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3 77 088 participants from 25 trials of statin therapy with 20 962 major vascular events were included,
4 270 participants from 24 trials of nonstatin therapy with 25 218 major vascular events and 177 088 pa
5 s are prescribed with chemo and/or radiation therapies, with 5-year relative survival rates of just 1
6 ntrol asthma were defined as requiring daily therapy with 500 mug or more of fluticasone propionate (
7 80 years were randomly assigned to induction therapy with 6 or 8 cycles of R-CHOP-14 with (RR-CHOP-14
8 Patients received 30 courses of maintenance therapy with 6-mercaptopurine, vincristine, methotrexate
9 randomly assigned (1:1) to receive standard therapy with 7-14 days of intravenous amphotericin B (0.
11 his review, we discuss the evolution of cell therapies with a focus on stem cell advantages, as well
14 These observations suggest that combination therapy with a cystine-depleting drug such as cysteamine
16 blation is increasingly used as a first-line therapy with a high acute success rate, but recurrence d
19 that acalabrutinib is active as single-agent therapy with a manageable safety profile in patients wit
21 s in whom previous first-line antiretroviral therapy with a non-nucleoside reverse transcriptase inhi
22 e findings show that combining an epigenetic therapy with a noncanonical WNT signaling pathway inhibi
23 adjunctive BUP/SAM 2 mg/2 mg combination, a therapy with a novel opioidergic mechanism of action, as
24 bowel syndrome has been shown to respond to therapy with a poorly absorbed antibiotic, the role of S
27 until better data are available, second-line therapy with a tyrosine kinase inhibitor may be recommen
29 n high-intensity or maximum-tolerated statin therapy, with a baseline low-density lipoprotein cholest
30 with HIV-1 who were naive to antiretroviral therapy, with a plasma HIV-1 RNA concentration of 1000 c
31 espond most highly with clinical response to therapy, with a reciprocal decrease in cell-cycle and WN
37 angiotensin receptor blocker as foundational therapy, with addition of a mineralocorticoid receptor a
39 s studies have shown a benefit of concurrent therapies with ADT in both low- and high-volume metastat
40 ude to the supplementation of antiretroviral therapy with ALOX5 antagonists to rescue patients with H
45 s may provide a promising new antithrombotic therapy with an improved benefit to bleeding risk profil
46 ot respond to antiosteoporosis pharmacologic therapy with an improvement in BMD, or who have an incid
47 Immune checkpoint inhibitors are one such therapy with an increasing number of case and cohort rep
48 ge, 65 years; median of three prior lines of therapy) with an ORR of 47.3% (SLL, 67.9%; FL, 42.2%; MZ
49 who had relapsed after at least one line of therapy, with an Eastern Cooperative Oncology Group perf
50 o had received one or more previous lines of therapy, with an Eastern Cooperative Oncology Group perf
51 eight sessions of individual problem-solving therapy, with an extra two to four sessions if needed) p
52 or failed Bruton's tyrosine kinase inhibitor therapy, with an overall response rate of 93% and an exp
53 ients were 38% and 50% after CD19 CAR T-cell therapy, with and without concurrent ibrutinib, respecti
55 The comparative efficacy of pharmacological therapy with angiotensin receptor-neprilysin inhibitors
58 e feasible the development and testing of co-therapies with antibiotics that would increase its antim
61 undergo prophylactic negative pressure wound therapy, with application of the negative pressure devic
63 nosed with breast cancer initiating hormonal therapy with aromatase inhibitors or tamoxifen between A
64 h to mild asthma has long relied on reliever therapy with as-needed short-acting beta-agonists (SABAs
68 n from 15 human tumors show that combination therapy with AZD2014 and dasatinib is more effective at
69 clinical responses sustained by maintenance therapy with belimumab, an antibody to B-cell activating
70 on (alloHSCT) is the only available curative therapy, with benefits derived from the antigenic dispar
71 Early diagnosis and initiation of antibiotic therapy with benzylpenicillin and clindamycin as seen in
74 Ts reported the outcomes of PSP modification therapy with bilaminar techniques, whereas 7 involved th
77 a have shown that anti-inflammatory reliever therapy with budesonide-formoterol, given on an as-neede
78 ombining outpatient parenteral antimicrobial therapy with buprenorphine treatment had similar clinica
