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1 e on the origin of mirror neurons, stressing the necessity to abandon the dichotomy between genetic a
2 ypothesis is without foundation, underlining the necessity to accept only similarity of sequence and/
9 s of nanomagnetic logic have been limited by the necessity to apply a magnetic field for clocking.
11 ked key benefits at small scales, indicating the necessity to apply models that include finer-grained
12 ristic of all positive-strand RNA viruses is the necessity to assemble viral RNA replication complexe
13 ersity of responses among species highlights the necessity to assess the effect of environmental stre
16 ends in cannabis legalization have increased the necessity to better understand the effects of cannab
17 us, while their coactivation may result from the necessity to bind promoters as heterodimers, it may
18 lty of similar discriminations may relate to the necessity to both strengthen rewarded representation
21 ducing IFN-beta pathways, but also highlight the necessity to check autophagy status upon taking 3-MA
22 MS probe and microbial biomass; resulting in the necessity to clean or replace the probes between ana
23 is a behavior that arose evolutionarily from the necessity to compete for limited resources and survi
24 nimal- and ex vivo/in vitro experiments, and the necessity to conduct long-term (several years) human
25 elop and test the mHealth audio messages and the necessity to conduct multiple statistical tests due
28 e at advanced stages of the disease suggests the necessity to consider modulation of the IL-23/Th17 p
29 ifferences in speech processing, emphasizing the necessity to consider oculomotor activity in future
30 a G-quadruplex folding funnel and highlight the necessity to consider solvent viscosity in studies o
32 rnal photosynthesis monitoring and highlight the necessity to consider the increased diurnal asymmetr
33 asevarion switching in NTHI pathogenesis and the necessity to considered phasevarion regulation when
34 tributions by natural emissions to ozone and the necessity to control anthropogenic emissions in ozon
35 aria-environment association and highlighted the necessity to control for interventions when they are
36 c and diagnostic first approaches underscore the necessity to decompose the heterogeneity hindering c
38 results from mean squared error highlighting the necessity to define model optimality with respect to
39 maternal supply of Cas9 to the zygote avoids the necessity to deliver the relatively large Cas9 prote
40 racterization of the patients, there is also the necessity to determine the drug-clearance properties
42 d-line fluoroquinolone antibiotics indicates the necessity to develop both novel therapeutics and our
47 d to translate to clinical use, highlighting the necessity to develop safe and effective pharmacologi
49 emia after cessation of HAART and underscore the necessity to develop therapies directed toward such
52 otential to improve recovery, and underscore the necessity to distinguish the role of tonic and phasi
53 f enantioenriched amides, but is hampered by the necessity to employ CO gas, often at elevated pressu
54 idelity and its control has been hampered by the necessity to employ complex DNA templates requiring
59 ncy for mass production of swabs highlighted the necessity to evaluate their efficiency against the g
61 ivore ranges outside these areas underscores the necessity to expand the network of conservation land
64 important proteins have long been impeded by the necessity to express such proteins in isotope-labele
65 thin a multidomain protein, achieved without the necessity to express the individual subunits separat
66 mbled particles with spherical symmetry, and the necessity to fill space at uniform density within th
68 e patients developing tuberculosis emphasize the necessity to find new antitubercular targets and dru
69 ay be related to its unique binding site and the necessity to fit its bulky macrocycle into this clef
70 a potential treatment of SSPE and highlights the necessity to functionally understand SSPE-causing Me
71 le steps of viral replication cycle indicate the necessity to further investigate BBI as an alternati
72 ccount the sex and fitness status as well as the necessity to further investigate the opioidergic inv
73 vious local-scale studies, while emphasizing the necessity to further reduce satellite-derived shorel
74 These techniques have limitations including the necessity to generate separate calibration curves fo
75 al mandates and authority to set priorities, the necessity to greatly improve the quality of care, an
76 minimise the size of hafting components and the necessity to haft them in the most efficient way.
