ライフサイエンスコーパス: the formation of

1 rium, and manganese were found to facilitate the formation of 1,4-dihydro-pyrrolo[3,2-b]pyrroles from

2 dol/hemiketalization/retro-aldol cascade for the formation of 3-acetoxyindanones possessing two conti

3 The formation of 3-methyl-2,4-nonanedione (MND) during r

4 fructofuranosyl cation contributed mostly to the formation of 5-hydroxymethylfurfural which was found

5 of microbial dormancy and resting stages in the formation of a "buffer" against elevated temperature

6 flow through their collar filter, thanks to the formation of a 'hydrodynamic gasket' above the colla

7 of the natural substrate lipid-II results in the formation of a 1:1 protein-lipid complex, where the

8 Here we demonstrate the formation of a boron-carbon bond between these subst

9 appears to dimerize and reductively mediate the formation of a bridging [4Fe-4S] cluster, aided by f

10 This results in the formation of a catalytic bimetallic site for the hyd

11 Upon hole doping, we observe the formation of a coherent, two-band Fermi surface, con

12 by means of helium-ion irradiation, enabling the formation of a completely amorphous region of well-d

13 es hydrolyze beta-lactam antibiotics through the formation of a covalent acyl-enzyme intermediate fol

14 l, and the slow step in the current block is the formation of a Cu-histidine coordination complex.

15 these factors directly and indirectly impact the formation of a diverse microbiota, which includes ba

16 mutation causes migraine because it leads to the formation of a dominant negative truncated TRESK fra

17 8-ring enhances the diffusion process due to the formation of a favorable pai-complex host-guest inte

18 Lead-tin gradient alloying allows the formation of a graded electronic bandgap, which incr

19 repertoire of presented peptide epitopes and the formation of a hierarchical immune response.

20 ation of membrane protrusions, and ends with the formation of a highly constricted Did2-Ist1 co-polym

21 Unexpectedly, our data support the formation of a ketoimine rather than an alpha,beta-d

22 previous one, and specifically, resulting in the formation of a known product, confirmed to be the Vi

23 promote the swelling of algae cell wall and the formation of a large oil - ethanol interphase area d

24 The cavity size of the macrocycle prevents the formation of a linear Fe-N(2)-Fe unit and leads to o

25 FT calculations, our strategy capitalizes on the formation of a metal-carbene bond which induces an a

26 cancer cell clusters was observed following the formation of a mosaic vessel.

27 This is due to the formation of a neuroinhibitory microenvironment at i

28 We find that initial association results in the formation of a non-native intermediate, separated by

29 However, their role in the formation of a permissive metastatic niche is unreso

30 We report the formation of a previously unknown intermediate in th

31 8-h]quinoline (17) as precursors has granted the formation of a range of substituted quinolinoquinoli

32 tions predisposes the copper active site for the formation of a stable Cu-O(2) intermediate.

33 However, this does not lead to the formation of a stable functional complex between the

34 e structural genomic innovations involved in the formation of a supergene controlling a complex socia

35 some-mediated degradation by PROTAC requires the formation of a ternary (three-component) complex, co

36 The formation of a tetramer was further studied by cross

37 nature: protonation with [LutH]I results in the formation of a Ti-formamidinate (4), while oxidation

38 se observations reveal that RNase L promotes the formation of a unique RNP complex that may have role

39 est the paleoenvironmental models describing the formation of a wide range of mudstones and elucidate

40 g of bread for 2.5 min considerably enhanced the formation of acrylamide and 3-MCPD esters.

41 ion binding impaired catalytic activity and the formation of active hexamers.

42 ned aldehyde and hydroxyl end groups lead to the formation of Ag nanocubes and nanowires respectively

43 than 50 kcal mol(-1), while the barriers for the formation of alkoxyl radicals are as low as 13 kcal

44 revealing that the lower energy barrier for the formation of alpha-lapachone is a result of lower Pa

45 However, tau knockout could modestly promote the formation of alpha-syn aggregates, accelerate the se

46 PLA2G1B) as the key molecule responsible for the formation of aMMDs.

47 ydrogen, and triphenylborane is suggested by the formation of ammonia-triphenylborane.

