ライフサイエンスコーパス: the necessity for

1 The necessity for 5 different analytical platforms and m

2 division and differentiation has illuminated the necessity for a cellular machinery that mediates mit

3 work's role in modeling human physiology and the necessity for a community-based consensus reconstruc

4 ission across different SNAREs, highlighting the necessity for a functional classification of SNAREop

5 ged residues in the polar region circumvents the necessity for a Mg(2+), which, by contrast, is a str

6 r of small molecules into cells and point to the necessity for a more complex model.

7 space by the reviewed NTA studies highlights the necessity for a more comprehensive approach in the e

8 The ongoing COVID-19 pandemic highlights the necessity for a more fundamental understanding of th

9 It highlights the necessity for a paradigmatic change of our disease-c

10 hobic contributions along the interface, and the necessity for a particular orientation of the spectr

11 -9-deaza nucleosides using Heck methodology, the necessity for a pyrrole protecting group was discove

12 evious functional misannotation and supports the necessity for a reclassification of these enzymes un

13 ncreased significantly in the last decade as the necessity for a renewable source of carbon has becom

14 confirmation should be performed to evaluate the necessity for a second dose.

15 f this segment with the beta subunit explain the necessity for a second highly conserved His residue

16 nts multiple molecular lifetimes, suggesting the necessity for a self-perpetuating signal.

17 errors suggests that the ampakine eliminated the necessity for a shift in response strategy that prod

18 corporation into virus particles and to test the necessity for a specific interaction between Env and

19 ture is facing multiple challenges including the necessity for a substantial increase in production t

20 The necessity for a summary of recent developments is hi

21 mposite end points of in-hospital mortality, the necessity for a temporary pacemaker, or the need for

22 ssion of neural crest markers, demonstrating the necessity for a Wnt signal during neural crest induc

23 The necessity for accurate diagnosis and management of p

24 fic and essential for cell viability, due to the necessity for accurate translation of the genetic co

25 ocks its nuclear translocation, demonstrates the necessity for active ERK1/2 nuclear localization for

26 The necessity for acyl protein thioesterases to have max

27 , sex differences in disease susceptibility, the necessity for adjuvants in experimental animal model

28 ldwide morbidity and mortality, highlighting the necessity for advanced therapeutic strategies.

29 e the limits of the neuromuscular system and the necessity for alternate forms of communication.

30 ions of free-roaming cats globally highlight the necessity for alternative contraceptive approaches.

31 roalkyl acids (PFAAs) from AFFFs resulted in the necessity for alternatives, and short-chained PFAAs

32 The necessity for an accurate, but at the same time, ine

33 tricted by technical limitations, especially the necessity for an acidic pH.

34 liferate in response to androgen, indicating the necessity for an additional factor not present in vi

35 compounds selectively (see example) without the necessity for an excess of the alkane substrate.

36 These results clearly demonstrate the necessity for an internal standard for quantitative

37 The necessity for an undiscovered series of steps and en

38 Thus, in this age group, the necessity for anticoagulation or its avoidance may b

39 troesophageal reflux disease or to determine the necessity for antireflux intervention.

40 roperties of organic molecules in respect of the necessities for applications such as for organic ele

41 We tested the necessity for appropriate spatial alignment of these

42 Full-length TAP mutagenesis demonstrates the necessity for at least one consensus site, supportin

43 e correction of refractive errors indicating the necessity for attention to other ocular diseases in

44 ous and prone to observer errors, leading to the necessity for automated methods.

45 plateau potential in B31/B32 and eliminates the necessity for B63 in B50-elicited motor programs.

46 ve been developed are examined, highlighting the necessity for better data to parameterise and fit th

47 These data emphasize the necessity for biopsy at the first recurrence of FL.

48 re is little mechanistic evidence to support the necessity for blocking H2R, a receptor best characte

49 The necessity for bone marrow aspiration and the lack of

50 o that achieved with other materials without the necessity for bone-graft harvesting or a second proc

51 s the requirement for cold-chain storage and the necessity for booster doses.

