ライフサイエンスコーパス: therapeutic dose

1 r, is often a limiting factor in achieving a therapeutic dose.

2 birth, is more than 20-fold higher than its therapeutic dose.

3 nd overlapping on the macula cumulating in a therapeutic dose.

4 8 years (range, 52 to 79 years) received the therapeutic dose.

5 re mild and had no consistent pattern at the therapeutic dose.

6 elivered in 2 parts, a dosimetric dose and a therapeutic dose.

7 Of 32 patients enrolled, 28 completed the therapeutic dose.

8 esis (comet) assay after administration of a therapeutic dose.

9 ured tissue temperature elevations, ensuring therapeutic dose.

10 ts were treated with a single dosimetric and therapeutic dose.

11 millicurie activity required to deliver the therapeutic dose.

12 ment of normal tissue uptake to optimize the therapeutic dose.

13 ex and large interpatient variability in the therapeutic dose.

14 infections, judged by treatment duration and therapeutic dose.

15 y package siRNA can significantly reduce its therapeutic dose.

16 o minimize thrombosis risk while maintaining therapeutic dose.

17 er drug in a prolonged controlled manner and therapeutic dose.

18 inistered as a dosimetric dose followed by a therapeutic dose.

19 ribution and hence whether to administer the therapeutic dose.

20 hundreds of nanograms per liter to achieve a therapeutic dose.

21 east 4 weeks of antipsychotic treatment at a therapeutic dose.

22 hibitors, exhibiting adverse side effects at therapeutic doses.

23 s mediated radioiodine uptake at potentially therapeutic doses.

24 s use can be limited by side effects at high therapeutic doses.

25 tolerated in primates at levels in excess of therapeutic doses.

26 -regulation, which is difficult to attain at therapeutic doses.

27 d should cause minimal toxicity to humans at therapeutic doses.

28 rum complement activity at minimum effective therapeutic doses.

29 al thrombosis, it prolongs bleeding times at therapeutic doses.

30 n serum cortisol concentrations at predicted therapeutic doses.

31 concordant with antipsychotic medication at therapeutic doses.

32 f-life and their severe toxicity at relevant therapeutic doses.

33 r EPS and prolactin-elevating liabilities at therapeutic doses.

34 xposure level differed from that observed at therapeutic doses.

35 to predict erlotinib tissue distribution at therapeutic doses.

36 mouse models with insignificant toxicity at therapeutic doses.

37 ers a useful strategy for achieving required therapeutic doses.

38 protection against established disease after therapeutic dosing.

39 morbidity and mortality after repeated supra-therapeutic dosing.

40 soluble Apo2L enhanced the lethality of low, therapeutic doses (1-2 Gy) of gamma-irradiation.

41 In the 3 trials evaluating azimilide in therapeutic doses (100 and 125 mg), asymptomatic atrial

42 Of these patients, 68 received at least 1 therapeutic dose (~18.5 GBq) of HSA (131)I-MIBG intraven

43 16 lesions exhibited reduced uptake from the therapeutic dose, 2 remained the same, and in 1 the upta

44 ht not be clinically indicated, but pdhC1INH therapeutic doses (20 U/kg) should be available.

45 g and to estimate dosimetry, followed by the therapeutic dose (4-23 mg and 44-268 mCi), based on the

46 15-d horizon or discharge) was shorter with therapeutic doses (4.8 +/- 0.4 vs. 6.1 +/- 0.5 d).

47 Of 2,649 therapeutic doses, 5 (0.2%) were cancelled because of al

48 Various therapeutic doses (8.25-3,300 mug/kg) of sodium nitrite

49 ng the hemodialysis sessions performed after therapeutic dose administration and under the same condi

50 ALI with therapeutic doses (ALITD) was defined as APAP intake <6

51 , but lacking these limiting side effects at therapeutic doses (an anxioselective agent), would repre

52 ia requires alternative anticoagulation at a therapeutic dose and immune thrombocytopenia immunomodul

53 impairment at up to 20 times the recommended therapeutic dose and may represent a useful alternative

54 m Burkholderia pseudomallei, indicating that therapeutic dose and metabolite effects have to be caref

55 tide, and tirzepatide), each administered at therapeutic doses and compared vs placebo or controls.

56 inimal central effects at potentially useful therapeutic doses and offer useful leads for further dev

57 nown to induce hepatotoxicity when exceeding therapeutic doses and was therefore selected as the test

58 ed, supporting future trial phases examining therapeutic dosing and efficacy.

