ライフサイエンスコーパス: therapeutically

1 s that potentially could be used as a target therapeutically.

2 of ClC-7, which can potentially be modulated therapeutically.

3 mise in animals and humans when administered therapeutically.

4 r an influenza A virus infection, when added therapeutically.

5 y in lung adenocarcinoma and can be targeted therapeutically.

6 l to understand how stem cells might be used therapeutically.

7 iver tumor suppressor, may also be exploited therapeutically.

8 instigated by leukocytes and can be targeted therapeutically.

9 ifying individual genes that can be targeted therapeutically.

10 d physiological cues that could be exploited therapeutically.

11 y novel vulnerabilities that can be targeted therapeutically.

12 ment of strategies to target senescent cells therapeutically.

13 abolic vulnerabilities that can be exploited therapeutically.

14 escribe recent attempts to target the stroma therapeutically.

15 ors in cancer cells, could be more effective therapeutically.

16 ed metabolic pathways that might be targeted therapeutically.

17 cells and viral particles might be exploited therapeutically.

18 that the signature might even be exploitable therapeutically.

19 , hindering efforts to optimally target them therapeutically.

20 atic cancer stem cells that may be exploited therapeutically.

21 rd the possibility of targeting this pathway therapeutically.

22 s and how these changes could be manipulated therapeutically.

23 in deterioration and potentially be targeted therapeutically.

24 tabolic vulnerabilities that can be targeted therapeutically.

25 RAS has been extremely challenging to target therapeutically.

26 ecular vulnerabilities that can be exploited therapeutically.

27 henomenon that could potentially be targeted therapeutically.

28 odies elicited during infection or delivered therapeutically.

29 to significantly impair cognition when used therapeutically.

30 del of human HPIV3 disease when administered therapeutically 48 h after infection.

31 naling, and increased expression of multiple therapeutically accessible immunosuppressive pathways.

32 lleviate degradation of p53 can be exploited therapeutically across Burkitt lymphoma and other cancer

33 indicates that acidosis induces potentially therapeutically actionable changes to alternative splici

34 Thus, PAK4 may be therapeutically actionable for a subset of MIBC patients

35 Therapeutically actionable fusions involving RAF1, BRD4

36 Therapeutically actionable molecular alterations are wid

37 We identified therapeutically actionable targets including kinesin spi

38 functional and, therefore, most likely to be therapeutically actionable.See related article by Hanrah

39 rected tyrosine kinase inhibitors (TKIs) are therapeutically active against these cancers, although o

40 ream effects on histone acetylation could be therapeutically active in AML.

41 Cannabidiol (CBD), the non-psychotropic therapeutically active ingredient of Cannabis sativa, is

42 , to gain mechanistic insights that could be therapeutically adapted for driving neovessel regression

43 Restored BMP4 expression or therapeutically administered BMP4 protein, blocked metas

44 Here, we explored the efficacy of therapeutically administered MK-4482/EIDD-2801 to mitiga

45 Lanthanum oxide (La(2)O(3)) NPs are therapeutically advantageous due to the unique chemical

46 4 fusion protein may be prophylactically and therapeutically advantageous in the treatment of multipl

47 These data emphasize that by therapeutically alleviating the demand for insulin in vi

48 Our results demonstrate a therapeutically amenable, KLF7-driven pathway that promo

49 (SARS-CoV-2) spike protein(1-5) show promise therapeutically and are being evaluated clinically(6-8).

50 hat their dependency on ATR can be leveraged therapeutically and potentially expanded to BRG1-mutant

51 c lethal relationships that may be exploited therapeutically and rare genetic lesions that favor ther

52 es for discovery of novel compounds that act therapeutically and specifically on cardiac or skeletal

53 from The Cancer Genome Atlas (TCGA) and the Therapeutically Applicable Research to Generate Effectiv

54 The effects were higher than that of the therapeutically applied drug cisplatin.

55 ient group direction users provided safe and therapeutically appropriate medication.

56 epilepsy and consequently could be harnessed therapeutically are discussed in this Review.

57 timulatory properties, DVGs may also be used therapeutically as antivirals and vaccine adjuvants.