79 nale for clinical development of combination therapy with BYL719 and LEE011 for treatment of metastat
82 review preclinical and clinical combination therapy with CAR T cells and CPB agents, with a focus on
83 ears of age, receiving stable antiretroviral therapy with CD4+ T-cell count >100 cells/mm3, and with
85 included uveal or mucosal melanoma, previous therapy with checkpoint inhibitors, and any previous imm
87 Chemophototherapy (CPT) merges photodynamic therapy with chemotherapy and can substantially enhance
90 ) and globus pallidus interna, is a surgical therapy with class 1 evidence for Parkinson's disease (P
92 rarchically dictated by the efficacy of each therapy with complete or partial independence from the t
94 onal and randomised studies comparing statin therapy with control (placebo or no treatment) in patien
95 ing prolonged intermittent renal replacement therapy with cooler dialysate experienced significantly
96 are refractory to traditional antirejection therapy with corticosteroids and polyclonal antilymphocy
99 his study investigated if blood purification therapy with CytoSorb (CS) porous polymer beads could im
100 as a prerequisite to personalize combination therapies with cytotoxic drugs and inhibitors of signal
101 examined the efficacy of augmenting behavior therapy with D-cycloserine (DCS) to reduce tic severity
102 ized Evaluation of Long-Term Anticoagulation Therapy With Dabigatran Etexilate) (n=11 955 in derivati
103 0E or V600K mutations, 12 months of adjuvant therapy with dabrafenib plus trametinib resulted in a lo
104 e regimens or combination BRAF/MEK inhibitor therapy with dabrafenib/trametinib, encorafenib/binimeti
105 he original KPC model and tested combination therapy with DAC followed by immune checkpoint inhibitor
107 se registry who had been given high-efficacy therapy, with data collected between Jan 1, 1975, and Ap
108 of Blood, Dalton et al show that epigenetic therapy with decitabine can upregulate immunogenic Epste
109 cell sheet technology as a breakthrough cell therapy with demonstrated therapeutic success across ind
110 d optimize the outcomes of tooth replacement therapy with dental implants in this specific anatomic l
111 drugs have been a major hurdle in designing therapies with desired efficacy and acceptable toxicity.
113 However, a small previous trial of such therapy with dolutegravir in healthy, HIV-negative adult
114 vir plus rilpivirine was noninferior to oral therapy with dolutegravir-abacavir-lamivudine with regar
116 [IQR 7-13]), 36 of whom received combination therapy with dose escalation, with a median follow-up of
117 yrA genes for patients undergoing sequential therapy with doxycycline-moxifloxacin (201 patients, inc
120 = 36), or both (TL; N = 58) as HER2-targeted therapy, with each participant given one cycle of this d
122 n Tanzania was prospectively observed during therapy with either FLC monotherapy or in combination wi
123 mpared safety and efficacy of antiretroviral therapy with either raltegravir or efavirenz in late pre
124 use of permuted blocks to receive induction therapy with either the VRd regimen or the KRd regimen f
125 HIV-1-infected men on stable antiretroviral therapy with elvitegravir, cobicistat, emtricitabine (E/
126 was to determine the safety and efficacy of therapy with entecavir and peginterferon in a group of c
127 al new target for monotherapy or combination therapy with established chemotherapeutics to improve tr
131 ore whether the efficacy of a platinum-based therapy with fluorouracil, leucovorin, and oxaliplatin (
132 p) or to receive continuous high-flow oxygen therapy with frequency of suctioning being the indicator
133 ical trials have shown the benefit of double therapy with full-dose novel oral anticoagulants and P2Y
138 ucted a randomized trial to compare physical therapy with glucocorticoid injection in the primary car
139 (18)F-FGln study 4-13 wk after initiation of therapy with glutaminase, dual TORC1/2, or programmed de
140 ts Undergoing Mechanical Circulatory Support Therapy With HeartMate 3) has demonstrated that the Hear
144 We analyzed the association of early NAI therapy with hospital lengths of stay (LOS) and in-hospi
145 ia caused by TBI could be alleviated by cell therapy with human bone marrow mesenchymal stromal cells
148 ransplants, 13 (76%) had previously received therapy with hypomethylating agents, and ten (59%) had r
