ](2-) anion, is rep

7 ar to the log Rd determined for the (solely) tetravalent actinide Th on calcite, suggesting reduction

8 Th(IV), as an analogue for Pu(IV) and other tetravalent actinides [An(IV)], in saturated columns pac

9 However, tetravalent actinides can also become mobile if they occ

10 esin (up to 330 mg of TEVA (abbreviation for tetravalent actinides)) through programmable beads trans

11 ty, and immunogenicity of a newly developed, tetravalent Ad26 vaccine with the previously tested triv

12 Homogeneous tetravalent AECs were successfully fabricated by fusing

13 The tetravalent, alpha-gal-binding Bandeiraea simplicifolia

14 2,6-(i)Pr(2))(2)) with NH(3) also afforded a tetravalent amide Ar'(2)Ge(H)NH(2) (3), whereas with H(2

15 However the tetravalent amido species Ar(2)Ge(H)NH(2) were obtained

16 ENV HR tetravalent vaccine (HR-Tet) showed a tetravalent anamnestic immune response in 100% (16/16) o

17 Streptavidin is tetravalent and the cross-linking of biotinylated target

18 nning a range of values for the ratio of the tetravalent and trivalent (RE) cation radii.

19 ue mainly to the natural substitution of the tetravalent and trivalent elements in the montmorillonit

20 Participants in tetravalent and trivalent groups were then further rando

21 nts were randomly assigned at a 2:1 ratio to tetravalent and trivalent groups.

22 we generated a novel, potently neutralizing, tetravalent, and bispecific antibody composed of 2 heavy

23 diameters were observed for large trivalent, tetravalent, and pentavalent counterions.

24 8)C(34) indicate the cerium in this phase is tetravalent, and the observed magnetic ordering at T(C)

25 We describe modular tetravalent antibodies that can recruit Frizzled and LRP

26 f TV005 dengue vaccine is safe and induces a tetravalent antibody response at an unprecedented freque

27 nnate immune cell engager, a first-in-class, tetravalent antibody, designed to create a bridge betwee

28 Expression of a tetravalent antigen fusion construct combining EDIII pol

29 d by the template into shaped NPs that mimic tetravalent atoms but on the length scale of colloids.

30 e stable, half-filled 5f(7) configuration of tetravalent berkelium.

31 Engineered anti-CD27 antibodies capable of tetravalent binding to CD27 and selective FcgammaRIIB as

32 hat enhanced efficacy was due to heterotypic tetravalent binding to two non-overlapping epitopes on S

33 ween anisotropic particles with well-defined tetravalent binding topology and isotropic particles.

34 y IGF-1R and ErbB3 ligands is blocked by the tetravalent bispecific antibody targeting IGF-1R and Erb

35 or molecular properties over two established tetravalent bispecific formats.

36 of ring aromaticity that would occur with a tetravalent boronate anion.

37 duction of an Fc domain-containing, IgG-like tetravalent BsAb, with two antigen-binding sites to each

38 resently licensed meningococcal vaccine is a tetravalent capsular polysaccharide vaccine that induces

39 (ITC) data for the binding of di-, tri-, and tetravalent carbohydrate analogues possessing terminal 3

40 revious report for binding of di-, tri-, and tetravalent carbohydrate analogues possessing terminal 3

41 dimer of cyanovirin-N that represents a new tetravalent carbohydrate binding protein that is stable

42 binding of a series of mono-, bi-, tri- and tetravalent carboxylate ligands to Ca(II) was examined b

43 t labeling efficiency and stability, whereas tetravalent cation (89)Zr(4+) could not label LDH since

44 In such applications the host tetravalent cation is often partially substituted by tri

45 h an increasing energetic preference for the tetravalent cations to have higher oxygen coordination.

