ライフサイエンスコーパス: therapeutic potential

1 erefore, manipulating this system has strong therapeutic potential.

2 ificity of these molecules jeopardizes their therapeutic potential.

3 f principle that D/N Vif variants could have therapeutic potential.

4 sed to improve the avidity of other mAb with therapeutic potential.

5 omaterials has become of interest due to its therapeutic potential.

6 hibitors or other approaches has significant therapeutic potential.

7 the essential first step in evaluating their therapeutic potential.

8 ors of the tumor suppressor protein p53 with therapeutic potential.

9 to their precise physiological relevance and therapeutic potential.

10 in the literature to date and evaluate their therapeutic potential.

11 BET-amplified ER-mediated transcription have therapeutic potential.

12 orally given to alcohol-fed mice to test the therapeutic potential.

13 ms, allowing fact-based speculation on their therapeutic potential.

14 cell activation suggests that they may have therapeutic potential.

15 ation and repair as well as to explore their therapeutic potential.

16 ctions that regulate their survival may have therapeutic potential.

17 at molecules that reduce tau inclusions have therapeutic potential.

18 ent of their suppressive function limits its therapeutic potential.

19 t key advances in inflammasome research with therapeutic potential.

20 hysicochemical properties, which limit their therapeutic potential.

21 signaling in albuminuric kidney disease has therapeutic potential.

22 Cell replacement therapies hold great therapeutic potential.

23 a safer, non-hallucinogenic variant that has therapeutic potential.

24 during injury or disease and has significant therapeutic potential.

25 the biosynthesis of numerous compounds with therapeutic potential.

26 t 5A6, one of the mAbs that target CD81, has therapeutic potential.

27 atment in allergic asthma and underscore its therapeutic potential.

28 clic molecules, and the exploration of their therapeutic potential.

29 broventricular outcomes, pointing to a novel therapeutic potential.

30 to uncover new cancer-associated genes with therapeutic potential.

31 l processes and, in doing so, optimize their therapeutic potential.

32 ource for biologically active compounds with therapeutic potential.

33 ting their biological functions and may have therapeutic potential.

34 S thereby offering the prospect of increased therapeutic potential.

35 glutamate signaling cascades may offer novel therapeutic potential.

36 ewed enthusiasm in the study of KRAS and its therapeutic potential.

37 can expression in cancer progression and for therapeutic potential.

38 ilities of different cancers that might have therapeutic potential.

39 haps the most holistic metric reflecting its therapeutic potential.

40 SLCs as well as growing recognition of their therapeutic potential.

41 ored structural class of compounds with high therapeutic potential.

42 ative effects on growth and health, limiting therapeutic potential.

43 PNFs, suggesting that an anti-miR might have therapeutic potential.

44 arget several cancer drivers has shown great therapeutic potential.

45 their optimization and characterization, and therapeutic potential.

46 t is crucial to study cDCs and harness their therapeutic potential.

47 rstudied GPCRs provides a wealth of untapped therapeutic potential.

48 g research into its mechanisms of action and therapeutic potential.

49 V-associated HCC and evaluating this model's therapeutic potential.

50 arcomagenesis, with CB-839 exhibiting potent therapeutic potential.

51 h significantly better than GDNF, suggesting therapeutic potential.

52 nt implications upon their physiological and therapeutic potentials.

53 utralizing monoclonal antibodies (nAbs) with therapeutic potential: 18A7, 14B10, and NA9D7.

54 Given their therapeutic potential, a general strategy to access thes

55 er to manipulate cell death holds tremendous therapeutic potential across different diseases, includi

56 d treatments modulating these vessels having therapeutic potential across the spectrum of kidney dise

57 ssive craniectomy may have an underestimated therapeutic potential after traumatic brain injury.

58 our findings indicate that chrysin may have therapeutic potential against inflammatory skin diseases

59 anding of the mode of action of LXA4 and its therapeutic potential against KSHV.IMPORTANCE The latent

60 cacy in the A129 mouse model, indicating its therapeutic potential against the dengue virus infection

61 ts that should be valuable for assessing the therapeutic potential and (patho)physiological importanc

62 ombining inherent toxicity with a remarkable therapeutic potential and arduous administration.

