ライフサイエンスコーパス: therapeutic benefit

1 of acute and chronic kidney injury to assess therapeutic benefit.

2 inase inhibitors could provide patients with therapeutic benefit.

3 introduction of miR-29b into B-CLL cells for therapeutic benefit.

4 ssociated with targeting the Wnt pathway for therapeutic benefit.

5 ugh it is unclear whether this regimen is of therapeutic benefit.

6 s the mechanism by which targeting K-Ras has therapeutic benefit.

7 models could test such approaches and assess therapeutic benefit.

8 o strategy to induce MC1R palmitoylation for therapeutic benefit.

9 hibiting their catalytic activity to achieve therapeutic benefit.

10 the amount of a specific protein might be of therapeutic benefit.

11 ract the initial stages of disease may offer therapeutic benefit.

12 on non-adherence is a missed opportunity for therapeutic benefit.

13 which could be one mechanism underlying the therapeutic benefit.

14 Thus, methods targeting LRV1 could have therapeutic benefit.

15 application of this approach has had limited therapeutic benefit.

16 not given prednisolone, which may offset its therapeutic benefit.

17 a consequence, targeting M-ILK could provide therapeutic benefit.

18 eve that repurposing of NTZ for PD may offer therapeutic benefit.

19 the individual biome predicts likelihood of therapeutic benefit.

20 teins arising from these expanded loci holds therapeutic benefit.

21 tential enzyme inhibitors with regulatory or therapeutic benefit.

22 ow efficacy of cell engraftment still limits therapeutic benefit.

23 ation is thought to be essential for lasting therapeutic benefit.

24 or whether this process can be targeted for therapeutic benefit.

25 ng, antidepressant modality with a prolonged therapeutic benefit.

26 trategies to activate expression may provide therapeutic benefit.

27 y opportunities to control heterogeneity for therapeutic benefit.

28 ants and ideas on how to manipulate them for therapeutic benefit.

29 NA-binding domain, which may be targeted for therapeutic benefit.

30 enchymal stromal cells (MSCs) with potential therapeutic benefit.

31 the potential for targeting hydroxylases for therapeutic benefit.

32 mands in the TME, which can be leveraged for therapeutic benefit.

33 ence cocaine-associated autophagy may afford therapeutic benefit.

34 ntial approach to modulate Wnt signaling for therapeutic benefit.

35 ing lead compounds to modulate autophagy for therapeutic benefit.

36 ependency on SIRT2 that can be exploited for therapeutic benefit.

37 h regard to harnessing unique properties for therapeutic benefit.

38 accommodation at near, possibly reducing the therapeutic benefit.

39 ent in ongoing attempts to modulate CAFs for therapeutic benefit.

40 global immune response to maximize potential therapeutic benefit.

41 treat metastatic melanoma (MM) has variable therapeutic benefit.

42 n have been introduced which promise a great therapeutic benefit.

43 nifest HD and have the sensitivity to detect therapeutic benefit.

44 emonstrate neuromodulation intervention with therapeutic benefit.

45 levant kinases to inhibit to achieve optimal therapeutic benefits.

46 cing Nemo through gene therapy might provide therapeutic benefits.

47 d pathologies and harnessing their potential therapeutic benefits.

48 promote anti-inflammatory responses and have therapeutic benefits.

49 n of daily buprenorphine while retaining its therapeutic benefits.

50 tentially be co-opted or interfered with for therapeutic benefits.

51 n the skin by dietary fish oil could provide therapeutic benefits.

52 ve approach to modulate the CB1 receptor for therapeutic benefits.

53 ulating their function or depleting them for therapeutic benefits.

54 ship that could potentially be harnessed for therapeutic benefits.

55 active KP metabolites could underlie several therapeutic benefits.

56 ith BET bromodomain inhibition may offer new therapeutic benefits.

57 , and that interferon antagonists could have therapeutic benefits.

58 activity or signaling in platelets may have therapeutic benefits.

59 his system under some conditions might bring therapeutic benefits.

60 c stem/progenitor cell functions may provide therapeutic benefits.

61 target in aging, affording preventative and therapeutic benefits.

62 approach, and the addition of TRP yielded no therapeutic benefits.

63 response, which can be exploited to achieve therapeutic benefits.

