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3 ing predators, and advertising toxicity [1], there remain a multitude of species that display conspic
6 ienced rapid growth over the last few years, there remain a relatively small number of material class
7 ssfully in murine embryonic stem (ES) cells, there remain a set of nearly two thousand genes that hav
9 ions used automatic tube current modulation, there remained a large variation of practice, on the ord
10 tatin therapy candidates at 55 years of age, there remained a significant association between cumulat
11 gitation from baseline to post intervention, there remained a statistically significant difference (p
15 ulates avoid energy infrastructure; however, there remains a common perception that ungulates habitua
16 cultural production throughout the world, so there remains a compelling need to develop new vector an
18 loss of VHL is an almost ubiquitous finding, there remains a conspicuous lack of targetable genetic d
19 ng to re-open and relax stay-at-home orders, there remains a continued need for careful surgical sche
22 quantification have decreased considerably, there remains a critical need for researchers to optimiz
24 ecies and environmental conditions; as such, there remains a critical need to focus research efforts
27 rovements in the microbial diagnostic field, there remains a disconnect between clinicians and some p
28 have been developed to improve performance, there remains a gap between promising laboratory results
29 potential of new drugs and small molecules, there remains a gap in the ability to efficiently delive
32 edict the anti-cancer therapeutic responses, there remains a great need to develop highly accurate pr
33 s event could have been anticipated and that there remains a high chance of exceeding observed record
34 anticipated, and that in the current climate there remains a high chance of exceeding the observed re
36 gnosis and high relapse after treatment, but there remains a lack of biomarkers and effective targete
38 tabolism are known to be implicated in MNDs, there remains a lack of clarity regarding the key functi
40 y can be enhanced by proteomic evidence, but there remains a lack of consensus on the performance of
45 psoriasis patients using an IL-17 inhibitor, there remains a lack of evidence to suggest a causal rel
47 ew vessels from the preexisting vasculature, there remains a lack of insight of the nuclear transcrip
50 e of death in pediatric neuroblastoma, where there remains a lack of therapies to target this stage o
53 variety of computational genomics problems, there remains a large gap in our understanding of how th
54 factors are well established as carcinogens, there remains a large knowledge gap of others owing to t
60 e recent improvements in sequencing methods, there remains a need for assays that provide high sequen
61 ing cause of death in developed nations, and there remains a need for cardiac therapeutic systems tha
63 ols are inconvenient to use in practice, and there remains a need for easy-to-use cross-platform tool
64 ment of advanced non-small-cell lung cancer, there remains a need for effective treatments for progre
67 ed the effects of key individual parameters, there remains a need for multi-factor experiments (e.g.,
68 n space, has significant clinical value, but there remains a need for neuroimaging techniques to impr
71 ed structure in data to generate hypotheses, there remains a need for testing hypotheses and interpre
73 toward the development of new IR probes, but there remains a need for those that can extend the exper
74 he emergence of site-specific endonucleases, there remains a need for tools capable of specifically d
75 ocesses that are enriched in the genes sets, there remains a need for tools that identify enrichment
77 costs and eliminate complicated procedures, there remains a need to address probe costs and generali
81 aneous mastocytosis (CM) have been proposed, there remains a need to better define subforms of cutane
82 key contributors to metastatic disease, and there remains a need to better understand and target the
85 er still carries a poor prognosis, and thus, there remains a need to elucidate the molecular mechanis
86 and mortality associated with this disease, there remains a need to elucidate the molecular mechanis
90 rapeutic potential in severe infections, but there remains a need to substantiate clinical benefit.
91 n tissue development and cell proliferation, there remains a paucity of approaches to investigate the
95 noid system has immunomodulatory properties, there remains a paucity of information on the effects of
99 e being a significant healthcare cost burden there remains a paucity of studies in the literature eva
100 smell can accomplish astonishing feats, yet there remains a prevailing belief that olfactory languag
101 ated control of clade B HIV-1 infection, yet there remains a relative paucity of data regarding the r
104 crease in women entering surgical residency, there remains a sex disparity in surgical leadership.