48 There, CRE reacts with the enzyme, and the formation of ammonium is dynamically monitored by po

49 IFITM3 reduces gamma-secretase activity and the formation of amyloid plaques in a transgenic mouse m

50 ocarboxylate transporters (MCTs), supporting the formation of an acidic microenvironment.

51 iers to engage chromatin, thereby initiating the formation of an activating or repressive regulatory

52 Instead, Lis1 promotes the formation of an active complex with dynactin.

53 ed as a signaling cascade that culminates in the formation of an autophagosome that degrades cellular

54 tramolecular aldol condensation and leads to the formation of an azatetraquinane scaffold.

55 tly impacts the traditional understanding of the formation of an electric double layer (EDL) at a liq

56 rmines the handedness of the host leading to the formation of an enantiopure cage is noteworthy.

57 se induced by chemotherapies, contributes to the formation of an immunosuppressive tumor microenviron

58 gh weak H-bonding interactions to facilitate the formation of an organogel.

59 and unconventionally uses an Arg residue in the formation of an oxyanion hole.

60 ar resistance and low friction are linked to the formation of an ultra-nanocrystalline near-surface l

61 hibits a pronounced preference for, promotes the formation of, and stabilizes ordered membrane domain

62 ases, but repeated administration can induce the formation of anti-drug antibodies.

63 The formation of any lateral shoots at the grafted sites

64 ent binding of As to organic carbon (C), but the formation of aqueous As-S species, so-called thioars

65 The formation of ARM inhibits PSD-LTM but the underlying

66 tecting groups, t-Bu, Boc, Trt, and Pbf, and the formation of aspartimide as an undesirable side reac

67 mpartments by nutrient depletion and reduced the formation of ATG16L1 membrane puncta.

68 Because the formation of binary copper selenide impurities seeme

69 n appears to either underly or contribute to the formation of biomolecular condensates.

70 of cells that can become adipocytes controls the formation of blood vessels in the bone marrow, and a

71 We present a model that accounts for the formation of both planar and nonplanar leaves throug

72 We find that the formation of branched morphologies relies strongly o

73 changes of calcium phosphate (CP) leading to the formation of brushite, monetite and hydroxyapatite.

74 rmation could aid in risk stratification for the formation of BTAs in high-risk patients.

75 S(2) platforms provided a novel template for the formation of C(60) nanosheets (NSs) within a very na

76 two decades as a straightforward method for the formation of C(sp(3))-C(sp(2)) bonds.

77 III) or Pd(IV) intermediates, which promotes the formation of C-O bonds.

78 (MICP) in which microbial activity leads to the formation of calcium carbonate precipitates.

79 The lack of an effect of ligands, the formation of carbon-centered radicals with long life

80 inked MOFs have lower activation energies in the formation of carboxyl intermediate, in line with the

81 we identified CAMSAP3 as being important for the formation of central MT pairs, proper orientation of

82 challenge with 2D semiconductors is to avoid the formation of charge scattering and trap sites from a

83 Our data suggest that CTCF enables the formation of chromatin loops by protecting cohesin a

84 anones was proven to be highly selective for the formation of cis alcohol (>90%), irrespective of the

85 pes (Tween 80, BSA and quillaja saponins) on the formation of clove oil nanoemulsion, the mitigation

86 eralization of BM-MSC cells, demonstrated by the formation of clusters around the cells.

87 acyl-activating enzymes (AAEs) that catalyze the formation of CoA esters of different organic acids r

88 Here, we present the first evidence of the formation of coffinite on the surface of UO(2) at th

89 iac myocyte Ca(2+) and Na(+) regulation from the formation of compensated hypertrophy (CH) until sign

90 t CCDC92 can inhibit viral transcription and the formation of complete virions via an interaction wit

91 The key ideas of our method are the formation of compressed zones and junctional spaces-

92 Through the formation of concentration gradients, morphogens dri

93 Ag transfer required cell-cell contact and the formation of connexin 43-containing gap junctions be

94 The molecular mechanisms underlying the formation of coronary arteries during development an

95 The formation of corticospinal (CS) circuits, which are

96 ted a much higher reactivity than Cr(III) in the formation of Cr(VI) by chlorine.

97 idated at a protonic bioenergetics level: 1) The formation of cristae creates more mitochondrial inne

98 ar proteins plays a vital role in catalyzing the formation of cross-links in fibrillar elastin and co

99 minus of Abeta as a region that may initiate the formation of damaging oligomeric species.