46 The presence of both tri- and tetravalent Ce, contrary to formulation, was confirmed u

47 Besides, tetravalent cerium [Ce(iv)] has been proven to be capabl

48 ort the synthesis and isolation of the first tetravalent cerium alkyl and benzyl complexes supported

49 Here we report tetravalent cerium, uranium and thorium bis(carbene) com

50 cetic acid (NTA) group, a group that forms a tetravalent chelate with Ni(II), and a second thiol that

51 AFM13 is a bispecific, tetravalent chimeric antibody construct (TandAb) designe

52 to differentiate antibodies elicited by the tetravalent chimeric yellow fever-17D/dengue vaccine or

53 Brain lesions produced by the tetravalent ChimeriVax-DEN vaccine were significantly le

54 An investigational tetravalent combined measles, mumps, rubella, and varice

55 The significant stability of the tetravalent complex enables its thorough characterizatio

56 Despite the tetravalent composition of the vaccine, we observed a ne

57 scopy, and HPLC studies showed that they are tetravalent, configurationally stable B-chiral acylboron

58 h an improved biological half-life makes the tetravalent construct an important reagent for cancer th

59 The in vitro binding properties of the tetravalent construct were analyzed by solid-phase RIA a

60 n NuMA that would convert a NuMA dimer to a "tetravalent" crosslinker of MTs.

61 e both DEN1 and DEN4 viruses suggests that a tetravalent DEN vaccine could be generated by introducti

62 Homogenous di- and tetravalent dendrimers incorporating the alpha7-nicotini

63 rior infection with DENV or vaccination with tetravalent dengue attenuated vaccines (TDLAV) recognize

64 injections of recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TDV) or placebo at month

65 imeric yellow fever-dengue, live-attenuated, tetravalent dengue vaccine (CYD-TDV) that is currently a

66 jections of a recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TDV), or placebo, at mon

67 effects of the Chimeric Yellow Fever Derived Tetravalent Dengue Vaccine (CYD-TDV, Dengvaxia) when adm

68 ety, and immunogenicity of a live attenuated tetravalent dengue vaccine (TAK-003) in healthy children

69 afety of three different dose schedules of a tetravalent dengue vaccine (TAK-003) over a 48-month per

70 Sanofi Pasteur has developed a tetravalent dengue vaccine (TDV) against the world's mos

71 previously vaccinated with a live attenuated tetravalent dengue vaccine (TDV) and 4 DENV-naive contro

72 We are developing a live-attenuated tetravalent dengue vaccine (TDV) candidate based on an a

73 fety and immunogenicity of a live attenuated tetravalent dengue vaccine (TV003), compared with those

74 th development and licensure of an effective tetravalent dengue vaccine a public health priority.

75 We developed a novel tetravalent dengue vaccine by using virus-like particles

76 To address this, we developed a novel tetravalent dengue vaccine by utilizing virus-like parti

77 to assess avidity of antibody responses to a tetravalent dengue vaccine candidate (TAK-003) in childr

78 g-term safety and immunogenicity of Takeda's tetravalent dengue vaccine candidate (TAK-003) in health

79 of an ongoing phase 3 randomized trial of a tetravalent dengue vaccine candidate (TAK-003) in region

80 2 clinical trial of Takeda's live-attenuated tetravalent dengue vaccine candidate (TAK-003).

81 high dose) of a live attenuated recombinant tetravalent dengue vaccine candidate (TDV) given in 2 do

82 nogenicity of a live attenuated, recombinant tetravalent dengue vaccine candidate (TDV) were evaluate

83 preplanned interim analyses at 6 months of a tetravalent dengue vaccine candidate (TDV), which is com

84 vaccinated by intramuscular inoculation of a tetravalent dengue vaccine formulated by combining the t

85 These results demonstrate that the tetravalent dengue vaccine formulation provides signific

86 omising vaccine candidate for inclusion in a tetravalent dengue vaccine formulation.

87 In a phase 3 efficacy trial of a tetravalent dengue vaccine in five Latin American countr

88 A safe, effective tetravalent dengue vaccine is a global health priority.

89 A candidate tetravalent dengue vaccine is being assessed in three cl

90 A strategy for the development of a tetravalent dengue vaccine is discussed.

91 This is the first recombinant tetravalent dengue vaccine successfully evaluated in non

92 unmet clinical need remains for an effective tetravalent dengue vaccine suitable for all age groups,

93 lity of a single dose of the live attenuated tetravalent dengue vaccine TV003 to induce a suitable ne

94 DENV) in two pivotal phase III trials of the tetravalent dengue vaccine, CYD-TDV, and thereby enabled

95 CYD-TDV, a live, attenuated, tetravalent dengue vaccine, has been approved for the pr

96 f a human subject who received an attenuated tetravalent dengue vaccine.