59 astic syndrome (one who had not received the therapeutic dose) and one with acute myelogenous leukemi

60 Six leiomyomas received full therapeutic doses, and 98.5% of the sonications were vis

61 ld lower than the respective proposed infant therapeutic doses, and tenofovir was not detected in 94%

62 enoxaparin and 4.9% of patients treated with therapeutic-dose anticoagulation (HR: 0.70; 95% CI: 0.52

63 available for 1098 patients (534 assigned to therapeutic-dose anticoagulation and 564 assigned to usu

64 e outcome was not significantly reduced with therapeutic-dose anticoagulation compared with prophylac

65 in the final analysis, the probability that therapeutic-dose anticoagulation increased organ support

66 owever, fewer patients who were treated with therapeutic-dose anticoagulation required intubation and

67 tients with Covid-19, an initial strategy of therapeutic-dose anticoagulation with heparin did not re

68 tients with Covid-19, an initial strategy of therapeutic-dose anticoagulation with heparin increased

69 to a pragmatically defined regimen of either therapeutic-dose anticoagulation with heparin or pharmac

70 therapeutic-dose enoxaparin (n = 1,136), or therapeutic-dose apixaban (n = 1,121) at 76 centers in 1

71 ause free plasma levels of these drugs after therapeutic doses approximate those concentrations that

72 To control vitamin A deficiency, large therapeutic doses are administered in developing countri

73 ns or body compartments and to concentrate a therapeutic dose at a specific site of pharmacological a

74 intratumoral sorafenib concentrations after therapeutic dosing, but the association between a decrea

75 dministered radioactivity dose and whether a therapeutic dose can be administered.

76 rmed indicates that a previously established therapeutic dose can be delivered effectively to the mac

77 Our study demonstrates Sfrp2 at therapeutic doses can inhibit fibrosis and improve LV fu

78 to the gastrointestinal mucosa when used at therapeutic doses, caused extensive damage to these tiss

79 All 10 patients in the therapeutic-dose cohort remained alive and without the n

80 nths; 7 females; low-dose cohort, n = 3; and therapeutic-dose cohort, n = 10).

81 The safety and tolerability profile at therapeutic doses compare favorably to other oral chelat

82 Ten of the 13 patients received initial therapeutic doses delivering 150-450 cGy to the red marr

83 led tositumomab followed one week later by a therapeutic dose, delivering 75 cGy of radiation to the

84 Fifty-three patients received individualized therapeutic doses, delivering a specified total-body rad

85 istration of PDSinh-C01 to mice at predicted therapeutic doses, determined from serum and urine pharm

86 Alas1-siRNA was well tolerated and a therapeutic dose did not cause hepatic heme deficiency.

87 In mouse liver, at human-equivalence (therapeutic) doses, dose-dependent loss of intercellular

88 to prophylactic-dose enoxaparin (n = 1,141), therapeutic-dose enoxaparin (n = 1,136), or therapeutic-

89 At therapeutic doses, eye drop application of the dnG1 retr

90 The single therapeutic dose following a dosimetric dose was adjuste

91 r trials are needed to determine the optimal therapeutic dose for juxtapapillary choroidal melanoma.

92 and may be useful in assessing a beneficial therapeutic dose for RPE65 gene therapy in humans.

93 esting and marble burying), at the effective therapeutic dose for spatial memory deficits.

94 would be needed for fish to receive a human therapeutic dose for these progestins according to model

95 l-group study of fluoxetine and dothiepin at therapeutic doses for 12 weeks.

96 h 5% particle loading can deliver timolol at therapeutic doses for about a month at room temperature,

97 cid), every 30 minutes: 20%-30%-50% of daily therapeutic dose, for the moderate absorption group, eve

98 ediction of erlotinib tissue distribution at therapeutic doses from PET with a microdose of (11)C-erl

99 sufficient MRI contrast to be visualized at therapeutic doses (>=10(8) NSs per milliliter).

100 human intestinal myofibroblasts, aspirin, at therapeutic doses, had the unexpected effect of inducing

101 hs and down to doses much lower than minimum therapeutic doses have shown greater success in reducing

102 12 April 2021 and were randomly assigned to therapeutic dose heparin (n=228) or prophylactic dose he

103 onventional subgroup analyses, the effect of therapeutic-dose heparin on organ support-free days diff

104 were similar between patients randomized to therapeutic-dose heparin or usual care (median age, 60 y

105 analysis of a multiplatform adaptive RCT of therapeutic-dose heparin vs usual care pharmacologic thr

106 nts hospitalized for COVID-19, the effect of therapeutic-dose heparin was heterogeneous.

