ライフサイエンスコーパス: the need for

1 Recently, however, the need for a bidirectional approach to social interact

2 d increase of global temperatures highlights the need for a clear assessment of how sex ratios of org

3 Our study demonstrates the need for a combination of biosystematics with biolog

4 effect on circuit performance and illustrate the need for a comparative approach in neuroscience.

5 econstitution of the TBSV replicase revealed the need for a complex mixture of phospholipids, especia

6 e clinical value of the approach, confirming the need for a consensus classification.

7 ecomes increasingly important in healthcare, the need for a consistent language for human genes becom

8 opment of any crop, this analysis underlines the need for a coordinated effort to quantify the geneti

9 mol %) as a catalytic precursor and without the need for a Cu salt as the co-catalyst.

10 To face the need for a more sustainable agriculture system, the

11 The results clearly indicate the need for a multifaceted analytical approach, to uneq

12 This highlights the need for a new antimalarial drug for IPTp that could

13 rall PCET reaction thermodynamics and avoids the need for a pK(a) scale in the solvent of interest.

14 s patient-specific cellular therapy, without the need for a priori knowledge of tumor antigen, ex viv

15 These data, taken together, highlight the need for a randomized, placebo-controlled efficacy t

16 nt for experimental observations, suggesting the need for a refined model.

17 Inconclusive results prompted the need for a second biopsy in 18 patients: 13 of 125 (

18 This study emphasizes the need for a standardized data analysis protocol for q

19 Recognizing the need for a systematic classification scheme, several

20 nce of known risk factors, reflecting either the need for a threshold of HCV for sexual transmission

21 However, increasing evidence points towards the need for a tumor priming step to improve intratumora

22 We therefore emphasise the need for a vent-specific approach at multi-vent volc

23 The need for active and stable oxidation catalysts is dr

24 e-risk disease and high-risk disease without the need for additional clinical data.

25 H in participants undergoing CAC-CT, without the need for additional imaging or radiation exposure.

26 estions than it could answer and underscores the need for additional investigations on the sources an

27 rength of the recommendations and highlights the need for additional research.

28 plication of the NBATS tool nationally shows the need for additional trauma infrastructure across a l

29 The need for additional treatment is much less with the

30 Despite the need for additional trials, these preliminary result

31 ffective compared to SCIT with alum, without the need for adjuvant.

32 ding toxicity and immunogenicity, escalating the need for an alternative.

33 A new 2-lead system eliminated the need for an atrial lead.

34 ng of the pathophysiology of OSB and support the need for an early fetal therapy (i.e., in the first

35 The need for an ester versus carboxylic acid-functionali

36 enerating coherent neuronal dynamics without the need for an oscillatory generator.SIGNIFICANCE STATE

37 intestinal organoids, potentially replacing the need for animal-derived matrices, while also allowin

38 The only significant drawback is the need for antireflux surgery in the first years of li

39 inical or mobile laboratory settings without the need for any additional medical equipment, with whic

40 e the unbound acetaminophen fraction without the need for any additional steps.

41 ng the vital proton abstraction step without the need for any external metal/base/oxidant.

42 omain-specific deep network likely to reduce the need for application-specific adaptation and tuning

43 Considering the need for availability of more chelation treatments i

44 Thereby, the need for axillary surgery should be reconsidered as

45 The imperfect effectiveness emphasizes the need for better influenza vaccines and other prevent

46 spectroscopy and machine learning to address the need for better screening and medical diagnostics in

47 tionships between these constructs highlight the need for better understanding of their bi-directiona

48 Our results suggest the need for bilateral cooperation to improve the health

49 ealth and environmental concerns are driving the need for bio-resourced foams for the building indust

50 n epidermal and dermal layers while reducing the need for biopsies.

51 heir choice is unrestricted by pair bonds or the need for biparental care, yet some females mate with

52 romal remodeling of the wounded area without the need for cadeveric donor corneas.

53 cause or worsen tissue injury, underscoring the need for calibration of activation and resolution of

54 ients with non-Hodgkin lymphoma and stresses the need for cardiac monitoring during and after chemoth

55 D-related complications, however, underlines the need for careful candidate selection.

56 Although safety data indicate the need for careful patient selection and monitoring, o

57 on growth and skeletal phenotypes underscore the need for caution in high-dose EGCG supplements as an

58 ate and robust cell characterization without the need for cell focusing systems.

59 have relied on pleural fluid pH to determine the need for chest tube drainage despite a lack of prosp

60 wn bicyclic diketone 7 in four steps without the need for chromatographic purification.

61 mune checkpoint has the potential to obviate the need for chronic immunosuppression.