52 The necessity for both Cry48Aa1 and Cry49Aa1 components

53 understanding of climate change makes clear the necessity for both emission reduction and carbon dio

54 These results emphasize the necessity for both redox-active disulfide centers in

55 hted the complex nature of air pollution and the necessity for broader monitoring strategies to prote

56 cellular cysteine pairs in CSF3R and suggest the necessity for broader screening of CSF3R extracellul

57 Risk factors influenced the necessity for C-CT.

58 These findings strongly imply the necessity for candidate EIAV and other lentivirus va

59 Our findings highlight the necessity for careful upfront cellular enrichment in

60 Thus, the necessity for CD103 emerges in the efferent CD8+ T-c

61 The necessity for CD4 help was overcome, however, if the

62 an target chemokines for degradation without the necessity for cell signaling, and without desensitiz

63 C) express notch and notch ligands; however, the necessity for cell-autonomous notch signaling during

64 We also characterized the necessity for cell-cell contact for these effects.

65 vely studied since the cells' isolation, but the necessity for cell-secreted factors in self-renewal

66 The necessity for changes in allocation in response to c

67 of the aspartase-fumarase enzyme family, and the necessity for chemically reasonable functionalities

68 lecule 3-oxo-C12-homoserine lactone, showing the necessity for cholinergic transmission.

69 extreme shortage of matched organ donors and the necessity for chronic immunosuppression has made it

70 through an in vitro approach, thus reducing the necessity for clinical studies.

71 Our findings emphasize the necessity for collaborative initiatives and solution

72 However, the necessity for collecting data at room temperature, e

73 ons is the need for new antiviral agents and the necessity for combination therapies as has been show

74 means of communication for learning without the necessity for committing multiple errors across tria

75 1 in different cellular compartments suggest the necessity for complex regulation.

76 ated intracranial pressure, which highlights the necessity for comprehensive evaluations in patients

77 f advancing stroke registries and emphasizes the necessity for comprehensive external validation of p

78 s been hampered by functional redundancy and the necessity for conditional inactivation strategies.

79 h OspA, their lack of specificity highlights the necessity for confirming equivocal or positive react

80 The findings emphasize the necessity for conservation strategies and policies f

81 We highlight the necessity for consideration of alternative (e.g., hy

82 ly variable changes that we report highlight the necessity for considering local factors such as topo

83 equential environmental events, illustrating the necessity for considering the temporal traits of pre

84 Overall, this review underscores the necessity for continued interdisciplinary research t

85 small- and large-scale laboratories suggest the necessity for continued microbiology-based understan

86 ted the effect of competitive pressures, and the necessity for cooperation among nutrition societies.

87 geoengineering"), typically characterized by the necessity for costly new infrastructures and industr

88 Our findings underscore the necessity for culturally tailored strategies, suppor

89 This difference may reflect the necessity for DCs to interact with multiple T cells

90 This study emphasizes the necessity for declaration of funding source.

91 s vigilance to permit timely recognition and the necessity for defibrillator implantation and heart t

92 This stresses the necessity for dermatologists to perform comprehensiv

93 This study highlights the necessity for developing a parameterization of dust

94 able in industry practice by: 1) eliminating the necessity for developing dedicated waste detection a

95 the proprietary nature of data sources, and the necessity for developing new software), the benefits

96 Our findings highlight the necessity for development of adaptation measures in

97 Zika virus (ZIKV) outbreaks have highlighted the necessity for development of novel vector control st

98 rature change in the CP region, highlighting the necessity for diabatic CP ENSO positive feedback dyn

99 recruitment of the 43S complex and alleviate the necessity for direct eIF4G/eIF3 interaction.