107 In the overall multiplatform RCT population, therapeutic-dose heparin was not associated with an incr

108 age (ICH) was not significantly increased at therapeutic doses; however, there was an increase in ICH

109 osimetry is not required for determining the therapeutic dose in patients meeting eligibility criteri

110 acute baclofen poisoning) or accumulation of therapeutic dose in the setting of impaired kidney funct

111 oes not cause dysphoria or hallucinations at therapeutic doses in humans.

112 assessment of novel drug delivery systems at therapeutic doses in models of diseased skin.

113 cribe systemic temporal response cascades to therapeutic doses in multiple tissues such as liver, ske

114 ations commensurate with probable achievable therapeutic doses in patients, including the PIKfyve kin

115 Chronic administration of both agents at therapeutic doses increased the expression of BAG-1 in r

116 At therapeutic doses, intratumoral or i.p. injection of all

117 of radioactivity in thyroid tissues after a therapeutic dose is <60% of the diagnostic dose in most

118 tes preclinical anticancer activity, but its therapeutic dose is limited by the development of hepato

119 The percentage uptake of the therapeutic dose is on average only one half of that pre

120 eins, such as monoclonal antibodies, at high therapeutic doses is challenging current production capa

121 Low molecular weight heparin (LMWH) in therapeutic doses is the treatment of choice during preg

122 ncipal pathway of chronic cardiotoxicity for therapeutic doses, leading to a progressive and irrevers

123 When these drugs are administered at therapeutic dose levels, a significant tumor growth arre

124 st cancer) show light delivery capability at therapeutic dose levels.

125 All 10 patients treated with the therapeutic dose maintained previously acquired motor mi

126 nflammatory drugs, AJA is not ulcerogenic at therapeutic doses, making it a promising anti-inflammato

127 Further, interindividual variability in therapeutic dose mandates frequent monitoring until targ

128 al and human studies suggest that lithium in therapeutic doses may improve learning and memory and mo

129 s monotherapy, with its difficult-to-achieve therapeutic dosing, may not be sufficient to maintain lo

130 Above therapeutic doses, mexiletine prolongs the cardiac AP.

131 At therapeutic doses, NSC59984 induces p73-dependent cell d

132 her increased by additional treatment with a therapeutic dose of (131)I (radiovirotherapy) and was as

133 stunning arose from the early effects of the therapeutic dose of (131)I and that the initial uptake o

134 ing"-defined as a reduction in uptake of the therapeutic dose of (131)I caused by some form of cell d

135 Thirty-four patients received a therapeutic dose of (131)I-antibody labeled with 76 to 6

136 After the extravasation of a therapeutic dose of (131)I-metaiodobenzylguanidine that

137 The therapeutic dose of (90)Y ibritumomab tiuxetan was follo

138 mab (dosimetric dose of 5 mCi on day -19 and therapeutic dose of 0.75 Gy on day -12), carmustine 300

139 Infarct volume was reduced at a therapeutic dose of 1 mEq/kg even when administered up t

140 binding of either the diagnostic dose or the therapeutic dose of 111In-pentetreotide.

141 tic tracer dose of 131I on the uptake of the therapeutic dose of 1311 in the ablation of a thyroid re

142 84%) had a successful outcome after a single therapeutic dose of 131I while 71 (16%) did not.

143 A total of 83 patients received a therapeutic dose of 166Ho-DOTMP followed by autologous h

144 The activity to deliver a therapeutic dose of 25 Gy to the marrow was determined.

145 tuximab within 2 h after administration of a therapeutic dose of 500 mg.m(-2) of cetuximab.

146 A therapeutic dose of 75 cGy total-body dose (attenuated t

147 inflammation) occurred at 3000 microg, and a therapeutic dose of 750-1500 microg was established.

148 re treatment, and 7 and 28 d after the first therapeutic dose of a TKI (gefitinib or erlotinib).

149 , which can cause immune pathology, a single therapeutic dose of anti-GITR did not induce splenomegal

150 In the mouse model, one therapeutic dose of antibody 1F2 was more protective tha

151 ivation that occurs in patients prescribed a therapeutic dose of aspirin and may underlie an unknown

152 of illness, duration of treatment, and total therapeutic dose of azathioprine and 6-MP.

153 r at least 4 h after the administration of a therapeutic dose of BMS-275291.