62 lower respiratory tract results underscores the need for close monitoring of the clinical evolution

63 ene therapy strategy for LCA that emphasizes the need for combinatorial therapies to both improve vis

64 nity is still open, but we need to recognize the need for communication with other research areas and

65 graded neutral density filter, circumventing the need for complex beam shaping apparatus.

66 , adventitious nanoparticle binding, without the need for complex surface chemistries acting as block

67 splice isoforms across 14,611 genes, without the need for computational reconstruction of gene models

68 ate noninvasive diagnosis of ATTR-CM without the need for confirmatory endomyocardial biopsies; obser

69 ence from generic emissive materials without the need for contact engineering.

70 ct risk factor trend differences, indicating the need for contemporary tailored prevention programs.

71 n early introducing countries has reinforced the need for continued evidence generation regarding typ

72 This study highlights the need for continued research on changes in photoreact

73 ll and the elements that surround it without the need for contrast agents; its ability to evaluate th

74 hat may enhance breast MRI protocols without the need for contrast material administration in breast

75 of the recombination of PRRSVs and indicate the need for coordinated epidemiological investigations

76 rogrammes to increase SOC at large scale, is the need for credible and reliable measurement/monitorin

77 om individual sorted virus particles without the need for cultivation.

78 nt Metage2Metabo (M2M) a resource that meets the need for de novo functional screening of genome-scal

79 basis for a meeting held in October 2018 on the need for decarbonization in our energy landscape, an

80 edly accurate and stable predictions without the need for deep learning.

81 ribute of DNA-binding ligands and underlines the need for detailed molecular descriptions of binding

82 The need for detailed structural characterization of gly

83 of current training strategies and highlight the need for developing new optimal metrics to accuratel

84 in this clinical setting further underlines the need for developing other technologies, such as phag

85 VID-19 are predictive of in-hospital AKI and the need for dialysis.

86 se of the Ayton tool for AGYW and underscore the need for diverse prognostic tools considering epidem

87 on methods retrieve these components without the need for DNA methylation profiles of purified cell t

88 Emerging therapies to replace the need for donor corneas include pre-formed biosynthet

89 etings was relatively common and underscores the need for DSD models to be flexible and patient-cente

90 There is increasing awareness of the need for early diagnosis and rapid specialist input

91 s and among younger and black PLWH highlight the need for early diagnosis and treatment of HIV infect

92 with resolution of SARS-CoV-2 infection and the need for early functional humoral immunity.

93 These findings highlight the need for early interventions for dementia prevention

94 er individuals aged >=65 years, highlighting the need for effective regular screening and early inter

95 ntal contamination in managing COVID-19, and the need for effective use of PPE, physical distancing,

96 This points to the need for efficient methods to accurately quantify la

97 ridescence and improves color purity without the need for either refractive index matching or the inc

98 anemic patients with cancer, which decreases the need for ESAs.

99 l-time multi-dimensional observation without the need for event repetition in decomposing the complex

100 into the lungs, in situ immunization without the need for exogenous antigens, inhibition of the progr

101 chromatin-activating machinery, eliminating the need for exogenous transcriptional activators.

102 nd Earth science uncertainties, illustrating the need for expanding on previous integrated analyses t

103 diction from the molecular structure without the need for experimental data.

104 These results demonstrate the need for experimental quantification of how the biol

105 d EMI shielding materials but also highlight the need for exploring fundamental mechanisms behind int

106 ing to powerful analytical tools that remove the need for external detection systems.

107 current community composition, highlighting the need for external recruitment sources to support the

108 The proportion of the need for family planning satisfied by modern methods

109 73.2%-78.0%) globally, yet less than half of the need for family planning was met in Middle and Weste

110 Our results highlight the need for further characterization of outdoor and ind

111 ferences in SOA potentials of VCPs, implying the need for further characterization of these nontradit

112 nduction before gRNA replication and without the need for further de novo sfRNA synthesis could form

113 s no cure for this disease, which highlights the need for further investigation about the pathophysio

114 Thus, the need for further investigation and development of ef

115 diet response prediction while highlighting the need for further research and larger samples in orde

116 tic dysfunction, and inflammation, highlight the need for further research into common copathologies,

117 natures associated with diabetes and support the need for further studies exploring these communities

118 Our results motivate the need for further studies to target agroecological an

119 he importance of the Wulst in stereopsis and the need for further study of the Wulst in relation to b

120 provide an overview of the state of the art, the needs for further development, and possible technica

121 Our work supports the need for future longitudinal studies of recent TB co

122 excessive alcohol consumption and highlight the need for future studies to examine how this is media

123 stimulation at subcellular precision without the need for genetic modification, with laser energies l

124 This highlights the need for greater study of HCM genetics in non-White

125 hat can guide spatial sampling and highlight the need for greater use of mixed-effects models that ac

126 olid-phase microextraction while eliminating the need for heating and shaking samples.