151 ere randomly assigned up front for induction therapy with idarubicin, cytarabine, etoposide, and all-
152 oral antidiabetic drugs, initial injectable therapy with IDegLira resulted in fewer patients reachin
153 afety of biologic monotherapy vs combination therapy with immunomodulators, (3) comparative efficacy
156 csMHCII correlated with response to anti-PD1 therapy, with immunotherapy-sensitive CMT167 cells being
157 enopausal patients (2.8 years after adjuvant therapy) with impaired peak oxygen consumption (VO(2)pea
158 onses are needed to design biomaterial-based therapies with improved outcomes in the setting of aging
160 tandardized off-the-shelf engineered NK cell therapy with improved ADCC properties to treat malignanc
161 synergistic effects due to sequencing of the therapies with in vitro imaging and mathematical modelin
162 ationship of cardiovascular disease and drug therapy with in-hospital death among hospitalized patien
163 Some studies have associated antiretroviral therapy with increased risk of myocardial infarction and
164 extraction or revision, long-term antibiotic therapy with infection recurrence, or death, within 12 m
165 itional recommendation for the use of triple therapy with inhaled corticosteroids (ICS)/LABA/LAMA ove
167 sess the safety and efficacy of insulin pump therapy with integrated continuous glucose monitoring (C
171 ial clinical benefits of metastasis-directed therapy with ionizing radiation (primarily stereotactic
175 ed corticosteroids (ICS)/LABA/LAMA over dual therapy with LABA/LAMA in patients with COPD and dyspnea
176 as, benefit from advanced treatments such as therapy with levodopa-carbidopa enteral suspension or de
177 CC who are eligible for potentially curative therapy with liver resection or ablation should defer DA
178 as well as integration of effective systemic therapies with localised interventions, might achieve be
181 cystectomy and urinary diversion or trimodal therapy with maximal endoscopic resection, radiosensitiz
183 drug to elicit renoprotective effects beyond therapy with metformin, ramipril, and empagliflozin (MRE
184 e demonstrated that long-term opioid agonist therapy with methadone and buprenorphine have great effi
187 e risk factors (eg, access to antiretroviral therapy with more benign cardiovascular disease side eff
188 st cancer who have disease progression after therapy with multiple HER2-targeted agents have limited
190 Pioneered by the Mayo Clinic, multimodal therapy with neoadjuvant chemoradiotherapy and orthotopi
191 f Pediatric MS Centers, who received initial therapy with newer (fingolimod, dimethyl fumarate, terif
193 tients undergoing long-term and/or high-dose therapy with nitrogen-containing bisphosphonates, a RANK
196 External validation was performed in four therapies, with no significant difference in the bootstr
197 mutations led to the development of targeted therapies with non-small cell lung cancer (NSCLC) being
198 Several studies demonstrated that antiviral therapy with NUCs could reduce the risk of HCC recurrenc
200 obinopathies require lifelong iron chelation therapy with one of the three iron chelators (deferipron
202 fy "qualified donors" for convalescent serum therapy with only one fixed dilution factor (200 x).
203 respond to commercially available antiviral therapies, with or without demonstrating genotypic mutat
205 3-ITD acute myeloid leukaemia after standard therapy with or without allogeneic haemopoietic stem-cel
206 essed efficacy of retreatment with anti-PD-1 therapy with or without ipilimumab in relapsing patients
213 mbining the current generation of epigenetic therapies with other classes of agents and the developme
217 se responses vary depending on antimicrobial therapy, with particular interest in whether the superio
218 eurologist preparedness to discuss stem cell therapies with patients and an alarming list of unreport
220 immune activation early after initiation of therapy with PD1-blocking antibodies and predicts a clin
221 rdioprotective and suggest that cardiac gene therapy with PDE4B might constitute a new promising appr
222 eyes, anti-VEGF monotherapy and combination therapy with PDT yielded comparable outcomes as those of
223 adults with metastatic melanoma who started therapy with pembrolizumab, nivolumab, or nivolumab/ipil
225 treatment, <60% of the cohort had induction therapy with polyclonal or monoclonal antibodies, 28% di
226 int blockade represent a novel combinatorial therapy with potential efficacy for this lethal disease.