63 antibodies have potential preventive and/or therapeutic potential and can serve as templates for vac

64 Rutin is a polyphenol with excellent therapeutic potential and good safety profile, but the p

65 elaxation of the respiratory tract, posses a therapeutic potential as a antispasmodic agent for respi

66 rcot-Marie-Tooth disease, highlighting their therapeutic potential as innovative and targeted disease

67 PK150 holds promising therapeutic potential as it did not induce in vitro resi

68 munosuppression, repair GPCRs have promising therapeutic potential because they trigger resolution pa

69 The latter has therapeutic potential beyond the refractive aspect and h

70 Enhancement of proteasome activity has many therapeutic potentials but is still a relatively unexplo

71 t the basic biology of cGAMP before its full therapeutic potential can be realized.

72 In this Perspective, we highlight the therapeutic potentials, current knowledge gaps, and late

73 Protein-based therapeutics have unique therapeutic potential due to their specificity, potency,

74 icient mice were fed a KD to investigate its therapeutic potential early in development, but this app

75 mmation, and demonstrate both endogenous and therapeutic potential for 15-epi-LXA(4) and 17-epi-RvD1

76 Thus, CSF1R inhibition could have therapeutic potential for a subset of SHH-MB patients.

77 force in nearly every organ system and hold therapeutic potential for a wide range of diseases.

78 ng that appropriate levels of Myc could have therapeutic potential for beta-cell regeneration.

79 mpounds may be effective CCC modulators with therapeutic potential for brain disorders associated wit

80 owing body of evidence currently points at a therapeutic potential for CD31 agonists in atherothrombo

81 al landscape in epithelial cells, exposing a therapeutic potential for direct targeting of the transl

82 lestat-mediated inhibition of CH24H may have therapeutic potential for diseases associated with neura

83 have been broadly studied due to their wide therapeutic potential for human diseases.

84 r the CaSR in epidermal regeneration and its therapeutic potential for improving skin wound repair.

85 side effects of PAHSAs, this lipid may have therapeutic potential for individuals at risk for or new

86 treatment of secretome and exosome exhibited therapeutic potential for lung regeneration in two exper

87 ctivated receptor gamma (PPARgamma) that has therapeutic potential for managing AD.

88 y that is an emerging drug target with great therapeutic potential for managing central nervous syste

89 e venom of marine cone snails and have broad therapeutic potential for managing pain and other condit

90 tamate receptor (mGluR) 5 exhibits promising therapeutic potential for many neurodevelopmental and ne

91 iclosamide, these derivatives may also offer therapeutic potential for other viral infections.

92 lled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of all

93 VEGF-A mRNA may have therapeutic potential for regenerative angiogenesis.

94 Recent studies have proposed therapeutic potential for repetitive transcranial magnet

95 We anticipate that CiPCs could have therapeutic potential for restoring vision.

96 vel drivers of invasion and metastasis holds therapeutic potential for the disease.

97 data identify MVT-602 as having considerable therapeutic potential for the treatment of female reprod

98 pharmacokinetic properties, indicating their therapeutic potential for the treatment of inflammatory

99 activation via a variety of means would have therapeutic potential for the treatment of prostate canc

100 w emerging CRT technologies and assess their therapeutic potential for treating a wide range of disea

101 ng the Notch transcription complex and shows therapeutic potential for treating Notch-driven cancers.

102 patients, reinforcing its translational and therapeutic potential for treating this disorder.

103 creasing interest in bioactive peptides with therapeutic potentials has been reflected in a large var

104 Despite their rapidly-expanding therapeutic potential, human pluripotent stem cell (hPSC

105 selenophene diamidine compound with emerging therapeutic potential in acute myeloid leukemia, debilit

106 ate that preventing myostatin activation has therapeutic potential in addressing muscle and bone defi

107 atment-related toxicity that limits the full therapeutic potential in adults.

108 g age-related osteoporosis, with a promising therapeutic potential in age-related diseases.