100 al reason to doubt that the peculiarities of the formation of DB anions of XS(-) can also be characte

101 rtant role in MS-associated inflammation and the formation of demyelinating lesions.

102 teresting and everyday natural phenomenon is the formation of different patterns after the evaporatio

103 that Hoxa13 acts hierarchically to initiate the formation of digit 1 by reducing Gli3 transcription

104 The formation of diketopiperazinoindolines proceeds via

105 The formation of dimers due to hydrogen bonding and disp

106 ome instabilities that lead in particular to the formation of dimers, trimers, and similar clusters i

107 The barriers for the formation of dioxetane derivatives are computed to b

108 The formation of dislocations, which severely degrade el

109 osition of the resulting CO directly affects the formation of distinct chromosome subdomains during m

110 Meiotic recombination starts with the formation of DNA double-strand breaks (DSBs) at spec

111 , the pseudoautosomal region (PAR), in which the formation of double-strand breaks (DSBs), pairing an

112 metallic phase of intrinsic VO(2) results in the formation of e(-) and h(+) pairs that lead to deloca

113 , rapamycin attenuated PEC proliferation and the formation of early FSGS lesions in experimental FSGS

114 he droplets, while simultaneously preventing the formation of electrolytic byproducts.

115 in the parasite invasion by participating in the formation of electron-dense band at the base of the

116 This study focuses on the formation of electrophilic ring cleavage products-a

117 n proceeds under mild conditions, leading to the formation of enantioenriched quaternary centers.

118 hazardous and greener alkylating agents with the formation of environmentally benign water as a bypro

119 ten occupies the central role in accounts of the formation of essentialist interpretations-especially

120 The formation of ester was confirmed by (1)HNMR, FTIR an

121 This includes the formation of fear memories when the anticipation of

122 signal for plasticity, thereby facilitating the formation of fear memories.

123 Here, we study the formation of fibrils and oligomers by exon 1 of hunt

124 pecific amygdala signals are integrated into the formation of food choices.

125 high viability, neural differentiation, and the formation of functional, stimulus-responsive neural

126 y 3 h of UV-C irradiation was able to reduce the formation of fungal colonies.

127 In several cases, we observed the formation of fused-TADs promoting ectopic enhancer-p

128 druplexes with high selectivity, and induced the formation of G-quadruplex DNA along with the related

129 n the precursor solution are responsible for the formation of gap states.

130 t feature of microstructural modification is the formation of gas bubbles, which is revealed at all s

131 This clustering results in the formation of gel-like or even crystal-like structure

132 tage in the oxygen evolution reaction (OER), the formation of H(2) nanobubbles requires a significant

133 ould partially safeguard the role of EZH2 in the formation of H3K27me2.

134 lorine species are partially responsible for the formation of halogenated DOM, haloacetic acids, and

135 al role for basement membrane composition in the formation of hematopoietic compartments.

136 lead to complex developmental behaviors and the formation of higher-order community structures.

137 s oxidized DNA bases and APE1 in controlling the formation of higher-order DNA secondary structures t

138 essful oxidation of fullerenes (oxC(60)) and the formation of highly hydrophilic fullerene derivative

139 sA and NfsB nitroreductases, suggesting that the formation of highly reactive nitroso intermediates i

140 The mechanisms underlying the formation of hippocampus-dependent memories during i

141 Effective differentiation of the formation of HNO from complex 1 with the pendant SH

142 that this developmental transition includes the formation of hundreds of cell-type-specific neuronal

143 cial energy offset of 0.4 eV, which promotes the formation of hybridised exciton/charge-transfer stat

144 ons in poly(1,2,4-triazolium)s that catalyze the formation of imine bonds, and the simultaneous salti

145 the pulsed-pH (ppH) protocol, one can detect the formation of individual endocytic vesicles (EVs) wit

146 redictions on the genetic factors that drive the formation of individual neuronal circuits.

147 an electrophysiological signal that indexes the formation of individuated object representations.