64 RAF or PI3K inhibition may provide potential therapeutic benefits.

65 gn and development of liposomes with greater therapeutic benefits.

66 Although first-line antidepressants offer therapeutic benefit, about 35% of depressed patients are

67 ion alone results in mild kidney injury, the therapeutic benefit afforded by puerarin in DN remained

68 that neural stem cells may offer significant therapeutic benefit after CNS injury; however, this proc

69 This method could provide therapeutic benefit against an intractable disease for w

70 that selective CDK2 inhibition may provide a therapeutic benefit against certain tumors, and it conti

71 ditional PrP-targeting ASOs, and demonstrate therapeutic benefit against four additional prion strain

72 mmune protection at mucosal surfaces and has therapeutic benefit against influenza A virus (IAV) infe

73 activating TRPML1 or BK channels may provide therapeutic benefit against latent HIV-1 infection, HIV-

74 ociated with improved survival and may offer therapeutic benefit among carefully selected patients.

75 eir target gene expression levels to achieve therapeutic benefits - an approach termed cis-regulation

76 in symptomatic older patients would confer a therapeutic benefit, an important consideration as the m

77 tion load and predicted neoantigen load with therapeutic benefit and (2) determine whether intratumor

78 n stimulation can sometimes yield suboptimal therapeutic benefit and can cause adverse effects.

79 setting is needed to determine predictors of therapeutic benefit and whether addition of durvalumab i

80 redox vulnerabilities could be exploited for therapeutic benefits and identify unsuspected combinatio

81 owever, several challenges exist which limit therapeutic benefits and reduce patient convenience.

82 science is important to further enhance the therapeutic benefits and reduce side effects.

83 and associations between electrode location, therapeutic benefit, and side effects.

84 tivity of RHC variants might be restored for therapeutic benefit are unknown.

85 ivated receptor gamma (PPARgamma), but their therapeutic benefits are compromised by severe side effe

86 e but the neural mechanisms underlying these therapeutic benefits are largely unknown.

87 distinct regimens, despite their respective therapeutic benefit as monotherapy, may together provide

88 cal and clinical trials, albeit with limited therapeutic benefit as single agents.

89 ion products (NDPs) and likely be of limited therapeutic benefit as well.

90 uggest that a PAR2 pepducin may confer broad therapeutic benefits as a disease-modifying treatment fo

91 inhibition via exogenous agents may provide therapeutic benefit, as has long been proposed.

92 function and may explain the angiogenic and therapeutic benefits associated with CD34(+) stem cell t

93 tient-derived models to assess the potential therapeutic benefits associated with intracranial 2-HG i

94 y or a neutrophil-depleting antibody yielded therapeutic benefits associated with reduced neutrophil

95 All RUX regimens demonstrated therapeutic benefit at week 4; 1.5% BID provided the gre

96 el therapeutic approach to achieve potential therapeutic benefits avoiding inherent side effects of o

97 mediator biosynthesis, resulted in a loss of therapeutic benefit bestowed on mesenchymal stromal cell

98 ted to reverse immunosuppression and augment therapeutic benefits beyond tumoricidal effects to harne

99 e innate antioxidant properties that provide therapeutic benefit both in vitro and in vivo.

100 ary, lamotrigine was associated with limited therapeutic benefit but not harm; lithium with both bene

101 he BRAF V600E inhibitor vemurafenib provides therapeutic benefits but the common emergence of drug re

102 sterase 4 (PDE4) exert a number of promising therapeutic benefits, but adverse effects, in particular

103 Cannabis may have therapeutic benefits, but few are cardiovascular in natu

104 ss-of-function MC1R in MC1R RHC variants for therapeutic benefit by activating MC1R protein palmitoyl

105 dynamics and RV performance, and might offer therapeutic benefit by modifying fundamental pathophysio

106 ly with NK cell-based therapies may heighten therapeutic benefits by augmenting NK cell-mediated anti

107 DP-ribosylation, and we anticipate potential therapeutic benefits by targeting this enzyme-enzyme TA

108 To maximize therapeutic benefit, drug combinations and schedules mus

109 nities for controlling the action of AGT for therapeutic benefit during chemotherapy.