109 hemosynthetic siRNAs against VAL shows great therapeutic potential in AKT overactivation-driven metas

110 miR-1 has therapeutic potential in asthmatic patients and patients

111 tive neuropathology in HD, and highlight the therapeutic potential in blocking generation of exon 1 H

112 the regulation of mRNA translation and have therapeutic potential in cancer and other diseases.

113 e range of tumors to chemotherapy, but their therapeutic potential in combination with non-cytotoxic

114 moderately modified guide RNA, and show its therapeutic potential in correcting pathogenic single nu

115 ion for its role in biological processes and therapeutic potential in diseases, such as ischemic repe

116 normalize their balance may have significant therapeutic potential in heart diseases with repolarizat

117 notypic polarization and thereby harness its therapeutic potential in human diseases, a systems-level

118 -activated receptor gamma has well-validated therapeutic potential in metabolic, inflammatory, and ne

119 pressed TLR9 in regulating lupus and suggest therapeutic potential in modulating and perhaps even enh

120 rmone structurally related to insulin with a therapeutic potential in multiple indications.

121 way for additional studies to explore their therapeutic potential in neuro-degenerative diseases, su

122 s expressed in microglia, underscoring their therapeutic potential in neurodegeneration.

123 egulator of SG composition and assembly with therapeutic potential in neurodegeneration.

124 broad range of cytotoxic proteins indicating therapeutic potential in neurodegenerative diseases.

125 inical studies evaluating the diagnostic and therapeutic potential in patients with progressive or me

126 mine transporter (DAT) inhibitors have shown therapeutic potential in preclinical models of psychosti

127 ts from prolonged ischemia, highlighting its therapeutic potential in preventing ischemia-reperfusion

128 fibrosis and the confirmation of its lack of therapeutic potential in reversing already established f

129 ophage-expressed receptors have demonstrated therapeutic potential in several cancers(4,5).

130 umoral function of T cells, highlighting the therapeutic potential in targeting certain cell types in

131 We further discuss its therapeutic potential in the context of different diseas

132 There is significant therapeutic potential in the development of small molecu

133 ing stem cell chondrogenesis, as well as its therapeutic potential in the treatment of cartilage-rela

134 ced by diabetes, and PPARalpha agonists have therapeutic potential in the treatment of diabetic kerat

135 These molecules have shown therapeutic potential in the treatment of several diseas

136 These and other studies hint at complement's therapeutic potential in these sequalae, and thus, to su

137 ilable immunomodulatory therapies could have therapeutic potential in these severe cases. This review

138 cancer, and PARP inhibitors have also shown therapeutic potential in treating non-oncological diseas

139 this edible plant exhibits a broad range of therapeutic potential including antioxidant, antimicrobi

140 Since its therapeutic potential is limited due to gastrointestinal

141 However, their therapeutic potential is limited, in part due to suscept

142 To fully exploit its therapeutic potential, it is critical to understand the

143 The diagnostic and therapeutic potential of (64)Cu and (67)Cu, respectively

144 Here, we report the therapeutic potential of (67)Cu-CuSarbisPSMA.

145 additional in vivo studies in mice show the therapeutic potential of 1-propargyl-4-styrylpiperidines

146 These data reveal the therapeutic potential of 4c as an anti-obesity candidate

147 These data support the therapeutic potential of a fatty acid synthase inhibitor

148 The therapeutic potential of a hu.32 serotype vector was eva

149 We investigated the therapeutic potential of a nonhypotensive pGC-A activato

150 We developed and evaluated the therapeutic potential of a novel delivery vehicle which

151 work demonstrates the clinical relevance and therapeutic potential of a novel, actionable miR/RBP axi

152 ate the expression of 15-PGDH in IPF and the therapeutic potential of a specific inhibitor of this en

153 protection post-MI, thereby highlighting the therapeutic potential of AC modRNA in ischemic heart dis

154 Here, we investigated the therapeutic potential of activating the "alternative" ax

155 purpose of this study was to investigate the therapeutic potential of activating the aryl hydrocarbon

156 apse and provide preclinical evidence of the therapeutic potential of ADAM10 inhibition in HD.