148 hippocampus, while simultaneously leading to the formation of integrated representations of related e

149 ectivity in the brain.SIGNIFICANCE STATEMENT The formation of interstitial axonal branches plays a pr

150 The formation of intricate microarchitectures typically

151 ient gene knockdown into the system revealed the formation of invasive leader cells with upregulated

152 to which adsorbed intermediates that lead to the formation of isopropanol were removed from the catal

153 Our minimal polymer model reproduces the formation of lamin-associated-domains and provides a

154 composition under illumination, resulting in the formation of lead and iodine in films.

155 the most fertile area for discovery has been the formation of lignins, including the identification o

156 were evaluated for their inhibition against the formation of lipid hydroperoxides and carbonyl compo

157 It has been suggested that Pif1 drives the formation of long 5'-flaps during Okazaki fragment m

158 re of H(1) and H(2)-AuNPs finally results in the formation of long double-stranded DNA-RNA (HCR produ

159 that can, on geological time scales, lead to the formation of massive reefs in shallow tropical and s

160 A reaction pathway that both explains the formation of MeIQx and is valid for the formation of

161 spiral polymers to helical filament to drive the formation of membrane protrusions, and ends with the

162 By contrast, low pH did not affect the formation of membrane-anchored TNFR1-containing sign

163 hase separation (LLPS) of proteins underlies the formation of membrane-less organelles.

164 O3 with these nonclassical NLSs may regulate the formation of membraneless organelles and subcellular

165 The formation of memory for a novel experience is a crit

166 and reversible binding to acetylene through the formation of metastable [Ni(II)(C(2)H(2))(3)] comple

167 potent cell killing activity associated with the formation of micronuclei, a clear sign of genome ins

168 Loss of Ena/VASP function also abolished the formation of microspikes normally embedded in lamell

169 cture of ecological communities by promoting the formation of mixed-species groups.

170 Moreover, AKI caused the formation of "mixed-identity cells" (expressing mark

171 gen redox process in such materials involves the formation of molecular O(2) trapped in the bulk stru

172 OPA naive hemi-parkinsonian rats resulted in the formation of morphologic and electrophysiological si

173 I-based (pMHCII-based) nanomedicines trigger the formation of multicellular regulatory networks by re

174 an almost complete reduction to Cu(I), under the formation of N(2).

175 the bridging species was found to facilitate the formation of N-H bonds via proton-coupled electron t

176 an in situ redox-neutral directing group for the formation of N-PAHs via isoquinoline.

177 water in the reaction was found to suppress the formation of nanohelices, producing nanoplates expre

178 trophil elastase (NE) has been implicated in the formation of NETs through proteolysis of nuclear pro

179 The formation of new blood vessels after myocardial infa

180 scovered that the tetrahedral linker directs the formation of new RE-MOFs, RE-ken-MOF-1 (RE: Y(3+), H

181 sticity leads to the sprouting of new axons, the formation of new synapses and the remapping of senso

182 g-term survivors that were then resistant to the formation of new tumors upon rechallenge at a distan

183 teins as structure-directed agents to direct the formation of new ZMOFs that can act as versatile pla

184 nduced aSyn aggregation in cells, leading to the formation of nontoxic aSyn species.

185 mbrane suggesting a physical explanation for the formation of nuclear membrane invaginations.

186 igh glycan density on MERS S that results in the formation of oligomannose-type glycan clusters, whic

187 The formation of oligomers of the amyloid-beta peptide p

188 This work provides a foundation for the formation of opposing magnetic-susceptibility-based

189 The design allows for the formation of ordered arrays of reorienting isoindoli

190 In other conditions, the formation of ordered domains in a SM and cholesterol

191 Despite extensive studies on the formation of organic molecules in various extraterre

192 In addition, the formation of organohalogen byproducts, chlorate and

193 ains the formation of MeIQx and is valid for the formation of other heterocyclic aromatic amines (HAA

194 ed in the biogenetic mechanisms proposed for the formation of oxasqualenoids.