78 from experience is used actively, relieving the necessity to hard-wire all connections and allowing
80 xity of the PTP-PEST interactome underscores the necessity to identify its interacting partners and p
81 d with standard chemotherapy has highlighted the necessity to identify targeted therapies that can im
82 tions of this exciting technology as well as the necessity to identify the mechanisms underlying any
83 ow over the sensing interface (i.e., without the necessity to implement an additional regeneration st
84 response to warming and eCO(2), highlighting the necessity to improve the genetic adaptability of pla
87 uses, but this effort is often encumbered by the necessity to initially identify compounds of interes
89 diness for advance care planning, suggesting the necessity to integrate readiness into future health
90 ilored functionalities is complicated due to the necessity to integrate various computational-chemist
91 p2 domain contains determinants which confer the necessity to interact with cyclophilin A for efficie
92 tumor cell-microenvironment interactions and the necessity to interpret experiments taking the contex
93 termine the domain of the problem, including the necessity to introduce mutability in the data struct
95 ase (RT) appears to have been constrained by the necessity to maintain function within an asymmetric
96 ttempts at analytical models are hindered by the necessity to make simplifying assumptions, because o
97 nd is over-expressed constitutively, without the necessity to manipulate factors such as cell growth
99 hat exist for TPV harvester transmission and the necessity to maximize transmission of PAR to create
100 by extensive ab initio calculation, implying the necessity to model catalytic reactions by highly cor
102 y evolving biological systems where there is the necessity to monitor in real time entire volumes to
103 complex in HCMV vaccine design and emphasize the necessity to monitor the integrity of the pentameric
104 f possible chemical modifications highlights the necessity to obtain structural information about the
105 ctivity to promote H5N1 infection underlines the necessity to optimize management strategies for a pl
106 nd target cell-specific delivery systems and the necessity to overcome numerous intracellular barrier
107 ll as suffering from high overpotentials and the necessity to overcome the competitive hydrogen evolu
109 ble, combined with disease heterogeneity and the necessity to predict diverse outcomes, make it diffi
110 plication of this modification is limited by the necessity to prepare corresponding acylated tRNA by
111 This difficulty is often exacerbated by the necessity to prepare the sample in the appropriate s
114 were only partially congruent, underscoring the necessity to probe HCMV immunomodulation using speci
115 ing use of chemical warfare agents highlight the necessity to produce efficient protective clothing a
116 challenge to developing a dengue vaccine is the necessity to produce fairly uniform protective immun
117 with raised expectations of next of kin and the necessity to provide early predictions of long-term
119 inct from those in the acute phase indicates the necessity to pursue alternative therapeutic targets
120 COPs during sun drying and storage indicate the necessity to re-evaluate the processing and storage
121 the Early Minoan period in Crete emphasizes the necessity to re-introduce infectious diseases as an
122 tion motifs are still revealed, highlighting the necessity to (re-)investigate these specificities de
123 sociation studies are challenging because of the necessity to realistically model the underlying alle
124 t ~20% of its current habitats, highlighting the necessity to reassess the effectiveness of current c
125 he plasma of COVID-19 patients, underscoring the necessity to reassess the forms of circulating histo
129 parities with global implications, harkening the necessity to refine existing architectures while dev
131 equirement for these structures derives from the necessity to regulate the directionality of recombin
132 o avoid these planetary nitrogen burdens and the necessity to remediate this problem, we foresee the
133 s increased lactose tolerance possibly lifts the necessity to remove nutrient-rich dairy foods comple
135 NCX3-AC compared with NCX3-B is in line with the necessity to restore Ca(2+) levels in the sarcoplasm
136 ral composition and fatty acids profile) and the necessity to revalorize and protect its traditional
137 ring the post-hospital transfers, indicating the necessity to review the appropriateness of medicatio
138 articles in amplifying radiative forcing and the necessity to revise models for the simulation of BC
139 onsiderable programmatic implications (e.g., the necessity to screen for iron status before intervent
140 termining ovarian cancer risk, and highlight the necessity to screen for missense alterations as well
141 w of photochemical efficiency and highlights the necessity to screen transition-metal complexes for s
143 ng biological mechanisms, but also highlight the necessity to seek optimal regimens of continual oxyt
145 gained popularity in medical studies due to the necessity to simultaneously track continuously measu
146 Using a nonfluorescent acceptor eliminates the necessity to spectrally isolate the donor fluorescen
147 effect sizes of single genetic variants, and the necessity to statistically correct for testing milli
148 CO(2)/d/m(3) in addition to alleviating the necessity to stop nitrification at nitrate, allowing
150 who harbor CD79 mutations also illustrating the necessity to stratify DLBCL patients according to th
151 k from climate change for tree diversity and the necessity to strengthen conservation and restoration
154 cy of single-site modified mRNAs underscores the necessity to study isolated modifications placed at
157 ces in a drug discovery program, by reducing the necessity to synthesize late-stage intermediates and
158 of even a single large inversion, confirming the necessity to thin SNPs by linkage disequilibrium at
159 e stress resistance and growth, illustrating the necessity to tightly control Get3's intrinsic chaper
160 sembles, there are downsides, most obviously the necessity to trade-off reversibility against structu
161 d for trained panel in the first lot confirm the necessity to train always before a sensory procedure
162 of neural networks to nuclei segmentation is the necessity to train the network using a set of applic
163 high cost of colony-stimulating factors and the necessity to treat large numbers of patients who do
165 tual disability disorders, thus highlighting the necessity to understand Las1 regulation and function
166 response elicited with diltiazem highlights the necessity to understand mutation-dependent progressi
167 entering the human body, our data emphasize the necessity to understand the biological role that the
168 nt technologies is steadily growing, driving the necessity to understand the interaction of these new
169 widely used actin-binding domain underlines the necessity to understand their structural interaction
170 of Ezrin in cancer metastasis have increased the necessity to understand this regulatory switch.
172 ding the impact of this evidence underscores the necessity to urgently prioritise universal access to
174 s, often containing similar information, and the necessity to use complicated tools to achieve the de
175 nterference from numerous other analytes and the necessity to use multiple probes was overcome by usi
176 h each boronic acid, the results confirm (1) the necessity to use pHs above their pK(a)'s to induce c
177 trolled RCTs seem to diverge, which stresses the necessity to use placebo in the control arms of thes
179 trend towards single origin products induced the necessity to verify and certify cocoa beans origin f