100 IM1 remotely gates the Orai1 channel without the necessity for direct STIM1 contact with the pore-for

101 s of the hammerhead ribozyme, and emphasizes the necessity for dynamic structural fluctuations in the

102 The necessity for earlier genetic alterations before bia

103 s onset of these biomarkers in DS highlights the necessity for early therapeutic interventions in thi

104 This highlights the necessity for efficient glutamate clearance from the

105 the effects of activity blockade, indicating the necessity for endogenous neurotrophins for developme

106 ound that lack of NFATc2 and NFATc3 obviates the necessity for engagement of CD28 on naive cells and

107 The increasing trend of HRs underscores the necessity for enhanced diagnostic and management str

108 gnificant obstacle to progress, highlighting the necessity for essential assistive tools tailored for

109 The approach removes the necessity for evenly spaced samples, an advantage il

110 ound in the perpendicular pose, highlighting the necessity for exploratory research in the search for

111 flexibility of the filter that demonstrates the necessity for extended simulations to study conducti

112 e in burn depth and area would likely reduce the necessity for extensive surgical debridement as well

113 Moreover, the method eliminates the necessity for extensive thermodynamic calculations.

114 e, noninnocent NO ligand in electron uptake, the necessity for Fe'-S bond breaking (or the hemilabili

115 f cells with natural C(16)-ceramide bypassed the necessity for forced antibody cross-linking and enab

116 of SecA via azide treatment, consistent with the necessity for formation of a preprotein-SecB-SecA co

117 aintaining fetal tolerance during pregnancy, the necessity for Foxp3(+) cells with fetal specificity

118 r, the limitation of this type of therapy is the necessity for frequent administration of cytokine pr

119 The necessity for full reperfusion after a preconditioni

120 Additionally, our methodology underscores the necessity for further characterization of numerous s

121 ma (HCC) are presently limited, underscoring the necessity for further elucidating molecular mechanis

122 The necessity for further evaluation, possible treatment

123 he implications of these findings underscore the necessity for further exploration of flavonoid-rich

124 Our work underscores the necessity for further investigation into other poten

125 omic growth in recent decades, thus implying the necessity for further investigations on both the int

126 Our study highlights the necessity for further research and clear policy init

127 This study highlights the necessity for further research focused on recurrence

128 The economic burden of CP highlights the necessity for further research into management optio

129 of similarity, and it probably results from the necessity for fusion to occur to establish the prima

130 ic management strategies remains, indicating the necessity for future research in this field.

131 ure of supports to enable aging-in-place and the necessity for future research to focus on drawing co

132 Numerous failed clinical trials suggest the necessity for greater mechanistic understanding in o

133 different from the general one, highlighting the necessity for guidance on prior elicitation.

134 rom low household income level, underscoring the necessity for heightened public attention and measur

135 it is limited by its temporal resolution and the necessity for Hg modified electrodes.

136 However, the necessity for high operating temperatures (800-1,000

137 icity and risk of side effects, highlighting the necessity for highly effective, less toxic, targeted

138 Here, we sought to define the necessity for histamine receptors in the pathology o

139 f cytotoxicity by alkylating agents includes the necessity for homologous recombination to repair DSB

140 RNA interference strategies confirmed the necessity for Hsp27 as well as both beta-arrestin is

141 consistent platelet product, while reducing the necessity for human donations.

142 scuss how interspecies differences highlight the necessity for human model systems to complement exis

143 live vaccine strategy against tularemia and the necessity for identifying novel, acellular vaccine c

144 Central injection is easy and avoids the necessity for image-guided injection of nonpalpable

145 nable chemicals manufacture is discussed and the necessity for immobilisation of enzymes as a key ena

146 recommendation for a new nutrient, and show the necessity for including nutrient interaction in the

147 tation of metabolic labeling experiments and the necessity for inclusion of additional controls.

148 comprehensive 2D gas chromatography (GCxGC): the necessity for individual compounds to be chromatogra

149 uted tomography (CT) scanning in determining the necessity for initial laryngectomy for advanced lary

150 ) emissions and conversion to fuels features the necessity for innovative solutions, one of which is

151 It highlights the necessity for integrated basin-scale land-water mana

152 Their conservation is probably due to the necessity for interaction of proximally bound transc

153 pment of this complication, which emphasizes the necessity for intermittent assessment of parathyroid

154 r of species detected simultaneously without the necessity for internal calibration and indicate the

155 r evasion of the PKR pathway likely explains the necessity for IRS1 or TRS1 for productive infection.