127 ine of >0.3 mg/dl or >=50%, respectively, or the need for hemodialysis during index hospitalization.

128 rly diagnosis and treatment, and thus reduce the need for high-cost care.

129 ditions in a contactless environment without the need for high-power light sources.

130 the trends of key parameters, demonstrating the need for high-quality, up-to-date data on TB determi

131 sone, and rituximab (DA-EPOCH-R) may obviate the need for highly dose-intensive chemotherapy in adult

132 The need for hospitalization, ICU care, and mechanical v

133 umerous efforts have been made to circumvent the need for immunosuppression by using various techniqu

134 nts and injectable microspheres to eliminate the need for implant removal and reduce provider interve

135 ses and low provider suspicion, highlighting the need for improved awareness about this disease.

136 Overall, our findings emphasize the need for improved diagnostic/risk prediction strateg

137 Overall, we highlight the need for improved mechanistic understanding of the c

138 t on PwPA, caregivers and family members and the need for improved PA management across Europe.

139 ted by proteoglycan interactions and suggest the need for improved polyplex targeting materials that

140 Last, we identify the need for improved tools to identify and functionally

141 Limited clinical benefit underpins the need for improved understanding of resistance mechan

142 ncing throughout the tree of life is driving the need for improved unsupervised annotation of genome

143 jor cause of disease and death, underscoring the need for improved vaccines.

144 ether baseline IL-6 serum levels can predict the need for IMV and the response to TCZ.

145 Results show the need for increased funding and evidence-based standa

146 Because of the need for increased knowledge regarding this practice

147 ntroversy, as they have attempted to balance the need for increasing test capacity with maintaining a

148 a custom graphical sequence display without the need for infrastructure investments or back-end depl

149 These findings could yield the need for intensified preventive treatment of patient

150 on in cardiac and biochemical parameters and the need for intensive care support (P<0.05).

151 olumn of the Canadian Arctic Ocean points to the need for international regulatory mechanisms for per

152 ically similar exposure rates, demonstrating the need for intervention strategies to be tailored to i

153 root cause of many pathologies necessitating the need for intrinsic control over molecular motor func

154 However, a major drawback is the need for invasive implantation of optical fibers.

155 rker of pleural fluid loculation, to predict the need for invasive management compared with conventio

156 Care delivery for HHT patients is impeded by the need for laborious, repeated phenotyping and gaps in

157 e spatial variation in defence, highlighting the need for large-scale studies that can differentiate

158 Our findings reinforce the need for legal and policy protections to shield part

159 ets on the CMOS imager surface we eliminated the need for lenses, dramatically scaling down the size

160 islets from donated pancreas tissue and (b) the need for life-long immunosuppression.

161 sia in newborns earlier can delay or prevent the need for liver transplant; however, treatment typica

162 m codes on real, near-term devices, removing the need for locality of syndromes or fast feed-forward.

163 These findings highlight the need for long-read sequencing of cancer genomes for

164 These results highlight the need for long-term screening of both childhood and e

165 inary tract malformation was associated with the need for longer transplantation workup time (P < 0.0

166 This study supports the need for longitudinal studies investigating whether

167 This study highlights the need for lung function surveillance and prevention o

168 These results emphasise the need for maintaining public health measures to avoid

169 talog of active LTR retrotransposons without the need for mapping transposition, as well as independe

170 lowed by CRP level, was highly predictive of the need for mechanical ventilation.

171 es its production in pure form, highlighting the need for metabolic engineering approaches for high-l

172 he extant metabolic mechanisms and obviating the need for metal-catalysed abiotic reductive amination

173 ms and allows identification of PTMs without the need for modification-specific enrichments.

174 itutively active MALT1 mutants that overcome the need for monoubiquitination, we reveal an allosteric

175 ia and lower QALYs after lobar ICH highlight the need for more effective prevention for this patient

176 among people diagnosed in 2015, highlighting the need for more effective strategies for earlier HIV d

177 e gaps in knowledge we illuminate underscore the need for more evidence to substantiate the claim tha

178 , unanswered questions remain, due partly to the need for more quantitative and structural studies wi

179 Our results reveal the need for more research among the older population of

180 identified the paucity of pediatric data and the need for more research involving resuscitation of in

181 se risk and polygenic scores, substantiating the need for multi-ethnic genome references.

182 d clinical care, hurdles to be overcome, and the need for multidisciplinary collaboration.