110 milar or below doses commonly used to induce therapeutic benefits (e.g., 0.04 mg/kg Rolipram), thus m

111 KIIIalpha pharmacological targeting may have therapeutic benefit for advanced prostate cancer patient

112 is reciprocal crosstalk mechanism may have a therapeutic benefit for cancers with PTEN loss or PI3K/A

113 of prebiotics or probiotics have yet to show therapeutic benefit for CVD.

114 Available CFTR modulators provide no therapeutic benefit for cystic fibrosis (CF) caused by m

115 h an uncoupling agent is unlikely to provide therapeutic benefit for DPN, DKD, or DR in T2D.

116 ules targeting CaMKIV activation may provide therapeutic benefit for patients with IBD.

117 dependent adaptive immune response may be of therapeutic benefit for PD patients.

118 ic adoptive T-cell therapy and its potential therapeutic benefit for SOT recipients with recurrent an

119 llergic sensitization would have significant therapeutic benefit for T(H) 2-type allergic asthma.

120 As such, they are hypothesized to have therapeutic benefit for the treatment of diseases that i

121 ally, inhibition of MAGL is known to provide therapeutic benefits for a number of neurological disord

122 rate exosome biology research but also offer therapeutic benefits for cancer patients.

123 with inhibition of MYB activity could offer therapeutic benefits for ER(+) breast cancer and possibl

124 hat modifying the gut microbiome may provide therapeutic benefits for ID and ASD patients.

125 ontract in proportion to need and to mediate therapeutic benefits for months or years following a sin

126 y restricted OTR agonist may offer potential therapeutic benefits for obesity.

127 ecent epidemiologic studies have suggested a therapeutic benefit from aspirin intake in cancers harbo

128 Despite this, the current evidence of therapeutic benefit from extended oxytocin treatment rem

129 p of PDAC patients that currently has little therapeutic benefit from surgical treatment.

130 ng in tumors is essential to achieve maximal therapeutic benefit from WNT inhibitory compounds.

131 elective targeting of their function confers therapeutic benefit in a number of diseases.

132 AC1903 also provided therapeutic benefit in a rat model of hypertensive prote

133 lective inflammasome blockers with potential therapeutic benefit in a wide range of human diseases.

134 esponse and that this can be manipulated for therapeutic benefit in acute liver injury.

135 ssion and thereby its function(s) might have therapeutic benefit in AD.

136 ggest that compounds targeting NMT1 may have therapeutic benefit in cancer by preventing mTORC1 activ

137 way, but if and how such treatments elicit a therapeutic benefit in cancer remains unclear.

138 re intestinal immune homeostasis and exert a therapeutic benefit in CeD, and potentially other inflam

139 rs such as palbociclib are likely to provide therapeutic benefit in combination with BRAF inhibitors

140 presentative bnAb and assessed its potential therapeutic benefit in controlling virus replication in

141 sis and fatty acidbeta-oxidation and provide therapeutic benefit in diseases associated with mitochon

142 ility to manipulate their function may be of therapeutic benefit in diverse disease conditions.

143 the proinflammatory leukotriene cascade for therapeutic benefit in early diabetic retinopathy.

144 targeting of eosinophil metabolism may be of therapeutic benefit in eosinophil-mediated diseases and

145 Nomacopan has been shown to provide therapeutic benefit in experimental autoimmune uveitis (

146 endoscopic GERD treatment modalities have no therapeutic benefit in functional heartburn and should n

147 survival, as well as reported to demonstrate therapeutic benefit in HD animal models.

148 her related metabolic supplements could have therapeutic benefit in HD.

149 can effectively reduce alpha-syn and provide therapeutic benefit in human midbrain neurons.

150 ting that targeting mast cells could provide therapeutic benefit in human osteoarthritis.

151 ogeneic T-cell products to produce long-term therapeutic benefit in immunocompetent recipients.

152 his study, we tested whether this effect had therapeutic benefit in improving protection against path

153 Furthermore, T2AA provided a therapeutic benefit in mice during trinitro-benzene-sulf

154 he use of transplanted astrocytes to produce therapeutic benefit in mouse models of HD.

155 t nucleoside supplementation has a potential therapeutic benefit in mtDNA depletion syndromes by subs

156 ing the FGF-Klotho endocrine axes might have therapeutic benefit in multiple systems; investigation o

157 t manipulating complement system may produce therapeutic benefit in muscle injury and regeneration.