97 tions for the development of live attenuated tetravalent dengue vaccines.

98 ts of a recent phase IIb clinical trial of a tetravalent dengue virus (DENV) vaccine suggest that NAb

99 across multiple species, reveal a promising tetravalent Dengue virus sub-unit vaccine candidate.

100 Unlike live vaccines, tetravalent DENV envelope (E) protein subunit vaccines a

101 the protective efficacy of a live attenuated tetravalent DENV vaccine (TDV) candidate against parente

102 to control this threat to global health is a tetravalent DENV vaccine.

103 For the greatest safety and efficacy, tetravalent DENV vaccines are designed to stimulate bala

104 table tolerability and immunogenicity of the tetravalent DENVax formulations in healthy, flavivirus-n

105 d to assess the safety and immunogenicity of tetravalent DENVax formulations.

106 The tetravalent DENVax vaccine contains a molecularly charac

107 Divalent and tetravalent displays of M2pep ([M2pep]2-Biotin and [M2pe

108 cells (PBMCs) from donors vaccinated with a tetravalent DLAV vaccine (TV005) with pools of dengue vi

109 Exothermic solution energies calculated for tetravalent dopants (Ge(4+) and Si(4+)) on the Ti site s

110 Tetravalent dopants were considered on both V and P site

111 INTERPRETATION: This tetravalent E coli bioconjugate vaccine candidate was we

112 Fourth, a tetravalent E85-VRP dengue vaccine induced a simultaneou

113 ering, and characterization of a bispecific, tetravalent endoplasmic reticulum (ER)-targeted intradia

114 man IgG Ab forms including tetravalent IgG1, tetravalent F(ab')2, and linear Fab multimers with eithe

115 Here, we developed a tetravalent FGFR3xFGFR3 bispecific antibody that inhibit

116 f Uranyl (U(VI)) to the relatively insoluble tetravalent form (U(IV)) by S. alga strain (BR-Y) were s

117 virus vaccine candidates were compared to a tetravalent formulation of wild-type DEN viruses (T-wt)

118 ining VLPs either as monovalent, bivalent or tetravalent formulation resulted in generation of high l

119 of these chimeric viruses (as monovalent or tetravalent formulation) developed viremia with magnitud

120 ty and protective efficacy of four different tetravalent formulations were evaluated in cynomolgus mo

121 In tetravalent formulations, DENV-1 and DENV-2 antagonized

122 Two tetravalent formulations, TV-2 and TV-3, possess propert

123 unologically dominant in both monovalent and tetravalent formulations.

124 erference did not occur in recipients of the tetravalent formulations.

125 heral blood mononuclear cells [PBMCs] in the tetravalent group and median 282 SFU/10(6) PBMCs in the

126 ine (10 413 EU/mL, 95% CI 7284-14 886 in the tetravalent group compared with 5494 EU/mL, 3759-8029 in

127 eived the first vaccination: 110 were in the tetravalent group, 55 in the trivalent group, and 33 in

128 We recently synthesized a tetravalent guanylhydrazone compound (CNI-1493) that inh

129 ctivation that prevents TNF production, this tetravalent guanylhydrazone could be useful in the devel

130 ry for macrophages to respond to CNI-1493, a tetravalent guanylhydrazone inhibitor of p38 mitogen-act

131 rve firing is also stimulated by CNI-1493, a tetravalent guanylhydrazone molecule that inhibits syste

132 CNI-1493, a tetravalent guanylhydrazone, is an inhibitor of macropha

133 Semapimod, a tetravalent guanylhydrazone, suppresses inflammatory cyt

134 otype-specific antigens in a live attenuated tetravalent human vaccine.