157 neous discomfort is revealed, indicating the therapeutic potential of agents that block that pathway.

158 To test the therapeutic potential of agrin in a preclinical porcine

159 These results provide evidence of the therapeutic potential of ALD for the prevention/treatmen

160 To evaluate therapeutic potential of ALPPL2 targeting, an ALPPL2-tar

161 erimental mouse model of MG, we assessed the therapeutic potential of an Ab raised to a modified surv

162 We tested the therapeutic potential of anti-PD-1 and anti-PD-L1 monocl

163 re efficient tumor control, underscoring the therapeutic potential of antiangiogenic immunotherapy in

164 To maximize the therapeutic potential of anticancer drugs, combination t

165 Our findings highlight the therapeutic potential of AOX1 and provide a basis for th

166 onal pacemaker cells in vitro, advancing the therapeutic potential of biological pacemakers.

167 or-induced CD8(+) T cell dysfunction and the therapeutic potential of blocking Chop or ER stress to u

168 Consistent with the therapeutic potential of blocking the PKCepsilon-TRPV1 p

169 Research into therapeutic potential of cannabis should continue, but t

170 In conclusion, these findings support the therapeutic potential of CD147-CAR-modified immune cells

171 To actuate the therapeutic potential of cell therapy toward worldwide c

172 The therapeutic potential of CH24H activation has been exten

173 In this study, the therapeutic potential of CH24H inhibition was investigat

174 This study investigated the therapeutic potential of combining niraparib, a highly s

175 In summary, our findings highlight the therapeutic potential of coupling ICB with immunotherapi

176 may be considered a tool to harness the full therapeutic potential of CUR.

177 human trial, we have assessed the safety and therapeutic potential of cytomegalovirus-specific (CMV-s

178 re also discussed for the realization of the therapeutic potential of derived beta-cells.

179 In this review, we discuss the therapeutic potential of different classes of molecular

180 To explore the therapeutic potential of direct PP2A activation in a div

181 Last, we discuss the translational and therapeutic potential of dispersing bacteria during infe

182 The therapeutic potential of donor-derived mesenchymal strom

183 Preclinical assessment of the therapeutic potential of dopamine (DA) neuron replacemen

184 in dBNST neuronal activity, underscoring the therapeutic potential of drugs targeting the brain's eCB

185 e results pave the way for investigating the therapeutic potential of dual 5-LOX/sEH inhibitors in ot

186 These findings highlight the therapeutic potential of dual-stage targeting acridones

187 ools suitable for further exploration of the therapeutic potential of EAAT2 and may provide molecular

188 These outcomes failed to support the therapeutic potential of EGCG, and the deleterious effec

189 Finally, we tested the therapeutic potential of environmental enrichment and ch

190 hotothrombotic stroke in mice as well as the therapeutic potential of EphA4 targeted therapy followed

191 pathogenesis of pulmonary fibrosis (PF) and therapeutic potential of ER stress inhibition in PF.Meth

192 Efforts to harness the therapeutic potential of EVs will require innovative app

193 ole in colon tumor growth and highlights the therapeutic potential of Gal2 in colon cancer.

194 However, challenges remain before the therapeutic potential of genome editing can be fully rea

195 tool for investigating the physiological and therapeutic potential of GPR52 activation.

196 acological tool allowed investigation of the therapeutic potential of GPR84 inhibition.

197 Furthermore, I discuss the therapeutic potential of harnessing these reciprocal mec

198 or HDAC1 in 8-oxoG repair and highlights the therapeutic potential of HDAC1 activation to counter fun

199 s, may be able to unlock the neuroprotective therapeutic potential of idebenone or related quinones.

200 induce NASH in HFD-fed mice and to test the therapeutic potential of IL-22 in this new NASH model.