156 n that of the cytoplasmic form, underscoring the necessity for its continuous nuclear transport to ma

157 rtificial dimerisation of Panoramix bypasses the necessity for its interaction with Ctp, demonstratin

158 olution below Rayleigh criterion and without the necessity for labeling with fluorescent probes is pr

159 This extraordinary event highlights the necessity for laboratories to remain vigilant in the

160 on of the mouse model is its small size, and the necessity for laborious histologic analyses to quant

161 hallenges for any future hydrogen economy is the necessity for large scale hydrogen production not in

162 not promote limb regeneration, demonstrating the necessity for limb progenitor cells.

163 erogeneity and non-Mendelian inheritance and the necessity for linkage methods to deal with these iss

164 iew of inner core formation does not include the necessity for liquids to be supercooled to below the

165 NA delivery to off-target tissues highlights the necessity for LNPs with enhanced tissue selectivity.

166 This study demonstrates the necessity for local information on common mental dis

167 yet, issues like result unpredictability and the necessity for long-term monitoring persist.

168 The necessity for long-term treatments of chronic diseas

169 In the MR imaging scenario, the necessity for lymph node dissection was based on MR

170 mited by complex manufacturing processes and the necessity for lymphodepleting chemotherapy, restrict

171 %) were maintained with disopyramide without the necessity for major non-pharmacologic intervention w

172 oxin concentration and load, which points to the necessity for measuring endotoxin levels in both the

173 This decay indicates the necessity for methods and reagents for the routine m

174 gs of the guide-specific approach highlights the necessity for meticulous guide design and assessment

175 systems will never be completely eliminated, the necessity for minute-to-minute intervention may.

176 ity on Polga and provide genetic evidence of the necessity for mitochondrial Hsp40 in preventing DCM.

177 f SAM synthesis and recycling and explaining the necessity for MTHFR to be regulated by SAM.

178 comparison to adult phase I trials, include the necessity for multiinstitutional participation and t

179 denture, retention of compromised teeth, and the necessity for multiple implant surgeries complicate

180 nation could provide the solution and reduce the necessity for multiple injections to achieve immunit

181 son to the BXSB parental strain, emphasizing the necessity for multiple interactions in the productio

182 needed for maintaining fidelity may reflect the necessity for multiple substrate recognition in vivo

183 ssful in treating hepatocellular carcinomas, the necessity for multiple treatments, injection of larg

184 The necessity for multiple wash steps for accurate quant

185 Conclusion: Abnormal CSF flow and the necessity for neurosurgical intervention must be con

186 vers their limited concordance, underscoring the necessity for new high-throughput experiments to val

187 nse of cells to drugs, this study emphasizes the necessity for new in vitro cancer models and the use

188 atment discontinuation with current therapy, the necessity for new therapies targeting CML stem cells

189 recovery and frequent relapses underscoring the necessity for new treatment strategies.

190 Our findings underscore the necessity for nuanced cultural considerations in the

191 increasing global population has highlighted the necessity for nutritious, equitable, and sustainable

192 Our results highlight the necessity for One Health-oriented research and inter

193 Overall, our results highlight the necessity for open data sharing to provide a more so

194 ethical considerations, data protection, and the necessity for open science principles.

195 s on laser coherence, frequency agility, and the necessity for optical amplifiers.

196 mpounds; however, they have also pointed out the necessity for optimization to improve their therapeu

197 The necessity for, or redundancy of, distinctive KChIP p

198 The necessity for pathogen recognition of viral infectio

199 These results demonstrate the necessity for peripherin/rds in ROS membrane fusion,

200 ted cosmic radiation exposure and highlights the necessity for personalized translational approaches

201 The necessity for PET attenuation correction required ne

202 sustainable chemical transformations without the necessity for phenolic mixture upgrading via dealkyl

203 Our findings highlight the necessity for policies to mitigate the indirect heal

204 However, the necessity for polyubiquitination of APOBEC3G in this

205 of managing HTN in patients with cancer and the necessity for precision medicine to manage it.