154 t to the pan PDE4 inhibitor roflumilast, the therapeutic dose of both the PDE4B-specific inhibitor A3

155 nt deprivation of lysine combined with a sub-therapeutic dose of cisplatin inhibited growth of ectopi

156 n model, peptide therapy combined with a sub-therapeutic dose of cyclosporin A significantly prolonge

157 The therapeutic dose of docetaxel (10 mg/kg/week) was determ

158 nd better informed administration of correct therapeutic dose of drugs used to treat alpha-amylase re

159 in vitro, exposure of volunteers to a single therapeutic dose of each NSAID followed by 325 mg aspiri

160 In addition, the effects of a therapeutic dose of furosemide on glomerular filtration

161 at depth in tissue can be used to deliver a therapeutic dose of heat by using moderately low exposur

162 omen) completed the trial and 87% received a therapeutic dose of heparin by the end of study day 1.

163 therapeutic dose of heparin, compared with a therapeutic dose of heparin only, did not result in an i

164 he use of a P2Y12 inhibitor in addition to a therapeutic dose of heparin, compared with a therapeutic

165 : Of the 68 patients who received at least 1 therapeutic dose of HSA (131)I-MIBG, 17 (25%; 95% confid

166 previous major depressive episodes and on a therapeutic dose of maintenance antidepressants, from pr

167 r and their potential reversal with a single therapeutic dose of methylphenidate.

168 Importantly, mice that received a therapeutic dose of MSCs were significantly less likely

169 We also demonstrate that a therapeutic dose of NA (250 mg/kg of body weight), previ

170 his is the first report demonstrating that a therapeutic dose of nonradioactive iodide has potent eff

171 M administration enables local delivery of a therapeutic dose of PE to the anal sphincter muscle laye

172 every day over 70 years is up to 2.5% of the therapeutic dose of pharmaceuticals considered in this s

173 Once a therapeutic dose of quetiapine was reached, ventilator s

174 y determine the appropriate patient-specific therapeutic dose of radiolabeled antibody needed to deli

175 rs rendered the tumor cells susceptible to a therapeutic dose of RAI.

176 Treatment with a therapeutic dose of rHuGH can rectify the IGF-1 deficien

177 ants were 100% protected after only a single therapeutic dose of the antibody used to generate the es

178 y i.v. dosed to humans, at T(max) of an oral therapeutic dose of the unlabeled drug, both drugs in pl

179 objective was to begin to accrue data on the therapeutic dose of these growth factors (GFs) required

180 TC entered exploratory clinical studies with therapeutic doses of 131I-labeled NP-4 and MN-14 murine

181 treated with HD-RIT received individualized therapeutic doses of 131I-tositumomab (median, 19.7 GBq

182 metastatic mediastinal 131I uptake following therapeutic doses of 131I.

183 regnancies were in women who received common therapeutic doses of 150 mg (56% of pregnancies) or 300

184 evaluation of acute liver injury (ALI) with therapeutic doses of acetaminophen (APAP; 6 g/d) is requ

185 rition, especially fasting demonstrates that therapeutic doses of acetaminophen do not place patients

186 plain some of the variability in response to therapeutic doses of albuterol in children.

187 ALI with therapeutic doses of APAP is associated with more severe

188 We now report that therapeutic doses of aspirin suppress lipopolysaccharide

189 ouse blood chemistry profiles indicated that therapeutic doses of bioengineered miR-34a prodrug were

190 , compared with traditional ocular steroids, therapeutic doses of BOL-303242-X elicit a reduced myoci

191 s well with subsequent clinical tolerance of therapeutic doses of carbapenems.

192 Treatment with therapeutic doses of ceftiofur or florfenicol resulted i

193 a pen and subsequent feeding/not feeding of therapeutic doses of chlortetracycline.

194 We observed that therapeutic doses of CsA increased tumor size and VEGF m

195 Our results suggest that therapeutic doses of CsA may not prevent the upregulatio

196 Delivery of alpha1hu70-77-RT1.Aa with therapeutic doses of cyclosporine (CsA) also prevented c

197 he current study aimed to test the effect of therapeutic doses of d-amphetamine on effort for reward

198 Mice were given therapeutic doses of dexamethasone before intracerebral

199 e response for up to 6 months despite weekly therapeutic doses of enzyme in the absence of immunosupp

200 Thus, we found that therapeutic doses of etoposide affect primarily meiotic

201 (+) cell infiltration at clinically relevant therapeutic doses of fingolimod.