58 Therapeutically, BAFF and combined BAFF/APRIL inhibition

59 aches that successfully target AR-SVs may be therapeutically beneficial for HCC.

60 a illustrate that low-avidity T cells can be therapeutically beneficial if cocultured with IL-12 cyto

61 the cellular level, whereas MSCs may not be therapeutically beneficial in patients with ARDS who dev

62 eotides that combine in one molecule several therapeutically beneficial properties still poses a majo

63 this aberrant activity in adults could be a therapeutically beneficial strategy.

64 ment and modulation of their activity can be therapeutically beneficial.

65 This insight can be translated therapeutically by further developing combinations of PI

66 mistry emerged to exploit this altered state therapeutically, by targeting the expanded cytosolic lab

67 ptability of melanoma cells in nutrient- and therapeutically-challenged environments distinguishes me

68 his represents a novel treatment option in a therapeutically challenging disease state.

69 mage and loss, has yet to be achieved and is therapeutically challenging, particularly during the pro

70 ring renal crystal deposition which could be therapeutically controlled by relatively simple measures

71 provide a framework toward understanding and therapeutically controlling nausea.

72 re underway to use the CRISPR-Cas9 system to therapeutically correct human genetic diseases(1-6).

73 s to identify host targets that, if targeted therapeutically, could be used to tackle these currently

74 ely, we reveal a mechanism-based approach to therapeutically degrade the CIC-DUX4 oncoprotein and pro

75 Such readthrough events can be therapeutically desirable when a premature termination c

76 ness of our approach on 759 structurally and therapeutically diverse drugs and 994 side effects from

77 tilizing RNA-guided endonucleases (RGENs) to therapeutically edit RNA and DNA in cancer patients were

78 otherapies, but the characteristics defining therapeutically effective anti-tumor T cells have not be

79 g the IP in autoimmune diseases proved to be therapeutically effective in preclinical mouse models.

80 stemic delivery of inflammogens to achieve a therapeutically effective neuroprotective response again

81 ediction of antibody doses needed to achieve therapeutically effective occupancy (defined as >90%).

82 , whether interneuron transplantation may be therapeutically effective only for conditions marked by

83 to target cells at levels high enough to be therapeutically effective while maintaining safety by mi

84 tumor-specific, imaging distinguishable and therapeutically efficacious.

85 ectly explore whether IL-7R targeting may be therapeutically efficient against T-ALL relapse, we focu

86 lls (MSCs), since their paracrine action can therapeutically enhance the SC regeneration, limiting th

87 Five therapeutically enucleated eyes were sampled in triplica

88 maturation in AML, highlighting the need to therapeutically eradicate cancer cells across a range of

89 Here, we therapeutically exploit the oncogenic GOF mechanisms of

90 ant loads leading to selective cell death, a therapeutically exploitable difference.

91 mine, APA), and pointed to NAT2 loss being a therapeutically exploitable vulnerability of CRC tumors.

92 MFS and UPS dependent on Skp2, which can be therapeutically exploited and could provide the basis fo

93 drives pancreatic islet NGSIS, which may be therapeutically exploited as an alternative way to halt

94 HR) found in BRCA1-associated cancers can be therapeutically exploited by treatment with DNA-damaging

95 at T cell engulfment by myeloid cells can be therapeutically exploited in vivo.

96 1, ER stress and HIV infection that could be therapeutically exploited to selectively reverse T-cell

97 (PDH) dependency in leader cells that can be therapeutically exploited with the mitochondria-targetin

98 reveal new mechanisms of action that can be therapeutically exploited.

99 onse modulatory function of MEKi that can be therapeutically exploited.

100 ons to examine how this reprogramming can be therapeutically exploited.

101 vulnerabilities of cancer cells that can be therapeutically exploited.

102 infiltration and how these mechanisms can be therapeutically exploited.

103 rs cancer-selective dependencies that can be therapeutically exploited.

104 ered mitochondrial functionality that can be therapeutically exploited.

105 em cells isolated from humans have been used therapeutically for decades.