106 gand interactions to identify new compounds, there remains a shortage of specific databases with prec
107 ial meningitis in children has decreased but there remains a significant burden of disease in adults,
109 of patients on the transplant waiting list, there remains a significant gap between the need for tra
110 aureus is a leading cause of bacteremia, yet there remains a significant knowledge gap in the identif
113 As a result, outcomes are generally poor and there remains a significant unmet need for novel therape
114 f high-quality evidence and robust guidance, there remains a significant variation in some elements o
115 several potent agonists have been described, there remains a strong need for suitable tracers to inte
121 able progress in DNA sequencing technologies there remains a trade-off between short-read platforms,
123 us studies in this area in recent years, but there remains an imperative to demonstrate that the curr
126 d differences in case mix between operators, there remains an inverse relationship between PCI operat
130 ious diseases caused by pathogenic bacteria, there remains an unmet need for diagnostic tools that ca
132 global threat from drug-resistant superbugs, there remains an unmet need for simple and accessible di
133 notechnological solutions to biosensing, yet there remains an unmet need in the development of biosen
136 ts in column technology and instrumentation, there remains an urgent need for creating innovative app
137 ite significant advancements over the years, there remains an urgent need for low cost diagnostic app
141 therapy for insulin-dependent diabetes, but there remain challenges towards achieving this goal(1-6)
146 transcatheter aortic valve replacement, yet there remain conflicting reports about the effect of sex
148 sed by critical care organizations; however, there remains confusion about what shared decision makin
149 n and the development of cold hardiness, but there remain considerable gaps deserving further researc
150 ite this significant pharmaceutical success, there remain considerable limitations to broad medicinal
152 echanisms of signal production and response, there remains considerable debate over the functional ro
153 ommon task in biological investigations, yet there remains considerable room for improvement in align
155 forests respond with increased productivity, there remains considerable uncertainty as to how the lon
157 rent histopathological classification system there remains considerable uncertainty in predicting tum
158 a leading cause of worldwide disability but there remains considerable uncertainty regarding its neu
163 dergoing percutaneous coronary intervention, there remains debate about differences in efficacy and t
164 entary imaging is occasionally required when there remains diagnostic uncertainty following transesop
165 lowing discussion among the consensus group, there remained disagreement in 10 cases (kappa = 0.91; 9
166 axSpA disease concept is universally agreed, there remains disagreement about operationalizing aspect
167 Hypertonic saline is used predominantly, yet there remains disagreement about whether hypertonic sali
169 AV pandemics can be traced to avian origins, there remains ever-present concern over emerging IAVs wi
170 e for the preparation of aromatic compounds, there remain few methods that allow their conversion int
172 nance of contemporary patterns of diversity, there remain few standardized biogeographic comparisons
173 idelines are appropriate for cardiology, but there remain fundamental differences between trauma and
178 iterative process of model development, and there remains great opportunity for advancing our unders
187 f the breadth of this public health problem, there remain important gaps in scientific knowledge rega
188 Mortality rates continue to be high and there remain important opportunities for further improve
189 ly on inefficient phenotypic approaches, and there remains incomplete understanding of AMR mechanisms
192 le nucleotide polymorphisms (SNPs); however, there remains large room for improvements in running tim
193 ave increased diversity in food choices, but there remains limited evidence linking these innovations
195 However, despite its clinical importance, there remains limited understanding of mechanisms underl
197 of charged energetic particles, for decades there remained little direct observational evidence that
198 d States have increased in recent years, yet there remains little attention on liposuction, or debulk
199 lume fluid administration for major surgery, there remains little consensus on optimal strategies, du
200 However, despite attention in model systems, there remains little data on how recombination rate vari
201 T1) can contribute to neuronal excitability, there remains little information on the physiological ro
204 the Expanded Program on Immunization (EPI), there remain major challenges to more effective vaccinat
205 and powerful analysis methods are available, there remain many challenges to reliable tree building.