183 s in a microtiter plate format, obliterating the need for multiple enrichment rounds to harvest high-

184 low efficiency, a reliance on recombination, the need for multiple vectors, and challenges in multipl

185 n this complex coordinates D1 synthesis with the need for nascent D1 during both PSII biogenesis and

186 ximate coarse-graining procedure that avoids the need for negative sampling of nonadjacent nodes in t

187 tors for faster therapeutic response without the need for neutralizing antibodies isolated from conva

188 Enhancing skin allograft longevity lessens the need for new allografts before optimal intervention

189 learned from studies in both populations is the need for new antiviral agents and the necessity for

190 s a neural marker of awareness and highlight the need for new approaches to the neuroscience of consc

191 oncrete, and iron and steel slag) to obviate the need for new mining, as well as uncertainties in soi

192 The findings of this report underscore the need for new research initiatives to determine the r

193 The high incidence of recurrence suggests the need for new treatments to prevent recurrent bacteri

194 growing use of fluorochemicals has elevated the need for nontargeted detection of unknown fluorinate

195 sulting in high interexperiment variability, the need for normalization, waste of materials, and sign

196 consistent with poor adherence, highlighting the need for novel approaches and long-acting formulatio

197 Together with lack of markers, the need for novel markers for the detection and monitor

198 ration antiseizure medications, highlighting the need for novel strategies in epilepsy drug developme

199 cular alterations in cancers and demonstrate the need for novel strategies to address this formidable

200 , including the definition of sex itself and the need for novel study designs.

201 Our results highlight the need for ongoing and enhanced postintervention monit

202 um computers in silicon that operate without the need for oscillating magnetic fields.

203 alone cannot support coexistence, suggesting the need for other mechanisms to explain the epidemiolog

204 th of biological impacts we reveal highlight the need for outdoor artificial night-time lighting to b

205 Somewhat contradicting the need for oxidant scavenging are previous observation

206 ity testing against P. aeruginosa and stress the need for P. aeruginosa-specific breakpoints.

207 ol and drainage of sub-retinal fluid without the need for pars plana vitrectomy.

208 sion of COVID-19 lung disease and highlights the need for peripheral blood biomarkers that inform abo

209 Findings identified the need for permission as key in enabling nurses to sel

210 hort-term synaptic plasticity (STSP) without the need for persistent activity.

211 rning the pump laser on, thereby eliminating the need for photonic and electronic control circuitry.

212 Faba bean can respond to the need for plant-based proteins for human consumption.

213 Following the need for point-of-care and wearable sensors, designs

214 highlights shortcomings in surveillance and the need for policies to address the burden and improve

215 ance on either 48-hour AKI, 7-day AKI, or on the need for postoperative renal replacement therapy aft

216 ry outcomes were the grade of AKI at 7 days, the need for postoperative renal replacement therapy, po

217 analyzing heterogeneous populations obviates the need for pre- or post-enrichment and simplifies sing

218 wever, this intervention is time-limited and the need for PrEP fluctuates as risk behaviours change.

219 e (40 vs 42, P < .0001) but no difference in the need for pretransplant ECMO (incidence rate ratio =

220 igned new rhesus-specific assays that remove the need for primers conventionally targeting variable r

221 ein scaffolds-known as megamolecules-without the need for protecting groups and with precisely define

222 This role goes beyond the need for protein and relates to vitamins, minerals,

223 t-gas nonlinear interactions and demonstrate the need for pump laser stabilization.

224 Further study of the need for QT interval monitoring is needed before fin

225 hospital discharge for COVID-19, emphasizing the need for randomized data to inform recommendations f

226 local, state, and federal levels, as well as the need for rapid dissemination of clinical information

227 The authors posit the need for rapid evaluation of therapies for COVID-19

228 This research suggests the need for re-evaluation of factors controlling SO(2)

229 rease the cumulative exposure-while reducing the need for red blood cell transfusions-is unknown.

230 This critical review discusses how the need for reduced clinical turnaround times has influ

231 To estimate the need for rehabilitation, data from the Global Burden

232 required to assess their sustainability and the need for reintervention.

233 reclinical and clinical phases have prompted the need for reliable and noninvasive assays to validate

234 FB, based on analysis of mutants that bypass the need for relief of SpoIVFB inhibition.

235 The need for reoperation to repair RRD within 90 days wa

236 Severe anaphylaxis and/or the need for repeated doses of epinephrine to treat anap

237 limination diets can be effective and reduce the need for repeated endoscopic assessment of disease a

238 ing derive from tropical reefs, highlighting the need for research in other ecosystems and habitat ty

239 tries are promising, but they also underline the need for research questions to be addressed from tec

240 the added risks from potential exposure and the need for resource reallocation.