158 We showed that T(reg) engraftment and therapeutic benefit in nonautoimmune models required abl

159 1061T variant protein can have a significant therapeutic benefit in patients carrying at least one co

160 Therefore, this drug combination might be of therapeutic benefit in patients with decompensated cirrh

161 g of sirolimus plus nintedanib might provide therapeutic benefit in patients with HHT.

162 rporeal photopheresis (ECP) has demonstrated therapeutic benefit in patients with Sezary syndrome (SS

163 le intervention (MEK-inhibition) could be of therapeutic benefit in preventing invasive migration and

164 sm by which intranasal OXT shows promise for therapeutic benefit in PWS.

165 the secretome, has demonstrated considerable therapeutic benefit in regenerative medicine.

166 human, this mechanism might be exploited for therapeutic benefit in rescue strategies.

167 e-1-phosphate receptor by FTY720 would be of therapeutic benefit in sarcomere-linked HCM.

168 s naloxone and naltrexone and evidence for a therapeutic benefit in schizophrenia for 4 pan-opioid an

169 uman tumors; this approach provided a modest therapeutic benefit in some patients but no lasting remi

170 the idea that blocking TNFalpha might be of therapeutic benefit in the disease.

171 onset of peripheral neuropathy can provide a therapeutic benefit in the Gjb1-null/Cx32 knockout model

172 n early human clinical trials, might provide therapeutic benefit in the mouse FXS model.

173 argeting H(2)S to the mitochondria may be of therapeutic benefit in the prevention of endothelial dys

174 vance: A short course of cyclosporine was of therapeutic benefit in the treatment of 2 patients with

175 Targeting the autophagy pathway may have therapeutic benefit in the treatment of kidney disorders

176 These aptamers could have a significant therapeutic benefit in the treatment of multiple diverse

177 ough TASK-1 channels could contribute to its therapeutic benefit in the treatment of PAH.

178 f peripheral neuropathy offers a significant therapeutic benefit in this disease model, providing a p

179 etyltransferase activity may be targeted for therapeutic benefit in this disease.

180 that suppressing the PAK pathway might be of therapeutic benefit in this type of melanoma.

181 at inhibition of IRAK4 has the potential for therapeutic benefit in treating lupus.

182 lencing and their potential manipulation for therapeutic benefit in treating the beta-hemoglobinopath

183 e activity of adherens junctions could be of therapeutic benefit in vascular ageing.

184 ance, as clozapine is more effective and has therapeutic benefits in a broader range of psychiatric d

185 vide novel protective strategies that confer therapeutic benefits in a mouse model of a severe LSD.

186 gulate trained immunity to achieve long-term therapeutic benefits in a range of immune-related diseas

187 e sclerosis, fingolimod may potentially have therapeutic benefits in AD at low doses that do not affe

188 hat inhibition of LTE4 and of GPR99 may have therapeutic benefits in asthma.

189 e pharmacological induction of autophagy has therapeutic benefits in cellular and transgenic animal m

190 water administered from postnatal day 21 has therapeutic benefits in Cln3(-/-) mice.

191 targeting of this enzyme may have important therapeutic benefits in disease mechanisms that involve

192 mate receptor 5 (mGluR5) receptor might hold therapeutic benefits in Fragile X syndrome (FXS).

193 Thus, targeting the cGAS pathway may offer therapeutic benefits in HD.

194 tissue repair or regeneration and to attain therapeutic benefits in ocular diseases.

195 ith checkpoint abrogation" (PPCA)] displayed therapeutic benefits in preclinical disease models of he

196 Anti-VEGF agents also provide therapeutic benefits in proliferative diabetic retinopat

197 ocytopenia, suggesting targeting it may have therapeutic benefits in such conditions.

198 cell function and angiogenesis and may have therapeutic benefits in the setting of diabetes.

199 abundance or activity of collectrin may have therapeutic benefits in the treatment of hypertension an

200 cal targeting of the primary cilium may have therapeutic benefits in the treatment of osteoarthritis.

201 Thus, thyromimetics may have limited therapeutic benefits in treating cholestatic liver disea

202 d preclinically and clinically and has shown therapeutic benefit, in both early and advanced stage me

203 led sustained release of EPO-R76E, providing therapeutic benefits including reduction in inflammation

204 ctrical stimulation of cells and tissues for therapeutic benefit is a well-established method.