135 We have developed a tetravalent human-bovine rotavirus (UK) reassortant vacc

136 Ar'(2)Ge(H)NH(2) (3), whereas with H(2) the tetravalent hydride Ar'GeH(3) (4) was obtained with Ar'H

137 cribe the production and characterization of tetravalent IgG-like BsAbs that combine the activities o

138 of multivalent human IgG Ab forms including tetravalent IgG1, tetravalent F(ab')2, and linear Fab mu

139 d a novel generic platform for production of tetravalent IgG1-like chimeric bispecific Abs.

140 nerally applicable model of a dual-specific, tetravalent immunoglobulin G (IgG)-like molecule--termed

141 Finland now recommends LAIV4 and injectable, tetravalent inactivated influenza vaccines replacing IIV

142 fering can be significantly improved using a tetravalent instead of a divalent molecule, since the te

143 to the stability of polynuclear complexes of tetravalent ions.

144 tical work was carried out for trivalent and tetravalent ions.

145 e potentially technologically transformative tetravalent ions.

146 nd physical properties of two new quaternary tetravalent iridates, MLa10Ir4O24 (M = Sr, Ba).

147 ield splitting, demonstrating that magnetic, tetravalent lanthanide ions engage in covalent metal-lig

148 has significant implications for the use of tetravalent lanthanide ions in magnetic applications sin

149 rol elements for further extending the known tetravalent lanthanide ions in molecular complexes.

150 Among the tetravalent lanthanide ions, only Ce(4+) forms stable co

151 4 different admixtures of a live attenuated tetravalent (LATV) dengue vaccine were evaluated in 113

152 In both systems, the predominantly tetravalent lead (PbO(2)) scales destabilized as a resul

153 n inhibitor in controlling lead release from tetravalent lead corrosion product PbO(2) in chloraminat

154 A tetravalent lead ZD-4, which was developed from an antit

155 -dimensional, cross-linked lattice between a tetravalent lectin and a bivalent carbohydrate.

156 ystallographic results showing that a single tetravalent lectin forms distinct cross-linked complexes

157 Immobilization of cortical movement with tetravalent lectins produces similar spindle defects to

158 JBalphaMan, which is outstanding for just a tetravalent ligand.

159 the nonspecific binding to DNA of all these tetravalent ligands is driven primarily by coulombic int

160 The final mono-, di-, and tetravalent ligands were resistant to enzymatic hydrolis

161 study the CD4 T cell responses elicited by a tetravalent live attenuated dengue vaccine and show that

162 udy participants receiving the monovalent or tetravalent live attenuated DENV vaccine (DLAV), develop

163 Current tetravalent live-attenuated DENV vaccines have faced cha

164 influenza vaccines (IIV3) and a nasal spray, tetravalent live-attenuated influenza vaccine (LAIV4) we

165 The leading DENV vaccines are based on tetravalent live-attenuated virus platforms.

166 ize interactions between DENV serotypes in a tetravalent live-attenuated virus vaccine candidate, we

167 Tetravalent (LLP2A-DOTA)(4)-PEG(10,000) (1.1 nM) had tum

168 Surprisingly, both divalent and tetravalent M2pep, without conjugation of any cytotoxic

169 -dimensional tetrahedral networks built from tetravalent (M4+ = Ge4+ or Sn4+, where M = meta) and tri

170 dentified as a manganese feroxyhyte in which tetravalent manganese is homogeneously distributed into

171 ormation of H-type dye aggregates within the tetravalent MAP system.

172 In 2005, a new meningococcal vaccine, tetravalent meningococcal conjugate vaccine (MCV4) was a

173 vention released guidelines for the use of a tetravalent meningococcal conjugate vaccine in adolescen

174 rene sulfonate) brush molecules and cationic tetravalent meso-tetrakis(4-N-methyl-pyridinium)porphyri

175 hrough self-assembly reactions with tri- and tetravalent metal ions such as Ga(III), Fe(III), Ti(IV)

176 valent metals (lanthanum and gadolinium) and tetravalent metals (tin and zirconium) but not divalent

177 cs and plateau level of GDS aggregation by a tetravalent model lectin: the leguminous agglutinin Con

178 nt instead of a divalent molecule, since the tetravalent molecule can form two intramolecular rings w

179 to the development of synthetic bivalent and tetravalent nAbs against SARS-CoV-2.