202 eurons in the human cortex are suppressed by therapeutic doses of fluoxetine (Prozac).

203 Therapeutic doses of GC induce growth-suppressive and cy

204 All animals tolerated the therapeutic doses of IL-13 toxin without any visible sig

205 d the ability of pulsed microjets to deliver therapeutic doses of insulin across the skin.

206 demonstrate that the continuous infusion of therapeutic doses of interferon-alpha (IFNalpha) control

207 els to analyze behavioral changes induced by therapeutic doses of ketamine, while rhesus macaques wer

208 In hippocampal neurons, therapeutic doses of Li(+) (1-2 mM) increased GIRK basal

209 zed that the treatment of rats with relevant therapeutic doses of long acting beta(2)AR agonist (LABA

210 thrombin and antithrombin in the presence of therapeutic doses of low- and high-molecular-weight hepa

211 He is treated with therapeutic doses of low-molecular weight heparin (LMWH)

212 rrhage associated with the administration of therapeutic doses of low-molecular-weight heparin, we pe

213 he interstitial administration of often high therapeutic doses of mAb in the clinic.

214 ce can serve as a platform to orally deliver therapeutic doses of macromolecule drugs.

215 In the present study, we evaluated whether therapeutic doses of metformin increase AMPK activity in

216 of dopamine transporter blockade achieved by therapeutic doses of methylphenidate are not known.

217 Therapeutic doses of MLN2704 can be administered safely

218 Finally, therapeutic doses of MMs mitigate mortality associated w

219 suggest that developmental exposure to high therapeutic doses of MPH has short-term effects on selec

220 C therapy by allowing on-site cryostorage of therapeutic doses of MSC at hospitals and clinics.

221 aparoid or fondaparinux; all others received therapeutic doses of nonheparin anticoagulants.

222 liomagenesis and progression and to optimize therapeutic doses of novel HDACs class IIa inhibitors in

223 gent to control their PSII were treated with therapeutic doses of oral tacrolimus.

224 Concerns of potential hepatotoxicity of therapeutic doses of paracetamol have been highlighted i

225 otectin, B. burgdorferi is not eliminated by therapeutic doses of penicillin G; in contrast, doxycycl

226 The therapeutic doses of pimozide and haloperidol were equiv

227 nd after 1 to 14 d of oral administration of therapeutic doses of prednisone.

228 Unexpectedly, therapeutic doses of RA and RA + As(2)O(3) can induce, b

229 n 11 Hodgkin's disease patients who received therapeutic doses of radiation to a mantle field at the

230 tudy indicate that most patients who receive therapeutic doses of radiation to a mantle field experie

231 The administration of therapeutic doses of recombinant cytokines to patients w

232 n AGM T cells in vitro Through administering therapeutic doses of recombinant human interleukin-2 (IL

233 Thus, larger therapeutic doses of specific nutrients may be required

234 cs human development; chronic treatment with therapeutic doses of sustained release MPH did not have

235 se to antigen stimulation in the presence of therapeutic doses of TAC.

236 ormed, but not untransformed, human cells to therapeutic doses of the anticancer agent Taxol, making

237 wn to possess sufficient capacity to deliver therapeutic doses of the potent BT protein.

238 r to those found in the serum of patients on therapeutic doses of this agent.

239 he CML-like illness, mice were maintained on therapeutic doses of this drug and serially monitored.

240 Therapeutic doses of tirofiban (0.35 microg/mL) and epti

241 gnificant adverse effects from inhalation of therapeutic doses of UTP/amiloride.

242 Therapeutic doses of VPA inhibited human cellular prolif

243 These data provide evidence that therapeutic dosing of a TGF-beta antagonist can diminish

244 od Klotho levels can serve as a biomarker of therapeutic dosing of AE, whereas IGF-1 is a key molecul

245 We demonstrate that therapeutic dosing of INCB3344 significantly reduces dis

246 T(H)17 differentiation in vivo and show that therapeutic dosing of the BET inhibitor is efficacious i

247 ntestinal epithelium, a valuable activity at therapeutic doses on a range of clinical pathogens, medi

248 ed from 2002 to 2019, either attributable to therapeutic doses or overdose.

249 When given in therapeutic doses over 14 days, acetaminophen produced s

250 thin 38.5 h followed by sustained release in therapeutic doses over 2 weeks.

251 the order of treatments, with the same total therapeutic dose, provided significant changes in overal

252 king paediatric antibiotic use and find that therapeutic-dose pulsed antibiotic treatment (PAT) with

253 explained four fifths of the variability in therapeutic dose (R(2)(adj) of 79%).