201 We investigated the therapeutic potential of IL-4 against fatal malaria in P

202 Studies have also focused on the therapeutic potential of inhibiting asprosin for treatme

203 Our experiments thus highlight the therapeutic potential of interfering with osteoclast-int

204 n light of previous studies, we explored the therapeutic potential of IRF8 inhibition as immunomodula

205 ghlight, in both mouse and human models, the therapeutic potential of iron restriction to modulate th

206 is to control IFN-I signaling and reveal the therapeutic potential of ISG15-deficient porcine and rhe

207 transcriptional targets in human PH and the therapeutic potential of isoform-selective enzyme modula

208 Moreover, the therapeutic potential of its inhibitors is in its infanc

209 We therefore demonstrate the therapeutic potential of La(2)O(3) NPs to treat GBM cell

210 Given the therapeutic potential of lubricin, it is essential to un

211 This study also uncovers the therapeutic potential of LXA4 and its targetable recepto

212 Finally, we confirm the therapeutic potential of miR-19a/19b in protecting cardi

213 ent FMRP synthesis, and they demonstrate the therapeutic potential of modulating CGG RAN translation

214 Recent data have shown the therapeutic potential of modulating PAR conjugation (PAR

215 ors of A(2A) receptors have demonstrated the therapeutic potential of modulating this pathway.

216 -principle studies demonstrate the potential therapeutic potential of molecular agents delivered to t

217 However, the precise mechanism of action and therapeutic potential of most epilepsy-associated miRNAs

218 Overall, our results emphasize the therapeutic potential of MS-275 as an adjunct to GLP-1R

219 The therapeutic potential of native EVs and bioengineered EV

220 Despite the therapeutic potential of new drugs and small molecules,

221 y.Significance: These findings highlight the therapeutic potential of NK cell-derived exosomes contai

222 Evidence regarding the therapeutic potential of Nur77-targeting molecules will

223 This highlights the therapeutic potential of oxytocin to treat social behavi

224 One of the major challenges to extend the therapeutic potential of PARP inhibitors to other cancer

225 nts an attractive opportunity to explore the therapeutic potential of PARP1 inhibition via G-quadrupl

226 rulence, furthering the understanding of the therapeutic potential of passive immunity in this fungal

227 These data support the therapeutic potential of pemigatinib in previously treat

228 Finally, we demonstrated the therapeutic potential of pharmacological AR inhibition a

229 Collectively, our data clarify the therapeutic potential of PKM2 activators in MS-like dise

230 he goal of the present study was to evaluate therapeutic potential of pulmonary treatment with combin

231 (MCAO) stroke model, we have established the therapeutic potential of recombinant mouse VEGFD deliver

232 Our study indicates a therapeutic potential of repurposing MTX for the treatme

233 We investigated the therapeutic potential of ruxolitinib cream in patients w

234 Our data demonstrate a promising therapeutic potential of S-220 in SCI, via beneficial ef

235 and functions of the SASP and highlight the therapeutic potential of SASP modulation as complimentar

236 These results establish the therapeutic potential of senolytic CAR T cells for senes

237 These results also reinforce the therapeutic potential of sGRm in AD.

238 n the preclinical setting to investigate the therapeutic potential of specific molecular targets, cha

239 rol of complex movements, and they suggest a therapeutic potential of stimulation of ChIs to restore

240 lic function, which could severely limit the therapeutic potential of targeting Grb14.

241 nd drug response/resistance, and discuss the therapeutic potential of targeting m(6)A regulators for

242 mitochondrial quality control pathways, the therapeutic potential of targeting mitophagy remains to

243 rin-1 in adult dopamine neuron fate, and the therapeutic potential of targeting netrin-1 signaling in

244 de phosphorylation in vivo and assessing the therapeutic potential of targeting phosphorylation for t

245 harmacological inhibitors to investigate the therapeutic potential of targeting SHP2 in MBC.

246 Our data support a therapeutic potential of targeting Sirt3 expression in v

247 To test the therapeutic potential of targeting Sirt3 expression, we

248 C self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m(6)A axis

249 model of ischemic stroke, demonstrating the therapeutic potential of targeting the auto-inhibition o

250 in cells expressing LIN28, highlighting the therapeutic potential of targeting the LLI fragment.

251 The current findings also highlight the therapeutic potential of targeting the platelet-inflamma

252 Lastly, to assess the therapeutic potential of targeting the PXR, we activated

253 ing the roles of myosin in parasites and the therapeutic potential of targeting them to block parasit

254 uring chronic aero-allergen exposure and the therapeutic potential of targeting these cells have not

255 logical significance of HA glycosylation and therapeutic potential of targeting these structures.