195 These mechanisms are (i) the formation of oxygen vacancies that couples to the el

196 This reaction involves the formation of P-C and H-C bonds.

197 the morphology of the glioma cell influences the formation of patterns of collective behavior such as

198 We demonstrate here the formation of PFOA and PFOS in earthworms (Lumbricus

199 t leads to cellular apoptosis accompanied by the formation of phase-separated intracellular membrane

200 Plate tectonics requires the formation of plate boundaries.

201 ional high-resolution imaging to investigate the formation of pleomorphic "megamitochondria" with alt

202 The formation of pollen wall is a complex but well-regul

203 Here, we report on the formation of polymer hexosomes whose inverted cylind

204 Mechanistically, talin1 was required for the formation of preassembled TLR complexes in DCs at st

205 pmental synaptic remodeling is important for the formation of precise neural circuitry, and its disru

206 requirement for Kif3a, a gene essential for the formation of primary cilia, in a mouse model of SCLC

207 ide aldehyde protease inhibitors, leading to the formation of "pro-pyrazinones" featuring a hetero-tr

208 By monitoring the formation of products of reactions between ring clea

209 The results reveal that the selectivity in the formation of products was obtained by controlling th

210 paB enhances, whereas activation suppresses, the formation of proliferating MGPCs.

211 ns will reduce methane production increasing the formation of propionic acid without affecting the di

212 estabalizing a large number of proteins, and the formation of protein aggregates.

213 control of membrane fluidity rather than for the formation of protein complexes via direct protein-pr

214 n MBn suppresses ARM consolidation, allowing the formation of PSD-LTM.

215 shared mechanism with lymphoid malignancy in the formation of public rheumatoid factor autoantibodies

216 ition reaction (Prato's protocol) results in the formation of pyrrolidine rings bearing a new stereog

217 ndings are helpful to the current studies on the formation of quantum liquid droplets from cold atoms

218 nd to support DNA replication by suppressing the formation of R-loops (DNA/RNA-hybrids).

219 ge to biological molecules, can also lead to the formation of reactive nitrogen species.

220 this purpose have faced a major obstacle in the formation of resistance alleles that prevent Cas9 cl

221 ft (WGS) activity of the material and detect the formation of Rh hydride species spectroscopically.

222 d the proposed adhesive polymers involved in the formation of rhizosheaths at root surfaces and for t

223 ntation of the vertebrate hindbrain leads to the formation of rhombomeres, each with a distinct anter

224 loped chemical reaction networks to describe the formation of RNA splicing machinery complexes and sp

225 en the membrane surfaces is used to identify the formation of saccharide bonds and to challenge their

226 GAT1 and DGAT2, are thought to contribute to the formation of seed oil, and previous characterization

227 of the cannabinoid type 1 receptor (CB1) in the formation of sensory maps in the cerebral cortex, th

228 ncing Purkinje cell neurotransmission blocks the formation of sharp Purkinje cell zones and disrupts

229 The cyclization can also be extended to the formation of six-membered rings and to N-homoallylin

230 nto a porous yolk-shell structure along with the formation of SMSIR upon treatment under a reductive

231 The casein-rich (>=50%) samples showed the formation of solid coagula that were persistent thro

232 and phonon-spin scattering processes induces the formation of spin fluctuations in the low-temperatur

233 equency in secondary transplants and reduced the formation of spontaneous lung micrometastases by PDX

234 proteins (commonly known as +TIPs) to induce the formation of stable microtubules soon after virus en

235 which are thermodynamically unstable in that the formation of stable multiply bonded N(2) is usually

236 y RNA-binding proteins (RBPs) that influence the formation of stress granules, the punctate protein-R

237 ne deficiency and stabilizes iodine ions via the formation of strong Cd-I ionic bonds.

238 This reaction sequence enables the formation of sulfonated amino acids during embryo de

239 lly delithiated LiNiO(2) , which facilitates the formation of superoxo/peroxo-like (O(2) )(n) (-) spe

240 pids and amphipathic 18A peptides to mediate the formation of supported phospholipid bilayers with tw

241 That is, early life adversity may inhibit the formation of supportive social ties, and weak social

242 g performance stems from the SMSIR, favoring the formation of surface hydrogen on Pd instead of hydri

243 The "LE-TA" method induces the formation of surface matrix on CsPbI(3) QDs, which i

244 The results suggest the formation of template induced 1-1 diad repeats in th

245 tion effect could be considered a marker for the formation of temporal expectations and the allocatio

246 The stability derives from the formation of ternary complexes of the initiator with

247 and CXCL13 in combination with CD20 reveals the formation of tertiary lymphoid structures in these C

248 of the thietane intermediate, its rate, and the formation of the (6-4) photoadduct using the 5'-TT(4

249 h a Dowd-Beckwith rearrangement and leads to the formation of the 13(14 -> 8),14(8 -> 7)diabeo-framew

250 beta-C(sp(3))-H activation pathway to favor the formation of the [5,6]-membered palladacycle interme

251 or RNP demonstrated the structural impact of the formation of the active site on RNP architecture.