254 ared any of the following antidepressants at therapeutic dose range for the acute treatment of unipol

255 d cancer, but the magnitude of risk over the therapeutic dose range has not been well established.

256 that fractionated radiation therapy within a therapeutic dose range is associated with a dose-related

257 demonstrated that ionizing radiation in the therapeutic dose range stimulates NF-kappaB activity by

258 der follows a flat response curve within the therapeutic dose range.

259 omolar range and no observed toxicity in the therapeutic dose range.

260 ELP-VEGF did not induce toxicity in the therapeutic dosing range, and doses one hundred times hi

261 MBq; mean, 85.1 MBq; median, 40 MBq) and the therapeutic dose (range, 1.073-5.713 GBq; mean, 2.991 GB

262 By applying only 10% (0.5 mg/kg) of the therapeutic dose rapamycin together with the CS (taste s

263 AY 50-4798, with human IL-2 (Proleukin) in a therapeutic dosing regimen in chimpanzees, and found tha

264 histologic end points was observed with the therapeutic dosing regimen of BMS-345541, with use of th

265 of 200 mg/kg per day Brd4 inhibitor JQ1 in a therapeutic dosing regimen substantially attenuated lung

266 complex systems ranging from coagulation to therapeutic dosing regimens for monoclonal antibodies.

267 st enzymatic degradation, hence reducing the therapeutic dose required and risk of dose-dependent tox

268 ical studies will be required to examine the therapeutic dose required for [(67)Cu]Cu-SARTATE for var

269 Mechanistic insights are elucidated and therapeutic dose responses are demonstrated.

270 uptake of the diagnostic dose to that of the therapeutic dose results in a slope of 0.42, with a corr

271 survival outcomes for patients treated with therapeutic dose RT plus ADT versus prostatectomy plus A

272 l natural history of disease was defined and therapeutic dose selected based on predegeneration resul

273 ckground ratios and the delivery of a higher therapeutic dose than when antibodies are directly conju

274 otectants for normal tissues also limits the therapeutic doses that can be delivered to treat cancers

275 ssue" component showed minimal uptake of the therapeutic dose, the "ossified component" showed intens

276 Compared to therapeutic doses, the cumulative pharmaceutical ingesti

277 Beyond normal therapeutic doses, the drug is hepatotoxic and genotoxic

278 A dose-finding study identified a nontoxic therapeutic dose to be approximately 75 microCi.

279 l uptake and to calculate a patient-specific therapeutic dose to deliver a nominal radiation dose of

280 n in clinical practice today, yet an optimal therapeutic dose to prevent dnDSAs has not been establis

281 117mSn and 33P are more likely to deliver a therapeutic dose to the bone while sparing the bone marr

282 Tracer studies reliably predicted the therapeutic dose to the CSF.

283 cysteine protease inhibitors can be given at therapeutic doses to animals to selectively arrest a par

284 dy was given prior to labeled dosimetric and therapeutic doses to improve biodistribution.

285 the bone marrow and at the same time deliver therapeutic doses to the bone.

286 tent antitumor efficacy when administered at therapeutic doses to tumor-bearing mice.

287 n reported with arsenic poisoning but not at therapeutic doses used in protocols for hematologic mali

288 A reduced effective therapeutic dose was achieved by selective LAmB delivery

289 The uptake of the therapeutic dose was then expressed as a percentage of t

290 dicted doses were within 20% of their actual therapeutic doses was determined.

291 Neither compound at therapeutic doses was significantly toxic in ex vivo cel

292 ndred times higher than the expected maximum therapeutic dose were needed to observe any adverse sign

293 agnostic doses were 1.0 mCi (37 MBq) in all; therapeutic doses were 150 and 30 mCi (5,550 and 1,110 M

294 plasma levels of sertraline exceeding human therapeutic doses were accurately modeled from external

295 Further, therapeutic dosing with [(177)Lu]-HP16 of trastuzumab-HP

296 findings, and sorafenib concentrations after therapeutic dosing with response.

297 g steps for DPT to BLs: 5-15-30-50% of daily therapeutic dose (with additional lower steps for index

298 Measurements suggest that therapeutic doses within localized volumes can already b

299 dium-channel blocker, can be administered at therapeutic doses without titration, and has shown good

300 s that treatment with warfarin at recognized therapeutic doses would reduce rates of mortality, hospi