206 nducer of homeostatic proliferation, without the necessity for prior immunodepletion.

207 ising target for sensitive detection without the necessity for prior in vitro amplification.

208 se of hypothermia for stroke to date include the necessity for proactive antishivering therapy for su

209 Our findings underscore the necessity for proactive measures, including early wa

210 ) owing to the severity of the diagnosis and the necessity for prompt action.

211 discuss has provided insights that emphasize the necessity for proper levels of stress response activ

212 The necessity for protection against diverse pathogens,

213 dy administration has limitations, including the necessity for purification and multiple injections f

214 For example, can we definitely prove the necessity for quantum, as opposed to classical, mode

215 ologic fracture, spinal cord compression, or the necessity for radiation or surgery to bone metastasi

216 in these high-stakes settings, highlighting the necessity for radiology teams to learn from and impr

217 The necessity for rapid evaluation and treatment of acut

218 mplex viral evolutionary landscape highlight the necessity for rapidly deploying updated vaccines fol

219 consequence for the production of fibers is the necessity for realignment by extension in the flow d

220 e groups and geographic locations underscore the necessity for region- and demography-specific interv

221 e sorting and cloning methods by eliminating the necessity for repetitive purification steps and incr

222 icacy, as well as potential side effects and the necessity for repetitive treatments.

223 nvolvement in these responses does not imply the necessity for resistance to URT infections.

224 Here we investigate the necessity for retinoic acid in motor neurogenesis fr

225 ngenic UBC-GFP mice and focuses attention on the necessity for rigor and reproducibility in scientifi

226 Our study, therefore, draws attention toward the necessity for rigorous characterization of transdiff

227 e emergence of newer variants and highlights the necessity for robust and sustained global genomic su

228 This review focuses on some of the necessities for screening: sensitive, specific, and

229 This supports the necessity for semantic cognition in internal process

230 HA and their parent HS in 2022, highlighting the necessity for separate characterization, an aspect s

231 ed diagnosis for HCM could potentially avoid the necessity for serial echocardiography in many such r

232 via inhibition of glial TLR4 and illustrate the necessity for sex-specific research and individualiz

233 One problem is the necessity for short- and long-term storage of islets

234 C S1PR2 dependency for chemokine release and the necessity for signal transducer and activator of tra

235 ses to accommodate Mg(2+) and Ca(2+) without the necessity for significant bending of the overall hel

236 These features and the necessity for significant remodeling of the Prx stru

237 ted to endothelial dysfunction, highlighting the necessity for simple assessment of endothelial funct

238 spectrum of BM contribution, we demonstrate the necessity for site-specific expression of stromal-de

239 results explain prior modeling failures with the necessity for somatic LOH in a developmentally regul

240 de the development of new therapies, such as the necessity for spatial and temporal control in neural

241 ze, the requirement of volatile buffers, and the necessity for specialized instrumentation to preserv

242 and functions of the surfaceome, emphasizing the necessity for specialized labeling, enrichment, and

243 The findings underscore the necessity for state-specific interventions aimed at

244 Lastly, we highlight the necessity for studying current, traditional building

245 , its clinical application is constrained by the necessity for subcutaneous administration and the hi

246 ergies for catalysis of AdoMet formation and the necessity for subsequent PPP(i) hydrolysis to allow

247 nd the severity of illness, which results in the necessity for surgery, there is little information o

248 s suggest ongoing urbanization, underscoring the necessity for sustainable land management techniques

249 preference for 2 + 2 cycloaddition is due to the necessity for syn-pyramidalization of the two CF(2)

250 The necessity for synchrotron-based uCT and the use of h

251 wn and Vav1 overexpression each circumvented the necessity for synergy because NKG2D or 2B4 alone bec

252 tentially useful tool in medicine highlights the necessity for systematic evaluation of its capabilit

253 To investigate the necessity for T-B cell contact in MRL autoimmunity,

254 The main findings underline the necessity for tailored interventions that cater to t

255 The key limitation of mAb treatments is the necessity for target antigen presentation on major h

256 demonstrated strong resistance, highlighting the necessity for targeted breeding.