205 intuitively appealing principle that maximum therapeutic benefit is achieved by killing the largest p

206 Historically, their therapeutic benefit is due to ADC targeting of lineage-r

207 e mechanism whereby DcpS inhibition leads to therapeutic benefit is unclear.

208 on, the refinement of emerging biomarkers of therapeutic benefits is critical to the streamlining of

209 To achieve therapeutic benefits, it is critical for phages to remai

210 reated with gefitinib and osimertinib show a therapeutic benefit limited by the appearance of seconda

211 rapy in hypertrophic cardiomyopathy although therapeutic benefit may depend on disease stage.

212 more specifically, provide evidence for the therapeutic benefit of a brain endothelial-targeted gene

213 Evidence of this includes the therapeutic benefit of a ketogenic diet in neurologic di

214 ytotoxicity of AbetaO, revealing a potential therapeutic benefit of ADAM10 activation in AD.

215 a valid strategy to enhance sensitivity and therapeutic benefit of AML chemotherapy.

216 ically, the findings may help to explain the therapeutic benefit of CGRP-mAb in reducing headaches of

217 These findings demonstrate how the therapeutic benefit of CHK1 inhibitors may potentially b

218 ransplanted hepatocytes, thus augmenting the therapeutic benefit of clinical hepatocyte transplantati

219 ly, our data demonstrate the feasibility and therapeutic benefit of CRISPR-dCas9-mediated upregulatio

220 es encouraging data to support the potential therapeutic benefit of cyclocreatine or other chemically

221 e model expressing human ROR1, we report the therapeutic benefit of enhanced survival via cellular re

222 hese predicted deficiencies and demonstrated therapeutic benefit of HIF-1alpha-stabilizing drugs.

223 fying enzymes (HMEs), indicating a potential therapeutic benefit of histone deacetylase inhibitors (H

224 proximately 80-90% of the maximum achievable therapeutic benefit of ICS is obtained in adult asthma a

225 e illustrate the functional significance and therapeutic benefit of miR-299-3p, an AR targeting micro

226 pes in Hu128/21 mice, suggesting a potential therapeutic benefit of miRNA-mediated non-selective HTT

227 While the therapeutic benefit of monoclonal antibodies against inf

228 cacy; however, the mechanisms underlying the therapeutic benefit of myeloid-targeting agents in combi

229 While a plethora of studies support a therapeutic benefit of Nrf2 activation and ROS inhibitio

230 bryonic and early postnatal stages, when the therapeutic benefit of restoring Ube3a is predicted to b

231 lung adenocarcinoma and reveal the potential therapeutic benefit of selectively targeting these pathw

232 nd cognitive deficits in AD, and a potential therapeutic benefit of senolytic treatments.

233 approach opens possibilities to enhance the therapeutic benefit of small-molecule TLR agonist for a

234 tochondrial respiration may help enhance the therapeutic benefit of targeted therapies.

235 clinical studies that evaluate the potential therapeutic benefit of targeting these stress-relieving

236 ti-inflammatory effect and therefore a novel therapeutic benefit of TAVI.

237 The potential therapeutic benefit of these engineered formulations rel

238 odynamic effects of the LAA may increase the therapeutic benefit of this procedure.

239 adoptive cell therapy and may limit expected therapeutic benefits of adoptive cell therapy.

240 To assess the therapeutic benefits of antidepressants in depressive wo

241 ese links will help us harness the potential therapeutic benefits of autophagy in combating age-relat

242 scuss whether altered selection accounts for therapeutic benefits of BAFF inhibition, and address whe

243 ne-compromised zebrafish reveal that maximal therapeutic benefits of Bdellovibrio result from the syn

244 e hypocretin responses may contribute to the therapeutic benefits of both rapid acting antidepressant

245 Further, we propose that the therapeutic benefits of EE could extend to other neurode

246 The therapeutic benefits of estradiol (E2) and symptom-provo

247 matory and immune-pathogenesis of AD and the therapeutic benefits of fingolimod, a structural analog

248 ovide mechanistic insight into the potential therapeutic benefits of intranasal insulin.

249 Mechanistically, the therapeutic benefits of LCD NP are achieved by inhibitin

250 We tested the therapeutic benefits of MEK1/2 inhibitors in reversing v

251 data suggests that in the context of HD, the therapeutic benefits of mHTT reduction may outweigh the

252 We also demonstrate the potential therapeutic benefits of modulating autophagy in the aged

253 electively targeting PDE4B should retain the therapeutic benefits of nonselective PDE4 inhibitors.