106 on the possibility of targeting these events therapeutically for inflammatory diseases.

107 Ceftaroline, when dosed supra-therapeutically for serious infections, may be a cause o

108 ibitors of these pathways could be effective therapeutically for these now untreatable tumors.

109 r the potential for these interactions to be therapeutically harnessed to benefit human health.

110 revious attempts to target metabolic changes therapeutically have been stymied by drug toxicity and t

111 tion will be an attractive method to achieve therapeutically important 2-pyridone analogues and aryla

112 pens access to pharmacological modulation of therapeutically important cytokine and growth factor rec

113 Our findings reveal a new and therapeutically important intrinsic role of IL-33 in T(r

114 ll facilitate design of SpCas9 guide RNAs in therapeutically important primary human cells.

115 erefore, targeting BTG2 and KLF15 might be a therapeutically important strategy for combat metabolic

116 Kynurenine 3-monooxygenase (KMO) is a therapeutically important target in the KP.

117 rete conformational classes sampled by these therapeutically important targets, informing strategies

118 discrete structural classes adopted by these therapeutically important targets.IMPORTANCE The genetic

119 Complement inhibitors may be useful therapeutically in acute TBI and post-concussion syndrom

120 mechanistic approach that might be exploited therapeutically in alleviation and prevention of pain.

121 ed in PDA pathogenesis and is being targeted therapeutically in clinical trials.

122 RAS/MYC axis, which we find can be targeted therapeutically in isogenic and primary DIPG cell lines

123 ow this IP-protective role could be restored therapeutically in patients with established AA.

124 quelae when administered prophylactically or therapeutically in rhesus macaques.

125 rinciple that HuR expression can be targeted therapeutically in skeletal muscles to combat cancer-ind

126 gonucleotide (ASO) to reduce IDOL expression therapeutically in the brains of APP/PS1 male mice.

127 rge caution when using hypothermia-rewarming therapeutically in TSCI.

128 vectors to the heart either have resulted in therapeutically inadequate levels of transgene expressio

129 Therapeutically, inducing Pak2 activation by genetic ove

130 ulation of canonical Wnt signalling can turn therapeutically inert mammalian cells into immortal exos

131 Therapeutically inhibiting matrix metalloproteases (MMPs

132 Targeting BMP signaling might allow to therapeutically interfere with cutaneous psoriatic manif

133 Finally, we summarize options to therapeutically interrupt this profibrogenic hepatocyte-

134 Diastolic dysfunction is a prevalent and therapeutically intractable feature of heart failure (HF

135 Targeting glycolysis has been considered therapeutically intractable owing to its essential house

136 onnected to many signaling pathways that are therapeutically involved in tumorigenesis.

137 The suitability of targeting CAFs therapeutically is also discussed.

138 rstanding this balance and how to exploit it therapeutically is one of the dominant themes of modern

139 Therapeutically, knowledge of type 3 immunity has transl

140 Therapeutically, LCD NP shows desirable efficacies for t

141 ese growth processes have not been exploited therapeutically, likely in part due to the extreme cellu

142 ess whether and how electro-acupuncture (EA) therapeutically manage the ACE-induced abnormal behavior

143 bacterial motility are potential targets for therapeutically managing bacterial spatial organization

144 nteractions or compounds that can be used to therapeutically manipulate autophagy.

145 elopment, response to infection, and ways to therapeutically manipulate the immune response to combat

146 ciated with their clinical use is sustaining therapeutically meaningful levels of the active agent wh

147 rt), a sufficiently stable baseline to allow therapeutically meaningful reductions in brain PrP to be

148 cer cell metabolism and immune metabolism in therapeutically meaningful ways.

149 to neurological disease, and how it might be therapeutically modified.

150 and offer suggestions to both understand and therapeutically modulate anti-COVID immunity.

151 te and convenient approaches to diagnose and therapeutically monitor respiratory viral infections.

152 of each single gene is generally modest, and therapeutically negligible.

153 d gene in cancer, yet these mutations remain therapeutically non-actionable.