257 idden within national statistics, confirming the necessity for targeted policies and metrics that rea

258 The data highlight the necessity for temporally and spatially distinct CD4

259 aining the most accurate discrimination, and the necessity for testing discriminatory functions again

260 l and peripheral metabolism, and illustrates the necessity for the "omics" data integration to uncove

261 To determine the necessity for the 4-allyl moiety in (+)-2, this subs

262 The necessity for the activation of one particular kinas

263 uired for virion maturation and infectivity, the necessity for the C-terminal cleavages of Gag is les

264 To directly assess the necessity for the combination of neu-specific cellul

265 findings predict and additional data confirm the necessity for the cooperation of multiple integrin a

266 Inspired by the necessity for the development of a protein drug of h

267 out the safety of consumers, and it suggests the necessity for the development of a sensitive and a r

268 e in human pathogenic bacteria has increased the necessity for the discovery of novel, yet unexplored

269 in the absence of CD4(+) T cells and support the necessity for the expression of distinct effector me

270 omprised exclusively of encoded amino acids, the necessity for the incorporation of unnatural amino a

271 antations, leading to price fluctuations and the necessity for the industry to find high quality coco

272 n of mitotic cells unnecessary and obviating the necessity for the more technically demanding DNA det

273 h prior neuraminidase treatment highlighting the necessity for the presence of available acceptors wi

274 ranial magnetic stimulation (rTMS) to assess the necessity for the short-term retention of spatial in

275 d the splice donor mutation, thus confirming the necessity for the splice donor site for Sag function

276 N, albeit with lower efficiency, challenging the necessity for the Tyr(224) aromatic ring.

277 al control as risk factors, thus emphasizing the necessity for therapeutic options that allow interfe

278 Furthermore, we show that the necessity for these two closely related, non-redunda

279 change in its function) that likely explains the necessity for tight co-regulation of the ybgF and to

280 gland during early pregnancy, but underscore the necessity for tight control of this signaling molecu

281 These findings highlight the necessity for timely antiretroviral care, for suppor

282 al requirements for selected recipients, and the necessity for traceability of blood components.

283 However, the necessity for translation of genetic changes restric

284 e posterior ROP (kappa = 0.35); moderate for the necessity for treatment (kappa = 0.41); and fair for

285 e posterior ROP (kappa = 0.60), moderate for the necessity for treatment (kappa = 0.47), and substant

286 7% for aggressive posterior ROP, and 25% for the necessity for treatment.

287 e show that B7 deprivation in mice overrides the necessity for Tregs in averting systemic autoimmunit

288 We propose that the necessity for two distributions is a criterion for c

289 The necessity for two types of thioredoxins (Trx f and m

290 The necessity for UBE2E3 in RPE proliferation was determ

291 ity to cardiac titins and this may eliminate the necessity for unfolding of Ig domains under physiolo

292 had a percutaneous drainage, and we assessed the necessity for urgent or emergent operation.

293 netic logic scheme at room temperature where the necessity for using a magnetic field clock can be co

294 ing exponential growth due to autolysis, and the necessity for using high starting inocula.

295 The results showed the necessity for using samples with an original concent

296 Overall, our study underscores the necessity for vaccine (re-)development and the creat

297 The necessity for VH 4-34 FR1 explains the almost exclus

298 In the present study, we also addressed the necessity for viral infection and/or replication in

299 nt C-type inactivation involving S4, without the necessity for voltage-dependent opening, allosteric

300 interventions remains limited, underscoring the necessity for well-designed intervention studies tar