254 adult dorsal striatum, supporting potential therapeutic benefits of RA supplementation in moderating

255 omal-autophagic impairment and the potential therapeutic benefits of rapamycin in neuronopathic GD.

256 studies are planned to investigate possible therapeutic benefits of recombinant human pGSN in this p

257 These findings highlight the very potent therapeutic benefits of Roniciclib in HR-NB through the

258 d, preclinical studies have demonstrated the therapeutic benefits of the MSC secretome in models of s

259 The therapeutic benefits of the neuraminidase (NA) inhibitor

260 ic and experimental rationale, the potential therapeutic benefits of using such compounds to block th

261 ast subsets could either provide substantial therapeutic benefit or accelerate disease progression.

262 The therapeutic benefit or detriment of resultant cell hybri

263 The therapeutic benefit or detriment of resultant hybrids is

264 Of important scientific and therapeutic benefit, our results reveal a diverse activa

265 46B8 demonstrates a superior therapeutic benefit over Tamiflu and has an additive ant

266 toration of miR-203 expression may provide a therapeutic benefit, particularly in poorly differentiat

267 ro evolution experiments may have overstated therapeutic benefit, predicting a collaterally sensitive

268 olling inflammation might provide an overall therapeutic benefit, regardless of whether it is seconda

269 hological processes underlying its potential therapeutic benefit remain largely unknown.

270 Full and effective use of this target for therapeutic benefit requires a complete understanding of

271 Despite the therapeutic benefit, responses are rarely complete, and

272 uscle function to wt levels offering greater therapeutic benefit than either single approach alone.

273 onally, LSC-Sec and LSC-Exo exhibit superior therapeutic benefits than their counterparts derived fro

274 lly since scientific literature reported its therapeutic benefits that are attributable to antioxidan

275 A transdermal SARM has a potential to have therapeutic benefit through anabolic activity in muscle

276 e cerebral insulin function that could offer therapeutic benefit to adults with Alzheimer's disease,

277 pport normal balance behaviors, suggesting a therapeutic benefit to balance with ASO-29 treatment at

278 ts indicate that acidified water may provide therapeutic benefit to CLN3 Batten disease patients, and

279 ygen-based therapies are unlikely to provide therapeutic benefit to DMD patients.

280 d manageable toxicity and safety but limited therapeutic benefit to HCC patients, suggesting low resp

281 y-mediated neutralization of IL-1Ra provided therapeutic benefit to Mtb-infected B6.Sst1(S) mice.

282 atus, therefore targeting Wnt/Fzd7 may be of therapeutic benefit to patients with gastric cancer.

283 ration-resistant prostate cancer to maximise therapeutic benefit to patients.

284 tin (APN), a pleiotropic adipokine, provides therapeutic benefit to prevent AngII-induced advanced AA

285 mice, and Sephin1 did not provide additional therapeutic benefit to the GADD34 mutant animals.

286 ecdin-KO pups, and that fluoxetine may offer therapeutic benefits to PWS patients with respiratory co

287 apy due to its promise in providing superior therapeutic benefits to the current drug combination the

288 tion and refinement of natural products with therapeutic benefit, to the systematic screening of mole

289 residual C5 activity may derogate the drug's therapeutic benefit under certain conditions.

290 The therapeutic benefit was mediated through a reduction in

291 table doses of tetrabenazine that provided a therapeutic benefit were switched overnight to deutetrab

292 Altruism and the potential for therapeutic benefit were the main motives for trial part

293 Such therapeutic benefits were associated with suppression of

294 romic activation became less robust, whereas therapeutic benefits were maintained.

295 arbon monoxide ex vivo would promote further therapeutic benefit when cells are administered in vivo

296 apeutic relevance, Sephin1 provided additive therapeutic benefit when combined with the first line mu

297 bution to the cell membrane can minimize the therapeutic benefits, which highlights the importance of

298 this capability has the potential to improve therapeutic benefit while preventing undesirable side ef

299 lipid form (krill oil) may confer additional therapeutic benefit, with improvements in DED symptoms a

300 E4 subtypes may be targeted individually for therapeutic benefits without inducing nausea or emesis.