252 polarization and that Aurora B has a role in the formation of the apical surface.

253 toxic impurities and, thus, played a role in the formation of the aquatic environment of our planet,

254 The formation of the bis-adducts and their spectroscopic

255 the Sushi-2 domain of C2, ARGX-117 prevents the formation of the C3 proconvertase and inhibits class

256 occur during neurogenesis are necessary for the formation of the characteristic laminar patterns.

257 y was driven predominantly by wind speed and the formation of the deciduous canopy.

258 roteins (UBLs)-Atg5, Atg12, and Atg8-play in the formation of the double-membrane vesicle autophagoso

259 ys to coordinate cell growth, migration, and the formation of the extracellular matrix.

260 The nature of bonding driving the formation of the first oxaphosphetane (OPA) intermed

261 nalysis also showed developmental defects in the formation of the fore-, mid- and hindbrain and somit

262 The formation of the fullerene-steroid hybrids proceeds

263 ormin treatment, and that metformin promotes the formation of the functional AMPK alphabetagamma hete

264 pounds were investigated in order to clarify the formation of the heterocyclic aromatic amine (HAA) 2

265 OER, the Co/Fe spinel-like surface promotes the formation of the highly active Co(Fe)OOH phase, whic

266 -functional theory calculations suggest that the formation of the highly charged tetra-reduced carban

267 The formation of the host-guest complex WP5 G quenches t

268 The formation of the human brain, which contains nearly

269 The metallobiochemistry underlying the formation of the inorganic N-N-bond-containing molec

270 ion of endoplasmic reticulum (ER) tubules in the formation of the interconnected ER network.

271 ment of Toxoplasma gondii infection, such as the formation of the intravacuolar network (IVN) within

272 concentrate on the positioning of the limbs, the formation of the limb bud, the establishment of the

273 tand the emergent chemistry that arises from the formation of the metal-organic interface.

274 he potential-dependent charging current upon the formation of the microscopic electrode-electrolyte i

275 th leukaemia inhibitory factor and regulates the formation of the mouse pluripotent blastocyst.

276 lmonary metastases, MDSCs are key factors in the formation of the premetastatic microenvironment afte

277 activated alkene is completely selective for the formation of the quaternary center, allowing differe

278 ing alone cannot quantitatively recapitulate the formation of the stripe and that control of the wind

279 cid (HOBr), a powerful oxidant that promotes the formation of the sulfilimine crosslink in collagen I

280 to demonstrate the excited state leading to the formation of the thietane intermediate, its rate, an

281 The identified electronic states explain the formation of the very large ordered magnetic moments

282 amond, SafAle, SafLager) in order to monitor the formation of these bioactives during the elaboration

283 The formation of these complexes was entropically driven

284 The formation of these complicated structures is control

285 The formation of these hollow HEA nanoparticles is enabl

286 The data are suggestive of the formation of these loops by interactions between rep

287 early phenotype of the disease, upregulates the formation of these transient DRMs by inducing the in

288 The presence of sulfide can lead to the formation of thiolated anions; however, their contri

289 SDs in the molecular mechanisms that lead to the formation of this class of CNVs.

290 action complex with the hydrogenase and that the formation of this complex depends on the cofactor co

291 ct conversion of ethanol to 1,3-butadiene or the formation of this product by the reaction of ethanol

292 n an exceptionally useful model for studying the formation of topographically organized maps, neural

293 The impact of the phenolic extract on the formation of total fluorescent advanced glycation en

294 Our results raise concerns about the formation of toxic ring-cleavage products during the

295 ced adhesion zones between the membranes and the formation of transient fusion stalks in molecular dy

296 son-Crick pair to a wobble-like pattern with the formation of two hydrogen bonds.

297 this work reveals that carefully controlling the formation of unreacted PbI(2) crystals in perovskite

298 epresents a previously unknown mechanism for the formation of various dimensions of phosphorene nanos

299 ight adhesion between adjacent membranes via the formation of weak saccharide bonds.

300 ontacts, oxoA:G forms a wobble conformation, the formation of which is suppressed in the catalytic si