180 Bivalent and tetravalent nAbs can be produced at large-scale and are

181 of Ag29(BDT)12(TPP)4, an atomically precise tetravalent nanocluster (NC) (BDT, 1,3-benzenedithiol; T

182 interaction and enhances the ionicity of the tetravalent Nb with unpaired electrons, yielding ferroma

183 Reduction to tetravalent neptunium (Np(IV)) effectively immobilizes t

184 Eliciting a protective tetravalent neutralizing antibody response is a major go

185 Although a small number of tetravalent NiX(4) complexes have been crystallographica

186 e-containing host rocks (7-8), confirmed the tetravalent Np oxidation state.

187 nsed structures form in the simulations with tetravalent or trivalent counterions.

188 24, vaccine groups received a third dose of tetravalent or trivalent together with clade C gp140, an

189 ular hydroamination/cyclization catalyzed by tetravalent organoactinide and organozirconium complexes

190 paradigm breaks down for praseodymium in the tetravalent oxidation state.

191 rsible redox chemistry between trivalent and tetravalent oxidation states.

192 Furthermore, we engineered a tetravalent palivizumab variant (P(scFv)P(IgG2)) capable

193 conjugate addition between thiol-terminated tetravalent PEG and multivalent ONDs yielded self-suppor

194 The tetravalent platinum stiboranyl complex [(o-(Ph2P)C6H4)2

195 2Poly(dT) triplex DNA in the presence of the tetravalent polyamine spermine using a centrifugation as

196 at 12 months they received MenACWY, a plain tetravalent polysaccharide vaccine, or no vaccine.

197 monovalent and divalent CD4-based proteins, tetravalent PRO 542 potently neutralizes diverse primary

198 6-Me(3))(2)) with H(2) or NH(3) afforded the tetravalent products Ar(#)(2)GeH(2) (1) or Ar(#)(2)Ge(H)

199 ox equilibrium, and the strong proclivity of tetravalent Pu to hydrolyze and form polymeric species.

200 es, the potency and activity spectrum of the tetravalent R4 dendrimer are comparable to protegrins an

201 A single dose of TV005 elicited a tetravalent response in 90% of vaccinees by 3 months aft

202 who had intussusception after receiving the tetravalent rhesus-human reassortant rotavirus vaccine (

203 The association between the tetravalent rhesus-human reassortant rotavirus vaccine a

204 st licensed rotavirus vaccine, a reassortant-tetravalent, rhesus-based rotavirus vaccine (RRV-TV), le

205 in licensure of the first live oral vaccine, tetravalent, rhesus-based rotavirus vaccine (RRV-TV), wh

206 combined peptide-modified, multiply-labelled tetravalent RNA imaging probes (MTRIPs), targeted to seq

207 e sensitivity, we developed multiply labeled tetravalent RNA imaging probes (MTRIPs).

208 ussusception after vaccination with the live tetravalent rotavirus vaccine RotaShield resulted in vol

209 us vaccine (OPV) and monovalent (RRV-S1) and tetravalent (RRV-TV) rhesus-human rotavirus vaccines was

210 rotavirus vaccine (rhesus rotavirus vaccine-tetravalent (RRV-TV)) to prevent rotavirus-related hospi

211 idin (SA)-AR-modified CEM cells captured the tetravalent SA with one biotin binding site.

212 rationalize the results obtained on regular (tetravalent) SAv.