256 er of melanoma metastasis, and highlight the therapeutic potential of targeting this axis to treat me

257 ctions of intratumoral T(reg) cells, and the therapeutic potential of targeting this pathway for repr

258 blockade, such as alphaPD-1, highlights the therapeutic potential of targeting this population.

259 otensin system, and discuss the function and therapeutic potential of targeting this system to treat

260 learning to analyze the binding strength and therapeutic potential of the 14 antibody-antigen complex

261 . abscessus clinical isolates, revealing the therapeutic potential of the amoxicillin-imipenem-releba

262 Investigation into the therapeutic potential of the secretome has enabled resea

263 Moreover, the therapeutic potential of the vector was demonstrated in

264 To better assess the therapeutic potential of their exogenous administration,

265 eir prognostic and predictive values and the therapeutic potential of their humanised and/or conjugat

266 es exist, which must be addressed before the therapeutic potential of these bioactive peptides can be

267 Our results provide evidence of the therapeutic potential of this antibody cocktail.

268 nd HSC transduction has further improved the therapeutic potential of this approach.

269 which has focused our attention towards the therapeutic potential of this factor in the putative tre

270 y retinal vessels, thereby demonstrating the therapeutic potential of this inhibitor.

271 ounds blocks HSV-1 propagation, suggesting a therapeutic potential of this pathway.

272 Finally, we explored the therapeutic potential of this phage and show that it can

273 a need for suitable compounds to explore the therapeutic potential of this target.

274 ion, highlighting both the unique nature and therapeutic potential of this treatment.

275 to dementia and may reveal the AD-modifying therapeutic potential of TNF-alpha inhibition in the cen

276 ed T cell differentiation and underscore the therapeutic potential of transiently inhibiting LDH duri

277 This study suggests the therapeutic potential of treating neuroinflammation with

278 Despite growing evidence supporting the therapeutic potential of TRPC6 inhibition in treating pa

279 ing abilities of NK cells, demonstrating the therapeutic potential of tumor-suppressive miRNAs in neu

280 Moreover, we tested the therapeutic potential of two strategies, environmental e

281 In this study, we sought to investigate the therapeutic potential of ubidecarenone in the highly tre

282 ine its mechanism of action, and explore the therapeutic potential of unacylated ghrelin or analog AZ

283 Finally, we showed as a proof of concept the therapeutic potential of using 2-deoxyglucose, a glycoly

284 mentarily, in order to screen preventive and therapeutic potentials of the antiparasitic drug Praziqu

285 is nanoparticle system demonstrates improved therapeutic potential owing to its long-acting glycemic

286 While enhancing CHIP functionality has broad therapeutic potential, prior efforts have all relied on

287 hes to drug discovery are unlocking enormous therapeutic potential residing in cancer-specific molecu

288 Bicyclic peptides have great therapeutic potential since they can bridge the gap betw

289 range of diseases; however, to harness their therapeutic potential, sophisticated ways to manipulate

290 Despite its therapeutic potential, targeting NF-kappaB using pharmac

291 ntiviral and describes a chemotype with high therapeutic potential that addresses major obstacles of

292 erest in this area has begun to showcase the therapeutic potential that lies in understanding how cha

293 a highly potent human neutralizing mAb with therapeutic potential that targets an epitope preferenti

294 and its downstream mediator TIMP-1 have the therapeutic potential to boost remyelination in demyelin

295 suggest that targeted inhibition of PTN has therapeutic potential to eradicate CML stem cells.

296 EGF has therapeutic potential to promote human hematopoietic reg

297 nhancing mitochondrial proteostasis may hold therapeutic potential to protect against protein aggrega

298 ural stem and progenitor cells (hNSPCs) have therapeutic potential to treat neural diseases and injur

299 ycle and oxidative stress, and highlight its therapeutic potential using cardiomyocyte-specific Pkm2

300 To further investigate their therapeutic potential, we have extended our studies o di