206 e databases, and better data analysis tools, there remain many challenges to the routine use and impl
208 However, despite their apparent success, there remain many open questions about their intrinsic p
209 t has been evaluated in clinical trials, and there remain many opportunities to further investigate k
210 merous cellular targets have been described, there remain many questions about the mechanism of NSP1
213 ector secretion and host defence mechanisms, there remain many unanswered questions about fundamental
214 ion referred to as "reverse seroconversion." There remain many uncertain areas that warrant further s
217 blast cells is a well-recognized phenomenon, there remains minimal data on differences in MDR activit
218 chanisms on simplified membrane systems, but there remain missing connections between the complex env
219 nergy nuclear reactions, and we contend that there remains much interesting science to be done in thi
221 f current management of ischemic stroke, but there remains much to be learned about mechanisms of neu
222 g the surfaces of these frameworks, although there remains much to be learned about the origins of th
223 ifferences between broad tissue types exist, there remains much to be understood about the splicing f
225 ry of 2-phosphaethynolate is burgeoning, but there remains much to learn about this ligand, for examp
229 n characterizing and modeling this response, there remains no consensus as to the mechanism that driv
230 munologic injury to the renal allograft, yet there remains no consensus on how best to monitor drug t
233 eserved ejection fraction (HFpEF) in humans, there remains no evidence-based therapies for HFpEF.
236 pite intense research for the past 25 years, there remains no safe and effective vaccine available.
238 hat target proteins for therapeutic benefit, there remains no substitute for the natural properties o
239 ver, despite importance for clinical trials, there remains no transcriptomic biomarker for FSHD progr
240 with high rejection rates in MPS1 children, there remains no treatment to prevent blindness or resto
241 vaccines in preventing infectious diseases, there remain numerous globally devastating diseases with
242 ed organic matter ((3)CDOM*) reactivity, but there remain open questions about the reaction kinetics
244 espite its widespread use over four decades, there remain open questions regarding its fundamental li
247 these early years following introduction, so there remains potential for further disease reductions.
248 not yet achieved any commercial success, as there remain problems with capacity fade after extended
249 ictions and total allowable catch (TAC), but there remain problems with compliance and high levels of
251 f recurrent cardiovascular events after ACS, there remain questions about how aggressively to reduce
255 is frequently associated with cataract, but there remains scant information about DS cataract morpho
256 andidates is fully assessed by these trials, there remains scope for the discovery of inhibitors from
257 tant viruses of grapevine but, despite this, there remain several gaps in our understanding of its bi
259 h in HCV therapeutic development approaches, there remain several key obstacles to the broad implemen
263 been made on materials performance; however, there remain significant concerns about operational and
264 h hiring additional staff may be beneficial, there remain significant financial limitations for many
267 rt of efforts to eliminate malaria, however, there remain significant gaps in our understanding of mo
270 ing advances in the field of nanotechnology, there remain significant research gaps and the opportuni
271 tment for biologically plausible covariates, there remained significant associations of total 25-hydr
273 AN practice parameters was readily apparent, there remained significant variability across all 5 cate
274 ers provide maps of the "spatial gradients," there remains significant confusion because of the lack
275 nder local or general anaesthesia exist, and there remains significant debate within the field regard
276 in the pathology of CNS disorders, however, there remains significant uncertainty about the neuropro
278 sets of identified palmitoyl-proteins and so there remains some uncertainty over what constitutes the
280 g the obligate liver stage of infection, yet there remains sparse knowledge of specific host regulato
281 GPCRs) can treat multiple diseases; however, there remains substantial interest in the development of
282 roved treatment such as methadone, for which there remains the best evidence of efficacy, may be the
288 etic variants associated with schizophrenia, there remains uncertainty about the causal genes involve
289 scribed sex differences in asthma incidence, there remains uncertainty about the role of female sex h
292 recedented opportunities for drug discovery, there remains uncertainty concerning the path to the cli
294 erstanding of the molecular characteristics, there remains uncertainty regarding epidemiologic trends
297 limb loss, morbidity and mortality; however, there remains unmet therapeutic needs for arterial revas
298 ged 9 years and older has been licensed, but there remains urgent medical need for a vaccine that is
300 ss to adequate care than that at present, as there remains variation in survival between European reg