213 Divalent (sc(Fv)(2)) and tetravalent ([sc(Fv)(2)](2)) scFv's of mAb CC49 were eva

214 Soluble tetravalent selenite is the predominant environmental fo

215 Immunization with a meningococcal tetravalent (serogroup ACWY) glycoconjugate vaccine is r

216 18-55 years old, were immunized once with a tetravalent (serogroups A, C, Y, and W-135) meningococca

217 165-290), and 46 (26-82) against DENV 4; and tetravalent seropositivity rate was 89% (79-96), 86% (80

218 ional radioimmunotherapy using a recombinant tetravalent single-chain Ab-streptavidin (SA) fusion pro

219 present study, we report the generation of a tetravalent single-chain Fv [[sc(Fv)2]2] of the murine M

220 tumor-targeting ability of an antimesothelin tetravalent single-chain Fv-streptavidin fusion protein

221 We have engineered a tetravalent singlechain 1F5 (scFv)4SA fusion protein and

222 y assemble above a critical concentration of tetravalent spermine and are stable over long times at r

223 valent spermidine, Triquat A, and Triquat 7; tetravalent spermine and Quatro-quat; and hexavalent Qua

224 ThO2, in which thorium is stable only in a tetravalent state, exhibits damage accumulation processe

225 onmental contaminant that accumulates in the tetravalent state, U(IV), in anoxic sediments, such as o

226 Biotinylated IGF-1 was complexed with tetravalent streptavidin and then bound to biotinylated

227 s- and trans-divalent streptavidins retained tetravalent streptavidin's high thermostability and low

228 building blocks to form paucivalent (di- to tetravalent) structures of controlled scaffold architect

229 observed for the binding of mono-, di-, and tetravalent sugars, respectively, to the two lectins.

230 Each Au(11) unit can be viewed as a tetravalent superatom forming four delocalized Au-H-Au b

231 tional data for the divalent, trivalent, and tetravalent systems, including their (15)N enriched isot

232 zation of an S(4) symmetric, four-coordinate tetravalent terbium complex, [Tb(NP(1,2-bis-(t)Bu-diamid

233 gand bonds sufficiently covalent so that the tetravalent terbium ion is stable and accessible via a m

234 atic stabilizing role is established for the tetravalent thorium and uranium ions in these systems.

235 ies established the presence of divalent and tetravalent tin centers in 16.

236 nt' magnetoelectric cross-field control in a tetravalent titanate film.

237 ted in the context of recent studies on both tetravalent transition metal and actinide hexahalides, M

238 onic acids behaves as a Lewis acid to form a tetravalent trihydroxyborate conjugate base, it has been

239 For example, DeltaH of a tetravalent trimannoside analog is nearly four times gre

240 plots for the binding of the di-, tri-, and tetravalent trimannoside analogues to both lectins are c

241 ogenic ligands may mobilize uranium (U) from tetravalent U (U(IV)) phases in the subsurface, especial

242 alluvial sediments, where it accumulates as tetravalent U [U(IV)], a form once considered largely im

243 Tetravalent U was interpreted as occurring within the co

244 anic-rich, reduced sediments that accumulate tetravalent U, U(IV).

245 rface of magnetite and is further reduced to tetravalent UO(2) as nanocrystals (~1-2 nm) with random

246 f hexavalent uranium (U(VI)) to less soluble tetravalent uranium (U(IV)) through enzymatic or abiotic

247 at 23 degrees C, which is consistent with a tetravalent uranium 5f(2) electronic configuration.

248 e reduction of soluble hexavalent uranium to tetravalent uranium can be catalyzed by bacteria and min

249 the first example observed at a homoleptic, tetravalent uranium complex.

250 pe zinc ore deposit indicate substitution of tetravalent uranium for divalent calcium.

251 Thus, tetravalent uranium has a stable location in calcite dep

252 of iron sulfide minerals in the stability of tetravalent uranium in the presence of oxygen in a field

253 eduction of U(VI) by the pili to mononuclear tetravalent uranium U(IV) complexed by carbon-containing

254 ra for ketimido (azavinylidene) complexes of tetravalent uranium, (C(5)Me(5))(2)U[-N=C(Ph)(R)](2) (R

255 lent vaccination, T cell responses following tetravalent vaccination were, dramatically, focused towa

256 , participants received a first injection of tetravalent vaccine (Ad26.Mos4.HIV or placebo) or trival