227 table theranostic scaffold for dosimetry and therapy with potentially broad applicability in pediatri
228 n novel perspectives for combining endocrine therapies with PRMT1 inhibitors in ERalpha-positive tumo
230 ues are currently being explored in targeted therapies with promising results in preclinical and clin
234 in current or former smokers, whereas cancer therapy with radiation, platinum and topoisomerase II in
235 ith muscle-invasive disease, more aggressive therapy with radical cystectomy and urinary diversion or
237 y for solid tumours, by combining CAR T-cell therapy with radiotherapy through the use of careful mon
238 inical gene therapy.IMPORTANCE Clinical gene therapy with recombinant AAV vectors has largely relied
240 Febuxostat is non-inferior to allopurinol therapy with respect to the primary cardiovascular endpo
241 ximab-based regimens were the most effective therapies with, respectively, 53% and 52% of partial or
242 imab resistance of OSCC and that combination therapy with resveratrol may provide an attractive means
244 cruited after prostatectomy and/or radiation therapy with rising prostate-specific antigen level (med
246 and 1192 (59.5%) used proton pump inhibitor therapy, with risk factors for the combined outcome bein
247 e patient was treated with immunosuppressive therapies, with rituximab demonstrating the most robust
249 s may help us understand the actions of drug therapies with selective effects on one population over
250 AML treatment relies primarily on untargeted therapies with severe side effects that limit patient el
251 indicate that selection of active comparator therapies with similar indications and use patterns enha
254 we did not find evidence that monoscavenger therapy with sodium or glycerol phenylbutyrate was super
256 rgeting parasite-produced MIF as combination therapy with standard antibiotics to reduce disease seve
259 iency virus (HIV) who were on antiretroviral therapy with suppressed HIV viremia and high CD4 T cell
260 inflammatory cytokines following delivery of therapy, with symptoms ranging from mild fever to life-t
262 fficacy, and treatment window of reperfusion therapy with t-PA by limiting hemorrhagic transformation
263 epressants might be compensated by combining therapies with targeted treatment as an optimized approa
264 tive at nanomolar concentrations, complement therapy with temozolomide, and synergize strongly with e
266 combining the immense potential of DNA gene-therapy with the absence of genome integration-associate
267 ssion, SRS can be recommended as the primary therapy with the advantage of low morbidity and satisfac
268 ation anti-HER2 therapy, as well as adjuvant therapy with the anti-HER2 antibody-drug conjugate T-DM1
270 in vitro and in vivo efficacy of combination therapy with the dual mTORC1/2 inhibitor AZD2014 and the
271 tment-naive phakic eyes who had DME, primary therapy with the intravitreal dexamethasone implant PRN
272 stance was overcome by combining ER-directed therapy with the irreversible HER2 kinase inhibitor nera
273 therapy followed by risk-adapted maintenance therapy with the longest follow-up and important informa
275 t a rapidly emerging form of adoptive T-cell therapy with the potential to overcome safety and antige
276 ic stem cell-engineered iNKT (HSC-iNKT) cell therapy with the potential to provide therapeutic levels
277 rcise represents a viable, nonpharmaceutical therapy with the potential to reverse and enhance the im
278 C1 are few, and classical enzyme replacement therapy with the recombinant protein is not possible as
279 asive tumors that do not respond to adjuvant therapy with the standard-of-care immunotherapy, bacille
280 its declined over time regardless of initial therapy, with the greatest decrease among the untreated
281 emerged as a promising class of nucleic acid therapy, with the potential to induce protein production
285 g man who developed CSCR following prolonged therapy with topical Minoxidil solution and was treated
286 ogressed after at least one previous line of therapy with trastuzumab plus chemotherapy in the locall
288 poisons can be enhanced through combination therapy with ubiquitin-activating enzyme inhibitors or b
291 ong patients who had a response to induction therapy with ustekinumab and underwent a second randomiz
293 ylococcal beta-lactam to standard antibiotic therapy with vancomycin or daptomycin did not result in
294 The addition of atezolizumab to targeted therapy with vemurafenib and cobimetinib was safe and to
296 egulatory microenvironment and combinatorial therapies with virotherapy, such as checkpoint inhibitor
300 there may be novel approaches and potential therapies with wider application to this and other forms