154 In a more therapeutically oriented approach, we found that adminis

155 Therapeutically, p85beta expression renders ovarian canc

156 Therapeutically, patients were allotted into four groups

157 Unfortunately, targeting these receptors therapeutically poses significant challenges including a

158 Binders at this epitope could be useful therapeutically, possibly in synergy with an antibody th

159 that, at least in osteomyelitis, it would be therapeutically preferable to target sarA rather than ms

160 helial cells so that it might be possible to therapeutically prevent transmission.

161 nce, making the glutaminase inhibitor CB-839 therapeutically promising for this tumor type.

162 tification of tractable molecular targets to therapeutically promote neovascularization and regenerat

163 esents a major challenge to the treatment of therapeutically recalcitrant HER2-positive breast cancer

164 lpha(IIb)beta(3) Blocking these pathways may therapeutically reduce amyloid plaque formation in cereb

165 Our findings identify a novel and therapeutically relevant anti-tumor facet of trained imm

166 oparticles were designed to selectively edit therapeutically relevant cell types including epithelial

167 redictive biomarkers and features as well as therapeutically relevant cell types, cell states, and ce

168 We therefore went on to test if therapeutically relevant changes in temperature could in

169 ver, the result of the cyst assay identified therapeutically relevant compounds, including agents tha

170 ceptors, our experiments demonstrate that at therapeutically relevant concentrations, amantadine pref

171 We conclude that therapeutically relevant doses of metformin lower G6P in

172 At therapeutically relevant dosing, hMGL-4.0 reduces serum

173 cell types making it challenging to pinpoint therapeutically relevant drivers of IMDs.

174 show that the conformal gel layer allows for therapeutically relevant drug delivery to the posterior

175 zed dual AAVs enable in vivo base editing at therapeutically relevant efficiencies and dosages in the

176 s that modulate bacterial communities may be therapeutically relevant for food allergy.

177 We explored if ligands of therapeutically relevant G-protein-coupled receptors cou

178 omyocytes (hPSC-CMs) have been proposed as a therapeutically relevant human platform to guide target

179 substrates could aid in biomanufacturing of therapeutically relevant iPSCs and be used to elucidate

180 of the beta-globin protein, but to maintain therapeutically relevant levels of beta-globin it would

181 eq to 110 single guide RNA targets across 13 therapeutically relevant loci in human primary T cells a

182 splay technique to develop disrupters of the therapeutically relevant MDM2-p53 interface.

183 normal developmental pathway and identify a therapeutically relevant mechanism of cell-intrinsic imm

184 ng in human CAR T cell recipients, providing therapeutically relevant mechanistic insights.

185 We identify therapeutically relevant molecular groups of pulmonary c

186 one disease setting, make the development of therapeutically relevant molecules challenging.

187 Many approaches to identify therapeutically relevant neoantigens couple tumor sequen

188 tural amino acids are key building blocks in therapeutically relevant peptides.

189 owerful platform for genetic modification of therapeutically relevant primary cell types.

190 However, several major classes of therapeutically relevant proteins have unknown or inacce

191 of this platform through the degradation of therapeutically relevant proteins, including apolipoprot

192 Thus, we report unexpected, therapeutically relevant roles for FLIP(L) in determinin

193 categorization of ccRCC into clinically and therapeutically relevant subtypes.

194 incorporation of morpholino-pS moieties and therapeutically relevant sugar modifications in tandem t

195 olids against a broad range of more than 100 therapeutically relevant targets is reported, leading to

196 sing synthetic strategies with an eye on the therapeutically relevant targets.

197 rther reduce cortical infarct expansion in a therapeutically relevant time frame and independent of r

198 us targeting of post-insult new neurons in a therapeutically relevant time period reduces chronic sei

199 lator of transport, enhances brain uptake of therapeutically relevant transferrin, transferrin recept

200 5-HTP SR might in particular be therapeutically relevant when brain 5-HT deficiency is p

201 serves HSC quiescence and potency and may be therapeutically relevant.

202 To determine if this gene retains therapeutically-relevant biological functions into adult

203 for cystic fibrosis (CF) has benefited from therapeutically responsive biomarkers to streamline drug

204 ggest the potential for kinase inhibitors to therapeutically restrict ANDV replication.