257 A leading tetravalent vaccine (Dengvaxia) stimulated NAbs to the 4

258 Additionally, the DENV HR tetravalent vaccine (HR-Tet) showed a tetravalent anamne

259 t dose of rhesus-human reassortant rotavirus tetravalent vaccine (RRV-TV) has been studied extensivel

260 al rhesus/rhesus-human reassortant rotavirus tetravalent vaccine (RRV-TV) was licensed in 1998 but wi

261 Three tetravalent vaccine (TV) formulations of previously desc

262 estigational, single-dose, live, attenuated, tetravalent vaccine against dengue disease, but data on

263 be the promising development of an effective tetravalent vaccine against the prevalent flavivirus.IMP

264 V and was immunized with the live attenuated tetravalent vaccine Butantan-DV, developed by the NIH an

265 NV-seropositive volunteer immunized with the tetravalent vaccine Butantan-DV, which is currently in p

266 In this article, we describe a new tetravalent vaccine candidate based on recombinant dengu

267 Current tetravalent vaccine candidates that are in the final sta

268 Regimens that use this tetravalent vaccine component are being advanced into fi

269 Chinchillas were given tetravalent vaccine composed of pneumococcal capsular po

270 Our tetravalent vaccine elicited potent neutralizing antibod

271 erotypes were combined in 16 live-attenuated tetravalent vaccine formulations (N = 64) and administer

272 Dengvaxia, a live-virus tetravalent vaccine from Sanofi Pasteur, was recently ap

273 strate the safety of a recombinant DEN virus tetravalent vaccine in a formal neurovirulence test, as

274 chimeric yellow fever-dengue live-attenuated tetravalent vaccine is now being marketed.

275 ates, and serum from humans immunized with a tetravalent vaccine neutralize DENV-4 and DKE-121 infect

276 The tetravalent vaccine regimen was generally safe, well-tol

277 the serotype G1 monovalent or serotype G1-G4 tetravalent vaccine seroconverted for at least one of th

278 tion, with higher total IgG titres after the tetravalent vaccine than after the trivalent vaccine (10

279 medical need remains for an effective dengue tetravalent vaccine that can be administered irrespectiv

280 For this reason, the development of a safe, tetravalent vaccine to produce a balanced immune respons

281 The safety of a tetravalent vaccine was determined and compared to that

282 ine (TV003), compared with those of a second tetravalent vaccine with an enhanced DENV-2 component (T

283 For use as a tetravalent vaccine, DENV1-4 VLPs elicited high levels o

284 r immune responses were also higher with the tetravalent vaccine, including the magnitude and breadth

285 phase 3, Takeda's TAK-003, a chimeric DENV 2 tetravalent vaccine, protected against DENV 2 but was le

286 assortants with G8 and G9 specificity to the tetravalent vaccine, thereby formulating a "designed" he

287 ions to reduce capillary leakage, and a safe tetravalent vaccine.

288 the chances that one or more live attenuated tetravalent vaccines (LATVs) will be introduced worldwid

289 ity may limit the efficacy of MAb therapy or tetravalent vaccines against DENV, as neutralization pot

290 Nonetheless, it is still unclear if tetravalent vaccines can elicit or recall nAbs.

291 Current dengue tetravalent vaccines contain four live attenuated seroty

292 Furthermore, a tetravalent version of this molecule bound specifically

293 Two tetravalent virus formulations, comprised of either PDK5

294 Interestingly, the potential tetravalent VLP vaccine candidate provided strong neutra

295 These experiments revealed Pu to be tetravalent, while the strong pre-edge absorption from t

296 h was comparable to antibodies elicited by a tetravalent wild-type E SVP vaccination mixture.

297 When monkeys were boosted with a tetravalent YF/DEN1-4 dose 6 months later, four of nine

298 une and nonimmune monkeys which received the tetravalent YF/DEN1-4 vaccine or between tetravalent YF/

299 ccine and six of six monkeys inoculated with tetravalent YF/DEN1-4 vaccine seroconverted after a sing

300 the tetravalent YF/DEN1-4 vaccine or between tetravalent YF/DEN1-4-immune and nonimmune monkeys which