241 Progress, however, has been limited by the need for reversibly responsive materials that host s

242 mation about the emergent population without the need for sacrificing living organisms.

243 ur optimized workflow effectively eliminated the need for sample desalting and enabled compatible sam

244 om those induced by persistent infection and the need for selection and immortalization.IMPORTANCE To

245 rates in women with confirmed infertility or the need for semen donation who were eligible for standa

246 ine for next-generation healthcare highlight the need for sensitive and accurate point-of-care platfo

247 Eliminating the need for separate products and protocols could impro

248 However, the need for several reagents and steps and the high cos

249 neurons on energy metabolism and demonstrate the need for sex-specific approaches in obesity research

250 opulation-level HIV reductions, highlighting the need for simplifying delivery and reducing current b

251 ructure and dynamics of biomolecules without the need for site-directed modifications or bio-orthogon

252 Analysis is further complicated by the need for so-called cross-world counterfactuals to de

253 sonance energy transfer trajectories without the need for solving complex single-molecule differentia

254 To address the need for spatially resolved protease activity profil

255 oice of ABO blood group and Rhesus D status, the need for special requirements for selected recipient

256 on of small quantities of AAV vector without the need for specialized equipment.

257 ential geometric configurations, and without the need for specialized equipment.

258 However, costs of operation and the need for specialized staff remain major hurdles for

259 Thus, our findings support the need for standardization and harmonization of REA da

260 ient uptake kinetics provides insights about the need for standardization of reporting, the differenc

261 The use of DEBs eliminates the need for stents so that serious side effects includi

262 yl and alkyl radicals, respectively, without the need for stoichiometric base.

263 ghly enantioselective hydrocyanation without the need for stoichiometric oxidants.

264 These results underscore the need for strategies to deal with intraseasonal vacci

265 Here, we highlight the need for strategies to disrupt environmental AMR tra

266 argeting transboundary species, highlighting the need for strengthened effective and equitable intern

267 ss, DNA damage and oncogenesis, highlighting the need for strict regulation.

268 history in diagnosing food allergy (FA) and the need for studies investigating its value using stand

269 rugs have significant limitations, including the need for subcutaneous injections and frequent monito

270 minimizing submission errors and eliminating the need for submitting sequencing files via a separate

271 visits at postoperative month 1 and beyond, the need for subsequent operative intervention or additi

272 thelialization of the surface, thus reducing the need for subsequent surgeries in the chronic stage a

273 lens (IOL), visual acuity (VA) outcome, and the need for surgery for visual axis opacification.

274 nign products without residues, to eliminate the need for surgical extraction.

275 These results signal the need for sustained stringent suppression measures as

276 challenges in providing such methodology is the need for tailoring algorithms to the specifics of th

277 Our results point to the need for targeted field and experimental studies to

278 mber of methods have been devised to address the need for targeted genomic resequencing.

279 These findings highlight the need for targeted outreach to prevent Pb exposure fo

280 ed by loss or reduction of protein function, the need for technologies that can selectively increase

281 or simplifying quantitative analysis without the need for tedious chromatographic separation.

282 production consistency, possibly eliminating the need for tests in animals.

283 at could confound quantitation, highlighting the need for the "aberration compensated" aspect of AC-L

284 These findings highlight the need for the development and evaluation of intervent

285 diversity of eukaryotic viruses, reinforcing the need for the isolation of new viruses of protists.

286 y and scar size, corneal perforation, and/or the need for therapeutic penetrating keratoplasty (TPK).

287 tive management start at least 1 year before the need for therapy.

288 A consequence of the need for this permanent immunosuppression is the hig

289 ations from a desired function, resulting in the need for time-consuming reassembly to fix these issu

290 cess new architectures of n-type CPs without the need for transition-metal catalysis.

291 ully insert into a synthetic bilayer without the need for translocon insertase apparatus that is esse

292 ely used in computationally identifying PAS, the need for tremendous amounts of annotation data hinde

293 rtical neurons in a rat brain slice, without the need for trial averaging.

294 coring tools for stratifying risk of IE, and the need for undergoing a TEE, among cases of SAB. We al

295 of this potential complication and recognize the need for urgent intervention.

296 h risk of bias, which are most likely due to the need for urgent publication of findings in the first

297 To eliminate the need for using standards or calibration curves, here

298 ulatory shock (< 12 hr duration), defined as the need for vasopressors to maintain mean arterial pres

299 levated serum aminotransferases, reinforcing the need for vigilant monitoring during treatment.

300 These include 1) the need for wider and more deeply transdiagnostic sampl