205 served LV20.19 CAR T cells were feasible and therapeutically safe, showing low toxicity and high effi

206 apeutic effect (CITE) represent distinct and therapeutically separable activities of anti-CTLA-4 anti

207 ineering of this large class of molecules is therapeutically significant.

208 l approaches in fracture healing designed to therapeutically stimulate endochondral ossification.

209 even smaller fraction are ultimately deemed therapeutically successful.

210 ies on proteins that are difficult to target therapeutically, such as transcription factors.

211 The difficulty in therapeutically tackling these viral systems stems in pa

212 e plausible mechanisms that could be used to therapeutically target COVID-19.

213 AML LSC program and provides a rationale to therapeutically target IKZF2 in myeloid leukemia.

214 ent of novel anti-inflammatory peptides that therapeutically target the chemokine network in inflamma

215 ation of specific effects when attempting to therapeutically target the ghrelin system.

216 tumors will help to determine how to better therapeutically target the immune system to fight cancer

217 ; conventional renoprotective agents did not therapeutically target this elevation.

218 ely, mutations in U2AF1 induce expression of therapeutically targetable 'active' IRAK4 isoforms and p

219 er and drug research communities to identify therapeutically targetable exon skipping events.

220 or which glymphatic failure may constitute a therapeutically targetable final common pathway.

221 RM1-dependent axon degeneration identifies a therapeutically targetable mechanism by which neuroinfla

222 Our results reveal a therapeutically targetable mechanism of IM resistance in

223 (2020) identify a therapeutically targetable mechanism of resistance to ve

224 demonstrate that the LIN9/NEK2 pathway is a therapeutically targetable mediator of taxane resistance

225 between early and late disease, a number of therapeutically targetable mutations have been found enr

226 This demonstrates that therapeutically targetable pathogenic Abeta seeds alread

227 ism in FL pathogenesis and as a possible new therapeutically targetable pathway.

228 ngs thus uncover ROCK2 as a multifaceted and therapeutically targetable regulator of GC responses.

229 results define a previously unrecognized and therapeutically targetable Sox2:miR-486-5p axis that enh

230 s of BRCA1 reprograms metabolism, creating a therapeutically targetable vulnerability in ovarian canc

231 ly a local, non-sensory pathway, potentially therapeutically targetable, must exist for cochlear bloo

232 ully understood, and RPTPs are generally not therapeutically targetable.

233 f 1q gain in a wide range of cancers that is therapeutically targetable.

234 Proteasome activity has been therapeutically targeted and considered as a treatment o

235 othesized that the enhancer domains could be therapeutically targeted by a BET bromodomain inhibitor

236 y in wall-residing T-cell populations can be therapeutically targeted by blocking CD28 signaling.

237 OCK2), a serine-threonine kinase that can be therapeutically targeted by ROCK inhibitors or statins,

238 ential regulator of novel miRNAs that can be therapeutically targeted for potent suppression of cuSCC

239 roprotection and axon growth and that may be therapeutically targeted in disease.SIGNIFICANCE STATEME

240 only a small fraction of the kinome has been therapeutically targeted in HGSOC.

241 This suggests that CYP24A1 could be therapeutically targeted in lung cancers in which its ex

242 static progression in melanoma that might be therapeutically targeted in patients.

243 he critical downstream effectors that can be therapeutically targeted remain to be identified.

244 work revealed several pathways that could be therapeutically targeted to prevent ifosfamide-induced h

245 iverse physiology and behavior and are often therapeutically targeted to treat affective disorders.

246 cation, suggesting that this activity may be therapeutically targeted.

247 hat PTP may be regulated by LLPS that can be therapeutically targeted.

248 pathways activated by TP53 mutations can be therapeutically targeted.

249 in myeloma-induced bone disease that can be therapeutically targeted.

250 cancer progression in the stroma that may be therapeutically targeted.

251 ) in genitourinary cancers and how it can be therapeutically targeted.

252 Therapeutically targeting B cell checkpoints represents

253 that FEN1 inhibitors have the potential for therapeutically targeting HR-defective cancers such as t

254 This and other findings predicted the use of therapeutically targeting JAKs as a new strategy for tre

255 Our data suggest that therapeutically targeting LIMK1 may provide dendritic sp

256 Therefore, therapeutically targeting metabolism may limit cancer ce

257 sporadic PD (sPD), opening opportunities for therapeutically targeting mitochondria in PD.

258 cted during tumorigenesis and strategies for therapeutically targeting mutant cancer cells are largel

259 Therapeutically targeting receptor tyrosine kinases has

260 Recently, interest in therapeutically targeting senescence to improve healthy

261 ht strategies to address the complexities of therapeutically targeting the EMP process that give cons

262 ing its role in blood cell formation and for therapeutically targeting this complex in human leukemia

263 Therapeutically, targeting VEGFR2-regulated VE-cadherin

264 y biomarkers for diagnosis and prognosis and therapeutically tenable molecular mechanisms.

265 and inhibition of GM-CSF are currently being therapeutically tested in COVID-19 clinical trials.

266 Therapeutically, the first human trial of an HTT-lowerin

267 hoped that quiescent NSCs could be activated therapeutically to contribute towards repair in humans.

268 iche via VEGF-C signaling could be exploited therapeutically to enhance hematopoietic regeneration.

269 s of PD-L1 and CD8 and therefore may respond therapeutically to immune checkpoint inhibition.

270 nal proteins and could therefore be promoted therapeutically to kill bacteria.

271 tions of these AD risk genes can be targeted therapeutically to modulate microglial cell state and sl

272 rs, a characteristic that could be exploited therapeutically to prevent and treat several inflammator

273 ht the key mechanisms that could be targeted therapeutically to prevent and/or treat these disorders.

274 lation, which could potentially be exploited therapeutically to reduce excessive inflammation in CGD.

275 e regenerative cells that could be activated therapeutically to repair damage.

276 Thus, NIRs could be leveraged therapeutically to restore RBP homeostasis and mitigate

277 disease outcomes and that could be targeted therapeutically to stimulate the innate immune response

278 ortant implications for using bacteriophages therapeutically to target gut symbionts.

279 tes and isolate TCRs that could be exploited therapeutically to treat cancer.

280 he need for cross-assay validation to define therapeutically tractable MET pathway dysregulation in E

281 uring pancreatic carcinogenesis and suggests therapeutically tractable strategies toward cDC1 repair.

282 Altogether, findings suggest PAR1 may be a therapeutically tractable target for demyelinating disor

283 i-tumour activity of effector T cells can be therapeutically unleashed, and is now being exploited fo

284 g glucose homeostasis and metabolism, and is therapeutically used to treat hyperglycemia in diabetes.

285 a CXCR4 antagonist AMD-3100 was found to be therapeutically useful as a stem cell mobilizer, and has

286 use of boronic acids in the construction of therapeutically useful bioconjugates will be discussed,

287 s as building blocks for the construction of therapeutically useful bioconjugates' by Joao P.

288 oting sleep in people with OSA, which may be therapeutically useful for people with OSA and comorbid

289 of the benefits of mining viral proteins for therapeutically useful information.

290 vation of M(1) receptor signaling may become therapeutically useful to promote retinal ganglion cell

291 lates negatively with tumor grade and may be therapeutically useful.

292 Human IgG2 antibody displays distinct therapeutically-useful properties compared with the IgG1

293 scence and approaches to target this pathway therapeutically using 'senolytic' drugs that kill senesc

294 sion in cancer cells, which can be exploited therapeutically using MTH1 inhibitors.See related commen

295 s with genetic support are more likely to be therapeutically valid(2,3), but the translational use of

296 ing SRC-2 to enhance SIRT3 expression may be therapeutically valuable.

297 indings uncover radiosensitivity as a novel, therapeutically viable vulnerability of BRCA1-deficient

298 To leverage this dependency therapeutically, we developed a highly potent small-mole

299 tor at-risk populations that can be targeted therapeutically with antiproteases.

300 dship is figuring out how to use antibiotics therapeutically without promoting the evolution of antib